The Experts below are selected from a list of 37941 Experts worldwide ranked by ideXlab platform
Athanase Billis - One of the best experts on this subject based on the ideXlab platform.
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multilocular cystic renal cell carcinoma a report of 45 cases of a Kidney Tumor of low malignant potential
American Journal of Clinical Pathology, 2006Co-Authors: Sueli Suzigan, Antonio Lopezbeltran, Rodolfo Montironi, Ricardo Drut, Ana Romero, Tomayoshi Hayashi, Ana L C Gentili, Paulo S P Fonseca, Ines Detorres, Athanase BillisAbstract:The 2004 World Health Organization (WHO) classification of Kidney Tumors recognizes multilocular cystic renal cell carcinoma (MCRCC) as a rare variant of clear cell renal cell carcinoma with a good prognosis. Available information on its clinical significance is limited. The study cohort included 45 MCRCC cases classified according to 2004 WHO criteria obtained through a multi-institutional international search. Most patients had unilateral MCRCC with no side predominance that was found incidentally; 62% were men, but women had Tumors at an earlier age (P = .385). MCRCC occurred slightly more often in men than in women (1.7:1). At diagnosis, 82% of patients had stage T1 and 16%, stage T2; 1 patient had stage T3. The Fuhrman grade was 1 (62%) or 2 (38%), with smaller Tumors (
Inderbir S Gill - One of the best experts on this subject based on the ideXlab platform.
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histological analysis of the Kidney Tumor parenchyma interface
The Journal of Urology, 2015Co-Authors: Raed A Azhar, Andre Luis De Castro Abreu, Eric J Broxham, Andy Sherrod, Tania Gill, Mihir M Desai, Inderbir S GillAbstract:Purpose: During enucleative partial nephrectomy excision is performed adjacent to the Tumor edge. To better determine the oncologic propriety of enucleative partial nephrectomy we histologically examined the Tumor-parenchyma interface.Materials and Methods: Archived hematoxylin and eosin stained slides of 124 nephrectomy specimens were rereviewed. We evaluated representative sections of Tumor abutting the renal parenchyma and overlying pseudocapsule/perirenal fat were selected at 4 mm2 sectors apportioned 1, 2, 3 and 4 mm, respectively, from the Tumor edge.Results: Median Tumor size was 3.5 cm. Of the Tumors 111 were malignant (90%) and 119 (96%) had a pseudocapsule with a median thickness of 0.6 mm. Of malignant and benign Tumors 82% and 31%, respectively, had an intrarenal pseudocapsule (p <0.001). Pseudocapsule invasion was noted in 45% of cancers and 15% of benign Tumors (p <0.04). Of pT1a cancers 36% showed intrarenal pseudocapsule invasion. No patient had positive surgical margins. Intrarenal pseudo...
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Kidney Tumor location measurement using the c index method
The Journal of Urology, 2010Co-Authors: Matthew N Simmons, Christina B Ching, Mary K Samplaski, Chin Hyong Park, Inderbir S GillAbstract:Purpose: Tumor location assessment is essential to plan nephron sparing Kidney surgery. We describe a method to quantify the proximity of Kidney Tumors to the renal central sinus for reporting and surgical management.Materials and Methods: Centrality index scoring was done using standard 2-dimensional cross-sectional computerized tomography images in 133 consecutive patients undergoing transperitoneal laparoscopic partial nephrectomy between September 2003 and November 2005. The Pythagorean theorem was used to calculate the distance from Tumor center to Kidney center. The distance was divided by Tumor radius to obtain the centrality index. We assessed the correlation of the centrality index with laparoscopic partial nephrectomy operative parameters and the urological complication rate. Centrality index accuracy and interobserver variability were assessed.Results: A centrality index of 0 equates to a Tumor that is concentric with the center of the Kidney. A centrality index of 1 equates to a Tumor with its...
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factors predicting renal functional outcome after partial nephrectomy
The Journal of Urology, 2007Co-Authors: Brian R. Lane, Inderbir S Gill, Christopher J. Weight, Benjamin T. Larson, Denise C Babineau, Emilio D Poggio, Andrew C. NovickAbstract:Purpose: Compared to radical nephrectomy, partial nephrectomy better preserves renal parenchyma and function. Although several clinical factors may impact renal function after partial nephrectomy including preoperative function, age, gender and comorbidities, the contributions of Tumor and surgical factors have not been well studied. We evaluate independent factors predicting functional outcomes after partial nephrectomy.Materials and Methods: Preoperative and all postoperative serum creatinine values for 1,169 patients undergoing partial nephrectomy were used to estimate glomerular filtration rate. Postoperative nadir glomerular filtration rate and ultimate glomerular filtration rate were analyzed using multiple pertinent covariates.Results: Median preoperative, postoperative nadir and ultimate glomerular filtration rates were 77, 57 and 71 ml per minute per 1.73 m2, respectively. Increasing age, gender, lower preoperative glomerular filtration rate, solitary Kidney, Tumor size, ischemia time and longer ...
Qianjin Shen - One of the best experts on this subject based on the ideXlab platform.
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study of 320 slice dynamic volume ct perfusion in different pathologic types of Kidney Tumor preliminary results
PLOS ONE, 2014Co-Authors: Chao Chen, Qi Liu, Qiang Hao, Huojun Zhang, Qianjin ShenAbstract:Objective To investigate microcirculatory differences between pathologic types of Kidney Tumor using 320-slice dynamic volume CT perfusion. Methods Perfusion imaging with 320-slice dynamic volume CT was prospectively performed in 85 patients with pathologically proven clear cell renal cell carcinoma (RCC) (n = 66), papillary RCC (n = 7), chromophobe RCC (n = 5), angiomyolipoma (AML) with minimal fat (n = 7), or RCC (n = 78). Equivalent blood volume (Equiv BV), permeability surface-area product (PS; clearance/unit volume = permeability), and blood flow (BF) of Tumor and normal renal cortex were measured and analyzed. Effective radiation dose was calculated. Results There was a significant difference in all three parameters between Tumor and normal renal cortex (P<0.001). Equiv BV was significantly different between RCC and AML with minimal fat (P = 0.038) and between clear cell RCC and AML with minimal fat (P<0.001). Mean Equiv BV and BF were significantly higher in clear cell RCC than in papillary RCC (P<0.001 for both) and mean Equiv BV was higher in clear cell RCC than in chromophobe RCC (P<0.001). The effective radiation dose of the CT perfusion protocol was 18.5 mSv. Conclusion Perfusion imaging using 320-slice dynamic volume CT can be used to evaluate hemodynamic features of the whole Kidney and Kidney Tumors, which may be useful in the differential diagnosis of these four pathologic types of Kidney Tumor.
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Study of 320-Slice Dynamic Volume CT Perfusion in Different Pathologic Types of Kidney Tumor: Preliminary Results
2014Co-Authors: Chao Chen, Qi Liu, Qiang Hao, Huojun Zhang, Qianjin ShenAbstract:ObjectiveTo investigate microcirculatory differences between pathologic types of Kidney Tumor using 320-slice dynamic volume CT perfusion.MethodsPerfusion imaging with 320-slice dynamic volume CT was prospectively performed in 85 patients with pathologically proven clear cell renal cell carcinoma (RCC) (n = 66), papillary RCC (n = 7), chromophobe RCC (n = 5), angiomyolipoma (AML) with minimal fat (n = 7), or RCC (n = 78). Equivalent blood volume (Equiv BV), permeability surface-area product (PS; clearance/unit volume = permeability), and blood flow (BF) of Tumor and normal renal cortex were measured and analyzed. Effective radiation dose was calculated.ResultsThere was a significant difference in all three parameters between Tumor and normal renal cortex (P
Sueli Suzigan - One of the best experts on this subject based on the ideXlab platform.
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multilocular cystic renal cell carcinoma a report of 45 cases of a Kidney Tumor of low malignant potential
American Journal of Clinical Pathology, 2006Co-Authors: Sueli Suzigan, Antonio Lopezbeltran, Rodolfo Montironi, Ricardo Drut, Ana Romero, Tomayoshi Hayashi, Ana L C Gentili, Paulo S P Fonseca, Ines Detorres, Athanase BillisAbstract:The 2004 World Health Organization (WHO) classification of Kidney Tumors recognizes multilocular cystic renal cell carcinoma (MCRCC) as a rare variant of clear cell renal cell carcinoma with a good prognosis. Available information on its clinical significance is limited. The study cohort included 45 MCRCC cases classified according to 2004 WHO criteria obtained through a multi-institutional international search. Most patients had unilateral MCRCC with no side predominance that was found incidentally; 62% were men, but women had Tumors at an earlier age (P = .385). MCRCC occurred slightly more often in men than in women (1.7:1). At diagnosis, 82% of patients had stage T1 and 16%, stage T2; 1 patient had stage T3. The Fuhrman grade was 1 (62%) or 2 (38%), with smaller Tumors (
Antonio Cardesa - One of the best experts on this subject based on the ideXlab platform.
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malignant pigmented clear cell epithelioid Tumor of the Kidney clear cell sugar Tumor versus malignant melanoma
Human Pathology, 2000Co-Authors: Teresa Ribalta, Josep Lloreta, Assumpcio Munne, Sergi Serrano, Antonio CardesaAbstract:Abstract A 73-year-old woman presented with an hemorrhagic KidneyTumor initially interpreted as a renal cell carcinoma (RCC). A retroperitoneal recurrence infiltrating the duodenal wall was made up of clear cells, some of which contained Fontana-Masson positive pigment, immunopositive for HMB45, 5-100 protein, actin, and vimentin. The same immunohistochemical profile was retrospectively reproduced in the Kidney Tumor, where melanosomes were also found ultrastructurally. Lipomatous differentiation was not observed. There was no history of malignant melanoma (MM), or stigmata of tuberous sclerosis. The patient died of disease 5 years after the initial diagnosis. This neoplasm can be considered as a malignant, pigmented, clearcell epithelioid variant of angiomyolipoma, or "sugar" Tumor of the Kidney, with the peculiarity of having a previously unreported component of pigmented cells visible on light microscopy. This finding raises the possibility that the exceptional cases of MM reported in renal parenchyma may be pigmented variants of epithelioid angiomyolipoma rather than true MM.
