The Experts below are selected from a list of 25371 Experts worldwide ranked by ideXlab platform
Xue Z Wang - One of the best experts on this subject based on the ideXlab platform.
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metastable zone width crystal nucleation and growth Kinetics Measurement in anti solvent crystallization of β artemether in the mixture of ethanol and water
Chemical Engineering Research & Design, 2015Co-Authors: Yang Zhang, Yanbin Jiang, Duanke Zhang, Yu Qian, Xue Z WangAbstract:Abstract The production of β-artemether, (3,12-epoxy-12 h-pyrano (4,3-j)-1,2-benzodioxepin, C16H26O5), an important active pharmaceutical ingredient for the treatment of malaria, uses crystallization as the purification step. This paper investigates the Metastable Zone Width (MSZW), nucleation and crystal growth Kinetics of anti-solvent crystallization for β-artemether in ethanol + water system where water is the anti-solvent. Using a turbidity probe, the effect of process variables on MSZW was investigated, including initial the mass ratio of the solute to solvent, temperature, introduction rate as well as introduction location of the anti-solvent. The prediction model for MSZW was calibrated and proved reliable for this system. For anti-solvent crystallization of β-artemether in ethanol + water system, the chord length distribution data was collected using Focused Beam Reflectance Measurement, based on which the nucleation and crystal growth parameters were estimated using the method of moment. The crystal growth mechanism of β-artemether was also studied using a hot stage and imaging system and was found to follow a layer-by-layer growth mechanism.
Kazuhiro Mae - One of the best experts on this subject based on the ideXlab platform.
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Operation of microfluidic liquid slug formation and slug design for Kinetics Measurement
Chemical Engineering Science, 2007Co-Authors: Kazuo Matsuyama, Wiroon Tanthapanichakoon, Nobuaki Aoki, Kazuhiro MaeAbstract:Abstract This paper reports experimental investigation of mixing performances inside microfluidic liquid slugs using the Villermaux–Dushman reaction. Slug-based microfluidics offers rapid mixing by internal circulation and transport with narrow residence time distribution, making it suitable for precise reaction and mixing operations. The experimental investigation presents operation methods to form microfluidic liquid slugs having the reactant arrangements. Mixing performances of flows with and without internal circulation are compared and mixing rates for the axial and radial arrangements of reactants are also compared. Moreover, for the radial arrangement, mixing performances can be evaluated using a dimensionless number irrespective of flow rate and slug length, based on the novel method discussed in our previous paper, which proposes the modified Peclet number Pe * to estimate mixing rates and design liquid slugs to obtain desired mixing rates. These results give support to the suggestions by the previous simulation results.
Yang Zhang - One of the best experts on this subject based on the ideXlab platform.
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Towards a consistent understanding of the metal hydride reaction Kinetics: Measurement, modeling and data processing
Journal of Alloys and Compounds, 2018Co-Authors: Fusheng Yang, Yang Zhang, Francesco Ciucci, Shumao Wang, Yuqi Wang, Zaoxiao ZhangAbstract:Abstract Hydriding/dehydriding reaction Kinetics of metal hydrides (MH) is an important yet controversial issue. In the last few decades, numerous studies have been dedicated to elaborate the reaction phenomena for various hydride materials. Some crucial aspects sketching the physical picture of the reaction, e.g. the controlling mechanism, Avrami exponent as well as apparent activation energy, are frequently discussed using the solid-state kinetic models. It is noted, however, that the results show considerable disagreement even for the material prepared in a single batch. From the literature review, it appears that no consistent understanding on the reaction Kinetics of hydride materials could ever be achieved, unless carefully selected models and appropriate statistical processing techniques are used to interpret data obtained from well-designed experiments.
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metastable zone width crystal nucleation and growth Kinetics Measurement in anti solvent crystallization of β artemether in the mixture of ethanol and water
Chemical Engineering Research & Design, 2015Co-Authors: Yang Zhang, Yanbin Jiang, Duanke Zhang, Yu Qian, Xue Z WangAbstract:Abstract The production of β-artemether, (3,12-epoxy-12 h-pyrano (4,3-j)-1,2-benzodioxepin, C16H26O5), an important active pharmaceutical ingredient for the treatment of malaria, uses crystallization as the purification step. This paper investigates the Metastable Zone Width (MSZW), nucleation and crystal growth Kinetics of anti-solvent crystallization for β-artemether in ethanol + water system where water is the anti-solvent. Using a turbidity probe, the effect of process variables on MSZW was investigated, including initial the mass ratio of the solute to solvent, temperature, introduction rate as well as introduction location of the anti-solvent. The prediction model for MSZW was calibrated and proved reliable for this system. For anti-solvent crystallization of β-artemether in ethanol + water system, the chord length distribution data was collected using Focused Beam Reflectance Measurement, based on which the nucleation and crystal growth parameters were estimated using the method of moment. The crystal growth mechanism of β-artemether was also studied using a hot stage and imaging system and was found to follow a layer-by-layer growth mechanism.
Enzo Mangano - One of the best experts on this subject based on the ideXlab platform.
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Sorption Kinetics: Measurement of surface resistance
Adsorption, 2020Co-Authors: Douglas M. Ruthven, Jörg Kärger, Stefano Brandani, Enzo ManganoAbstract:The problem of measuring sorption Kinetics in microporous adsorbents and distinguishing experimentally between surface resistance and internal diffusion is discussed and reviewed with reference to several commonly used experimental techniques; direct uptake rate Measurements, zero length column (ZLC), frequency response, PFG NMR and interference microscopy.
Kazuo Matsuyama - One of the best experts on this subject based on the ideXlab platform.
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Operation of microfluidic liquid slug formation and slug design for Kinetics Measurement
Chemical Engineering Science, 2007Co-Authors: Kazuo Matsuyama, Wiroon Tanthapanichakoon, Nobuaki Aoki, Kazuhiro MaeAbstract:Abstract This paper reports experimental investigation of mixing performances inside microfluidic liquid slugs using the Villermaux–Dushman reaction. Slug-based microfluidics offers rapid mixing by internal circulation and transport with narrow residence time distribution, making it suitable for precise reaction and mixing operations. The experimental investigation presents operation methods to form microfluidic liquid slugs having the reactant arrangements. Mixing performances of flows with and without internal circulation are compared and mixing rates for the axial and radial arrangements of reactants are also compared. Moreover, for the radial arrangement, mixing performances can be evaluated using a dimensionless number irrespective of flow rate and slug length, based on the novel method discussed in our previous paper, which proposes the modified Peclet number Pe * to estimate mixing rates and design liquid slugs to obtain desired mixing rates. These results give support to the suggestions by the previous simulation results.
