The Experts below are selected from a list of 11460 Experts worldwide ranked by ideXlab platform
Walter Land - One of the best experts on this subject based on the ideXlab platform.
-
Follow-up study of sensory-motor polyneuropathy in type 1 (insulin-dependent) diabetic subjects after simultaneous pancreas and Kidney transplantation and after Graft Rejection.
Diabetologia, 1991Co-Authors: Wolfgang Müller-felber, Rüdiger Landgraf, St. Wagner, N. Mair, J. Nusser, M. M. C. Landgraf-leurs, A. Abendroth, Wolf-dieter Illner, Walter LandAbstract:The influence of successful simultaneous pancreas and Kidney transplantation on peripheral polyneuropathy was investigated in 53 patients for a mean observation period of 40.3 months. Seventeen patients were followed-up for more than 3 years. Symptoms and signs were assessed every 6 months using a standard questionnaire, neurological examination and measurement of sensory and motor nerve conduction velocities. While symptoms of polyneuropathy improved (pain, paraesthesia, cramps, restless-legs) and nerve conduction velocity increased, there was no change of clinical signs (sensation, muscle-force, tendon-reflexes). Following Kidney-Graft-Rejection there was a slight decrease of nerve conduction verlocity during the first year, which was not statistically significant. Following pancreas-Graft Rejection there was no change of nerve conduction velocity during the first year. Comparing the maximum nerve conduction velocity of the patients with pancreas-Graft-Rejection to the nerve conduction velocities of these patients at the end of the study, there was a statistically significant decrease of 6.5 m/s.
-
Follow-up study of sensory-motor polyneuropathy in Type 1 (insulin-dependent) diabetic subjects after simultaneous pancreas and Kidney transplantation and after Graft Rejection
Diabetologia, 1991Co-Authors: W. M�ller-felber, Rüdiger Landgraf, St. Wagner, N. Mair, J. Nusser, M. M. C. Landgraf-leurs, A. Abendroth, Wolf-dieter Illner, Walter LandAbstract:The influence of successful simultaneous pancreas and Kidney transplantation on peripheral polyneuropathy was investigated in 53 patients for a mean observation period of 40.3 months. Seventeen patients were followed-up for more than 3 years. Symptoms and signs were assessed every 6 months using a standard questionnaire, neurological examination and measurement of sensory and motor nerve conduction velocities. While symptoms of polyneuropathy improved (pain, paraesthesia, cramps, restless-legs) and nerve conduction velocity increased, there was no change of clinical signs (sensation, muscle-force, tendon-reflexes). Following Kidney-Graft-Rejection there was a slight decrease of nerve conduction verlocity during the first year, which was not statistically significant. Following pancreas-Graft Rejection there was no change of nerve conduction velocity during the first year. Comparing the maximum nerve conduction velocity of the patients with pancreas-Graft-Rejection to the nerve conduction velocities of these patients at the end of the study, there was a statistically significant decrease of 6.5 m/s. In conclusion, we believe that strict normalization of glucose metabolism alters the progressive course of diabetic polyneuropathy. It may be stabilized or partly reversed after successful Grafting even in long-term diabetic patients.
Robert L. Fairchild - One of the best experts on this subject based on the ideXlab platform.
-
natural killer cells play a critical role in mediating inflammation and Graft failure during antibody mediated Rejection of Kidney alloGrafts
Kidney International, 2016Co-Authors: Naoki Kohei, William M Baldwin, Toshiaki Tanaka, Kazunari Tanabe, Naoya Masumori, Nina Dvorina, Anna Valujskikh, Robert L. FairchildAbstract:While the incidence of antibody-mediated Kidney Graft Rejection has increased, the key cellular and molecular participants underlying this Graft injury remain unclear. Rejection of Kidney alloGrafts in mice lacking the chemokine receptor CCR5 is dependent on production of donor-specific antibody. Here we determine if cells expressing cytotoxic function contributed to antibody-mediated Kidney alloGraft Rejection in these recipients. Wild-type C57BL/6, B6.CCR5 -/- , and B6.CD8 -/- /CCR5 -/- mice were transplanted with complete MHC-mismatched A/J Kidney Grafts, and intraGraft inflammatory components were followed to Rejection. B6.CCR5 -/- and B6.CD8 -/- /CCR5 -/- recipients rejected Kidney alloGrafts by day 35, whereas 65% of alloGrafts in wild-type recipients survived past day 80 post-transplant. Rejected alloGrafts in wild-type C57BL/6, B6.CCR5 -/- , and B6.CD8 -/- /CCR5 -/- recipients expressed high levels of VCAM-1 and MMP7 mRNA that was associated with high serum titers of donor-specific antibody. High levels of perforin and granzyme B mRNA expression peaked on day 6 post-transplant in alloGrafts in all recipients, but were absent in isoGrafts. Depletion of natural killer cells in B6.CD8 -/- /CCR5 -/- recipients reduced this expression to background levels and promoted the long-term survival of 40% of the Kidney alloGrafts. Thus, natural killer cells have a role in increased inflammation during antibody-mediated Kidney alloGraft injury and in Rejection of the Grafts.
-
Urine CXCL10/IP-10 Fingers Ongoing Antibody-Mediated Kidney Graft Rejection
Journal of the American Society of Nephrology : JASN, 2015Co-Authors: Robert L. Fairchild, Manikkam SuthanthiranAbstract:Location matters! The trafficking and positioning of cells within the innate and adaptive immune compartments are key features of the immune system that optimize the generation of responses to pathogens and to other inflammatory stimuli. This positioning is directed through the production of
-
urine cxcl10 ip 10 fingers ongoing antibody mediated Kidney Graft Rejection
Journal of The American Society of Nephrology, 2015Co-Authors: Robert L. Fairchild, Manikkam SuthanthiranAbstract:Location matters! The trafficking and positioning of cells within the innate and adaptive immune compartments are key features of the immune system that optimize the generation of responses to pathogens and to other inflammatory stimuli. This positioning is directed through the production of
Manikkam Suthanthiran - One of the best experts on this subject based on the ideXlab platform.
-
Urine CXCL10/IP-10 Fingers Ongoing Antibody-Mediated Kidney Graft Rejection
Journal of the American Society of Nephrology : JASN, 2015Co-Authors: Robert L. Fairchild, Manikkam SuthanthiranAbstract:Location matters! The trafficking and positioning of cells within the innate and adaptive immune compartments are key features of the immune system that optimize the generation of responses to pathogens and to other inflammatory stimuli. This positioning is directed through the production of
-
urine cxcl10 ip 10 fingers ongoing antibody mediated Kidney Graft Rejection
Journal of The American Society of Nephrology, 2015Co-Authors: Robert L. Fairchild, Manikkam SuthanthiranAbstract:Location matters! The trafficking and positioning of cells within the innate and adaptive immune compartments are key features of the immune system that optimize the generation of responses to pathogens and to other inflammatory stimuli. This positioning is directed through the production of
M. M. C. Landgraf-leurs - One of the best experts on this subject based on the ideXlab platform.
-
Follow-up study of sensory-motor polyneuropathy in type 1 (insulin-dependent) diabetic subjects after simultaneous pancreas and Kidney transplantation and after Graft Rejection.
Diabetologia, 1991Co-Authors: Wolfgang Müller-felber, Rüdiger Landgraf, St. Wagner, N. Mair, J. Nusser, M. M. C. Landgraf-leurs, A. Abendroth, Wolf-dieter Illner, Walter LandAbstract:The influence of successful simultaneous pancreas and Kidney transplantation on peripheral polyneuropathy was investigated in 53 patients for a mean observation period of 40.3 months. Seventeen patients were followed-up for more than 3 years. Symptoms and signs were assessed every 6 months using a standard questionnaire, neurological examination and measurement of sensory and motor nerve conduction velocities. While symptoms of polyneuropathy improved (pain, paraesthesia, cramps, restless-legs) and nerve conduction velocity increased, there was no change of clinical signs (sensation, muscle-force, tendon-reflexes). Following Kidney-Graft-Rejection there was a slight decrease of nerve conduction verlocity during the first year, which was not statistically significant. Following pancreas-Graft Rejection there was no change of nerve conduction velocity during the first year. Comparing the maximum nerve conduction velocity of the patients with pancreas-Graft-Rejection to the nerve conduction velocities of these patients at the end of the study, there was a statistically significant decrease of 6.5 m/s.
-
Follow-up study of sensory-motor polyneuropathy in Type 1 (insulin-dependent) diabetic subjects after simultaneous pancreas and Kidney transplantation and after Graft Rejection
Diabetologia, 1991Co-Authors: W. M�ller-felber, Rüdiger Landgraf, St. Wagner, N. Mair, J. Nusser, M. M. C. Landgraf-leurs, A. Abendroth, Wolf-dieter Illner, Walter LandAbstract:The influence of successful simultaneous pancreas and Kidney transplantation on peripheral polyneuropathy was investigated in 53 patients for a mean observation period of 40.3 months. Seventeen patients were followed-up for more than 3 years. Symptoms and signs were assessed every 6 months using a standard questionnaire, neurological examination and measurement of sensory and motor nerve conduction velocities. While symptoms of polyneuropathy improved (pain, paraesthesia, cramps, restless-legs) and nerve conduction velocity increased, there was no change of clinical signs (sensation, muscle-force, tendon-reflexes). Following Kidney-Graft-Rejection there was a slight decrease of nerve conduction verlocity during the first year, which was not statistically significant. Following pancreas-Graft Rejection there was no change of nerve conduction velocity during the first year. Comparing the maximum nerve conduction velocity of the patients with pancreas-Graft-Rejection to the nerve conduction velocities of these patients at the end of the study, there was a statistically significant decrease of 6.5 m/s. In conclusion, we believe that strict normalization of glucose metabolism alters the progressive course of diabetic polyneuropathy. It may be stabilized or partly reversed after successful Grafting even in long-term diabetic patients.
Wolf-dieter Illner - One of the best experts on this subject based on the ideXlab platform.
-
Follow-up study of sensory-motor polyneuropathy in type 1 (insulin-dependent) diabetic subjects after simultaneous pancreas and Kidney transplantation and after Graft Rejection.
Diabetologia, 1991Co-Authors: Wolfgang Müller-felber, Rüdiger Landgraf, St. Wagner, N. Mair, J. Nusser, M. M. C. Landgraf-leurs, A. Abendroth, Wolf-dieter Illner, Walter LandAbstract:The influence of successful simultaneous pancreas and Kidney transplantation on peripheral polyneuropathy was investigated in 53 patients for a mean observation period of 40.3 months. Seventeen patients were followed-up for more than 3 years. Symptoms and signs were assessed every 6 months using a standard questionnaire, neurological examination and measurement of sensory and motor nerve conduction velocities. While symptoms of polyneuropathy improved (pain, paraesthesia, cramps, restless-legs) and nerve conduction velocity increased, there was no change of clinical signs (sensation, muscle-force, tendon-reflexes). Following Kidney-Graft-Rejection there was a slight decrease of nerve conduction verlocity during the first year, which was not statistically significant. Following pancreas-Graft Rejection there was no change of nerve conduction velocity during the first year. Comparing the maximum nerve conduction velocity of the patients with pancreas-Graft-Rejection to the nerve conduction velocities of these patients at the end of the study, there was a statistically significant decrease of 6.5 m/s.
-
Follow-up study of sensory-motor polyneuropathy in Type 1 (insulin-dependent) diabetic subjects after simultaneous pancreas and Kidney transplantation and after Graft Rejection
Diabetologia, 1991Co-Authors: W. M�ller-felber, Rüdiger Landgraf, St. Wagner, N. Mair, J. Nusser, M. M. C. Landgraf-leurs, A. Abendroth, Wolf-dieter Illner, Walter LandAbstract:The influence of successful simultaneous pancreas and Kidney transplantation on peripheral polyneuropathy was investigated in 53 patients for a mean observation period of 40.3 months. Seventeen patients were followed-up for more than 3 years. Symptoms and signs were assessed every 6 months using a standard questionnaire, neurological examination and measurement of sensory and motor nerve conduction velocities. While symptoms of polyneuropathy improved (pain, paraesthesia, cramps, restless-legs) and nerve conduction velocity increased, there was no change of clinical signs (sensation, muscle-force, tendon-reflexes). Following Kidney-Graft-Rejection there was a slight decrease of nerve conduction verlocity during the first year, which was not statistically significant. Following pancreas-Graft Rejection there was no change of nerve conduction velocity during the first year. Comparing the maximum nerve conduction velocity of the patients with pancreas-Graft-Rejection to the nerve conduction velocities of these patients at the end of the study, there was a statistically significant decrease of 6.5 m/s. In conclusion, we believe that strict normalization of glucose metabolism alters the progressive course of diabetic polyneuropathy. It may be stabilized or partly reversed after successful Grafting even in long-term diabetic patients.
