The Experts below are selected from a list of 37008 Experts worldwide ranked by ideXlab platform
Bruce R Smoller - One of the best experts on this subject based on the ideXlab platform.
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lack of specificity in Skin Biopsy specimens to assess for acute graft versus host disease in initial 3 weeks after bone marrow transplantation
Journal of The American Academy of Dermatology, 2003Co-Authors: Tracy D Kuykendall, Bruce R SmollerAbstract:Abstract Acute graft-versus-host disease is a serious and common complication after allogeneic bone-marrow transplantation, occurring in more than 20% of HLA antigen–identical sibling transplants and unrelated donor transplants. Bone-marrow transplantation is considered standard therapy for several hematologic malignancies and several nonhematologic disorders. In this retrospective study, we searched our institutional dermatopathology database between January 1998 and November 2002 for patients in whom Skin Biopsy specimens were examined less than 3 weeks after bone-marrow transplantation. A total of 40 slides from 38 patients were examined for the presence of the histologic features characteristic of acute graft-versus-host disease. Specimens of Skin biopsies examined in the study varied from 3 to 21 days, with a mean of 12 days, status post-bone-marrow transplantation. The histologic findings of the 40 slides we examined were nonspecific and could be accounted for by a number of diagnoses. In summary, we propose that Skin biopsies need not be preformed before 3 weeks status post-bone-marrow transplantation if the sole purpose is to rule out acute graft-versus-host disease.
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intraepidermal bile pigment in Skin Biopsy specimens for graft versus host disease versus erythema multiforme
Modern Pathology, 1998Co-Authors: B R Dilday, Bruce R SmollerAbstract:The differentiation of graft-verus-host disease (GVHD) from erythema multiforme (EM) presents a common diagnostic challenge in Skin Biopsy specimens from patients who have received patients allogeneic bone marrow transplants. The presence of gastrointestinal involvement might be the only way to make a diagnosis of GVHD in these cases. In the absence of liver function tests, gastrointestinal Biopsy, or molecular techniques such as microsatellite DNA analysis, the presence of intraepidermal bile pigment might prove helpful in elucidating hyperbilirubinemia and allowing a pathologist to favor a diagnosis of GVHD over EM. Routinely processed archival tissue from 50 cases of GVHD (42 Caucasian and 8 of unknown race) and 50 cases of EM (31 Caucasian and 19 of unknown race) was examined for pigmentation. Intraepidermal pigmentation was stained for bile pigment and melanin. Among the intraepidermal EM lesions, 4 (8%) stained for intracorneal melanin, but none stained for bile pigment. Among the intraepidermal GVHD lesions, 8 (16%) stained for intracorneal melanin, but 3 (6%) stained for intracorneal bile pigment. In addition, 13 (26%) GVHD lesions and 9 (18%) EM lesions showed melanosis with melanin in all layers of the epidermis as well as within papillary dermal melanophages. Thus, when presented with a differential diagnosis of GVHD versus EM, the presence of intraepidermal bile pigment might suggest liver involvement and a diagnosis of GVHD.
Esteban Abad - One of the best experts on this subject based on the ideXlab platform.
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assessment of toxicological status of a sw mediterranean segment population of striped dolphin stenella coeruleoalba using Skin Biopsy
Marine Environmental Research, 2004Co-Authors: Cristina M Fossi, Claudio Leonzio, Giancarlo Lauriano, Simone Canese, Teresa Romeo, Ruben Merino, Letizia Marsili, Stefania Ancora, Caterina Maria Fortuna, Esteban AbadAbstract:Various studies have revealed high concentrations of contaminants such as organochlorines (OCs) and heavy metals in Mediterranean cetaceans. A geographical trend of contamination (PCBs and DDTs) has been found for striped dolphin (Stenella coeruleoalba). In this study we used a non-lethal approach (Skin Biopsy) to investigate bioaccumulation of OCs, including polychlorobiphenyls (PCBs), DDTs, polychlorodibenzo-p-dioxins (PCDDs), polychlorodibenzofurans (PCDFs), trace elements (Hg, Cd, Pb) and CYP1A activity (BPMO) in nine striped dolphins sampled in the Aeolian area (Sicily – Italy) in summer 2002. The arithmetic mean value of BPMO activity in this group was 43.46 AUF/g tissue/h. This value is approximately 3 times and 5 times lower, respectively, than the value found in the Ionian and in the Ligurian groups. Skin biopsies of striped dolphins emerged as a suitable material for assessing the toxicological status of the various Mediterranean groups. 2004 Elsevier Ltd. All rights reserved.
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assessment of toxicological status of a sw mediterranean segment population of striped dolphin stenella coeruleoalba using Skin Biopsy
Marine Environmental Research, 2004Co-Authors: Cristina M Fossi, Claudio Leonzio, Giancarlo Lauriano, Simone Canese, Teresa Romeo, Ruben Merino, Letizia Marsili, Stefania Ancora, Caterina Maria Fortuna, Esteban AbadAbstract:Various studies have revealed high concentrations of contaminants such as organochlorines (OCs) and heavy metals in Mediterranean cetaceans. A geographical trend of contamination (PCBs and DDTs) has been found for striped dolphin (Stenella coeruleoalba). In this study we used a non-lethal approach (Skin Biopsy) to investigate bioaccumulation of OCs, including polychlorobiphenyls (PCBs), DDTs, polychlorodibenzo-p-dioxins (PCDDs), polychlorodibenzofurans (PCDFs), trace elements (Hg, Cd, Pb) and CYP1A activity (BPMO) in nine striped dolphins sampled in the Aeolian area (Sicily - Italy) in summer 2002. The arithmetic mean value of BPMO activity in this group was 43.46 AUF/g tissue/h. This value is approximately 3 times and 5 times lower, respectively, than the value found in the Ionian and in the Ligurian groups. Skin biopsies of striped dolphins emerged as a suitable material for assessing the toxicological status of the various Mediterranean groups.
Claudia Sommer - One of the best experts on this subject based on the ideXlab platform.
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nerve and Skin Biopsy in neuropathies
Current Opinion in Neurology, 2018Co-Authors: Claudia SommerAbstract:PURPOSE OF REVIEW To give an overview of recent data on the use of nerve and Skin Biopsy as a diagnostic tool in neuropathies. RECENT FINDINGS Axonal damage in a Biopsy from a patient with chronic inflammatory demyelinating polyradiculoneuropathy may point to the presence of autoantibodies to paranodal proteins. In nonsystemic vasculitis of the peripheral nervous system, nerve Biopsy is still the only means to make a definite diagnosis. Increased autophagy has been found in idiopathic neuropathy and may also be a common final pathway in various types of neuropathy. Nerve Biopsy has unexpectedly revealed familial amyloid neuropathy in a number of cases that were taken for idiopathic, for Charcot-Marie-Tooth disease, or for chronic inflammatory demyelinating polyradiculoneuropathy. Skin Biopsy can differentiate between length-dependent and non-length-dependent small fiber neuropathy, which aids in the etiological differential diagnosis. It can also be used to identify small fiber involvement in mixed neuropathies and for follow-up studies. SUMMARY Nerve Biopsy is still the gold standard for the diagnosis of peripheral nerve vasculitis. In other indications, sural or superficial peroneal nerve biopsies are less frequently done, because less invasive methods have become available. Modern imaging methods allow localization of nerve damage, such that targeted fascicular biopsies can be done. Immunofluorescence staining of teased nerve fibers has contributed to the understanding of the pathophysiology of inflammatory neuropathies. Skin Biopsy has become a routine method to diagnose small fiber neuropathy.
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efns guidelines on the use of Skin Biopsy in the diagnosis of peripheral neuropathy
European Journal of Neurology, 2005Co-Authors: Giuseppe Lauria, David R. Cornblath, Justin C. Mcarthur, Olle Johansson, S I Mellgren, M Nolano, N Rosenberg, Claudia SommerAbstract:immunostaining, intraepidermal, nerve fibres, painful neuropathy, peripheral neuropathy, Skin Biopsy, small fibre neuropathy
Cristina M Fossi - One of the best experts on this subject based on the ideXlab platform.
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assessment of toxicological status of a sw mediterranean segment population of striped dolphin stenella coeruleoalba using Skin Biopsy
Marine Environmental Research, 2004Co-Authors: Cristina M Fossi, Claudio Leonzio, Giancarlo Lauriano, Simone Canese, Teresa Romeo, Ruben Merino, Letizia Marsili, Stefania Ancora, Caterina Maria Fortuna, Esteban AbadAbstract:Various studies have revealed high concentrations of contaminants such as organochlorines (OCs) and heavy metals in Mediterranean cetaceans. A geographical trend of contamination (PCBs and DDTs) has been found for striped dolphin (Stenella coeruleoalba). In this study we used a non-lethal approach (Skin Biopsy) to investigate bioaccumulation of OCs, including polychlorobiphenyls (PCBs), DDTs, polychlorodibenzo-p-dioxins (PCDDs), polychlorodibenzofurans (PCDFs), trace elements (Hg, Cd, Pb) and CYP1A activity (BPMO) in nine striped dolphins sampled in the Aeolian area (Sicily – Italy) in summer 2002. The arithmetic mean value of BPMO activity in this group was 43.46 AUF/g tissue/h. This value is approximately 3 times and 5 times lower, respectively, than the value found in the Ionian and in the Ligurian groups. Skin biopsies of striped dolphins emerged as a suitable material for assessing the toxicological status of the various Mediterranean groups. 2004 Elsevier Ltd. All rights reserved.
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assessment of toxicological status of a sw mediterranean segment population of striped dolphin stenella coeruleoalba using Skin Biopsy
Marine Environmental Research, 2004Co-Authors: Cristina M Fossi, Claudio Leonzio, Giancarlo Lauriano, Simone Canese, Teresa Romeo, Ruben Merino, Letizia Marsili, Stefania Ancora, Caterina Maria Fortuna, Esteban AbadAbstract:Various studies have revealed high concentrations of contaminants such as organochlorines (OCs) and heavy metals in Mediterranean cetaceans. A geographical trend of contamination (PCBs and DDTs) has been found for striped dolphin (Stenella coeruleoalba). In this study we used a non-lethal approach (Skin Biopsy) to investigate bioaccumulation of OCs, including polychlorobiphenyls (PCBs), DDTs, polychlorodibenzo-p-dioxins (PCDDs), polychlorodibenzofurans (PCDFs), trace elements (Hg, Cd, Pb) and CYP1A activity (BPMO) in nine striped dolphins sampled in the Aeolian area (Sicily - Italy) in summer 2002. The arithmetic mean value of BPMO activity in this group was 43.46 AUF/g tissue/h. This value is approximately 3 times and 5 times lower, respectively, than the value found in the Ionian and in the Ligurian groups. Skin biopsies of striped dolphins emerged as a suitable material for assessing the toxicological status of the various Mediterranean groups.
Letizia Marsili - One of the best experts on this subject based on the ideXlab platform.
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assessment of toxicological status of a sw mediterranean segment population of striped dolphin stenella coeruleoalba using Skin Biopsy
Marine Environmental Research, 2004Co-Authors: Cristina M Fossi, Claudio Leonzio, Giancarlo Lauriano, Simone Canese, Teresa Romeo, Ruben Merino, Letizia Marsili, Stefania Ancora, Caterina Maria Fortuna, Esteban AbadAbstract:Various studies have revealed high concentrations of contaminants such as organochlorines (OCs) and heavy metals in Mediterranean cetaceans. A geographical trend of contamination (PCBs and DDTs) has been found for striped dolphin (Stenella coeruleoalba). In this study we used a non-lethal approach (Skin Biopsy) to investigate bioaccumulation of OCs, including polychlorobiphenyls (PCBs), DDTs, polychlorodibenzo-p-dioxins (PCDDs), polychlorodibenzofurans (PCDFs), trace elements (Hg, Cd, Pb) and CYP1A activity (BPMO) in nine striped dolphins sampled in the Aeolian area (Sicily – Italy) in summer 2002. The arithmetic mean value of BPMO activity in this group was 43.46 AUF/g tissue/h. This value is approximately 3 times and 5 times lower, respectively, than the value found in the Ionian and in the Ligurian groups. Skin biopsies of striped dolphins emerged as a suitable material for assessing the toxicological status of the various Mediterranean groups. 2004 Elsevier Ltd. All rights reserved.
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assessment of toxicological status of a sw mediterranean segment population of striped dolphin stenella coeruleoalba using Skin Biopsy
Marine Environmental Research, 2004Co-Authors: Cristina M Fossi, Claudio Leonzio, Giancarlo Lauriano, Simone Canese, Teresa Romeo, Ruben Merino, Letizia Marsili, Stefania Ancora, Caterina Maria Fortuna, Esteban AbadAbstract:Various studies have revealed high concentrations of contaminants such as organochlorines (OCs) and heavy metals in Mediterranean cetaceans. A geographical trend of contamination (PCBs and DDTs) has been found for striped dolphin (Stenella coeruleoalba). In this study we used a non-lethal approach (Skin Biopsy) to investigate bioaccumulation of OCs, including polychlorobiphenyls (PCBs), DDTs, polychlorodibenzo-p-dioxins (PCDDs), polychlorodibenzofurans (PCDFs), trace elements (Hg, Cd, Pb) and CYP1A activity (BPMO) in nine striped dolphins sampled in the Aeolian area (Sicily - Italy) in summer 2002. The arithmetic mean value of BPMO activity in this group was 43.46 AUF/g tissue/h. This value is approximately 3 times and 5 times lower, respectively, than the value found in the Ionian and in the Ligurian groups. Skin biopsies of striped dolphins emerged as a suitable material for assessing the toxicological status of the various Mediterranean groups.
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Skin Biopsy as a nondestructive tool for the toxicological assessment of endangered populations of pinnipeds preliminary results on mixed function oxidase in otaria flavescens
Chemosphere, 1997Co-Authors: Maria Cristina Fossi, Letizia Marsili, C Savelli, Silvia Casini, B Jimenez, M Junin, H Castello, J LorenzaniAbstract:The aim of this study was to develop and validate a method for assessing the toxicological risk of endangered populations of pinnipeds based on a nondestructive biological tool, the Skin Biopsy specimen. Skin biopsies can be obtained from pinnipeds by anaesthetising the animals and taking a small amount of Skin in the anterior flipper area, or by shooting a Biopsy dart with a crossbow. Skin Biopsy material is suitable for a wide range of chemical and biomarker analysis. Organochlorines and polycyclic aromatic hydrocarbons can be analysed in subcutaneous fat and MFO activity (BPMO), Cyt.P450 isoforms, and DNA damage can be detected in epidermis.
