The Experts below are selected from a list of 264 Experts worldwide ranked by ideXlab platform
Kazuo Kubota - One of the best experts on this subject based on the ideXlab platform.
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Kikuchi Disease 18f fdg positron emission tomography computed tomography of lymph node uptake
Japanese Journal of Radiology, 2010Co-Authors: Kimiteru Ito, Miyako Morooka, Kazuo KubotaAbstract:Purpose This study evaluated 18F-fluorodeoxyglucose (FDG) positron emission tomography (PET)/computed tomography (CT) findings in patients with Kikuchi Disease (KD), or histiocytic necrotizing lymphadenitis.
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Kikuchi Disease: ^18F-FDG positron emission tomography/computed tomography of lymph node uptake
Japanese Journal of Radiology, 2010Co-Authors: Kimiteru Ito, Miyako Morooka, Kazuo KubotaAbstract:Purpose This study evaluated ^18F-fluorodeoxyglucose (FDG) positron emission tomography (PET)/computed tomography (CT) findings in patients with Kikuchi Disease (KD), or histiocytic necrotizing lymphadenitis. Materials and methods We evaluated the ^18F-FDG PET/ CT findings of seven patients (one man, six women) with KD, ranging in age from 23 to 66 years (mean 36 years). All the patients had been diagnosed based on the pathological findings of a biopsy and clinical course. Results The maximum standard uptake values (SUVmax) of FDG uptake in affected lymph nodes were 2.05–13.94 (mean ± SD, 6.25 ± 3.32). In all the patients but two, the lymph nodes with the SUVmax were located in the neck. All the lymph nodes had a diameter of
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f 18 fdg pet ct findings showing lymph node uptake in patients with Kikuchi Disease
Clinical Nuclear Medicine, 2009Co-Authors: Kimiteru Ito, Miyako Morooka, Kazuo KubotaAbstract:Two women with Kikuchi Disease (KD) underwent F-18 fluorodeoxyglucose (FDG) positron emission tomography (PET)/computed tomography (CT). These findings mimicked malignant lymphoma. KD had been diagnosed based on the pathologic findings of a biopsy. The lymph nodes with the maximum standardized uptake value (SUVmax) were located in the neck and the axilla. All the lymph nodes had a diameter of less than 2.5 cm. F-18 FDG PET/CT was capable of visualizing general regions containing lymph nodes. KD should be considered when making a differential diagnosis of FDG-avid lymph node lesions in the neck or axilla.
Kimiteru Ito - One of the best experts on this subject based on the ideXlab platform.
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Kikuchi Disease 18f fdg positron emission tomography computed tomography of lymph node uptake
Japanese Journal of Radiology, 2010Co-Authors: Kimiteru Ito, Miyako Morooka, Kazuo KubotaAbstract:Purpose This study evaluated 18F-fluorodeoxyglucose (FDG) positron emission tomography (PET)/computed tomography (CT) findings in patients with Kikuchi Disease (KD), or histiocytic necrotizing lymphadenitis.
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Kikuchi Disease: ^18F-FDG positron emission tomography/computed tomography of lymph node uptake
Japanese Journal of Radiology, 2010Co-Authors: Kimiteru Ito, Miyako Morooka, Kazuo KubotaAbstract:Purpose This study evaluated ^18F-fluorodeoxyglucose (FDG) positron emission tomography (PET)/computed tomography (CT) findings in patients with Kikuchi Disease (KD), or histiocytic necrotizing lymphadenitis. Materials and methods We evaluated the ^18F-FDG PET/ CT findings of seven patients (one man, six women) with KD, ranging in age from 23 to 66 years (mean 36 years). All the patients had been diagnosed based on the pathological findings of a biopsy and clinical course. Results The maximum standard uptake values (SUVmax) of FDG uptake in affected lymph nodes were 2.05–13.94 (mean ± SD, 6.25 ± 3.32). In all the patients but two, the lymph nodes with the SUVmax were located in the neck. All the lymph nodes had a diameter of
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f 18 fdg pet ct findings showing lymph node uptake in patients with Kikuchi Disease
Clinical Nuclear Medicine, 2009Co-Authors: Kimiteru Ito, Miyako Morooka, Kazuo KubotaAbstract:Two women with Kikuchi Disease (KD) underwent F-18 fluorodeoxyglucose (FDG) positron emission tomography (PET)/computed tomography (CT). These findings mimicked malignant lymphoma. KD had been diagnosed based on the pathologic findings of a biopsy. The lymph nodes with the maximum standardized uptake value (SUVmax) were located in the neck and the axilla. All the lymph nodes had a diameter of less than 2.5 cm. F-18 FDG PET/CT was capable of visualizing general regions containing lymph nodes. KD should be considered when making a differential diagnosis of FDG-avid lymph node lesions in the neck or axilla.
Hae Young Seol - One of the best experts on this subject based on the ideXlab platform.
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Comparison of ultrasonographic findings of biopsy-proven tuberculous lymphadenitis and Kikuchi Disease
Korean journal of radiology, 2015Co-Authors: Inseon Ryoo, Sang-il Suh, Young Hen Lee, Hyung Suk Seo, Hae Young SeolAbstract:OBJECTIVE Although tuberculous lymphadenitis and Kikuchi Disease are common causes of cervical lymphadenopathy in Asians and exhibit similar clinical manifestations, their treatment strategies are totally different. The purpose of this study was to identify ultrasonographic features that distinguish these two Diseases. MATERIALS AND METHODS This study was approved by the Institutional Review Board. The study included 77 patients with tuberculous lymphadenitis and 135 patients with Kikuchi Disease. The sex and age distributions of the patients were analyzed. The size and shape of lymph nodes (LNs), presence of conglomeration, increased perinodal echogenicity, echogenic hilum, posterior neck involvement, internal calcification, patterns of internal necrosis, laterality of involved LNs, and hilar vascular patterns on ultrasonography were compared between the two groups. Multiple logistic regression analysis was conducted to identify independent findings to discriminate tuberculous lymphadenitis from Kikuchi Disease. Finally, diagnostic accuracies were calculated using the independent findings. RESULTS The presence of an echogenic hilum, internal calcification, patterns of internal necrosis, and LN hilar vascular structures on power Doppler ultrasonography were independent findings that discriminated tuberculous lymphadenitis from Kikuchi Disease. The diagnostic accuracy of each of these four factors was 84.9% (181/212), 76.9% (163/212), 84% (178/212), and 89.2% (189/212), respectively. A combination of internal calcification and hilar vascular structures showed the best accuracy of 89.6% (190/212) (sensitivity, 86.7% [117/135]; specificity, 94.8% [73/77]) for diagnosing Kikuchi Disease. CONCLUSION The presence of an echogenic hilum, internal calcification, pattern of internal necrosis, and LN hilar vascular structures are useful ultrasonographic findings to differentiate tuberculous lymphadenitis from Kikuchi Disease.
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Gray Scale and Power Doppler Study of Biopsy-Proven Kikuchi Disease
Journal of ultrasound in medicine : official journal of the American Institute of Ultrasound in Medicine, 2011Co-Authors: Jung Lim Yoo, Sang-il Suh, Young Hen Lee, Hyung Suk Seo, Kyoung Min Kim, Bong Kyung Shin, Joon Young Song, Hae Young SeolAbstract:OBJECTIVES Kikuchi Disease is a benign, self-limiting cause of cervical lymphadenopathy. It can show sonographic features similar to those of other common causes of lymphadenopathy. The purpose of this study was to characterize the sonographic features of Kikuchi Disease that can contribute in differentiating between Kikuchi Disease and other Diseases causing cervical lymphadenopathy. METHODS Sonographic findings of 175 patients with biopsy-proven Kikuchi Disease were retrospectively reviewed. The mean age of the patients was 27.3 years, and the female to male ratio was 3.5:1. All patients had undergone sonographically guided core biopsy. Pathologic findings were classified into proliferative (n = 57), necrotizing (n = 109), and xanthomatous (n = 9) types. On gray scale sonography, lymph nodes were assessed by their size, shape (shortest/longest axis ratio), location, echogenicity, presence of conglomeration, gross necrosis, calcification, echogenic nodal hilum, and increased perinodal echogenicity. The vascular pattern was assessed on power Doppler imaging. RESULTS The mean maximum diameter of the lymph nodes was 1.6 cm. Forty-four percent of them (77 of 175) were oval (shortest/longest axis ratio, 0.5-0.7) and 48% (84 of 175) were elongated (shortest/longest axis ratio,
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ct findings in Kikuchi Disease analysis of 96 cases
American Journal of Neuroradiology, 2004Co-Authors: Soon Young Kwon, Taik Kun Kim, Young Sik Kim, Ki Yeol Lee, Nam Joon Lee, Hae Young SeolAbstract:BACKGROUND AND PURPOSE: Although CT findings of Kikuchi Disease (KD), or histiocytic necrotizing lymphadenitis, are reported in several case reports, large-scale analysis of the Disease has not been undertaken. We characterized the clinical and CT findings in a large group of patients with KD. METHODS: Between 1990 and 2002, 96 patients (68 women, 28 men; mean age, 24.4 years) underwent biopsy of the cervical lymph nodes and had histologically proved KD at our institution. We reviewed their clinical and CT findings and recorded the total number of affected nodes; location and size of the lymph nodes; and characteristic findings including necrosis, perinodal infiltration, and contrast enhancement. RESULTS: We identified 1196 affected lymph nodes (12.5 nodes per patient). The affected lymph nodes were 0.5–3.5 cm (mean, 1.62 cm). Perinodal infiltration was found in 78 patients (81.3%). Eighty (83.3%) had homogeneous nodal contrast enhancement. Nine patients (9.4%) had lymph nodes with a focal low attenuation, and seven (7.3%) had ring-shaped lymph nodes. Unilateral and bilateral cervical lymph nodes were affected in 76 and 20 patients, respectively. Lymph nodes were mainly located at levels II (IIA, 174 nodes; IIB, 254 nodes), III (222 nodes), IV (160 nodes), and V (VA 126 nodes, VB 130 nodes). Follow-up CT in 32 patients showed complete resolution in 14 and partially improved lymphadenopathy in 18. CONCLUSION: Awareness of the various CT appearances of KD and follow-up CT may be helpful for more accurate diagnosis of the Disease.
Bo Kyu Kim - One of the best experts on this subject based on the ideXlab platform.
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Cervical necrotic lymphadenopathy: a diagnostic tree analysis model based on CT and clinical findings
European Radiology, 2019Co-Authors: Sung-hye You, Byungjun Kim, Kyung-sook Yang, Bo Kyu KimAbstract:Objectives To establish a diagnostic tree analysis (DTA) model based on computed tomography (CT) findings and clinical information for differential diagnosis of cervical necrotic lymphadenopathy, especially in regions where tuberculous lymphadenitis and Kikuchi Disease are common. Methods A total of 290 patients (147 men and 143 women; mean age (years), 46.2 ± 19.5; range, 3–91) with pathologically confirmed metastasis ( n = 110), tuberculous lymphadenitis ( n = 73), Kikuchi Disease ( n = 71), and lymphoma ( n = 36) who underwent contrast-enhanced neck CT were included. The patients were randomly divided into training (86%, 248/290) and validation (14%, 42/290) datasets to assess diagnostic performance of the DTA model. Two sorts of DTA models were created using a classification and regression tree algorithm on the basis of CT findings alone and that combined with clinical findings. Results In the DTA model based on CT findings alone, perinodal infiltration, number of the necrotic foci, percentage of necrotic lymph node (LN), degree of necrosis, margin and shape of the necrotic portion, shape of the LN, and enhancement ratio (cutoff value, 1.93) were significant predictors for differential diagnosis of cervical necrotic lymphadenopathy. The overall accuracy was 80.6% and 73.8% in training and validation datasets. In the model based on imaging and clinical findings, tenderness, history of underlying malignancy, percentage of necrotic LN, degree of necrosis, and number of necrotic foci were significant predictors. The overall accuracy was 87.1% and 88.1% in training and external validation datasets. Conclusions The DTA model based on CT imaging and clinical findings may be helpful for the diagnosis of cervical necrotic lymphadenopathy. Key Points • The diagnostic tree analysis model based on CT may be useful for differential diagnosis of cervical necrotic lymphadenopathy. • Perinodal infiltration, number of necrotic foci, percentage of necrotic lymph nodes, degree of necrosis, margin and shape of necrotic portion, lymph node shape, and enhancement ratio were the most significant predictors.
Woo Ick Yang - One of the best experts on this subject based on the ideXlab platform.
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Questionable Role of Human Herpesviruses in the Pathogenesis of Kikuchi Disease
Archives of Pathology & Laboratory Medicine, 2007Co-Authors: Min-sun Cho, Hee Jung Choi, Hae Kyung Park, Sung Eun Cho, Woon Sup Han, Woo Ick YangAbstract:Abstract Context.—Kikuchi Disease is a self-limiting febrile lymphadenopathy characterized by a patchy area of apoptosis. Kikuchi Disease is thought to be caused by a virus, but this has not been clearly demonstrated. Human herpesviruses 6 and 7 (HHV-6 and HHV-7) are lymphotropic viruses that can induce apoptosis in infected lymphocytes. Recently, HHV-8 was reported to be a possible etiologic agent of Kikuchi Disease. Objective.—To investigate the incidence of HHV-6, HHV-7, and HHV-8 infection in patients with Kikuchi Disease. Design.—Seventy archival tissue specimens (from 50 Kikuchi Disease cases and 20 control cases) were tested for the presence of HHV-6 and HHV-7 using a nested polymerase chain reaction, and for the presence of HHV-8 using single-step polymerase chain reaction. Immunohistochemistry for HHV-8 expression was carried out in those cases in which HHV-8 was detected using polymerase chain reaction. Results.—Of the 50 cases with Kikuchi Disease, 21 (42%) were HHV-6 positive and 32 (64%) were HHV-7 positive. Eight (40%) of the 20 control cases were HHV-6 positive and 9 (45%) were HHV-7 positive. Both HHV-6 and HHV-7 were detected in 15 (30%) of the cases with Kikuchi Disease and in 3 (15%) of the control cases. Three (6%) of the 50 cases of Kikuchi Disease were HHV-8 positive but revealed no positive cells on immunohistochemical analysis for HHV-8. Human herpesvirus 8 was not expressed in any of the control cases. Conclusions.—There was no association between the presence of HHV-6 or HHV-7 and Kikuchi Disease. Because the HHV-8 genome but not protein was detected in a small proportion of the cases of Kikuchi Disease, its potential causative role in this Disease should be determined by further studies.
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Questionable Role of Human Herpesviruses in the Pathogenesis of Kikuchi Disease
Archives of pathology & laboratory medicine, 2007Co-Authors: Min-sun Cho, Hee Jung Choi, Hae Kyung Park, Sung Eun Cho, Woon Sup Han, Woo Ick YangAbstract:Abstract Context.—Kikuchi Disease is a self-limiting febrile lymphadenopathy characterized by a patchy area of apoptosis. Kikuchi Disease is thought to be caused by a virus, but this has not been clearly demonstrated. Human herpesviruses 6 and 7 (HHV-6 and HHV-7) are lymphotropic viruses that can induce apoptosis in infected lymphocytes. Recently, HHV-8 was reported to be a possible etiologic agent of Kikuchi Disease. Objective.—To investigate the incidence of HHV-6, HHV-7, and HHV-8 infection in patients with Kikuchi Disease. Design.—Seventy archival tissue specimens (from 50 Kikuchi Disease cases and 20 control cases) were tested for the presence of HHV-6 and HHV-7 using a nested polymerase chain reaction, and for the presence of HHV-8 using single-step polymerase chain reaction. Immunohistochemistry for HHV-8 expression was carried out in those cases in which HHV-8 was detected using polymerase chain reaction. Results.—Of the 50 cases with Kikuchi Disease, 21 (42%) were HHV-6 positive and 32 (64%) were...
