The Experts below are selected from a list of 147 Experts worldwide ranked by ideXlab platform
Samuel M. Cohen - One of the best experts on this subject based on the ideXlab platform.
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diuron induced rat urinary bladder carcinogenesis mode of action and human relevance evaluations using the international programme on chemical safety framework
Critical Reviews in Toxicology, 2014Co-Authors: Mitscheli Sanches Da Rocha, Lora L Arnold, Maria Luiza Cotrim Sartor De Oliveira, Shadia Ihlaseh M Catalano, Ana Paula Ferragut Cardoso, Merielen Garcia Nascimento E Pontes, Bianca Ferrucio, Puttappa R Dodmane, Samuel M. CohenAbstract:Diuron, a high volume substituted urea herbicide, induced high incidences of urinary bladder carcinomas and low incidences of Kidney Pelvis papillomas and carcinomas in rats exposed to high doses (2500 ppm) in a 2-year bioassay. Diuron is registered for both occupational and residential uses and is used worldwide for more than 30 different crops. The proposed rat urothelial mode of action (MOA) for this herbicide consists of metabolic activation to metabolites that are excreted and concentrated in the urine, leading to cytotoxicity, urothelial cell necrosis and exfoliation, regenerative hyperplasia, and eventually tumors. We show evidence for this MOA for diuron using the International Programme on Chemical Safety (IPCS) conceptual framework for evaluating an MOA for chemical carcinogens, and the United States Environmental Protection Agency (USEPA) and IPCS framework for assessing human relevance.
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Handbook of Toxicologic Pathology (Second Edition) - 34 – Lower Urinary Tract
Handbook of Toxicologic Pathology, 2002Co-Authors: Samuel M. Cohen, Hideaki Wanibuchi, Shoji FukushimaAbstract:This chapter describes toxicologic pathology of lower urinary tract. The lower urinary tract extends from the Kidney Pelvis bilaterally through the ureters, into the urinary bladder, and ultimately out the urethra. It functions primarily to transport urine formed in the Kidneys to the urinary bladder for storage until ultimate excretion. The structure and function of the lower urinary tract are similar in all mammals, including the structure of a unique lining epithelium, the urothelium. The urothelium lining the Kidney Pelvis is a continuation of the single cell epithelial lining of the renal papilla. It becomes the usual three-celled thickness of rodent urothelium within a short distance of the fornix, increasing in cell number as it approaches the ureter. The urothelium (particularly of the urinary bladder) can be the target for toxic effects because it comes in contact with most chemicals or their metabolites excreted in the urine in concentrated quantities. The response to toxicity and the development of tumors are similar in rats and mice and both have numerous similarities to the response in humans, making these species excellent animal models for a variety of human disorders.
Mitscheli Sanches Da Rocha - One of the best experts on this subject based on the ideXlab platform.
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diuron induced rat urinary bladder carcinogenesis mode of action and human relevance evaluations using the international programme on chemical safety framework
Critical Reviews in Toxicology, 2014Co-Authors: Mitscheli Sanches Da Rocha, Lora L Arnold, Maria Luiza Cotrim Sartor De Oliveira, Shadia Ihlaseh M Catalano, Ana Paula Ferragut Cardoso, Merielen Garcia Nascimento E Pontes, Bianca Ferrucio, Puttappa R Dodmane, Samuel M. CohenAbstract:Diuron, a high volume substituted urea herbicide, induced high incidences of urinary bladder carcinomas and low incidences of Kidney Pelvis papillomas and carcinomas in rats exposed to high doses (2500 ppm) in a 2-year bioassay. Diuron is registered for both occupational and residential uses and is used worldwide for more than 30 different crops. The proposed rat urothelial mode of action (MOA) for this herbicide consists of metabolic activation to metabolites that are excreted and concentrated in the urine, leading to cytotoxicity, urothelial cell necrosis and exfoliation, regenerative hyperplasia, and eventually tumors. We show evidence for this MOA for diuron using the International Programme on Chemical Safety (IPCS) conceptual framework for evaluating an MOA for chemical carcinogens, and the United States Environmental Protection Agency (USEPA) and IPCS framework for assessing human relevance.
Felix E. Karpinski - One of the best experts on this subject based on the ideXlab platform.
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Urinary-Tract Malformations
2009Co-Authors: Leonard S. Girsh, Felix E. KarpinskiAbstract:IN the past twenty years little mention has been made in the American literature of the familial occurrence of urinary-tract malformations. Reports on cases of double Kidney, Pelvis and ureter in families are rare and confined entirely to foreign publications.1 2 3 4 Because the literature on this subject is scanty and the relation is probably much more common than has previously been known, it was thought advisable to publish our observations of upper-urinary-tract duplication involving 3 of 4 members of a family. Case Reports Case 1. N.T., a 5-year-old girl, was admitted to the hospital on February 2, 1953, with complaints of . . .
Christoffer Johansen - One of the best experts on this subject based on the ideXlab platform.
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Incidences of Kidney, Pelvis, Ureter, and Bladder Cancer in a Nationwide, Population-based Cancer Registry, Denmark, 1944-2003
Urology, 2009Co-Authors: Axel Wihlborg, Christoffer JohansenAbstract:Objectives To determine changes in the population-based incidence rates, degree of histologic verification, and morphologic distribution of tumors of the Kidney, Pelvis, and ureter and bladder in both sexes for the duration of 60 years in Denmark. Methods Age-standardized incidence rates in 5-year age and calendar intervals, histologic verification and morphologic distribution were derived from reports to the Danish Cancer Registry. Results The incidence of Kidney tumors increased by 78% among men and 32% among women during the study period; the incidence of Pelvis and ureter tumors increased by 1070% and 2785%, respectively, and those of bladder tumors increased by 325% and 195%, respectively. The incidence of Wilms tumor was stable; the incidence of other Kidney tumors leveled out during the last 30 years of the period and those of other 2 groups during the last 20 years. The frequency of histologic verification was stable for Pelvis and ureter cancers and Wilms tumor and increased for Kidney and bladder tumors. Most of the Kidney tumors were of epithelial origin and most others were of urothelial origin. Conclusions The overall incidences of all tumors increased in both sexes during the 60-year period. Some of the increase could be due to improved diagnosis. The recent decline in rates might be due to reduced exposure to risk factors.
Ninghan Feng - One of the best experts on this subject based on the ideXlab platform.
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The Pelvis urinary microbiome in patients with Kidney stones and clinical associations
BMC microbiology, 2020Co-Authors: Fengping Liu, Nan Zhang, Wu Yunhong, Peng Jiang, Tingting Jiang, Yang Wang, Yuwei Zhang, Qixiao Zhai, Yeqing Zou, Ninghan FengAbstract:The long-held notion that, without urinary tract or circulatory infection, bladder urine and blood are sterile biofluids has been disproven. There have been no previous reports on the Kidney Pelvis urinary microbiome after bladder disinfection in Kidney stone patients. This study aimed to determine whether a Kidney Pelvis urinary microbiome is present after eliminating the influence of the bladder urinary microbiome, whether the microbiome composition is different in patients with stone Kidney Pelvis (SKP) and non-stone Kidney Pelvis (NSKP), and the correlation between SKP and patient clinical characteristics. Comparisons of bacterial diversity and community structure exhibited that urine in bladder was similar to SKP and NSKP. However, the comparisons showed that urine samples were different from blood. The most common operational taxonomic units were shared by all three types of urine samples. Corynebacterium was significantly higher in SKP compared to NSKP. Several bacteria were associated with patient characteristics, including Lactobacillus, which was positively correlated with fasting blood glucose, and Prevotella was negatively correlated with BMI. Lactobacillus was significantly higher in SKP compared to blood but not in NSKP compared to blood. The composition of the Kidney Pelvis urinary microbiome after disinfection of the bladder and its similarity to the bladder microbiome indicate that bladder urine can be used to replace Kidney Pelvis urine in microbiome research. Additionally, the comparison of SKP and NSKP and clinical associations suggest that the occurrence of Kidney stones is responsible for the SKP urinary microbiome.
