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Steven J Svoboda - One of the best experts on this subject based on the ideXlab platform.

  • control normalized fisher ratio analysis of comprehensive two dimensional gas chromatography time of flight mass spectrometry data for enhanced biomarker discovery in a metabolomic study of orthopedic Knee Ligament Injury
    Analytical Chemistry, 2020
    Co-Authors: Sarah E Prebihalo, Kenneth L Cameron, Steven J Svoboda, Grant S Ochoa, Kelsey L Berrier, Kristen J Skogerboe, Jesse R Trump, Kenneth J Wickiser, Robert E Synovec
    Abstract:

    An innovative form of Fisher ratio (F-ratio) analysis (FRA) is developed for use with comprehensive two-dimensional gas chromatography/time-of-flight mass spectrometry (GC × GC-TOFMS) data and applied to the investigation of the changes in the metabolome in human plasma for patients with Injury to their anterior cruciate Ligament (ACL). Specifically, FRA provides a supervised discovery of metabolites that express a statistically significant variance in a two-sample class comparison: patients and healthy controls. The standard F-ratio utilizes the between-class variance relative to the pooled within-class variance. Because standard FRA is adversely impacted by metabolites expressed with a large within-class variance in the patient class, "control-normalized FRA" has been developed to provide complementary information, by normalizing the between-class variance to the variance of the control class only. Thirty plasma samples from patients who recently suffered from an ACL Injury, along with matched controls, were subjected to GC × GC-TOFMS analysis. Following both standard and control-normalized FRA, the concentration ratio for the top 30 "hits" in each comparison was obtained and then t-tested for statistical significance. Twenty four out of 30 metabolites plus the therapeutic agent, naproxen (24/30), passed the t-test for the control-normalized FRA, which included 8/24 unique to control-normalized FRA and 16/24 in common with the standard FRA. Likewise, standard FRA provided 21/30 metabolites passing the t-test, with 5/21 undiscovered by control-normalized FRA. The complementary information obtained by both F-ratio analyses demonstrates the general utility of the new approach for a variety of applications.

  • reference values for the marx activity rating scale in a young athletic population history of Knee Ligament Injury is associated with higher scores
    Sports Health: A Multidisciplinary Approach, 2015
    Co-Authors: Kenneth L Cameron, Brandon S Thompson, Karen Y Peck, Brett D Owens, Steven J Svoboda, Stephen W Marshall
    Abstract:

    Background:Activity-related patient-reported outcome measures are an important component of assessment after Knee Ligament Injury in young and physically active patients; however, normative data for most activity scales are limited.Objective:To present reference values by sex for the Marx Activity Rating Scale (MARS) within a young and physically active population while accounting for Knee Ligament Injury history and sex.Study Design:Cross-sectional study.Level of Evidence:Level 2.Methods:All incoming freshman entering a US Service Academy in June of 2011 were recruited to participate in this study. MARS was administered to 1169 incoming freshmen (203 women) who consented to participate within the first week of matriculation. All subjects were deemed healthy and medically fit for military service on admission. Subjects also completed a baseline questionnaire that asked for basic demographic information and Injury history. We calculated means with standard deviations, medians with interquartile ranges, and...

  • normative values for the koos and womac in a young athletic population history of Knee Ligament Injury is associated with lower scores
    American Journal of Sports Medicine, 2013
    Co-Authors: Kenneth L Cameron, Stephen W Marshall, Brandon S Thompson, Karen Y Peck, Brett D Owens, Steven J Svoboda
    Abstract:

    Background:The use of patient-reported outcome measures to assess clinical outcomes after Injury and surgery has become common in treating young athletes with orthopaedic injuries; however, normative data for these measures are limited and often include a wide range of ages and activity levels.Purpose:To provide normative data for the Knee Injury and Osteoarthritis Outcome Score (KOOS) and Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) in a young and athletic population, and to compare scores between participants with a history of Knee Ligament Injury and those with no history.Study Design:Cross-sectional study; Level of evidence, 3.Methods:We administered the KOOS and WOMAC to 1177 college freshmen entering the United States Military Academy in June 2011. All participants were healthy and had been medically screened to meet the physical induction standards for military service. We calculated means, standard deviations, percentiles, ranges, and interquartile ranges for the KOOS and...

Kenneth L Cameron - One of the best experts on this subject based on the ideXlab platform.

  • control normalized fisher ratio analysis of comprehensive two dimensional gas chromatography time of flight mass spectrometry data for enhanced biomarker discovery in a metabolomic study of orthopedic Knee Ligament Injury
    Analytical Chemistry, 2020
    Co-Authors: Sarah E Prebihalo, Kenneth L Cameron, Steven J Svoboda, Grant S Ochoa, Kelsey L Berrier, Kristen J Skogerboe, Jesse R Trump, Kenneth J Wickiser, Robert E Synovec
    Abstract:

    An innovative form of Fisher ratio (F-ratio) analysis (FRA) is developed for use with comprehensive two-dimensional gas chromatography/time-of-flight mass spectrometry (GC × GC-TOFMS) data and applied to the investigation of the changes in the metabolome in human plasma for patients with Injury to their anterior cruciate Ligament (ACL). Specifically, FRA provides a supervised discovery of metabolites that express a statistically significant variance in a two-sample class comparison: patients and healthy controls. The standard F-ratio utilizes the between-class variance relative to the pooled within-class variance. Because standard FRA is adversely impacted by metabolites expressed with a large within-class variance in the patient class, "control-normalized FRA" has been developed to provide complementary information, by normalizing the between-class variance to the variance of the control class only. Thirty plasma samples from patients who recently suffered from an ACL Injury, along with matched controls, were subjected to GC × GC-TOFMS analysis. Following both standard and control-normalized FRA, the concentration ratio for the top 30 "hits" in each comparison was obtained and then t-tested for statistical significance. Twenty four out of 30 metabolites plus the therapeutic agent, naproxen (24/30), passed the t-test for the control-normalized FRA, which included 8/24 unique to control-normalized FRA and 16/24 in common with the standard FRA. Likewise, standard FRA provided 21/30 metabolites passing the t-test, with 5/21 undiscovered by control-normalized FRA. The complementary information obtained by both F-ratio analyses demonstrates the general utility of the new approach for a variety of applications.

  • reference values for the marx activity rating scale in a young athletic population history of Knee Ligament Injury is associated with higher scores
    Sports Health: A Multidisciplinary Approach, 2015
    Co-Authors: Kenneth L Cameron, Brandon S Thompson, Karen Y Peck, Brett D Owens, Steven J Svoboda, Stephen W Marshall
    Abstract:

    Background:Activity-related patient-reported outcome measures are an important component of assessment after Knee Ligament Injury in young and physically active patients; however, normative data for most activity scales are limited.Objective:To present reference values by sex for the Marx Activity Rating Scale (MARS) within a young and physically active population while accounting for Knee Ligament Injury history and sex.Study Design:Cross-sectional study.Level of Evidence:Level 2.Methods:All incoming freshman entering a US Service Academy in June of 2011 were recruited to participate in this study. MARS was administered to 1169 incoming freshmen (203 women) who consented to participate within the first week of matriculation. All subjects were deemed healthy and medically fit for military service on admission. Subjects also completed a baseline questionnaire that asked for basic demographic information and Injury history. We calculated means with standard deviations, medians with interquartile ranges, and...

  • normative values for the koos and womac in a young athletic population history of Knee Ligament Injury is associated with lower scores
    American Journal of Sports Medicine, 2013
    Co-Authors: Kenneth L Cameron, Stephen W Marshall, Brandon S Thompson, Karen Y Peck, Brett D Owens, Steven J Svoboda
    Abstract:

    Background:The use of patient-reported outcome measures to assess clinical outcomes after Injury and surgery has become common in treating young athletes with orthopaedic injuries; however, normative data for these measures are limited and often include a wide range of ages and activity levels.Purpose:To provide normative data for the Knee Injury and Osteoarthritis Outcome Score (KOOS) and Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) in a young and athletic population, and to compare scores between participants with a history of Knee Ligament Injury and those with no history.Study Design:Cross-sectional study; Level of evidence, 3.Methods:We administered the KOOS and WOMAC to 1177 college freshmen entering the United States Military Academy in June 2011. All participants were healthy and had been medically screened to meet the physical induction standards for military service. We calculated means, standard deviations, percentiles, ranges, and interquartile ranges for the KOOS and...

Laura Bond - One of the best experts on this subject based on the ideXlab platform.

  • lack of effect of a Knee Ligament Injury prevention program on the incidence of noncontact anterior cruciate Ligament Injury
    Journal of Bone and Joint Surgery American Volume, 2006
    Co-Authors: Ronald P Pfeiffer, Kevin G Shea, Dana Roberts, Sara L Grandstrand, Laura Bond
    Abstract:

    Background: Studies have suggested that exercise programs can reduce the incidence of noncontact injuries of the anterior cruciate Ligament in female athletes. We conducted a two-year prospective study to assess the effects of a Knee Ligament Injury prevention exercise program on the incidence of noncontact anterior cruciate Ligament injuries in high-school female athletes. Methods: A prospective cohort design was used to study high-school female athletes (playing soccer, basketball, and volleyball) from fifteen schools (112 teams) for two consecutive seasons. The schools were divided into treatment and control groups. The treatment group participated in a plyometric-based exercise program twice a week throughout the season. Practice and game exposures and compliance with the exercise program were recorded on a weekly basis. Suspected noncontact anterior cruciate Ligament injuries were confirmed on the basis of the history as well as at the time of surgery and/or with magnetic resonance imaging. Results: A total of 1439 athletes (862 in the control group and 577 in the treatment group) were monitored. There were six confirmed noncontact anterior cruciate Ligament injuries: three in the treatment group, and three in the control group. The incidence of noncontact anterior cruciate Ligament injuries per 1000 exposures was 0.167 in the treatment group and 0.078 in the control group, yielding an odds ratio of 2.05, which was not significant (p > 0.05). Conclusions: Our results suggest that a twenty-minute plyometric-based exercise program that focuses on the mechanics of landing from a jump and deceleration when running performed twice a week throughout the season will not reduce the rate of noncontact anterior cruciate Ligament injuries in high-school female athletes. Level of Evidence: Therapeutic Level II. See Instructions to Authors for a complete description of levels of evidence.

Ronald P Pfeiffer - One of the best experts on this subject based on the ideXlab platform.

  • lack of effect of a Knee Ligament Injury prevention program on the incidence of noncontact anterior cruciate Ligament Injury
    Journal of Bone and Joint Surgery American Volume, 2006
    Co-Authors: Ronald P Pfeiffer, Kevin G Shea, Dana Roberts, Sara L Grandstrand, Laura Bond
    Abstract:

    Background: Studies have suggested that exercise programs can reduce the incidence of noncontact injuries of the anterior cruciate Ligament in female athletes. We conducted a two-year prospective study to assess the effects of a Knee Ligament Injury prevention exercise program on the incidence of noncontact anterior cruciate Ligament injuries in high-school female athletes. Methods: A prospective cohort design was used to study high-school female athletes (playing soccer, basketball, and volleyball) from fifteen schools (112 teams) for two consecutive seasons. The schools were divided into treatment and control groups. The treatment group participated in a plyometric-based exercise program twice a week throughout the season. Practice and game exposures and compliance with the exercise program were recorded on a weekly basis. Suspected noncontact anterior cruciate Ligament injuries were confirmed on the basis of the history as well as at the time of surgery and/or with magnetic resonance imaging. Results: A total of 1439 athletes (862 in the control group and 577 in the treatment group) were monitored. There were six confirmed noncontact anterior cruciate Ligament injuries: three in the treatment group, and three in the control group. The incidence of noncontact anterior cruciate Ligament injuries per 1000 exposures was 0.167 in the treatment group and 0.078 in the control group, yielding an odds ratio of 2.05, which was not significant (p > 0.05). Conclusions: Our results suggest that a twenty-minute plyometric-based exercise program that focuses on the mechanics of landing from a jump and deceleration when running performed twice a week throughout the season will not reduce the rate of noncontact anterior cruciate Ligament injuries in high-school female athletes. Level of Evidence: Therapeutic Level II. See Instructions to Authors for a complete description of levels of evidence.

  • effects of a Knee Ligament Injury prevention exercise program on impact forces in women
    Journal of Strength and Conditioning Research, 2004
    Co-Authors: Bobbie S Irmischer, Chad Harris, Ronald P Pfeiffer, Mark Debeliso, Kent J Adams, Kevin G Shea
    Abstract:

    Previous research suggests high impact forces generated during landings contribute to noncontact anterior cruciate Ligament (ACL) injuries. In women, neuromuscular differences appear to modify the ability to dissipate landing forces when compared to men. This study examined peak vertical impact forces (F(p)) and rate of force development (RFD) following a 9-week, low-intensity (simple jump-landing-jump tasks) and volume (number of foot contacts per workout) plyometric-based Knee Ligament Injury prevention (KLIP) program. Female subjects were randomly assigned into control (n = 14) and treatment (n = 14) groups. Treatment subjects attended KLIP sessions twice a week for 9 weeks, and control subjects received no intervention. Ground reaction forces (F(p) and RFD) generated during a step-land protocol were assessed at study onset and termination. Significant reductions in F(p) (p = 0.0004) and RFD (p = 0.0205) were observed in the treatment group. Our results indicate that 9 weeks of KLIP training altered landing strategies in women to lower F(p) and RFD. These changes are considered conducive to a reduced risk of Knee Injury while landing.

Stephen W Marshall - One of the best experts on this subject based on the ideXlab platform.

  • reference values for the marx activity rating scale in a young athletic population history of Knee Ligament Injury is associated with higher scores
    Sports Health: A Multidisciplinary Approach, 2015
    Co-Authors: Kenneth L Cameron, Brandon S Thompson, Karen Y Peck, Brett D Owens, Steven J Svoboda, Stephen W Marshall
    Abstract:

    Background:Activity-related patient-reported outcome measures are an important component of assessment after Knee Ligament Injury in young and physically active patients; however, normative data for most activity scales are limited.Objective:To present reference values by sex for the Marx Activity Rating Scale (MARS) within a young and physically active population while accounting for Knee Ligament Injury history and sex.Study Design:Cross-sectional study.Level of Evidence:Level 2.Methods:All incoming freshman entering a US Service Academy in June of 2011 were recruited to participate in this study. MARS was administered to 1169 incoming freshmen (203 women) who consented to participate within the first week of matriculation. All subjects were deemed healthy and medically fit for military service on admission. Subjects also completed a baseline questionnaire that asked for basic demographic information and Injury history. We calculated means with standard deviations, medians with interquartile ranges, and...

  • normative values for the koos and womac in a young athletic population history of Knee Ligament Injury is associated with lower scores
    American Journal of Sports Medicine, 2013
    Co-Authors: Kenneth L Cameron, Stephen W Marshall, Brandon S Thompson, Karen Y Peck, Brett D Owens, Steven J Svoboda
    Abstract:

    Background:The use of patient-reported outcome measures to assess clinical outcomes after Injury and surgery has become common in treating young athletes with orthopaedic injuries; however, normative data for these measures are limited and often include a wide range of ages and activity levels.Purpose:To provide normative data for the Knee Injury and Osteoarthritis Outcome Score (KOOS) and Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) in a young and athletic population, and to compare scores between participants with a history of Knee Ligament Injury and those with no history.Study Design:Cross-sectional study; Level of evidence, 3.Methods:We administered the KOOS and WOMAC to 1177 college freshmen entering the United States Military Academy in June 2011. All participants were healthy and had been medically screened to meet the physical induction standards for military service. We calculated means, standard deviations, percentiles, ranges, and interquartile ranges for the KOOS and...

  • incidence of anterior cruciate Ligament Injury and other Knee Ligament injuries a national population based study
    Journal of Science and Medicine in Sport, 2009
    Co-Authors: Simon Gianotti, Stephen W Marshall, Patria A Hume, Lorna Bunt
    Abstract:

    Abstract There has been an intensive research effort directed at determining the cause of non-contact anterior cruciate Ligament (ACL) Injury over the past decade, but few studies have reported data on the incidence of ACL and other Knee Ligament Injury in the general population. New Zealand’s no-fault Injury compensation data provides a national Injury resource of data on claims for Knee Ligament Injury. The goal of this paper was to provide a descriptive epidemiology of Knee Ligament Injury in this country. Data were obtained for Knee Ligament injuries between 1 July 2000 and 30 June 2005. Injuries were categorised as non-surgical (NS), ACL surgeries (ACLS) and other Knee Ligament surgeries (OKLS). Incidence rates per 100,000 person-years were computed using population estimates. Costs and number of treatment/rehabilitation visits were obtained as an indication of severity. The incidence rate per 100,000 person-years was 1147.1 for NS, 36.9 for ACLS and 9.1 for OKLS. Males had a higher incidence rate than females for NS, ACLS, and OKLS. The mean (and median) number of treatment visits were NS: 6.6 (4), ACLS: 27.1 (24), and OKLS: 31.3 (24). The mean (median) treatment costs of these injuries were NS $885 ($129), ACLS $11,157 ($8574), and OKLS $15,663 ($8054). Analysis of Injury descriptions for ACLS injuries indicated that 58% involved a non-contact mechanism of Injury. These data underscore the high level of short-term disability associated with Knee Ligament injuries, especially ACL injuries that require surgery.