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Xiangning Wang - One of the best experts on this subject based on the ideXlab platform.
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tear film and Lacrimal excretion changes after Lacrimal Gland Tumor removal
Chinese journal of ophthalmology, 2013Co-Authors: Yanqing Zhang, Jiang Qian, Yifei Yuan, Kang Xue, Jie Guo, Xiangning WangAbstract:Objective To study the change of tear film and Lacrimal secretion after Lacrimal Gland Tumor removal operation. Methods It was a retrospective case series study.Nineteen cases (19 eyes) with pleomorphic adenoma of the Lacrimal Gland from January,2010 to July,2011 in Eye and ENT Hospital of Fudan University were elected.The evaluation included subjective complaints of dry eye,tear break up time (BUT),reflex Lacrimal secretion,corneal fluorescein staining,and size of Lacrimal lake were analyzed before surgery and 3 days,1 month and 6 months postoperatively.Simultaneously,the opposite eye was set as control. Results Subjective complaints of dry eye increased and the mean tear break up time,reflex Lacrimal secretion,and size of Lacrimal lake were significantly reduced (t=23.91,16.90,11.47;t=19.31,20.81,11.95,P<0.05) on day 3 and 1 month after operation which were (4.9±2.0) s (3 d),(5.2±1.6) s (1 moth) ; (4.05±2.07) mm (3 d),(3.58±1.98) mm (1 moth) ; (0.009±0.004) mm2 (3 d),(0.008±0.003) mm2 (1 moth) respectively.However,only reflex secretion test (3.53±1.50 mm) was significantly reduced (t=21.57,P<0.05),other values (BUT:17.4±4.9 s,size of lake:0.032±0.005 mm2) recovered to preoperative levels by the time of the sixth month follow up visit.Corneal fluorescein staining score increased greatly when measured at day 3 and 1 month visit (t=0.23,1.69,P<0.05),but had returned to preoperative values at the sixth month visit.The result of the opposite eye control is the same as preoperative control. Conclusions During the early stage after Lacrimal Gland Tumor removal,tear film present abnormal changes,mainly in tear stability and reduction of reflex Lacrimal secretion. (Chin J Ophthalmol,2013,49:27-31) Key words: Lacrimal apparatus diseases; Adenoma,pleomorphic; Postoperative complications;Dry eye syndromes; Tears
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Tear film and Lacrimal excretion changes after Lacrimal Gland Tumor removal
Chinese journal of ophthalmology, 2013Co-Authors: Yanqing Zhang, Jiang Qian, Yifei Yuan, Kang Xue, Jie Guo, Xiangning WangAbstract:Objective To study the change of tear film and Lacrimal secretion after Lacrimal Gland Tumor removal operation. Methods It was a retrospective case series study.Nineteen cases (19 eyes) with pleomorphic adenoma of the Lacrimal Gland from January,2010 to July,2011 in Eye and ENT Hospital of Fudan University were elected.The evaluation included subjective complaints of dry eye,tear break up time (BUT),reflex Lacrimal secretion,corneal fluorescein staining,and size of Lacrimal lake were analyzed before surgery and 3 days,1 month and 6 months postoperatively.Simultaneously,the opposite eye was set as control. Results Subjective complaints of dry eye increased and the mean tear break up time,reflex Lacrimal secretion,and size of Lacrimal lake were significantly reduced (t=23.91,16.90,11.47;t=19.31,20.81,11.95,P
Sebastian Adeberg - One of the best experts on this subject based on the ideXlab platform.
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Carbon-ion radiotherapy in accelerated hypofractionated active raster-scanning technique for malignant Lacrimal Gland Tumors: feasibility and safety.
Cancer management and research, 2019Co-Authors: Sati Akbaba, Kristin Lang, Thomas Held, Klaus Herfarth, J. Rieber, Peter Plinkert, Gerd U. Auffarth, Stefan Rieken, Juergen Debus, Sebastian AdebergAbstract:Introduction We evaluated treatment outcomes of CIRT in an active raster-scanning technique alone or in combination with IMRT for Lacrimal Gland Tumors. Methods A total of 24 patients who received CIRT for a malignant Lacrimal Gland Tumor at the HIT between 2009 and 2018 were analyzed retrospectively for LC, OS, and distant progression-free survival (DPFS) using Kaplan-Meier estimates. Toxicity was assessed according to the CTCAE version 5. Results Median follow-up was 30 months and overall median LC, OS, and DPFS 24 months, 36 months, and 31 months, respectively. Two-year LC, OS, and DPFS of 93%, 96%, and 87% with CIRT was achieved for all patients. Local failure occurred only in patients with ACC and after a median follow-up of 30 months after the completion of RT (n=5, 21%; P=0.09). We identified a significant negative impact of a macroscopic Tumor disease, which was diagnosed on planning CT or MRI before RT, on LC (P=0.026). In contrast, perineural spread (P=0.661), T stage (P=0.552), and resection margins in operated patients (P=0.069) had no significant impact on LC. No grade ≥3 acute or grade >3 chronic toxicity occurred. Late grade 3 side effects were identified in form of a wound-healing disorder 3 months after RT in one patient and temporal lobe necrosis 6 months after RT in another (n=2, 8%). Conclusion Accelerated hypofractionated active raster-scanning CIRT for relative radio-resistant malignant Lacrimal Gland Tumors results in adequate LC rates and moderate acute and late toxicity. Nevertheless, LC for ACC histology remains challenging and risk factors for local recurrence are still unclear. Further follow-up is necessary to evaluate long-term clinical outcome.
Adeberg S - One of the best experts on this subject based on the ideXlab platform.
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Carbon-ion radiotherapy in accelerated hypofractionated active raster-scanning technique for malignant Lacrimal Gland Tumors: feasibility and safety
Dove Medical Press, 2019Co-Authors: Akbaba S, Lang K, Held T, Herfarth K, Rieber J, Plinkert P, Rieken S, Debus J, Adeberg SAbstract:Sati Akbaba,1–3 Kristin Lang,1,2 Thomas Held,1,2 Klaus Herfarth,1–3 Juliane Rieber,1–3 Peter Plinkert,4 Gerd U Auffarth,5 Stefan Rieken,1–3 Juergen Debus,1–3 Sebastian Adeberg1–3 1Department of Radiation Oncology, University Hospital Heidelberg, Heidelberg 69120, Germany; 2Heidelberg Institute of Radiation Oncology (HIRO), National Center for Radiation Research in Oncology (NCRO), University Hospital Heidelberg, Heidelberg 69120, Germany; 3Heidelberg Ion-Beam Therapy Center (HIT), University Hospital Heidelberg, Heidelberg 69120, Germany; 4Department of Otorhinolaryngology, Head and Neck Surgery, University Hospital Heidelberg, Heidelberg 69120, Germany; 5Department of Ophthalmology, University Hospital Heidelberg, Heidelberg 69120, Germany Introduction: We evaluated treatment outcomes of CIRT in an active raster-scanning technique alone or in combination with IMRT for Lacrimal Gland Tumors.Methods: A total of 24 patients who received CIRT for a malignant Lacrimal Gland Tumor at the HIT between 2009 and 2018 were analyzed retrospectively for LC, OS, and distant progression-free survival (DPFS) using Kaplan–Meier estimates. Toxicity was assessed according to the CTCAE version 5.Results: Median follow-up was 30 months and overall median LC, OS, and DPFS 24 months, 36 months, and 31 months, respectively. Two-year LC, OS, and DPFS of 93%, 96%, and 87% with CIRT was achieved for all patients. Local failure occurred only in patients with ACC and after a median follow-up of 30 months after the completion of RT (n=5, 21%; P=0.09). We identified a significant negative impact of a macroscopic Tumor disease, which was diagnosed on planning CT or MRI before RT, on LC (P=0.026). In contrast, perineural spread (P=0.661), T stage (P=0.552), and resection margins in operated patients (P=0.069) had no significant impact on LC. No grade ≥3 acute or grade >3 chronic toxicity occurred. Late grade 3 side effects were identified in form of a wound-healing disorder 3 months after RT in one patient and temporal lobe necrosis 6 months after RT in another (n=2, 8%).Conclusion: Accelerated hypofractionated active raster-scanning CIRT for relative radioresistant malignant Lacrimal Gland Tumors results in adequate LC rates and moderate acute and late toxicity. Nevertheless, LC for ACC histology remains challenging and risk factors for local recurrence are still unclear. Further follow-up is necessary to evaluate long-term clinical outcome. Keywords: carbon-ion radiotherapy, bimodal RT, malignant Lacrimal Gland Tumor, adenoid cystic carcinoma, local contro
Meir Lipschitz - One of the best experts on this subject based on the ideXlab platform.
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Metastatic thyroid carcinoma masquerading as Lacrimal Gland Tumor
Graefe's Archive for Clinical and Experimental Ophthalmology, 1990Co-Authors: Liora Bernstein-lipschitz, Moshe Lahav, Varda Chen, Itzhak Gutman, Rivka Gall, Meir LipschitzAbstract:A 56-year-old woman presented with orbital signs and symptoms suggestive of Lacrimal Gland Tumor. An excised biopsy specimen was obtained and showed Glandular tissue, which could be confused with Lacrimal Gland acini. Closer microscopic examination and immunohistochemical studies revealed a metastatic Tumor of thyroid Gland origin. Initially, there was no identifiable nodule in the thyroid, but 3 months later a thyroid nodule was found by ultrasound and radioisotope scan. The histopathologic appearance of the thyroid nodule was similar to that found in the orbit. This case demonstrates the usefulness of immunohistochemistry in establishing a diagnosis when the microscopic appearance is inconclusive.
Abolfazl Kassaee - One of the best experts on this subject based on the ideXlab platform.
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Spontaneous Rupture of Lacrimal Gland Pleomorphic Adenoma: Pivotal Role in Masquerading Orbital Cellulitis.
Ophthalmic Plastic and Reconstructive Surgery, 2017Co-Authors: Farzad Pakdel, Niloofar Pirmarzdashti, Sasan Soltani, Zohreh Nozarian, Fahimeh Asadi Amoli, Abolfazl KassaeeAbstract:The authors aim to report a 68-year-old patient presenting with acute swelling and redness of orbital area diagnosed initially as orbital cellulitis. Surgical excision was decided based on clinical and imaging findings with the diagnosis of pleomorphic adenoma of the Lacrimal Gland. Lacrimal Gland pleomorphic adenoma usually presents with painless gradual swelling of upper eyelid. In an exceptionally rare circumstance, this case showed acute orbital inflammation, and imaging findings of orbital inflammation mostly focused around the cystic space of the Lacrimal Gland Tumor. Histologic evaluation confirmed a ruptured cystic space of pleomorphic adenoma with foreign body-type inflammatory reaction. The authors propose spontaneous rupture of cystic space in the Lacrimal Gland pleomorphic adenoma as underlying mechanism for acute presentation of this Tumor. Imaging and clinical characteristics and also prognostic implication of this phenomenon are discussed.
