The Experts below are selected from a list of 36 Experts worldwide ranked by ideXlab platform
Thomas D Bannister - One of the best experts on this subject based on the ideXlab platform.
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Sequential Sonagashira and Larock Indole Synthesis Reactions in a General Strategy To Prepare Biologically Active β‑Carboline- Containing Alkaloids
2016Co-Authors: Xiaohong Pan, Thomas D BannisterAbstract:ABSTRACT: A general synthetic approach to β-carboline-containing alkaloids was developed. Two consecutive palladium-mediated processes, a Sonagashira coupling and a Larock Indole annulation reaction, are central to the method. The scope of the approach was investigated and found to be amenable for constructing a variety of biologically significant natural products and also for preparing substituted analogues for optimization and analysis of their biological properties. Efficient palladium-mediated reactions allow easy access tohighly substituted heterocycles, including Indoles, one of the most significant and biologically active core structures in natural products.1 We sought to apply Larock’s method of Indole Synthesis2 to prepare 2-pyridyl-Indoles 1 by the retroSynthesis shown in Scheme 1. The required Larock substrate 3 would arise from a Sonagashira reaction.3 An expected advantage of this approach is that each of these consecutive coupling processes would likely tolerate significan
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sequential sonagashira and Larock Indole Synthesis reactions in a general strategy to prepare biologically active β carboline containing alkaloids
ChemInform, 2015Co-Authors: Xiaohong Pan, Thomas D BannisterAbstract:The two palladium-mediated title processes serve as key steps for the Synthesis of various β-carboline-containing natural products.
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sequential sonagashira and Larock Indole Synthesis reactions in a general strategy to prepare biologically active β carboline containing alkaloids
Organic Letters, 2014Co-Authors: Xiaohong Pan, Thomas D BannisterAbstract:A general synthetic approach to β-carboline-containing alkaloids was developed. Two consecutive palladium-mediated processes, a Sonagashira coupling and a Larock Indole annulation reaction, are central to the method. The scope of the approach was investigated and found to be amenable for constructing a variety of biologically significant natural products and also for preparing substituted analogues for optimization and analysis of their biological properties.
Xiaohong Pan - One of the best experts on this subject based on the ideXlab platform.
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Sequential Sonagashira and Larock Indole Synthesis Reactions in a General Strategy To Prepare Biologically Active β‑Carboline- Containing Alkaloids
2016Co-Authors: Xiaohong Pan, Thomas D BannisterAbstract:ABSTRACT: A general synthetic approach to β-carboline-containing alkaloids was developed. Two consecutive palladium-mediated processes, a Sonagashira coupling and a Larock Indole annulation reaction, are central to the method. The scope of the approach was investigated and found to be amenable for constructing a variety of biologically significant natural products and also for preparing substituted analogues for optimization and analysis of their biological properties. Efficient palladium-mediated reactions allow easy access tohighly substituted heterocycles, including Indoles, one of the most significant and biologically active core structures in natural products.1 We sought to apply Larock’s method of Indole Synthesis2 to prepare 2-pyridyl-Indoles 1 by the retroSynthesis shown in Scheme 1. The required Larock substrate 3 would arise from a Sonagashira reaction.3 An expected advantage of this approach is that each of these consecutive coupling processes would likely tolerate significan
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sequential sonagashira and Larock Indole Synthesis reactions in a general strategy to prepare biologically active β carboline containing alkaloids
ChemInform, 2015Co-Authors: Xiaohong Pan, Thomas D BannisterAbstract:The two palladium-mediated title processes serve as key steps for the Synthesis of various β-carboline-containing natural products.
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sequential sonagashira and Larock Indole Synthesis reactions in a general strategy to prepare biologically active β carboline containing alkaloids
Organic Letters, 2014Co-Authors: Xiaohong Pan, Thomas D BannisterAbstract:A general synthetic approach to β-carboline-containing alkaloids was developed. Two consecutive palladium-mediated processes, a Sonagashira coupling and a Larock Indole annulation reaction, are central to the method. The scope of the approach was investigated and found to be amenable for constructing a variety of biologically significant natural products and also for preparing substituted analogues for optimization and analysis of their biological properties.
Jia Yanxing - One of the best experts on this subject based on the ideXlab platform.
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Total Synthesis of Dictyodendrins B and E, and Formal Synthesis of Dictyodendrin C
欧洲有机化学杂志, 2014Co-Authors: Tao Pengyu, Liang Jingjing, Jia YanxingAbstract:A full account of the concise total syntheses of dictyodendrins B and E, and the formal Synthesis of dictyodendrin C are described. A palladium-catalysed Larock Indole Synthesis was used to form the highly substituted Indole core, and a palladium-mediated one-pot consecutive Buchwald-Hartwig amination/C-H activation reaction was used to construct the key pyrrolo[2,3-c]carbazole core. Unsuccessful synthetic strategies are also discussed.http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000341769700015&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=8e1609b174ce4e31116a60747a720701Chemistry, OrganicSCI(E)6ARTICLEyxjia@bjmu.edu.cn265735-574
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Total Synthesis of Dictyodendrins B and E
journal of organic chemistry, 2013Co-Authors: Liang Jingjing, Hu Weimin, Tao Pengyu, Jia YanxingAbstract:The concise Synthesis of the novel telomerase inhibitors dictyodendrins B and E was completed in only 9 and 11 steps (longest linear sequence). The highly convergent strategy employed a palladium-catalyzed Larock Indole Synthesis and a palladium-mediated one-pot consecutive Buchwald-Hartwig amination/C H activation reaction as key steps. The present Synthesis exhibits respectable levels of atom-, redox-, and step-economy.Chemistry, OrganicSCI(E)EIPubMed7ARTICLE115810-58157
Liang Jingjing - One of the best experts on this subject based on the ideXlab platform.
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Total Synthesis of Dictyodendrins B and E, and Formal Synthesis of Dictyodendrin C
欧洲有机化学杂志, 2014Co-Authors: Tao Pengyu, Liang Jingjing, Jia YanxingAbstract:A full account of the concise total syntheses of dictyodendrins B and E, and the formal Synthesis of dictyodendrin C are described. A palladium-catalysed Larock Indole Synthesis was used to form the highly substituted Indole core, and a palladium-mediated one-pot consecutive Buchwald-Hartwig amination/C-H activation reaction was used to construct the key pyrrolo[2,3-c]carbazole core. Unsuccessful synthetic strategies are also discussed.http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000341769700015&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=8e1609b174ce4e31116a60747a720701Chemistry, OrganicSCI(E)6ARTICLEyxjia@bjmu.edu.cn265735-574
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Total Synthesis of Dictyodendrins B and E
journal of organic chemistry, 2013Co-Authors: Liang Jingjing, Hu Weimin, Tao Pengyu, Jia YanxingAbstract:The concise Synthesis of the novel telomerase inhibitors dictyodendrins B and E was completed in only 9 and 11 steps (longest linear sequence). The highly convergent strategy employed a palladium-catalyzed Larock Indole Synthesis and a palladium-mediated one-pot consecutive Buchwald-Hartwig amination/C H activation reaction as key steps. The present Synthesis exhibits respectable levels of atom-, redox-, and step-economy.Chemistry, OrganicSCI(E)EIPubMed7ARTICLE115810-58157
Yasushi Obora - One of the best experts on this subject based on the ideXlab platform.
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n n dimethylformamide stabilized palladium nanoclusters as a catalyst for Larock Indole Synthesis
RSC Advances, 2018Co-Authors: Kaito Onishi, Kei Oikawa, Hiroki Yano, Takeyuki Suzuki, Yasushi OboraAbstract:We show that N,N-dimethylformamide-stabilized Pd nanoclusters (NCs) have high catalytic activity in the reaction of substituted 2-iodoanilines with alkynes to give 2,3-disubstituted Indoles. This Indole Synthesis does not require phosphine ligands and proceeds with low Pd catalyst loadings. The Pd NCs were separated from the mixture after the reaction, and recycled at least three times. Transmission electron microscopy images showed that the Pd particle size before the reaction was 1.5–2.5 nm. The particle size after the reaction was 2–3 nm. X-ray photoelectron spectroscopy showed that the binding energy of the Pd NCs before the reaction was 335.0 eV.
