The Experts below are selected from a list of 15 Experts worldwide ranked by ideXlab platform
Lata Panicker - One of the best experts on this subject based on the ideXlab platform.
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interaction of Keratolytic Drug salicylic acid with dipalmitoyl phosphatidylethanolamine vesicles
Phase Transitions, 2008Co-Authors: Lata Panicker, V Sugandhi, K P MishraAbstract:Salicylic acid (SA), a Keratolytic Drug, is used to treat skin disorder like corns, warts, and acne. To understand the mechanism by which SA interacts with the cell membranes, we have investigated its interaction with dipalmitoyl phosphatidylethanolamine (DPPE) vesicles using DSC, 1H NMR and Raman spectroscopy. Presence of Drug asymmetrically broadened the acyl chain melting transition and shifted the transition temperature, T m, to lower value. Both, NMR and DSC studies indicate that the Drug molecules are located in the glycerol backbone region of the lipid bilayer and increase the membrane headgroup fluidity. At high Drug concentration, additional transitions are observed whose intensity increases with increasing Drug concentration. In cholesterol doped DPPE dispersion the interaction of SA with DPPE bilayer is more. The transformation of the gel phase of DPPE dispersion to a stable crystalline subgel phase(s) is accelerated by the presence of SA.
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Drug-Lipid Interactions in the Model Membrane, Dppc-Water: A DSC and Proton NMR Study
Molecular Crystals and Liquid Crystals Science and Technology. Section A. Molecular Crystals and Liquid Crystals, 1996Co-Authors: K. Usha Deniz, Lata Panicker, P. S. Parvathanathan, Geeta Datta, Subramanian Vivekanandan, K. V. Ramanathan, C.l. KhetrapalAbstract:Abstract The interactions of the Keratolytic Drug Salicylic Acid (SA) and the antifungal Drugs Methyl Paraben (MPB) and Propyl Paraben (PPB) with the model membrane, DPPC-Water, have been studied using DSC and 1H NMR. The results show that these Drug molecules are situated near the membrane interface with their polar group (s) interacting with the vicinal water, while the aromatic regions and the methyl and propyl groups of MPB and PPB interact with the neighbouring hydrophobic regions of the DPPC molecule. The strength of interaction of the aromatic group is in the order PPB > MPB > SA.
K P Mishra - One of the best experts on this subject based on the ideXlab platform.
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interaction of Keratolytic Drug salicylic acid with dipalmitoyl phosphatidylethanolamine vesicles
Phase Transitions, 2008Co-Authors: Lata Panicker, V Sugandhi, K P MishraAbstract:Salicylic acid (SA), a Keratolytic Drug, is used to treat skin disorder like corns, warts, and acne. To understand the mechanism by which SA interacts with the cell membranes, we have investigated its interaction with dipalmitoyl phosphatidylethanolamine (DPPE) vesicles using DSC, 1H NMR and Raman spectroscopy. Presence of Drug asymmetrically broadened the acyl chain melting transition and shifted the transition temperature, T m, to lower value. Both, NMR and DSC studies indicate that the Drug molecules are located in the glycerol backbone region of the lipid bilayer and increase the membrane headgroup fluidity. At high Drug concentration, additional transitions are observed whose intensity increases with increasing Drug concentration. In cholesterol doped DPPE dispersion the interaction of SA with DPPE bilayer is more. The transformation of the gel phase of DPPE dispersion to a stable crystalline subgel phase(s) is accelerated by the presence of SA.
Chavan Bhagwat - One of the best experts on this subject based on the ideXlab platform.
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QUANTITATIVE ANALYSIS OF SALICYLIC ACID BULK SAMPLE USING HYDROTROPIC SOLUBILIZING AGENTS
'Innovare Academic Sciences Pvt Ltd', 2016Co-Authors: Patil Sampatti, Mehta Preeti, Chavan BhagwatAbstract:ABSTRACTObjective: The objective of this study was to facilitate titrimetric analysis of poorly water-soluble Drug, salicylic acid, using hydrotropic solubilizationtechnique, precluding the use organic solvent.Methods: In the present investigation, poorly water-soluble Keratolytic Drug, salicylic acid, has been solubilized using nicotinamide (2 M) and sodiumbenzoate (2 M) as hydrotropic agents for its titrimetric analysis instead of using an organic solvent.Results: There was an enhancement in solubility of salicylic acid in 2 M nicotinamide and sodium benzoate solutions as compared to solubility in distilledwater. The mean percent estimation in the bulk Drug sample of salicylic acid by Indian Pharmacopeial method is 98.89% while by use of proposed method,i.e., using 2 M nicotinamide and 2 M sodium benzoate solutions were 98.90% and 98.97%, respectively. Compared to sodium benzoate, salicylic acid wasfound to be more soluble in nicotinamide solution. The results of analysis by proposed method are very close to the results of the standard method.Conclusion: Proposed method is simple, economic, accurate, and reproducible and can be successfully employed in the routine quantitative analysisof Drug in bulk Drug and dosage form in industries.Keywords: Salicylic acid, Hydrotropy, Sodium benzoate, Nicotinamide, Titrimetry
Patil Sampatti - One of the best experts on this subject based on the ideXlab platform.
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QUANTITATIVE ANALYSIS OF SALICYLIC ACID BULK SAMPLE USING HYDROTROPIC SOLUBILIZING AGENTS
'Innovare Academic Sciences Pvt Ltd', 2016Co-Authors: Patil Sampatti, Mehta Preeti, Chavan BhagwatAbstract:ABSTRACTObjective: The objective of this study was to facilitate titrimetric analysis of poorly water-soluble Drug, salicylic acid, using hydrotropic solubilizationtechnique, precluding the use organic solvent.Methods: In the present investigation, poorly water-soluble Keratolytic Drug, salicylic acid, has been solubilized using nicotinamide (2 M) and sodiumbenzoate (2 M) as hydrotropic agents for its titrimetric analysis instead of using an organic solvent.Results: There was an enhancement in solubility of salicylic acid in 2 M nicotinamide and sodium benzoate solutions as compared to solubility in distilledwater. The mean percent estimation in the bulk Drug sample of salicylic acid by Indian Pharmacopeial method is 98.89% while by use of proposed method,i.e., using 2 M nicotinamide and 2 M sodium benzoate solutions were 98.90% and 98.97%, respectively. Compared to sodium benzoate, salicylic acid wasfound to be more soluble in nicotinamide solution. The results of analysis by proposed method are very close to the results of the standard method.Conclusion: Proposed method is simple, economic, accurate, and reproducible and can be successfully employed in the routine quantitative analysisof Drug in bulk Drug and dosage form in industries.Keywords: Salicylic acid, Hydrotropy, Sodium benzoate, Nicotinamide, Titrimetry
V Sugandhi - One of the best experts on this subject based on the ideXlab platform.
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interaction of Keratolytic Drug salicylic acid with dipalmitoyl phosphatidylethanolamine vesicles
Phase Transitions, 2008Co-Authors: Lata Panicker, V Sugandhi, K P MishraAbstract:Salicylic acid (SA), a Keratolytic Drug, is used to treat skin disorder like corns, warts, and acne. To understand the mechanism by which SA interacts with the cell membranes, we have investigated its interaction with dipalmitoyl phosphatidylethanolamine (DPPE) vesicles using DSC, 1H NMR and Raman spectroscopy. Presence of Drug asymmetrically broadened the acyl chain melting transition and shifted the transition temperature, T m, to lower value. Both, NMR and DSC studies indicate that the Drug molecules are located in the glycerol backbone region of the lipid bilayer and increase the membrane headgroup fluidity. At high Drug concentration, additional transitions are observed whose intensity increases with increasing Drug concentration. In cholesterol doped DPPE dispersion the interaction of SA with DPPE bilayer is more. The transformation of the gel phase of DPPE dispersion to a stable crystalline subgel phase(s) is accelerated by the presence of SA.
