The Experts below are selected from a list of 3183 Experts worldwide ranked by ideXlab platform
Kirsty G. Pringle - One of the best experts on this subject based on the ideXlab platform.
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relationship between maternal global nutrient restriction during pregnancy and offspring Kidney Structure and function a systematic review of animal studies
American Journal of Physiology-renal Physiology, 2019Co-Authors: Yu Qi Lee, Clare E. Collins, Kym Rae, Emma L Beckett, Dean V Sculley, Kirsty G. PringleAbstract:Maternal undernutrition during pregnancy is prevalent across the globe, and the origins of many chronic diseases can be traced back to in utero conditions. This systematic review considers the curr...
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The relationship between maternal obesity and diabetes during pregnancy on offspring Kidney Structure and function in humans: a systematic review.
Journal of developmental origins of health and disease, 2018Co-Authors: Yu Qi Lee, Clare E. Collins, Adrienne Gordon, Kym Rae, Kirsty G. PringleAbstract:Evidence from animal models indicates that exposure to an obesogenic or hyperglycemic intrauterine environment adversely impacts offspring Kidney development and renal function. However, evidence from human studies has not been evaluated systematically. Therefore, the aim of this systematic review was to synthesize current research in humans that has examined the relationship between gestational obesity and/or diabetes and offspring Kidney Structure and function. Systematic electronic database searches were conducted of five relevant databases (CINAHL, Cochrane, EMBASE, MEDLINE and Scopus). Preferred Reporting Items for Systematic Reviews and Meta-analysis guidelines were followed, and articles screened by two independent reviewers generated nine eligible papers for inclusion. Six studies were assessed as being of 'neutral' quality, two of 'negative' and one 'positive' quality. Observational studies suggest that offspring exposed to a hyperglycemic intrauterine environment are more likely to display markers of renal dysfunction and are at higher risk of end-stage renal disease. There was limited and inconsistent evidence for a link between exposure to an obesogenic intrauterine environment and offspring renal outcomes. Offspring renal outcome measures across studies were diverse, with a large variation in offspring age at follow-up, limiting comparability across studies. The collective current body of evidence suggests that intrauterine exposure to maternal obesity and/or diabetes adversely impacts renal programming in offspring, with an increased risk of Kidney disease in adulthood. Further high-quality, longitudinal, prospective cohort studies that measure indicators of offspring renal development and function, including fetal Kidney volume and albuminuria, at standardized follow-up time points, are warranted.
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The Relationship between Maternal Nutrition during Pregnancy and Offspring Kidney Structure and Function in Humans: A Systematic Review.
Nutrients, 2018Co-Authors: Yu Qi Lee, Clare E. Collins, Adrienne Gordon, Kym Rae, Kirsty G. PringleAbstract:The intrauterine environment is critical for fetal growth and organ development. Evidence from animal models indicates that the developing Kidney is vulnerable to suboptimal maternal nutrition and changes in health status. However, evidence from human studies are yet to be synthesised. Therefore, the aim of the current study was to systematically review current research on the relationship between maternal nutrition during pregnancy and offspring Kidney Structure and function in humans. A search of five databases identified 9501 articles, of which three experimental and seven observational studies met the inclusion criteria. Nutrients reviewed to date included vitamin A (n = 3), folate and vitamin B12 (n = 2), iron (n = 1), vitamin D (n = 1), total energy (n = 2) and protein (n = 1). Seven studies were assessed as being of “positive” and three of “neutral” quality. A variety of populations were studied, with limited studies investigating maternal nutrition during pregnancy, while measurements of offspring Kidney outcomes were diverse across studies. There was a lack of consistency in the timing of follow-up for offspring Kidney Structure and/or function assessments, thus limiting comparability between studies. Deficiencies in maternal folate, vitamin A, and total energy during pregnancy were associated with detrimental impacts on Kidney Structure and function, measured by Kidney volume, proteinuria, eGFRcystC and mean creatinine clearance in the offspring. Additional experimental and longitudinal prospective studies are warranted to confirm this relationship, especially in Indigenous populations where the risk of renal disease is greater.
Clare E. Collins - One of the best experts on this subject based on the ideXlab platform.
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relationship between maternal global nutrient restriction during pregnancy and offspring Kidney Structure and function a systematic review of animal studies
American Journal of Physiology-renal Physiology, 2019Co-Authors: Yu Qi Lee, Clare E. Collins, Kym Rae, Emma L Beckett, Dean V Sculley, Kirsty G. PringleAbstract:Maternal undernutrition during pregnancy is prevalent across the globe, and the origins of many chronic diseases can be traced back to in utero conditions. This systematic review considers the curr...
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The relationship between maternal obesity and diabetes during pregnancy on offspring Kidney Structure and function in humans: a systematic review.
Journal of developmental origins of health and disease, 2018Co-Authors: Yu Qi Lee, Clare E. Collins, Adrienne Gordon, Kym Rae, Kirsty G. PringleAbstract:Evidence from animal models indicates that exposure to an obesogenic or hyperglycemic intrauterine environment adversely impacts offspring Kidney development and renal function. However, evidence from human studies has not been evaluated systematically. Therefore, the aim of this systematic review was to synthesize current research in humans that has examined the relationship between gestational obesity and/or diabetes and offspring Kidney Structure and function. Systematic electronic database searches were conducted of five relevant databases (CINAHL, Cochrane, EMBASE, MEDLINE and Scopus). Preferred Reporting Items for Systematic Reviews and Meta-analysis guidelines were followed, and articles screened by two independent reviewers generated nine eligible papers for inclusion. Six studies were assessed as being of 'neutral' quality, two of 'negative' and one 'positive' quality. Observational studies suggest that offspring exposed to a hyperglycemic intrauterine environment are more likely to display markers of renal dysfunction and are at higher risk of end-stage renal disease. There was limited and inconsistent evidence for a link between exposure to an obesogenic intrauterine environment and offspring renal outcomes. Offspring renal outcome measures across studies were diverse, with a large variation in offspring age at follow-up, limiting comparability across studies. The collective current body of evidence suggests that intrauterine exposure to maternal obesity and/or diabetes adversely impacts renal programming in offspring, with an increased risk of Kidney disease in adulthood. Further high-quality, longitudinal, prospective cohort studies that measure indicators of offspring renal development and function, including fetal Kidney volume and albuminuria, at standardized follow-up time points, are warranted.
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The Relationship between Maternal Nutrition during Pregnancy and Offspring Kidney Structure and Function in Humans: A Systematic Review.
Nutrients, 2018Co-Authors: Yu Qi Lee, Clare E. Collins, Adrienne Gordon, Kym Rae, Kirsty G. PringleAbstract:The intrauterine environment is critical for fetal growth and organ development. Evidence from animal models indicates that the developing Kidney is vulnerable to suboptimal maternal nutrition and changes in health status. However, evidence from human studies are yet to be synthesised. Therefore, the aim of the current study was to systematically review current research on the relationship between maternal nutrition during pregnancy and offspring Kidney Structure and function in humans. A search of five databases identified 9501 articles, of which three experimental and seven observational studies met the inclusion criteria. Nutrients reviewed to date included vitamin A (n = 3), folate and vitamin B12 (n = 2), iron (n = 1), vitamin D (n = 1), total energy (n = 2) and protein (n = 1). Seven studies were assessed as being of “positive” and three of “neutral” quality. A variety of populations were studied, with limited studies investigating maternal nutrition during pregnancy, while measurements of offspring Kidney outcomes were diverse across studies. There was a lack of consistency in the timing of follow-up for offspring Kidney Structure and/or function assessments, thus limiting comparability between studies. Deficiencies in maternal folate, vitamin A, and total energy during pregnancy were associated with detrimental impacts on Kidney Structure and function, measured by Kidney volume, proteinuria, eGFRcystC and mean creatinine clearance in the offspring. Additional experimental and longitudinal prospective studies are warranted to confirm this relationship, especially in Indigenous populations where the risk of renal disease is greater.
Yu Qi Lee - One of the best experts on this subject based on the ideXlab platform.
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relationship between maternal global nutrient restriction during pregnancy and offspring Kidney Structure and function a systematic review of animal studies
American Journal of Physiology-renal Physiology, 2019Co-Authors: Yu Qi Lee, Clare E. Collins, Kym Rae, Emma L Beckett, Dean V Sculley, Kirsty G. PringleAbstract:Maternal undernutrition during pregnancy is prevalent across the globe, and the origins of many chronic diseases can be traced back to in utero conditions. This systematic review considers the curr...
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The relationship between maternal obesity and diabetes during pregnancy on offspring Kidney Structure and function in humans: a systematic review.
Journal of developmental origins of health and disease, 2018Co-Authors: Yu Qi Lee, Clare E. Collins, Adrienne Gordon, Kym Rae, Kirsty G. PringleAbstract:Evidence from animal models indicates that exposure to an obesogenic or hyperglycemic intrauterine environment adversely impacts offspring Kidney development and renal function. However, evidence from human studies has not been evaluated systematically. Therefore, the aim of this systematic review was to synthesize current research in humans that has examined the relationship between gestational obesity and/or diabetes and offspring Kidney Structure and function. Systematic electronic database searches were conducted of five relevant databases (CINAHL, Cochrane, EMBASE, MEDLINE and Scopus). Preferred Reporting Items for Systematic Reviews and Meta-analysis guidelines were followed, and articles screened by two independent reviewers generated nine eligible papers for inclusion. Six studies were assessed as being of 'neutral' quality, two of 'negative' and one 'positive' quality. Observational studies suggest that offspring exposed to a hyperglycemic intrauterine environment are more likely to display markers of renal dysfunction and are at higher risk of end-stage renal disease. There was limited and inconsistent evidence for a link between exposure to an obesogenic intrauterine environment and offspring renal outcomes. Offspring renal outcome measures across studies were diverse, with a large variation in offspring age at follow-up, limiting comparability across studies. The collective current body of evidence suggests that intrauterine exposure to maternal obesity and/or diabetes adversely impacts renal programming in offspring, with an increased risk of Kidney disease in adulthood. Further high-quality, longitudinal, prospective cohort studies that measure indicators of offspring renal development and function, including fetal Kidney volume and albuminuria, at standardized follow-up time points, are warranted.
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The Relationship between Maternal Nutrition during Pregnancy and Offspring Kidney Structure and Function in Humans: A Systematic Review.
Nutrients, 2018Co-Authors: Yu Qi Lee, Clare E. Collins, Adrienne Gordon, Kym Rae, Kirsty G. PringleAbstract:The intrauterine environment is critical for fetal growth and organ development. Evidence from animal models indicates that the developing Kidney is vulnerable to suboptimal maternal nutrition and changes in health status. However, evidence from human studies are yet to be synthesised. Therefore, the aim of the current study was to systematically review current research on the relationship between maternal nutrition during pregnancy and offspring Kidney Structure and function in humans. A search of five databases identified 9501 articles, of which three experimental and seven observational studies met the inclusion criteria. Nutrients reviewed to date included vitamin A (n = 3), folate and vitamin B12 (n = 2), iron (n = 1), vitamin D (n = 1), total energy (n = 2) and protein (n = 1). Seven studies were assessed as being of “positive” and three of “neutral” quality. A variety of populations were studied, with limited studies investigating maternal nutrition during pregnancy, while measurements of offspring Kidney outcomes were diverse across studies. There was a lack of consistency in the timing of follow-up for offspring Kidney Structure and/or function assessments, thus limiting comparability between studies. Deficiencies in maternal folate, vitamin A, and total energy during pregnancy were associated with detrimental impacts on Kidney Structure and function, measured by Kidney volume, proteinuria, eGFRcystC and mean creatinine clearance in the offspring. Additional experimental and longitudinal prospective studies are warranted to confirm this relationship, especially in Indigenous populations where the risk of renal disease is greater.
Ryuichi Nishinakamura - One of the best experts on this subject based on the ideXlab platform.
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Generation of a Three-Dimensional Kidney Structure from Pluripotent Stem Cells.
Methods in molecular biology (Clifton N.J.), 2017Co-Authors: Yasuhiro Yoshimura, Atsuhiro Taguchi, Ryuichi NishinakamuraAbstract:The Kidney is a vital organ that has an important role in the maintenance of homeostasis by fluid volume regulation and waste product excretion. This role cannot be performed without the three-dimensional (3D) Structure of the Kidney. Therefore, it is important to generate the 3D Structure of the Kidney when inducing functional Kidney tissue or the whole organ from pluripotent stem cells. In this chapter, we describe the detailed methods to induce Kidney progenitor cells from pluripotent stem cells, which are based on embryological development. We also provide a method to generate 3D Kidney tissue with vascularized glomeruli upon transplantation.
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Essential roles of Sall family genes in Kidney development.
The journal of physiological sciences : JPS, 2006Co-Authors: Ryuichi Nishinakamura, Kenji OsafuneAbstract:We isolated a mouse Sall1, a mammalian homologue of the Drosophila region-specific homeotic gene spalt (sal), and found that mice deficient in Sall1 die in the perinatal period from Kidney agenesis. Sall1 is expressed in the metanephric mesenchyme surrounding the ureteric bud, and the homozygous deletion of Sall1 results in an incomplete ureteric bud outgrowth. Therefore Sall1 is essential for ureteric bud invasion, the initial key step for metanephros development. We also set up an in vitro culture system, using NIH3T3 cells stably expressing Wnt4 as a feeder layer, to identify Kidney progenitors in the metanephric mesenchyme. In this culture condition, a single renal progenitor in the mesenchyme forms colonies consisting of several types of epithelial cells that exist in glomeruli and renal tubules. We found that only cells strongly expressing Sall1 (Sall1-GFP(high) cells) form colonies and that they reconstitute a three-dimensional Kidney Structure in an organ culture setting. Thus our colony-forming assay, which identifies multipotent progenitors in the embryonic mouse Kidney, can be used for examining mechanisms of renal progenitor differentiation.
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Identification of multipotent progenitors in the embryonic mouse Kidney by a novel colony-forming assay.
Development (Cambridge England), 2005Co-Authors: Kenji Osafune, Minoru Takasato, Andreas Kispert, Makoto Asashima, Ryuichi NishinakamuraAbstract:Renal stem or progenitor cells with a multilineage differentiation potential remain to be isolated, and the differentiation mechanism of these cell types in Kidney development or regeneration processes is unknown. In an attempt to resolve this issue, we set up an in vitro culture system using NIH3T3 cells stably expressing Wnt4 (3T3Wnt4) as a feeder layer, in which a single renal progenitor in the metanephric mesenchyme forms colonies consisting of several types of epithelial cells that exist in glomeruli and renal tubules. We found that only cells strongly expressing Sall1 (Sall1-GFPhigh cells), a zinc-finger nuclear factor essential for Kidney development, form colonies, and that they reconstitute a three-dimensional Kidney Structure in an organ culture setting. We also found that Rac- and JNK-dependent planar cell polarity (PCP) pathways downstream of Wnt4 positively regulate the colony size, and that the JNK pathway is also involved in mesenchymal-to-epithelial transformation of colony-forming progenitors. Thus our colony-forming assay, which identifies multipotent progenitors in the embryonic mouse Kidney, can be used for examining mechanisms of renal progenitor differentiation.
Kym Rae - One of the best experts on this subject based on the ideXlab platform.
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relationship between maternal global nutrient restriction during pregnancy and offspring Kidney Structure and function a systematic review of animal studies
American Journal of Physiology-renal Physiology, 2019Co-Authors: Yu Qi Lee, Clare E. Collins, Kym Rae, Emma L Beckett, Dean V Sculley, Kirsty G. PringleAbstract:Maternal undernutrition during pregnancy is prevalent across the globe, and the origins of many chronic diseases can be traced back to in utero conditions. This systematic review considers the curr...
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The relationship between maternal obesity and diabetes during pregnancy on offspring Kidney Structure and function in humans: a systematic review.
Journal of developmental origins of health and disease, 2018Co-Authors: Yu Qi Lee, Clare E. Collins, Adrienne Gordon, Kym Rae, Kirsty G. PringleAbstract:Evidence from animal models indicates that exposure to an obesogenic or hyperglycemic intrauterine environment adversely impacts offspring Kidney development and renal function. However, evidence from human studies has not been evaluated systematically. Therefore, the aim of this systematic review was to synthesize current research in humans that has examined the relationship between gestational obesity and/or diabetes and offspring Kidney Structure and function. Systematic electronic database searches were conducted of five relevant databases (CINAHL, Cochrane, EMBASE, MEDLINE and Scopus). Preferred Reporting Items for Systematic Reviews and Meta-analysis guidelines were followed, and articles screened by two independent reviewers generated nine eligible papers for inclusion. Six studies were assessed as being of 'neutral' quality, two of 'negative' and one 'positive' quality. Observational studies suggest that offspring exposed to a hyperglycemic intrauterine environment are more likely to display markers of renal dysfunction and are at higher risk of end-stage renal disease. There was limited and inconsistent evidence for a link between exposure to an obesogenic intrauterine environment and offspring renal outcomes. Offspring renal outcome measures across studies were diverse, with a large variation in offspring age at follow-up, limiting comparability across studies. The collective current body of evidence suggests that intrauterine exposure to maternal obesity and/or diabetes adversely impacts renal programming in offspring, with an increased risk of Kidney disease in adulthood. Further high-quality, longitudinal, prospective cohort studies that measure indicators of offspring renal development and function, including fetal Kidney volume and albuminuria, at standardized follow-up time points, are warranted.
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The Relationship between Maternal Nutrition during Pregnancy and Offspring Kidney Structure and Function in Humans: A Systematic Review.
Nutrients, 2018Co-Authors: Yu Qi Lee, Clare E. Collins, Adrienne Gordon, Kym Rae, Kirsty G. PringleAbstract:The intrauterine environment is critical for fetal growth and organ development. Evidence from animal models indicates that the developing Kidney is vulnerable to suboptimal maternal nutrition and changes in health status. However, evidence from human studies are yet to be synthesised. Therefore, the aim of the current study was to systematically review current research on the relationship between maternal nutrition during pregnancy and offspring Kidney Structure and function in humans. A search of five databases identified 9501 articles, of which three experimental and seven observational studies met the inclusion criteria. Nutrients reviewed to date included vitamin A (n = 3), folate and vitamin B12 (n = 2), iron (n = 1), vitamin D (n = 1), total energy (n = 2) and protein (n = 1). Seven studies were assessed as being of “positive” and three of “neutral” quality. A variety of populations were studied, with limited studies investigating maternal nutrition during pregnancy, while measurements of offspring Kidney outcomes were diverse across studies. There was a lack of consistency in the timing of follow-up for offspring Kidney Structure and/or function assessments, thus limiting comparability between studies. Deficiencies in maternal folate, vitamin A, and total energy during pregnancy were associated with detrimental impacts on Kidney Structure and function, measured by Kidney volume, proteinuria, eGFRcystC and mean creatinine clearance in the offspring. Additional experimental and longitudinal prospective studies are warranted to confirm this relationship, especially in Indigenous populations where the risk of renal disease is greater.
