The Experts below are selected from a list of 204 Experts worldwide ranked by ideXlab platform
Nicole M Scherrer - One of the best experts on this subject based on the ideXlab platform.
-
porcine urinary bladder extracellular matrix grafts acell vet corneal discs for Keratomalacia in 17 equids 2012 2013
Veterinary Ophthalmology, 2016Co-Authors: Laura A Mancuso, Mary E Lassaline, Nicole M ScherrerAbstract:Objective To describe the clinical course, outcomes, and complications associated with use of commercially available porcine urinary bladder extracellular matrix (ECM) grafts (ACell Vet® Corneal Discs) in equid patients with Keratomalacia, and to evaluate the efficacy of ECM grafts as a viable alternative to other biomaterials for corneal grafting in equid patients. Animals Sixteen horses and one donkey (17 eyes) with unilateral Keratomalacia severe enough to warrant surgical repair between August 2012 and September 2013. Procedure Retrospective medical record review to identify equid patients meeting inclusion criteria of (i) diagnosis with Keratomalacia severe enough to warrant surgical repair and (ii) surgical repair with an extracellular matrix graft. Results Eleven geldings, four mares, and two colts met inclusion criteria. Patients averaged 9 years of age. Twelve of 17 eyes (71%) were considered infected based on either corneal cytology (10/17, or 59%) or corneal culture (12/17, or 71%) positive for bacteria (8/17, or 47%) or fungi (9/17, or 53%). At the time topical medications were discontinued, 16 eyes (94%) were visual. One operated eye ruptured 5 days postoperatively and was enucleated. Keratouveitis developed in 14/14 eyes that underwent regular examinations approximately 2 weeks postoperatively which responded to systemic nonsteroidal anti-inflammatory drug therapy. Conclusions Extracellular matrix grafts may be a viable alternative to other biomaterials for corneal grafting in equids. Advantages include commercial availability and shelf storage.
-
Porcine urinary bladder extracellular matrix grafts (ACell Vet® Corneal Discs) for Keratomalacia in 17 equids (2012–2013)
Veterinary Ophthalmology, 2014Co-Authors: Laura A Mancuso, Mary E Lassaline, Nicole M ScherrerAbstract:Objective To describe the clinical course, outcomes, and complications associated with use of commercially available porcine urinary bladder extracellular matrix (ECM) grafts (ACell Vet® Corneal Discs) in equid patients with Keratomalacia, and to evaluate the efficacy of ECM grafts as a viable alternative to other biomaterials for corneal grafting in equid patients. Animals Sixteen horses and one donkey (17 eyes) with unilateral Keratomalacia severe enough to warrant surgical repair between August 2012 and September 2013. Procedure Retrospective medical record review to identify equid patients meeting inclusion criteria of (i) diagnosis with Keratomalacia severe enough to warrant surgical repair and (ii) surgical repair with an extracellular matrix graft. Results Eleven geldings, four mares, and two colts met inclusion criteria. Patients averaged 9 years of age. Twelve of 17 eyes (71%) were considered infected based on either corneal cytology (10/17, or 59%) or corneal culture (12/17, or 71%) positive for bacteria (8/17, or 47%) or fungi (9/17, or 53%). At the time topical medications were discontinued, 16 eyes (94%) were visual. One operated eye ruptured 5 days postoperatively and was enucleated. Keratouveitis developed in 14/14 eyes that underwent regular examinations approximately 2 weeks postoperatively which responded to systemic nonsteroidal anti-inflammatory drug therapy. Conclusions Extracellular matrix grafts may be a viable alternative to other biomaterials for corneal grafting in equids. Advantages include commercial availability and shelf storage.
Suzanne E Slaughter - One of the best experts on this subject based on the ideXlab platform.
-
a new classification system predicting Keratomalacia after trauma in vitamin a deficiency sodium citrate does not prevent disease progression
Cornea, 1997Co-Authors: Jeffrey L Haddox, Roswell R Pfister, Richard L Daniel, Suzanne E SlaughterAbstract:PURPOSE: The purpose of this study was to develop a classification system to predict Keratomalacia after trauma in vitamin A-deficient eyes and to determine whether citrate impedes polymorphonuclear leukocyte infiltration into the cornea, thus preventing Keratomalacia. METHODS: Preliminary classification studies showed that a 7.0-mm corneal epithelial scrape, before clinical findings of corneal xerosis, did not induce Keratomalacia. Primary studies were conducted concurrently on the same animals to develop the classification system and test the effect of citrate in vitamin A deficiency. A 7.0-mm corneal epithelial scrape was performed on vitamin A-deficient eyes in various stages of corneal xerosis and treated as follows. Experiment 1: group 1, 10% citrate drops; group 2, phosphate buffer solution (PBS) drops; experiment II: group 3, drops and subconjunctival injection of 10% citrate; group 4, drops and subconjunctival injection of PBS. RESULTS: Corneal abrasion in eyes with 2+ corneal xerosis yielded Keratomalacia in 50% of cases; the remainder healed with xerotic epithelium. Eighty-three percent of eyes with > 2+ xerosis developed Keratomalacia after corneal abrasion, whereas only 7.1% of eyes with < 2+ xerosis advanced to this stage. In experiment I, 27% of citrate-treated eyes and 38% of PBS-treated eyes developed Keratomalacia (not significant). In experiment II, two of six citrate-treated eyes perforated and one eye developed Keratomalacia. One of six control PBS eyes perforated and four developed Keratomalacia. CONCLUSION: We correlated the degree of corneal xerosis with the occurrence of Keratomalacia after corneal trauma. This led to the development of a classification scale that is of research and clinical significance. Additionally, citrate did not significantly reduce Keratomalacia or perforation in the vitamin. A-deficient eye.
Mary E Lassaline - One of the best experts on this subject based on the ideXlab platform.
-
porcine urinary bladder extracellular matrix grafts acell vet corneal discs for Keratomalacia in 17 equids 2012 2013
Veterinary Ophthalmology, 2016Co-Authors: Laura A Mancuso, Mary E Lassaline, Nicole M ScherrerAbstract:Objective To describe the clinical course, outcomes, and complications associated with use of commercially available porcine urinary bladder extracellular matrix (ECM) grafts (ACell Vet® Corneal Discs) in equid patients with Keratomalacia, and to evaluate the efficacy of ECM grafts as a viable alternative to other biomaterials for corneal grafting in equid patients. Animals Sixteen horses and one donkey (17 eyes) with unilateral Keratomalacia severe enough to warrant surgical repair between August 2012 and September 2013. Procedure Retrospective medical record review to identify equid patients meeting inclusion criteria of (i) diagnosis with Keratomalacia severe enough to warrant surgical repair and (ii) surgical repair with an extracellular matrix graft. Results Eleven geldings, four mares, and two colts met inclusion criteria. Patients averaged 9 years of age. Twelve of 17 eyes (71%) were considered infected based on either corneal cytology (10/17, or 59%) or corneal culture (12/17, or 71%) positive for bacteria (8/17, or 47%) or fungi (9/17, or 53%). At the time topical medications were discontinued, 16 eyes (94%) were visual. One operated eye ruptured 5 days postoperatively and was enucleated. Keratouveitis developed in 14/14 eyes that underwent regular examinations approximately 2 weeks postoperatively which responded to systemic nonsteroidal anti-inflammatory drug therapy. Conclusions Extracellular matrix grafts may be a viable alternative to other biomaterials for corneal grafting in equids. Advantages include commercial availability and shelf storage.
-
Porcine urinary bladder extracellular matrix grafts (ACell Vet® Corneal Discs) for Keratomalacia in 17 equids (2012–2013)
Veterinary Ophthalmology, 2014Co-Authors: Laura A Mancuso, Mary E Lassaline, Nicole M ScherrerAbstract:Objective To describe the clinical course, outcomes, and complications associated with use of commercially available porcine urinary bladder extracellular matrix (ECM) grafts (ACell Vet® Corneal Discs) in equid patients with Keratomalacia, and to evaluate the efficacy of ECM grafts as a viable alternative to other biomaterials for corneal grafting in equid patients. Animals Sixteen horses and one donkey (17 eyes) with unilateral Keratomalacia severe enough to warrant surgical repair between August 2012 and September 2013. Procedure Retrospective medical record review to identify equid patients meeting inclusion criteria of (i) diagnosis with Keratomalacia severe enough to warrant surgical repair and (ii) surgical repair with an extracellular matrix graft. Results Eleven geldings, four mares, and two colts met inclusion criteria. Patients averaged 9 years of age. Twelve of 17 eyes (71%) were considered infected based on either corneal cytology (10/17, or 59%) or corneal culture (12/17, or 71%) positive for bacteria (8/17, or 47%) or fungi (9/17, or 53%). At the time topical medications were discontinued, 16 eyes (94%) were visual. One operated eye ruptured 5 days postoperatively and was enucleated. Keratouveitis developed in 14/14 eyes that underwent regular examinations approximately 2 weeks postoperatively which responded to systemic nonsteroidal anti-inflammatory drug therapy. Conclusions Extracellular matrix grafts may be a viable alternative to other biomaterials for corneal grafting in equids. Advantages include commercial availability and shelf storage.
-
equine amniotic membrane transplantation for corneal ulceration and Keratomalacia in three horses
Veterinary Ophthalmology, 2005Co-Authors: Mary E Lassaline, Dennis Brooks, F J Ollivier, Andras M Komaromy, M E Kallberg, K N GelattAbstract:Purpose Amniotic membrane has antifibrotic, anti-angiogenic and antiprotease properties. This retrospective study was designed to investigate the use of equine amniotic membrane transplants (AMT) at preserving vision, maintaining the structural integrity of the globe and maximizing cosmesis in equine eyes with corneal ulceration and severe Keratomalacia. Methods Equine amnion had previously been aseptically harvested from a 12-year-old Thoroughbred mare during an elective Cesarean section. Sections of amnion were stored at −80 °C and thawed as needed. Records of equine cases at the University of Florida with Keratomalacia that received an AMT without adjunctive conjunctival grafting were examined. Clinical description, details of medical and surgical treatment, globe survival and visual outcome were documented. Etiologies were determined by cytology, culture or histology. Results Three horses with corneal ulceration and severe Keratomalacia received an AMT without conjunctival graft between December 2002 and April 2003. Pseudomonas spp. were cultured from all three eyes, with evidence of a concurrent fungal infection in two eyes. The three ulcers were 50, 72, and 76% of corneal diameter, and each one worsened in the face of aggressive medical therapy. In all three cases, the AMT sloughed over a 4 to 6-week period. At last follow-up, all three eyes receiving AMT were comfortable and receiving no medication, with light perception and an inconsistent location-dependent menace response. All three horses returned to their prior work. Conclusions Results of a small number of equine AMT suggest that amnion can be used successfully to preserve both globe structure and limited vision, as well as optimize cosmesis, in horse eyes with corneal ulceration and severe Keratomalacia.
Laura A Mancuso - One of the best experts on this subject based on the ideXlab platform.
-
porcine urinary bladder extracellular matrix grafts acell vet corneal discs for Keratomalacia in 17 equids 2012 2013
Veterinary Ophthalmology, 2016Co-Authors: Laura A Mancuso, Mary E Lassaline, Nicole M ScherrerAbstract:Objective To describe the clinical course, outcomes, and complications associated with use of commercially available porcine urinary bladder extracellular matrix (ECM) grafts (ACell Vet® Corneal Discs) in equid patients with Keratomalacia, and to evaluate the efficacy of ECM grafts as a viable alternative to other biomaterials for corneal grafting in equid patients. Animals Sixteen horses and one donkey (17 eyes) with unilateral Keratomalacia severe enough to warrant surgical repair between August 2012 and September 2013. Procedure Retrospective medical record review to identify equid patients meeting inclusion criteria of (i) diagnosis with Keratomalacia severe enough to warrant surgical repair and (ii) surgical repair with an extracellular matrix graft. Results Eleven geldings, four mares, and two colts met inclusion criteria. Patients averaged 9 years of age. Twelve of 17 eyes (71%) were considered infected based on either corneal cytology (10/17, or 59%) or corneal culture (12/17, or 71%) positive for bacteria (8/17, or 47%) or fungi (9/17, or 53%). At the time topical medications were discontinued, 16 eyes (94%) were visual. One operated eye ruptured 5 days postoperatively and was enucleated. Keratouveitis developed in 14/14 eyes that underwent regular examinations approximately 2 weeks postoperatively which responded to systemic nonsteroidal anti-inflammatory drug therapy. Conclusions Extracellular matrix grafts may be a viable alternative to other biomaterials for corneal grafting in equids. Advantages include commercial availability and shelf storage.
-
Porcine urinary bladder extracellular matrix grafts (ACell Vet® Corneal Discs) for Keratomalacia in 17 equids (2012–2013)
Veterinary Ophthalmology, 2014Co-Authors: Laura A Mancuso, Mary E Lassaline, Nicole M ScherrerAbstract:Objective To describe the clinical course, outcomes, and complications associated with use of commercially available porcine urinary bladder extracellular matrix (ECM) grafts (ACell Vet® Corneal Discs) in equid patients with Keratomalacia, and to evaluate the efficacy of ECM grafts as a viable alternative to other biomaterials for corneal grafting in equid patients. Animals Sixteen horses and one donkey (17 eyes) with unilateral Keratomalacia severe enough to warrant surgical repair between August 2012 and September 2013. Procedure Retrospective medical record review to identify equid patients meeting inclusion criteria of (i) diagnosis with Keratomalacia severe enough to warrant surgical repair and (ii) surgical repair with an extracellular matrix graft. Results Eleven geldings, four mares, and two colts met inclusion criteria. Patients averaged 9 years of age. Twelve of 17 eyes (71%) were considered infected based on either corneal cytology (10/17, or 59%) or corneal culture (12/17, or 71%) positive for bacteria (8/17, or 47%) or fungi (9/17, or 53%). At the time topical medications were discontinued, 16 eyes (94%) were visual. One operated eye ruptured 5 days postoperatively and was enucleated. Keratouveitis developed in 14/14 eyes that underwent regular examinations approximately 2 weeks postoperatively which responded to systemic nonsteroidal anti-inflammatory drug therapy. Conclusions Extracellular matrix grafts may be a viable alternative to other biomaterials for corneal grafting in equids. Advantages include commercial availability and shelf storage.
Jeffrey L Haddox - One of the best experts on this subject based on the ideXlab platform.
-
a new classification system predicting Keratomalacia after trauma in vitamin a deficiency sodium citrate does not prevent disease progression
Cornea, 1997Co-Authors: Jeffrey L Haddox, Roswell R Pfister, Richard L Daniel, Suzanne E SlaughterAbstract:PURPOSE: The purpose of this study was to develop a classification system to predict Keratomalacia after trauma in vitamin A-deficient eyes and to determine whether citrate impedes polymorphonuclear leukocyte infiltration into the cornea, thus preventing Keratomalacia. METHODS: Preliminary classification studies showed that a 7.0-mm corneal epithelial scrape, before clinical findings of corneal xerosis, did not induce Keratomalacia. Primary studies were conducted concurrently on the same animals to develop the classification system and test the effect of citrate in vitamin A deficiency. A 7.0-mm corneal epithelial scrape was performed on vitamin A-deficient eyes in various stages of corneal xerosis and treated as follows. Experiment 1: group 1, 10% citrate drops; group 2, phosphate buffer solution (PBS) drops; experiment II: group 3, drops and subconjunctival injection of 10% citrate; group 4, drops and subconjunctival injection of PBS. RESULTS: Corneal abrasion in eyes with 2+ corneal xerosis yielded Keratomalacia in 50% of cases; the remainder healed with xerotic epithelium. Eighty-three percent of eyes with > 2+ xerosis developed Keratomalacia after corneal abrasion, whereas only 7.1% of eyes with < 2+ xerosis advanced to this stage. In experiment I, 27% of citrate-treated eyes and 38% of PBS-treated eyes developed Keratomalacia (not significant). In experiment II, two of six citrate-treated eyes perforated and one eye developed Keratomalacia. One of six control PBS eyes perforated and four developed Keratomalacia. CONCLUSION: We correlated the degree of corneal xerosis with the occurrence of Keratomalacia after corneal trauma. This led to the development of a classification scale that is of research and clinical significance. Additionally, citrate did not significantly reduce Keratomalacia or perforation in the vitamin. A-deficient eye.
