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A Alzahaby - One of the best experts on this subject based on the ideXlab platform.
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Pre-micro RNA polymorphism detection in small versus Large Vessel Disease in stroke Egyptian patients
Metabolic Brain Disease, 2021Co-Authors: Ekrami A. Hassan, A Alzahaby, Hala M. El-khawas, Afify H., Mustafa M. M. Elbakry, Hossam M. ShokriAbstract:Stroke is the main cause of adult disability and is responsible for around 11% of deaths all over the world. Ischemic stroke encompasses about 80–85% of total stroke cases. Several studies have shown the relation between microRNAs polymorphism and ischemic stroke. The aim of the study was to evaluate the influence of three common single nucleotide polymorphisms in pre-miRNAs (hsa-miR-146a/rs2910164, hsa-miR-196a2/rs11614913 and hsa-miR-499/rs3746444) on individual susceptibility to the risk of ischemic stroke subtypes in Egyptian population with 117 ischemic stroke patients. Results showed that hsa-miR-146a/rs2910164 was significantly associated with the risk of small Vessel Disease stroke in Egyptian population with no significant association between hsa-miR-196a2/rs11614913 and hsa-miR-499/rs3746444 with the risk of ischemic stroke. Therefore, it can be concluded that miR-146a/rs2910164 polymorphism is involved in the vulnerability to small Vessel Disease ischemic stroke risk in Egyptian population.
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Pre-micro RNA polymorphism detection in small versus Large Vessel Disease in stroke patients
QJM: An International Journal of Medicine, 2020Co-Authors: H H Elkhawas, H H Afify, H Shokri, E M M A Hassan, A AlzahabyAbstract:Abstract Article Outline Abstract Introduction Patients and methods Procedure Statistical analysis Results Discussion Conclusion References Background Cerebrovascular accidents are the second leading cause of death and the third leading cause of disability worldwide. The methods currently available for diagnosis and prognosis of cerebral ischaemia still require further improvements. Micro-RNAs (small non-coding RNAs) have been recently reported as useful biomarkers in Diseases such as cancer and diabetes. Further research concerned with microRNA (miRNA) profiling from peripheral blood to detect and identify characteristic patterns in ischaemic stroke is crucial. Aim of the work This study aims to investigate the association between three potentially functional polymorphisms in pre-miRNAs and stroke subtypes (small Vessel Disease and Large Vessel Disease) in a sample of Egyptian stroke patients. Patients and Methods This is a cross sectional study conducted in Ain Shams University Hospitals in which 81 patients presenting with cerebrovascular stroke fulfilling criteria of small Vessel Disease (SVD) or Large Vessel Disease (LVD) according to TOAST [2] classification in the period from March 2018 to August 2018 were included. Blood samples were withdrawn for DNA extraction to investigate the association between three potentially functional polymorphisms (rs2910164, rs11614913, and rs3746444) in pre-miRNAs (hsamiR-146a, hsa-miR-196a2, and hsa-miR-499, respectively). Results Smoking, hypertension and diabetes were significant value in both stroke subtypes. Meanwhile, age and gender showed no significance between both stroke subtypes. Conclusion Ischemic stroke has polygenic basis, but identification of stroke susceptibility gene and quantification of associated risks has been hindered by conflicting results from different studies.
Andrzej Szczudlik - One of the best experts on this subject based on the ideXlab platform.
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Comparison of plasma concentrations of fibrinogen in patients with ischemic stroke due to Large Vessel Disease and small Vessel Disease
Neurologia i neurochirurgia polska, 2006Co-Authors: Wojciech Turaj, Agnieszka Slowik, Roman Pułyk, Mateusz G. Adamski, Andrzej SzczudlikAbstract:BACKGROUND AND PURPOSE Hyperfibrinogenemia is a known cardiovascular risk factor, but its role as a risk factor for ischemic stroke remains controversial. Most studies on this topic did not consider the different etiologies of ischemic stroke. We designed this study to compare plasma fibrinogen concentrations in patients with acute ischemic stroke due to Large Vessel Disease (LVD) or small Vessel Disease (SVD). MATERIAL AND METHODS We studied 203 patients with acute ischemic stroke, including 107 patients with SVD and 96 subjects with LVD. Etiology of stroke was established according to the TOAST criteria, using computed tomography, ultrasonography of the carotid and vertebral arteries as well as echocardiography. The plasma concentration of fibrinogen was measured in venous blood samples drawn within 48 hours from the onset of stroke. RESULTS Patients with LVD were more likely to be men and more likely to have ischemic heart Disease. The median plasma concentration of fibrinogen was higher in patients with LVD [3.7 g/l (2.9-4.9 g/l)] than in patients with SVD [3.2 g/l (2.6-3.8 g/l); p=0.0001]. Hyperfibrinogenemia (i.e. plasma fibrinogen concentration >3.5 g/l) occurred more frequently in patients with LVD (54.2%) than in patients with SVD (35.5%; p=0.008). CONCLUSIONS Patients with ischemic stroke due to LVD have a higher concentration of plasma fibrinogen than patients with SVD, they also present more frequently with hyperfibrinogenemia. Further studies of risk factors for stroke should take into account various etiologies of ischemic stroke.
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A2 Alelle of GpIIIa Gene Is a Risk Factor for Stroke Caused by Large-Vessel Disease in Males
Stroke, 2004Co-Authors: Agnieszka Slowik, Wojciech Turaj, Tomasz Dziedzic, Joanna Pera, Lidia Glodzik-sobanska, Paweł Szermer, Maciej T. Malecki, Denise A. Figlewicz, Andrzej SzczudlikAbstract:Background and Purpose— Glycoprotein IIIa (GpIIIa) is a platelet membrane receptor for fibrinogen and von Willebrand factor. It plays a key role in platelet aggregation. Previous studies in stroke patients, without analysis based on specific subtypes of stroke cause, have not shown any link between GpIIIa A1/A2 polymorphism and stroke risk. We studied the significance of the GpIIIa gene A1/A2 polymorphism in stroke patients with different stroke causes. Methods— We genotyped 92 patients with stroke caused by Large-Vessel Disease (LVD stroke) and 184 matched controls; 103 patients with stroke caused by small-Vessel Disease (SVD stroke) and 206 controls; and 182 patients with cardioembolic stroke (CE stroke) and 182 controls (TOAST criteria). The GpIIIa A1/A2 polymorphism was analyzed by polymerase chain reaction followed by restriction enzyme digestion and electrophoresis. Results— The genotype distribution of the GpIIIa gene in patients with LVD stroke (A1/A1, 63%; A1/A2, 34.8%; A2/A2, 2.2%) differed sign...
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ldl phenotype b and other lipid abnormalities in patients with Large Vessel Disease and small Vessel Disease
Journal of the Neurological Sciences, 2003Co-Authors: Agnieszka Slowik, Tomasz Iskra, Wojciech Turaj, Jadwiga Hartwich, Aldona Dembinskakiec, Andrzej SzczudlikAbstract:Background and purpose: Controversies concerning the significance of lipid abnormalities in stroke come mostly from the researches that studied lipid profile without considering stroke aetiologies. We investigated the prevalence of LDL phenotype B and other lipid abnormalities in stroke survivors with Large Vessel Disease (LVD) or small Vessel Disease (SVD) (TOAST criteria) and in control subjects (CS). Methods: We studied 30 patients with LVD and 41 patients with SVD screened out of 585 stroke patients and 30 CS who fulfilled the following exclusion criteria: cardiac disorders, renal or hepatic failure, diabetes mellitus, or treatment with lipid-lowering agents. At least 3 months after stroke, the concentrations of total cholesterol (TC), HDL cholesterol (HDL-C), LDL cholesterol (LDL-C), triglycerides (TGs), apolipoprotein E (apoE), and lipoprotein (a) [lp(a)] were measured and LDL phenotypes and apoE isoforms were identified. Results: Patients with LVD had significantly higher concentrations of LDL-C than CS (p 30 mg/ml) was greater in patients with LVD (36.7%) than in CS (10%) (p<0.05). Conclusions: Patients with stroke due to LVD, but not SVD, have high prevalence of atherogenic lipid abnormalities, including increased frequency of LDL phenotype B and higher percentage of increased lp(a) level, like patients with other atherogenic Diseases.
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LDL phenotype B and other lipid abnormalities in patients with Large Vessel Disease and small Vessel Disease.
Journal of the neurological sciences, 2003Co-Authors: Agnieszka Slowik, Tomasz Iskra, Wojciech Turaj, Jadwiga Hartwich, Aldona Dembinska-kiec, Andrzej SzczudlikAbstract:Controversies concerning the significance of lipid abnormalities in stroke come mostly from the researches that studied lipid profile without considering stroke aetiologies. We investigated the prevalence of LDL phenotype B and other lipid abnormalities in stroke survivors with Large Vessel Disease (LVD) or small Vessel Disease (SVD) (TOAST criteria) and in control subjects (CS). We studied 30 patients with LVD and 41 patients with SVD screened out of 585 stroke patients and 30 CS who fulfilled the following exclusion criteria: cardiac disorders, renal or hepatic failure, diabetes mellitus, or treatment with lipid-lowering agents. At least 3 months after stroke, the concentrations of total cholesterol (TC), HDL cholesterol (HDL-C), LDL cholesterol (LDL-C), triglycerides (TGs), apolipoprotein E (apoE), and lipoprotein (a) [lp(a)] were measured and LDL phenotypes and apoE isoforms were identified. Patients with LVD had significantly higher concentrations of LDL-C than CS (p<0.05). They had higher concentrations of TGs and lower concentrations of HDL-C than patients with SVD and CS (p<0.05). LDL phenotype B was more frequent in patients with LVD (63.3%) than in patients with SVD (39.0%) or in CS (16.7%) (p<0.05). The concentration of apoE was higher in patients with LVD than in patients with SVD or in CS (p<0.05). The percentage of patients with increased level of lp(a) (i.e., >30 mg/ml) was greater in patients with LVD (36.7%) than in CS (10%) (p<0.05). Patients with stroke due to LVD, but not SVD, have high prevalence of atherogenic lipid abnormalities, including increased frequency of LDL phenotype B and higher percentage of increased lp(a) level, like patients with other atherogenic Diseases.
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LDL phenotype B and other lipid abnormalities in patients with Large Vessel Disease and small Vessel Disease
Journal of the Neurological Sciences, 2003Co-Authors: Agnieszka Slowik, Tomasz Iskra, Wojciech Turaj, Jadwiga Hartwich, Aldona Dembinska-kiec, Andrzej SzczudlikAbstract:Background and purpose: Controversies concerning the significance of lipid abnormalities in stroke come mostly from the researches that studied lipid profile without considering stroke aetiologies. We investigated the prevalence of LDL phenotype B and other lipid abnormalities in stroke survivors with Large Vessel Disease (LVD) or small Vessel Disease (SVD) (TOAST criteria) and in control subjects (CS). Methods: We studied 30 patients with LVD and 41 patients with SVD screened out of 585 stroke patients and 30 CS who fulfilled the following exclusion criteria: cardiac disorders, renal or hepatic failure, diabetes mellitus, or treatment with lipid-lowering agents. At least 3 months after stroke, the concentrations of total cholesterol (TC), HDL cholesterol (HDL-C), LDL cholesterol (LDL-C), triglycerides (TGs), apolipoprotein E (apoE), and lipoprotein (a) [lp(a)] were measured and LDL phenotypes and apoE isoforms were identified. Results: Patients with LVD had significantly higher concentrations of LDL-C than CS (p 30 mg/ml) was greater in patients with LVD (36.7%) than in CS (10%) (p
Agnieszka Slowik - One of the best experts on this subject based on the ideXlab platform.
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Paraoxonase 2 Gene C311S Polymorphism Is Associated with a Risk of Large Vessel Disease Stroke in a Polish Population
Cerebrovascular diseases (Basel Switzerland), 2007Co-Authors: Agnieszka Slowik, Wojciech Turaj, Tomasz Dziedzic, Joanna Pera, Paweł Szermer, Maciej T. Malecki, Dorota Wloch, Paweł Wołkow, Aleksandra Klimkowicz-mrowiec, Grzegorz KopećAbstract:Background: Oxidative stress plays a role in atherosclerosis. Human paraoxonase (PON) gene products exhibit antioxidant properties. We studied the significance of the Q192R and M55L polymorphisms of the PON1 gene and the C311S polymorphism of the PON2 gene in different etiologies of ischemic stroke. Methods: One hundred and thirty-six patients with Large Vessel Disease (LVD) stroke, 140 with small Vessel Disease stroke, 272 with cardioembolic stroke, and their age- and sex-matched controls were included. PON genotypes were evaluated by PCR-RFLP analyses. Results: The distribution of PON1 polymorphisms was similar in each stroke group and in the respective controls. Genotypes with the C allele of the PON2 gene C311S polymorphism were overrepresented in LVD stroke patients as compared with their controls, both in univariate and multivariate (dominant model: OR = 1.58, 95% CI: 1.006–2.48) analyses. Conclusion: The genotype with the C allele of the PON2 gene is a risk factor for LVD stroke in a Polish population.
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Comparison of plasma concentrations of fibrinogen in patients with ischemic stroke due to Large Vessel Disease and small Vessel Disease
Neurologia i neurochirurgia polska, 2006Co-Authors: Wojciech Turaj, Agnieszka Slowik, Roman Pułyk, Mateusz G. Adamski, Andrzej SzczudlikAbstract:BACKGROUND AND PURPOSE Hyperfibrinogenemia is a known cardiovascular risk factor, but its role as a risk factor for ischemic stroke remains controversial. Most studies on this topic did not consider the different etiologies of ischemic stroke. We designed this study to compare plasma fibrinogen concentrations in patients with acute ischemic stroke due to Large Vessel Disease (LVD) or small Vessel Disease (SVD). MATERIAL AND METHODS We studied 203 patients with acute ischemic stroke, including 107 patients with SVD and 96 subjects with LVD. Etiology of stroke was established according to the TOAST criteria, using computed tomography, ultrasonography of the carotid and vertebral arteries as well as echocardiography. The plasma concentration of fibrinogen was measured in venous blood samples drawn within 48 hours from the onset of stroke. RESULTS Patients with LVD were more likely to be men and more likely to have ischemic heart Disease. The median plasma concentration of fibrinogen was higher in patients with LVD [3.7 g/l (2.9-4.9 g/l)] than in patients with SVD [3.2 g/l (2.6-3.8 g/l); p=0.0001]. Hyperfibrinogenemia (i.e. plasma fibrinogen concentration >3.5 g/l) occurred more frequently in patients with LVD (54.2%) than in patients with SVD (35.5%; p=0.008). CONCLUSIONS Patients with ischemic stroke due to LVD have a higher concentration of plasma fibrinogen than patients with SVD, they also present more frequently with hyperfibrinogenemia. Further studies of risk factors for stroke should take into account various etiologies of ischemic stroke.
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A2 Alelle of GpIIIa Gene Is a Risk Factor for Stroke Caused by Large-Vessel Disease in Males
Stroke, 2004Co-Authors: Agnieszka Slowik, Wojciech Turaj, Tomasz Dziedzic, Joanna Pera, Lidia Glodzik-sobanska, Paweł Szermer, Maciej T. Malecki, Denise A. Figlewicz, Andrzej SzczudlikAbstract:Background and Purpose— Glycoprotein IIIa (GpIIIa) is a platelet membrane receptor for fibrinogen and von Willebrand factor. It plays a key role in platelet aggregation. Previous studies in stroke patients, without analysis based on specific subtypes of stroke cause, have not shown any link between GpIIIa A1/A2 polymorphism and stroke risk. We studied the significance of the GpIIIa gene A1/A2 polymorphism in stroke patients with different stroke causes. Methods— We genotyped 92 patients with stroke caused by Large-Vessel Disease (LVD stroke) and 184 matched controls; 103 patients with stroke caused by small-Vessel Disease (SVD stroke) and 206 controls; and 182 patients with cardioembolic stroke (CE stroke) and 182 controls (TOAST criteria). The GpIIIa A1/A2 polymorphism was analyzed by polymerase chain reaction followed by restriction enzyme digestion and electrophoresis. Results— The genotype distribution of the GpIIIa gene in patients with LVD stroke (A1/A1, 63%; A1/A2, 34.8%; A2/A2, 2.2%) differed sign...
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ldl phenotype b and other lipid abnormalities in patients with Large Vessel Disease and small Vessel Disease
Journal of the Neurological Sciences, 2003Co-Authors: Agnieszka Slowik, Tomasz Iskra, Wojciech Turaj, Jadwiga Hartwich, Aldona Dembinskakiec, Andrzej SzczudlikAbstract:Background and purpose: Controversies concerning the significance of lipid abnormalities in stroke come mostly from the researches that studied lipid profile without considering stroke aetiologies. We investigated the prevalence of LDL phenotype B and other lipid abnormalities in stroke survivors with Large Vessel Disease (LVD) or small Vessel Disease (SVD) (TOAST criteria) and in control subjects (CS). Methods: We studied 30 patients with LVD and 41 patients with SVD screened out of 585 stroke patients and 30 CS who fulfilled the following exclusion criteria: cardiac disorders, renal or hepatic failure, diabetes mellitus, or treatment with lipid-lowering agents. At least 3 months after stroke, the concentrations of total cholesterol (TC), HDL cholesterol (HDL-C), LDL cholesterol (LDL-C), triglycerides (TGs), apolipoprotein E (apoE), and lipoprotein (a) [lp(a)] were measured and LDL phenotypes and apoE isoforms were identified. Results: Patients with LVD had significantly higher concentrations of LDL-C than CS (p 30 mg/ml) was greater in patients with LVD (36.7%) than in CS (10%) (p<0.05). Conclusions: Patients with stroke due to LVD, but not SVD, have high prevalence of atherogenic lipid abnormalities, including increased frequency of LDL phenotype B and higher percentage of increased lp(a) level, like patients with other atherogenic Diseases.
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LDL phenotype B and other lipid abnormalities in patients with Large Vessel Disease and small Vessel Disease.
Journal of the neurological sciences, 2003Co-Authors: Agnieszka Slowik, Tomasz Iskra, Wojciech Turaj, Jadwiga Hartwich, Aldona Dembinska-kiec, Andrzej SzczudlikAbstract:Controversies concerning the significance of lipid abnormalities in stroke come mostly from the researches that studied lipid profile without considering stroke aetiologies. We investigated the prevalence of LDL phenotype B and other lipid abnormalities in stroke survivors with Large Vessel Disease (LVD) or small Vessel Disease (SVD) (TOAST criteria) and in control subjects (CS). We studied 30 patients with LVD and 41 patients with SVD screened out of 585 stroke patients and 30 CS who fulfilled the following exclusion criteria: cardiac disorders, renal or hepatic failure, diabetes mellitus, or treatment with lipid-lowering agents. At least 3 months after stroke, the concentrations of total cholesterol (TC), HDL cholesterol (HDL-C), LDL cholesterol (LDL-C), triglycerides (TGs), apolipoprotein E (apoE), and lipoprotein (a) [lp(a)] were measured and LDL phenotypes and apoE isoforms were identified. Patients with LVD had significantly higher concentrations of LDL-C than CS (p<0.05). They had higher concentrations of TGs and lower concentrations of HDL-C than patients with SVD and CS (p<0.05). LDL phenotype B was more frequent in patients with LVD (63.3%) than in patients with SVD (39.0%) or in CS (16.7%) (p<0.05). The concentration of apoE was higher in patients with LVD than in patients with SVD or in CS (p<0.05). The percentage of patients with increased level of lp(a) (i.e., >30 mg/ml) was greater in patients with LVD (36.7%) than in CS (10%) (p<0.05). Patients with stroke due to LVD, but not SVD, have high prevalence of atherogenic lipid abnormalities, including increased frequency of LDL phenotype B and higher percentage of increased lp(a) level, like patients with other atherogenic Diseases.
Wojciech Turaj - One of the best experts on this subject based on the ideXlab platform.
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Paraoxonase 2 Gene C311S Polymorphism Is Associated with a Risk of Large Vessel Disease Stroke in a Polish Population
Cerebrovascular diseases (Basel Switzerland), 2007Co-Authors: Agnieszka Slowik, Wojciech Turaj, Tomasz Dziedzic, Joanna Pera, Paweł Szermer, Maciej T. Malecki, Dorota Wloch, Paweł Wołkow, Aleksandra Klimkowicz-mrowiec, Grzegorz KopećAbstract:Background: Oxidative stress plays a role in atherosclerosis. Human paraoxonase (PON) gene products exhibit antioxidant properties. We studied the significance of the Q192R and M55L polymorphisms of the PON1 gene and the C311S polymorphism of the PON2 gene in different etiologies of ischemic stroke. Methods: One hundred and thirty-six patients with Large Vessel Disease (LVD) stroke, 140 with small Vessel Disease stroke, 272 with cardioembolic stroke, and their age- and sex-matched controls were included. PON genotypes were evaluated by PCR-RFLP analyses. Results: The distribution of PON1 polymorphisms was similar in each stroke group and in the respective controls. Genotypes with the C allele of the PON2 gene C311S polymorphism were overrepresented in LVD stroke patients as compared with their controls, both in univariate and multivariate (dominant model: OR = 1.58, 95% CI: 1.006–2.48) analyses. Conclusion: The genotype with the C allele of the PON2 gene is a risk factor for LVD stroke in a Polish population.
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Comparison of plasma concentrations of fibrinogen in patients with ischemic stroke due to Large Vessel Disease and small Vessel Disease
Neurologia i neurochirurgia polska, 2006Co-Authors: Wojciech Turaj, Agnieszka Slowik, Roman Pułyk, Mateusz G. Adamski, Andrzej SzczudlikAbstract:BACKGROUND AND PURPOSE Hyperfibrinogenemia is a known cardiovascular risk factor, but its role as a risk factor for ischemic stroke remains controversial. Most studies on this topic did not consider the different etiologies of ischemic stroke. We designed this study to compare plasma fibrinogen concentrations in patients with acute ischemic stroke due to Large Vessel Disease (LVD) or small Vessel Disease (SVD). MATERIAL AND METHODS We studied 203 patients with acute ischemic stroke, including 107 patients with SVD and 96 subjects with LVD. Etiology of stroke was established according to the TOAST criteria, using computed tomography, ultrasonography of the carotid and vertebral arteries as well as echocardiography. The plasma concentration of fibrinogen was measured in venous blood samples drawn within 48 hours from the onset of stroke. RESULTS Patients with LVD were more likely to be men and more likely to have ischemic heart Disease. The median plasma concentration of fibrinogen was higher in patients with LVD [3.7 g/l (2.9-4.9 g/l)] than in patients with SVD [3.2 g/l (2.6-3.8 g/l); p=0.0001]. Hyperfibrinogenemia (i.e. plasma fibrinogen concentration >3.5 g/l) occurred more frequently in patients with LVD (54.2%) than in patients with SVD (35.5%; p=0.008). CONCLUSIONS Patients with ischemic stroke due to LVD have a higher concentration of plasma fibrinogen than patients with SVD, they also present more frequently with hyperfibrinogenemia. Further studies of risk factors for stroke should take into account various etiologies of ischemic stroke.
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A2 Alelle of GpIIIa Gene Is a Risk Factor for Stroke Caused by Large-Vessel Disease in Males
Stroke, 2004Co-Authors: Agnieszka Slowik, Wojciech Turaj, Tomasz Dziedzic, Joanna Pera, Lidia Glodzik-sobanska, Paweł Szermer, Maciej T. Malecki, Denise A. Figlewicz, Andrzej SzczudlikAbstract:Background and Purpose— Glycoprotein IIIa (GpIIIa) is a platelet membrane receptor for fibrinogen and von Willebrand factor. It plays a key role in platelet aggregation. Previous studies in stroke patients, without analysis based on specific subtypes of stroke cause, have not shown any link between GpIIIa A1/A2 polymorphism and stroke risk. We studied the significance of the GpIIIa gene A1/A2 polymorphism in stroke patients with different stroke causes. Methods— We genotyped 92 patients with stroke caused by Large-Vessel Disease (LVD stroke) and 184 matched controls; 103 patients with stroke caused by small-Vessel Disease (SVD stroke) and 206 controls; and 182 patients with cardioembolic stroke (CE stroke) and 182 controls (TOAST criteria). The GpIIIa A1/A2 polymorphism was analyzed by polymerase chain reaction followed by restriction enzyme digestion and electrophoresis. Results— The genotype distribution of the GpIIIa gene in patients with LVD stroke (A1/A1, 63%; A1/A2, 34.8%; A2/A2, 2.2%) differed sign...
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ldl phenotype b and other lipid abnormalities in patients with Large Vessel Disease and small Vessel Disease
Journal of the Neurological Sciences, 2003Co-Authors: Agnieszka Slowik, Tomasz Iskra, Wojciech Turaj, Jadwiga Hartwich, Aldona Dembinskakiec, Andrzej SzczudlikAbstract:Background and purpose: Controversies concerning the significance of lipid abnormalities in stroke come mostly from the researches that studied lipid profile without considering stroke aetiologies. We investigated the prevalence of LDL phenotype B and other lipid abnormalities in stroke survivors with Large Vessel Disease (LVD) or small Vessel Disease (SVD) (TOAST criteria) and in control subjects (CS). Methods: We studied 30 patients with LVD and 41 patients with SVD screened out of 585 stroke patients and 30 CS who fulfilled the following exclusion criteria: cardiac disorders, renal or hepatic failure, diabetes mellitus, or treatment with lipid-lowering agents. At least 3 months after stroke, the concentrations of total cholesterol (TC), HDL cholesterol (HDL-C), LDL cholesterol (LDL-C), triglycerides (TGs), apolipoprotein E (apoE), and lipoprotein (a) [lp(a)] were measured and LDL phenotypes and apoE isoforms were identified. Results: Patients with LVD had significantly higher concentrations of LDL-C than CS (p 30 mg/ml) was greater in patients with LVD (36.7%) than in CS (10%) (p<0.05). Conclusions: Patients with stroke due to LVD, but not SVD, have high prevalence of atherogenic lipid abnormalities, including increased frequency of LDL phenotype B and higher percentage of increased lp(a) level, like patients with other atherogenic Diseases.
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LDL phenotype B and other lipid abnormalities in patients with Large Vessel Disease and small Vessel Disease.
Journal of the neurological sciences, 2003Co-Authors: Agnieszka Slowik, Tomasz Iskra, Wojciech Turaj, Jadwiga Hartwich, Aldona Dembinska-kiec, Andrzej SzczudlikAbstract:Controversies concerning the significance of lipid abnormalities in stroke come mostly from the researches that studied lipid profile without considering stroke aetiologies. We investigated the prevalence of LDL phenotype B and other lipid abnormalities in stroke survivors with Large Vessel Disease (LVD) or small Vessel Disease (SVD) (TOAST criteria) and in control subjects (CS). We studied 30 patients with LVD and 41 patients with SVD screened out of 585 stroke patients and 30 CS who fulfilled the following exclusion criteria: cardiac disorders, renal or hepatic failure, diabetes mellitus, or treatment with lipid-lowering agents. At least 3 months after stroke, the concentrations of total cholesterol (TC), HDL cholesterol (HDL-C), LDL cholesterol (LDL-C), triglycerides (TGs), apolipoprotein E (apoE), and lipoprotein (a) [lp(a)] were measured and LDL phenotypes and apoE isoforms were identified. Patients with LVD had significantly higher concentrations of LDL-C than CS (p<0.05). They had higher concentrations of TGs and lower concentrations of HDL-C than patients with SVD and CS (p<0.05). LDL phenotype B was more frequent in patients with LVD (63.3%) than in patients with SVD (39.0%) or in CS (16.7%) (p<0.05). The concentration of apoE was higher in patients with LVD than in patients with SVD or in CS (p<0.05). The percentage of patients with increased level of lp(a) (i.e., >30 mg/ml) was greater in patients with LVD (36.7%) than in CS (10%) (p<0.05). Patients with stroke due to LVD, but not SVD, have high prevalence of atherogenic lipid abnormalities, including increased frequency of LDL phenotype B and higher percentage of increased lp(a) level, like patients with other atherogenic Diseases.
Hossam M. Shokri - One of the best experts on this subject based on the ideXlab platform.
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Pre-micro RNA polymorphism detection in small versus Large Vessel Disease in stroke Egyptian patients
Metabolic Brain Disease, 2021Co-Authors: Ekrami A. Hassan, A Alzahaby, Hala M. El-khawas, Afify H., Mustafa M. M. Elbakry, Hossam M. ShokriAbstract:Stroke is the main cause of adult disability and is responsible for around 11% of deaths all over the world. Ischemic stroke encompasses about 80–85% of total stroke cases. Several studies have shown the relation between microRNAs polymorphism and ischemic stroke. The aim of the study was to evaluate the influence of three common single nucleotide polymorphisms in pre-miRNAs (hsa-miR-146a/rs2910164, hsa-miR-196a2/rs11614913 and hsa-miR-499/rs3746444) on individual susceptibility to the risk of ischemic stroke subtypes in Egyptian population with 117 ischemic stroke patients. Results showed that hsa-miR-146a/rs2910164 was significantly associated with the risk of small Vessel Disease stroke in Egyptian population with no significant association between hsa-miR-196a2/rs11614913 and hsa-miR-499/rs3746444 with the risk of ischemic stroke. Therefore, it can be concluded that miR-146a/rs2910164 polymorphism is involved in the vulnerability to small Vessel Disease ischemic stroke risk in Egyptian population.
