The Experts below are selected from a list of 303 Experts worldwide ranked by ideXlab platform
Dorothea Nitsch - One of the best experts on this subject based on the ideXlab platform.
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Pre-pregnancy obesity and risk of congenital abnormalities of the Kidney and urinary tract (CAKUT)—systematic review, meta-analysis and ecological study
Pediatric Nephrology, 2020Co-Authors: Lyda Jadresić, Howard Au, Christopher Woodhouse, Dorothea NitschAbstract:Background There is increasing evidence that maternal obesity is associated with several structural birth defects. Congenital abnormalities of the Kidney and urinary tract (CAKUT) account for 30 to 50% of children starting Kidney replacement therapy (KRT). We conducted a systematic review, meta-analysis and ecological study to explore the relationship between maternal obesity and CAKUT. Methods A systematic literature search was conducted in EMBASE, MEDLINE, Global Health, The Cochrane Library, Scopus and Web of Science. Study quality was assessed for bias and confounding. A meta-analysis using a random effect model was carried out to obtain a summary odds ratio (OR) and 95% confidence interval (CI). In the ecological study, country-level data were used to examine the correlation of secular trends in female obesity, CAKUT incidence and incidence of KRT. Results Eight epidemiological studies were included in the review—4 cohort studies and 4 case-control studies—7 of which were included in the meta-analysis. There was evidence of a positive association between obesity during pregnancy and the risk of CAKUT, with a summary OR = 1.14 (1.02–1.27). No association was seen with overweight, nor a dose response with increasing obesity. There was an increasing trend in countries’ proportion of female obesity and an increasing trend in reported CAKUT incidence with specific rises seen in congenital hydronephrosis (CH) and multicystic Kidney Dysplasia (MCKD). Conclusions Our findings suggest that pre-pregnancy obesity may be associated with increased risk of CAKUT at population level. Graphical abstract
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Pre-pregnancy obesity and risk of congenital abnormalities of the Kidney and urinary tract (CAKUT)-systematic review, meta-analysis and ecological study.
Pediatric nephrology (Berlin Germany), 2020Co-Authors: Lyda Jadresic, Christopher Woodhouse, Dorothea NitschAbstract:There is increasing evidence that maternal obesity is associated with several structural birth defects. Congenital abnormalities of the Kidney and urinary tract (CAKUT) account for 30 to 50% of children starting Kidney replacement therapy (KRT). We conducted a systematic review, meta-analysis and ecological study to explore the relationship between maternal obesity and CAKUT. A systematic literature search was conducted in EMBASE, MEDLINE, Global Health, The Cochrane Library, Scopus and Web of Science. Study quality was assessed for bias and confounding. A meta-analysis using a random effect model was carried out to obtain a summary odds ratio (OR) and 95% confidence interval (CI). In the ecological study, country-level data were used to examine the correlation of secular trends in female obesity, CAKUT incidence and incidence of KRT. Eight epidemiological studies were included in the review—4 cohort studies and 4 case-control studies—7 of which were included in the meta-analysis. There was evidence of a positive association between obesity during pregnancy and the risk of CAKUT, with a summary OR = 1.14 (1.02–1.27). No association was seen with overweight, nor a dose response with increasing obesity. There was an increasing trend in countries’ proportion of female obesity and an increasing trend in reported CAKUT incidence with specific rises seen in congenital hydronephrosis (CH) and multicystic Kidney Dysplasia (MCKD). Our findings suggest that pre-pregnancy obesity may be associated with increased risk of CAKUT at population level.
Lyda Jadresić - One of the best experts on this subject based on the ideXlab platform.
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Pre-pregnancy obesity and risk of congenital abnormalities of the Kidney and urinary tract (CAKUT)—systematic review, meta-analysis and ecological study
Pediatric Nephrology, 2020Co-Authors: Lyda Jadresić, Howard Au, Christopher Woodhouse, Dorothea NitschAbstract:Background There is increasing evidence that maternal obesity is associated with several structural birth defects. Congenital abnormalities of the Kidney and urinary tract (CAKUT) account for 30 to 50% of children starting Kidney replacement therapy (KRT). We conducted a systematic review, meta-analysis and ecological study to explore the relationship between maternal obesity and CAKUT. Methods A systematic literature search was conducted in EMBASE, MEDLINE, Global Health, The Cochrane Library, Scopus and Web of Science. Study quality was assessed for bias and confounding. A meta-analysis using a random effect model was carried out to obtain a summary odds ratio (OR) and 95% confidence interval (CI). In the ecological study, country-level data were used to examine the correlation of secular trends in female obesity, CAKUT incidence and incidence of KRT. Results Eight epidemiological studies were included in the review—4 cohort studies and 4 case-control studies—7 of which were included in the meta-analysis. There was evidence of a positive association between obesity during pregnancy and the risk of CAKUT, with a summary OR = 1.14 (1.02–1.27). No association was seen with overweight, nor a dose response with increasing obesity. There was an increasing trend in countries’ proportion of female obesity and an increasing trend in reported CAKUT incidence with specific rises seen in congenital hydronephrosis (CH) and multicystic Kidney Dysplasia (MCKD). Conclusions Our findings suggest that pre-pregnancy obesity may be associated with increased risk of CAKUT at population level. Graphical abstract
Christopher Woodhouse - One of the best experts on this subject based on the ideXlab platform.
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Pre-pregnancy obesity and risk of congenital abnormalities of the Kidney and urinary tract (CAKUT)—systematic review, meta-analysis and ecological study
Pediatric Nephrology, 2020Co-Authors: Lyda Jadresić, Howard Au, Christopher Woodhouse, Dorothea NitschAbstract:Background There is increasing evidence that maternal obesity is associated with several structural birth defects. Congenital abnormalities of the Kidney and urinary tract (CAKUT) account for 30 to 50% of children starting Kidney replacement therapy (KRT). We conducted a systematic review, meta-analysis and ecological study to explore the relationship between maternal obesity and CAKUT. Methods A systematic literature search was conducted in EMBASE, MEDLINE, Global Health, The Cochrane Library, Scopus and Web of Science. Study quality was assessed for bias and confounding. A meta-analysis using a random effect model was carried out to obtain a summary odds ratio (OR) and 95% confidence interval (CI). In the ecological study, country-level data were used to examine the correlation of secular trends in female obesity, CAKUT incidence and incidence of KRT. Results Eight epidemiological studies were included in the review—4 cohort studies and 4 case-control studies—7 of which were included in the meta-analysis. There was evidence of a positive association between obesity during pregnancy and the risk of CAKUT, with a summary OR = 1.14 (1.02–1.27). No association was seen with overweight, nor a dose response with increasing obesity. There was an increasing trend in countries’ proportion of female obesity and an increasing trend in reported CAKUT incidence with specific rises seen in congenital hydronephrosis (CH) and multicystic Kidney Dysplasia (MCKD). Conclusions Our findings suggest that pre-pregnancy obesity may be associated with increased risk of CAKUT at population level. Graphical abstract
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Pre-pregnancy obesity and risk of congenital abnormalities of the Kidney and urinary tract (CAKUT)-systematic review, meta-analysis and ecological study.
Pediatric nephrology (Berlin Germany), 2020Co-Authors: Lyda Jadresic, Christopher Woodhouse, Dorothea NitschAbstract:There is increasing evidence that maternal obesity is associated with several structural birth defects. Congenital abnormalities of the Kidney and urinary tract (CAKUT) account for 30 to 50% of children starting Kidney replacement therapy (KRT). We conducted a systematic review, meta-analysis and ecological study to explore the relationship between maternal obesity and CAKUT. A systematic literature search was conducted in EMBASE, MEDLINE, Global Health, The Cochrane Library, Scopus and Web of Science. Study quality was assessed for bias and confounding. A meta-analysis using a random effect model was carried out to obtain a summary odds ratio (OR) and 95% confidence interval (CI). In the ecological study, country-level data were used to examine the correlation of secular trends in female obesity, CAKUT incidence and incidence of KRT. Eight epidemiological studies were included in the review—4 cohort studies and 4 case-control studies—7 of which were included in the meta-analysis. There was evidence of a positive association between obesity during pregnancy and the risk of CAKUT, with a summary OR = 1.14 (1.02–1.27). No association was seen with overweight, nor a dose response with increasing obesity. There was an increasing trend in countries’ proportion of female obesity and an increasing trend in reported CAKUT incidence with specific rises seen in congenital hydronephrosis (CH) and multicystic Kidney Dysplasia (MCKD). Our findings suggest that pre-pregnancy obesity may be associated with increased risk of CAKUT at population level.
K. S. Heling - One of the best experts on this subject based on the ideXlab platform.
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Antenatal diagnostic aspects of unilateral multicystic Kidney Dysplasia--sensitivity, specificity, predictive values, differential diagnoses, associated malformations and consequences.
Fetal diagnosis and therapy, 2004Co-Authors: Felicitas Eckoldt, R. Woderich, R.d. Smith, K. S. HelingAbstract:Objectives: Unilateral multicystic Kidney Dysplasia (MCKD) is the second most common urinary tract abnormality diagnosed antenatally. Whilst an isolated unilateral MCKD has a good p
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Pränatalsonographische Befunde bei obstruktiven Uropathien - positive Vorhersagefähigkeit und Bedeutung für die postnatale Therapie
Zeitschrift Fur Geburtshilfe Und Neonatologie, 2003Co-Authors: F. Eckoldt, S. Wolke, B. Stöver, C. Heinick, K. S. HelingAbstract:INTRODUCTION Prenatal diagnosis of urological anomalies is a standard procedure nowadays. The aim of this study was first to define the frequency of urinary tract anomalies in the selected patients in a level III center for prenatal diagnostics and therapy. The second aim was to show the accuracy of prenatal diagnosis in the special groups of obstructive uropathies. PATIENTS AND METHODS Postnatal diagnoses were used for control of the prenatal findings. In the 12-year retrospective study, we analyzed 21 616 pregnancies scanned for fetal anomalies. In 1 574 fetuses pediatric surgical anomalies were diagnosed. Out of 1 077 follow-ups 618 patients with urinary tract anomalies were found. RESULTS It could be shown that prenatal ultrasound has a high sensitivity for the diagnosis of obstructive renal tract anomalies. The diagnosis of subpelvine obstruction and muticystic Kidney Dysplasia can be made with an accuracy of 97 and 98 %. The therapeutic relevance of the diagnosis "isolated hydronephrosis" increases up to 60 % when mild dilatation is neglected. False negative scans for urinary tract anomalies are low at 10 %. CONCLUSION Hence, prenatal ultrasound for urinary tract anomalies is a method of high sensitivity. The therapeutic relevance is rather high. The most important question is to find all those patients who need a postnatal therapeutic approach immediately.
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Follow-up of unilateral multicystic Kidney Dysplasia after prenatal diagnosis.
The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine the Federation of Asia and , 2003Co-Authors: F. Eckoldt, R. Woderich, K. S. Heling, S. Wolke, B. Stöver, C. TennstedtAbstract:Objectives: Since the introduction of antenatal diagnostic screening, multicystic Kidney Dysplasia (MCKD) has been diagnosed in 1 of 4300 live births. We analyze our own experience and demonstrate a management regime based on these results and existing studies. Methods: Retrospective data analysis was carried out in 110 patients, prenatally diagnosed with MCDK. A total of 93 patients with confirmed diagnosis of unilateral MCDK were born alive and followed up in our institutions. Results: A total of 110 unilateral cystic Kidneys were prenatally diagnosed; 93 were confirmed postnatally. These children were retrospectively allocated to two treatment groups: 51 were operated upon; 42 were treated conservatively. A micturition cystourethrogram was performed 88 times, yielding 20 pathological findings. Vesicoureteral reflux was identified 11 times (12.5%). Eleven children (12%) had associated non-urological abnormalities. Cardiac and musculoskeletal malformations predominated. After 1995, nephrectomy was perfor...
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Prenatal diagnosis of obstructive uropathies - positive predictive value and effect on postnatal therapy
Zeitschrift fur Geburtshilfe und Neonatologie, 2003Co-Authors: F. Eckoldt, S. Wolke, B. Stöver, C. Heinick, K. S. HelingAbstract:Prenatal diagnosis of urological anomalies is a standard procedure nowadays. The aim of this study was first to define the frequency of urinary tract anomalies in the selected patients in a level III center for prenatal diagnostics and therapy. The second aim was to show the accuracy of prenatal diagnosis in the special groups of obstructive uropathies. Postnatal diagnoses were used for control of the prenatal findings. In the 12-year retrospective study, we analyzed 21 616 pregnancies scanned for fetal anomalies. In 1 574 fetuses pediatric surgical anomalies were diagnosed. Out of 1 077 follow-ups 618 patients with urinary tract anomalies were found. It could be shown that prenatal ultrasound has a high sensitivity for the diagnosis of obstructive renal tract anomalies. The diagnosis of subpelvine obstruction and muticystic Kidney Dysplasia can be made with an accuracy of 97 and 98 %. The therapeutic relevance of the diagnosis "isolated hydronephrosis" increases up to 60 % when mild dilatation is neglected. False negative scans for urinary tract anomalies are low at 10 %. Hence, prenatal ultrasound for urinary tract anomalies is a method of high sensitivity. The therapeutic relevance is rather high. The most important question is to find all those patients who need a postnatal therapeutic approach immediately.
Howard Au - One of the best experts on this subject based on the ideXlab platform.
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Pre-pregnancy obesity and risk of congenital abnormalities of the Kidney and urinary tract (CAKUT)—systematic review, meta-analysis and ecological study
Pediatric Nephrology, 2020Co-Authors: Lyda Jadresić, Howard Au, Christopher Woodhouse, Dorothea NitschAbstract:Background There is increasing evidence that maternal obesity is associated with several structural birth defects. Congenital abnormalities of the Kidney and urinary tract (CAKUT) account for 30 to 50% of children starting Kidney replacement therapy (KRT). We conducted a systematic review, meta-analysis and ecological study to explore the relationship between maternal obesity and CAKUT. Methods A systematic literature search was conducted in EMBASE, MEDLINE, Global Health, The Cochrane Library, Scopus and Web of Science. Study quality was assessed for bias and confounding. A meta-analysis using a random effect model was carried out to obtain a summary odds ratio (OR) and 95% confidence interval (CI). In the ecological study, country-level data were used to examine the correlation of secular trends in female obesity, CAKUT incidence and incidence of KRT. Results Eight epidemiological studies were included in the review—4 cohort studies and 4 case-control studies—7 of which were included in the meta-analysis. There was evidence of a positive association between obesity during pregnancy and the risk of CAKUT, with a summary OR = 1.14 (1.02–1.27). No association was seen with overweight, nor a dose response with increasing obesity. There was an increasing trend in countries’ proportion of female obesity and an increasing trend in reported CAKUT incidence with specific rises seen in congenital hydronephrosis (CH) and multicystic Kidney Dysplasia (MCKD). Conclusions Our findings suggest that pre-pregnancy obesity may be associated with increased risk of CAKUT at population level. Graphical abstract
