The Experts below are selected from a list of 30 Experts worldwide ranked by ideXlab platform
Hans-christoph Scholle - One of the best experts on this subject based on the ideXlab platform.
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Comparison between Intramuscular Multichannel Electrodes and Supramysial Multichannel Electrodes via EMG Measurements for Potential Use as Larynx Stimulation Electrodes: In Vivo Animal Analysis
Sensors (Basel Switzerland), 2019Co-Authors: Bernd Faenger, Dirk Arnold, Nikolaus P. Schumann, Orlando Guntinas-lichius, Roland Grassme, Christoph Anders, Hans-christoph ScholleAbstract:One of the most common causes for Larynx paralysis is the injury of the recurrent laryngeal nerve which, among others, causes the paralysis of the posterior cricoarytenoideus Muscle (PCA). Electrical stimulation of PCA offers an approach to retaining the function of the paralyzed Larynx Muscle. The study aim was to test the applicability of an intramuscular multichannel array electrode as a measuring electrode for myoelectrical potentials and as a possible electrode for stimulation, e.g., posterior cricoarytenoideus Muscle stimulation. For this purpose, two different kinds of electrodes were compared. 42 intramuscular multichannel array electrodes and 11 supramysial multichannel electrodes were implanted into the triceps brachii Muscle of rats. The triceps brachii Muscle of rats is suitable to serve as a substitute Muscle for the human PCA Muscle in an in vivo animal model. It has the same striated Muscle cells, is of comparable size, and fundamentally serves a similar function to the human PCA Muscle during normal respiration. Walking and breathing are circular functions that cause minimal Muscle fatigue when carried out steadily. In total, the myoelectrical activity of 6703 steps could be recorded, allowing a comparison and statistical analysis of the EMG amplitudes and EMG activation patterns. Small differences can be detected between the EMG signals of both electrode types which, however, can be explained physiologically. Both electrode types reveal the basic characteristics of the triceps brachii Muscle activity, namely the Muscle contraction strength and the coordination pattern. This indicates that the intramuscular electrode may be applied for a detailed analysis of the human Larynx.
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Method to test the long-term stability of functional electrical stimulation via multichannel electrodes (e.g., applicable for laryngeal pacing) and to define best points for stimulation: in vivo animal analysis
European Archives of Oto-Rhino-Laryngology, 2017Co-Authors: Bernd Faenger, Dirk Arnold, Nikolaus P. Schumann, Orlando Guntinas-lichius, Hans-christoph ScholleAbstract:The study aim was to identify and analyze intramuscular electrically sensitive points. Electrically sensitive points are herein defined as positions, which allow Muscles stimulation with a minimum possible fatigue for a maximum amount of time. A multichannel array electrode was used which could be interesting to retain the function of Larynx Muscle after paralysis. Eight array electrodes were implanted in the triceps brachii Muscle of four rats. While being under anesthesia, the animals were intramuscularly stimulated at 16 different positions. Sihler’s staining technique was used to make visible the nerves routes and the intramuscular position of the individual electrode plate. The positions of the motor end plates were determined by means of multichannel-electromyography. The positions that allow longest stimulation periods are located close to the points where the nerves enter the Muscle. Stimulation at the position of the motor end plates does not result in stimulation periods above average. Locations initially causing strong Muscle contractions are not necessarily identical to the ones allowing long stimulation periods. The animal model identified the stimulation points for minimal possible Muscle fatigue stimulation as being located close to the points of entrance of the nerve into the Muscle. Stimulation causing an initially strong contraction response is no indication of optimal location of the stimulation electrode in terms of chronic stimulation. The array electrode of this study could be interesting as a stimulation electrode for a Larynx pacemaker.
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Development of a novel Larynx pacemaker multichannel array electrode: In vivo animal analysis
The Laryngoscope, 2015Co-Authors: Bernd Faenger, Dirk Arnold, Nikolaus P. Schumann, Orlando Guntinas-lichius, Roland Grassme, Hans-christoph ScholleAbstract:Objectives/Hypothesis Electrical stimulation of posterior cricoarytenoid Muscle offers a physiological approach to retain the function of the paralyzed Larynx Muscle after paralysis. The aim of this study was to develop and evaluate a durable, biocompatible, and atraumatic array electrode for inclusion in a Larynx pacemaker. In addition to developing the electrode array, an evaluation methodology using in vivo multichannel electromyography was assessed. Study Design In vivo test procedures for material evaluation: an animal model. Methods Over the research period, 42 array electrodes representing nine different prototypes were implanted in the triceps brachii Muscle of 21 rats. Biocompatibility and atraumatic functions were evaluated via observation. Electrode function and durability were determined by comparison of daily electromyographic measurements of the Muscle activity of the front leg (triceps brachii Muscle) during locomotion. Results The used animal model demonstrated electrode material problems that could not be material evaluation from in vitro tests alone. Through use of this in vivo method, it was found that an array tip that is durable, biocompatible, and atraumatic should consist of many small electrode plates cast in flexible silicone. The connecting wires to the individual electrode plates should be Litz wire, which consists of multiple strands. Conclusions The here demonstrated in vivo test method was a suitable animal model for designing and evaluating electrodes to be further developed for inclusion in human implants. Level of Evidence N/A. Laryngoscope, 2015
Bernd Faenger - One of the best experts on this subject based on the ideXlab platform.
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Comparison between Intramuscular Multichannel Electrodes and Supramysial Multichannel Electrodes via EMG Measurements for Potential Use as Larynx Stimulation Electrodes: In Vivo Animal Analysis
Sensors (Basel Switzerland), 2019Co-Authors: Bernd Faenger, Dirk Arnold, Nikolaus P. Schumann, Orlando Guntinas-lichius, Roland Grassme, Christoph Anders, Hans-christoph ScholleAbstract:One of the most common causes for Larynx paralysis is the injury of the recurrent laryngeal nerve which, among others, causes the paralysis of the posterior cricoarytenoideus Muscle (PCA). Electrical stimulation of PCA offers an approach to retaining the function of the paralyzed Larynx Muscle. The study aim was to test the applicability of an intramuscular multichannel array electrode as a measuring electrode for myoelectrical potentials and as a possible electrode for stimulation, e.g., posterior cricoarytenoideus Muscle stimulation. For this purpose, two different kinds of electrodes were compared. 42 intramuscular multichannel array electrodes and 11 supramysial multichannel electrodes were implanted into the triceps brachii Muscle of rats. The triceps brachii Muscle of rats is suitable to serve as a substitute Muscle for the human PCA Muscle in an in vivo animal model. It has the same striated Muscle cells, is of comparable size, and fundamentally serves a similar function to the human PCA Muscle during normal respiration. Walking and breathing are circular functions that cause minimal Muscle fatigue when carried out steadily. In total, the myoelectrical activity of 6703 steps could be recorded, allowing a comparison and statistical analysis of the EMG amplitudes and EMG activation patterns. Small differences can be detected between the EMG signals of both electrode types which, however, can be explained physiologically. Both electrode types reveal the basic characteristics of the triceps brachii Muscle activity, namely the Muscle contraction strength and the coordination pattern. This indicates that the intramuscular electrode may be applied for a detailed analysis of the human Larynx.
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Method to test the long-term stability of functional electrical stimulation via multichannel electrodes (e.g., applicable for laryngeal pacing) and to define best points for stimulation: in vivo animal analysis
European Archives of Oto-Rhino-Laryngology, 2017Co-Authors: Bernd Faenger, Dirk Arnold, Nikolaus P. Schumann, Orlando Guntinas-lichius, Hans-christoph ScholleAbstract:The study aim was to identify and analyze intramuscular electrically sensitive points. Electrically sensitive points are herein defined as positions, which allow Muscles stimulation with a minimum possible fatigue for a maximum amount of time. A multichannel array electrode was used which could be interesting to retain the function of Larynx Muscle after paralysis. Eight array electrodes were implanted in the triceps brachii Muscle of four rats. While being under anesthesia, the animals were intramuscularly stimulated at 16 different positions. Sihler’s staining technique was used to make visible the nerves routes and the intramuscular position of the individual electrode plate. The positions of the motor end plates were determined by means of multichannel-electromyography. The positions that allow longest stimulation periods are located close to the points where the nerves enter the Muscle. Stimulation at the position of the motor end plates does not result in stimulation periods above average. Locations initially causing strong Muscle contractions are not necessarily identical to the ones allowing long stimulation periods. The animal model identified the stimulation points for minimal possible Muscle fatigue stimulation as being located close to the points of entrance of the nerve into the Muscle. Stimulation causing an initially strong contraction response is no indication of optimal location of the stimulation electrode in terms of chronic stimulation. The array electrode of this study could be interesting as a stimulation electrode for a Larynx pacemaker.
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Development of a novel Larynx pacemaker multichannel array electrode: In vivo animal analysis
The Laryngoscope, 2015Co-Authors: Bernd Faenger, Dirk Arnold, Nikolaus P. Schumann, Orlando Guntinas-lichius, Roland Grassme, Hans-christoph ScholleAbstract:Objectives/Hypothesis Electrical stimulation of posterior cricoarytenoid Muscle offers a physiological approach to retain the function of the paralyzed Larynx Muscle after paralysis. The aim of this study was to develop and evaluate a durable, biocompatible, and atraumatic array electrode for inclusion in a Larynx pacemaker. In addition to developing the electrode array, an evaluation methodology using in vivo multichannel electromyography was assessed. Study Design In vivo test procedures for material evaluation: an animal model. Methods Over the research period, 42 array electrodes representing nine different prototypes were implanted in the triceps brachii Muscle of 21 rats. Biocompatibility and atraumatic functions were evaluated via observation. Electrode function and durability were determined by comparison of daily electromyographic measurements of the Muscle activity of the front leg (triceps brachii Muscle) during locomotion. Results The used animal model demonstrated electrode material problems that could not be material evaluation from in vitro tests alone. Through use of this in vivo method, it was found that an array tip that is durable, biocompatible, and atraumatic should consist of many small electrode plates cast in flexible silicone. The connecting wires to the individual electrode plates should be Litz wire, which consists of multiple strands. Conclusions The here demonstrated in vivo test method was a suitable animal model for designing and evaluating electrodes to be further developed for inclusion in human implants. Level of Evidence N/A. Laryngoscope, 2015
Walter Metzner - One of the best experts on this subject based on the ideXlab platform.
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Behavioural and neurobiological implications of linear and non-linear features in Larynx phonations of horseshoe bats
Nature communications, 2012Co-Authors: Kohta I. Kobayasi, Steffen R. Hage, Sean Berquist, Jiang Feng, Shuyi Zhang, Walter MetznerAbstract:Mammalian vocalizations exhibit large variations in their spectrotemporal features, although it is still largely unknown which result from intrinsic biomechanical properties of the Larynx and which are under direct neuromuscular control. Here we show that mere changes in laryngeal air flow yield several non-linear effects on sound production, in an isolated Larynx preparation from horseshoe bats. Most notably, there are sudden jumps between two frequency bands used for either echolocation or communication in natural vocalizations. These jumps resemble changes in 'registers' as in yodelling. In contrast, simulated contractions of the main Larynx Muscle produce linear frequency changes, but are limited to echolocation or communication frequencies. Only by combining non-linear and linear properties can this Larynx, therefore, produce sounds covering the entire frequency range of natural calls. This may give behavioural meaning to yodelling-like vocal behaviour and reshape our thinking about how the brain controls the multitude of spectral vocal features in mammals.
Nikolaus P. Schumann - One of the best experts on this subject based on the ideXlab platform.
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Comparison between Intramuscular Multichannel Electrodes and Supramysial Multichannel Electrodes via EMG Measurements for Potential Use as Larynx Stimulation Electrodes: In Vivo Animal Analysis
Sensors (Basel Switzerland), 2019Co-Authors: Bernd Faenger, Dirk Arnold, Nikolaus P. Schumann, Orlando Guntinas-lichius, Roland Grassme, Christoph Anders, Hans-christoph ScholleAbstract:One of the most common causes for Larynx paralysis is the injury of the recurrent laryngeal nerve which, among others, causes the paralysis of the posterior cricoarytenoideus Muscle (PCA). Electrical stimulation of PCA offers an approach to retaining the function of the paralyzed Larynx Muscle. The study aim was to test the applicability of an intramuscular multichannel array electrode as a measuring electrode for myoelectrical potentials and as a possible electrode for stimulation, e.g., posterior cricoarytenoideus Muscle stimulation. For this purpose, two different kinds of electrodes were compared. 42 intramuscular multichannel array electrodes and 11 supramysial multichannel electrodes were implanted into the triceps brachii Muscle of rats. The triceps brachii Muscle of rats is suitable to serve as a substitute Muscle for the human PCA Muscle in an in vivo animal model. It has the same striated Muscle cells, is of comparable size, and fundamentally serves a similar function to the human PCA Muscle during normal respiration. Walking and breathing are circular functions that cause minimal Muscle fatigue when carried out steadily. In total, the myoelectrical activity of 6703 steps could be recorded, allowing a comparison and statistical analysis of the EMG amplitudes and EMG activation patterns. Small differences can be detected between the EMG signals of both electrode types which, however, can be explained physiologically. Both electrode types reveal the basic characteristics of the triceps brachii Muscle activity, namely the Muscle contraction strength and the coordination pattern. This indicates that the intramuscular electrode may be applied for a detailed analysis of the human Larynx.
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Method to test the long-term stability of functional electrical stimulation via multichannel electrodes (e.g., applicable for laryngeal pacing) and to define best points for stimulation: in vivo animal analysis
European Archives of Oto-Rhino-Laryngology, 2017Co-Authors: Bernd Faenger, Dirk Arnold, Nikolaus P. Schumann, Orlando Guntinas-lichius, Hans-christoph ScholleAbstract:The study aim was to identify and analyze intramuscular electrically sensitive points. Electrically sensitive points are herein defined as positions, which allow Muscles stimulation with a minimum possible fatigue for a maximum amount of time. A multichannel array electrode was used which could be interesting to retain the function of Larynx Muscle after paralysis. Eight array electrodes were implanted in the triceps brachii Muscle of four rats. While being under anesthesia, the animals were intramuscularly stimulated at 16 different positions. Sihler’s staining technique was used to make visible the nerves routes and the intramuscular position of the individual electrode plate. The positions of the motor end plates were determined by means of multichannel-electromyography. The positions that allow longest stimulation periods are located close to the points where the nerves enter the Muscle. Stimulation at the position of the motor end plates does not result in stimulation periods above average. Locations initially causing strong Muscle contractions are not necessarily identical to the ones allowing long stimulation periods. The animal model identified the stimulation points for minimal possible Muscle fatigue stimulation as being located close to the points of entrance of the nerve into the Muscle. Stimulation causing an initially strong contraction response is no indication of optimal location of the stimulation electrode in terms of chronic stimulation. The array electrode of this study could be interesting as a stimulation electrode for a Larynx pacemaker.
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Development of a novel Larynx pacemaker multichannel array electrode: In vivo animal analysis
The Laryngoscope, 2015Co-Authors: Bernd Faenger, Dirk Arnold, Nikolaus P. Schumann, Orlando Guntinas-lichius, Roland Grassme, Hans-christoph ScholleAbstract:Objectives/Hypothesis Electrical stimulation of posterior cricoarytenoid Muscle offers a physiological approach to retain the function of the paralyzed Larynx Muscle after paralysis. The aim of this study was to develop and evaluate a durable, biocompatible, and atraumatic array electrode for inclusion in a Larynx pacemaker. In addition to developing the electrode array, an evaluation methodology using in vivo multichannel electromyography was assessed. Study Design In vivo test procedures for material evaluation: an animal model. Methods Over the research period, 42 array electrodes representing nine different prototypes were implanted in the triceps brachii Muscle of 21 rats. Biocompatibility and atraumatic functions were evaluated via observation. Electrode function and durability were determined by comparison of daily electromyographic measurements of the Muscle activity of the front leg (triceps brachii Muscle) during locomotion. Results The used animal model demonstrated electrode material problems that could not be material evaluation from in vitro tests alone. Through use of this in vivo method, it was found that an array tip that is durable, biocompatible, and atraumatic should consist of many small electrode plates cast in flexible silicone. The connecting wires to the individual electrode plates should be Litz wire, which consists of multiple strands. Conclusions The here demonstrated in vivo test method was a suitable animal model for designing and evaluating electrodes to be further developed for inclusion in human implants. Level of Evidence N/A. Laryngoscope, 2015
Orlando Guntinas-lichius - One of the best experts on this subject based on the ideXlab platform.
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Comparison between Intramuscular Multichannel Electrodes and Supramysial Multichannel Electrodes via EMG Measurements for Potential Use as Larynx Stimulation Electrodes: In Vivo Animal Analysis
Sensors (Basel Switzerland), 2019Co-Authors: Bernd Faenger, Dirk Arnold, Nikolaus P. Schumann, Orlando Guntinas-lichius, Roland Grassme, Christoph Anders, Hans-christoph ScholleAbstract:One of the most common causes for Larynx paralysis is the injury of the recurrent laryngeal nerve which, among others, causes the paralysis of the posterior cricoarytenoideus Muscle (PCA). Electrical stimulation of PCA offers an approach to retaining the function of the paralyzed Larynx Muscle. The study aim was to test the applicability of an intramuscular multichannel array electrode as a measuring electrode for myoelectrical potentials and as a possible electrode for stimulation, e.g., posterior cricoarytenoideus Muscle stimulation. For this purpose, two different kinds of electrodes were compared. 42 intramuscular multichannel array electrodes and 11 supramysial multichannel electrodes were implanted into the triceps brachii Muscle of rats. The triceps brachii Muscle of rats is suitable to serve as a substitute Muscle for the human PCA Muscle in an in vivo animal model. It has the same striated Muscle cells, is of comparable size, and fundamentally serves a similar function to the human PCA Muscle during normal respiration. Walking and breathing are circular functions that cause minimal Muscle fatigue when carried out steadily. In total, the myoelectrical activity of 6703 steps could be recorded, allowing a comparison and statistical analysis of the EMG amplitudes and EMG activation patterns. Small differences can be detected between the EMG signals of both electrode types which, however, can be explained physiologically. Both electrode types reveal the basic characteristics of the triceps brachii Muscle activity, namely the Muscle contraction strength and the coordination pattern. This indicates that the intramuscular electrode may be applied for a detailed analysis of the human Larynx.
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Method to test the long-term stability of functional electrical stimulation via multichannel electrodes (e.g., applicable for laryngeal pacing) and to define best points for stimulation: in vivo animal analysis
European Archives of Oto-Rhino-Laryngology, 2017Co-Authors: Bernd Faenger, Dirk Arnold, Nikolaus P. Schumann, Orlando Guntinas-lichius, Hans-christoph ScholleAbstract:The study aim was to identify and analyze intramuscular electrically sensitive points. Electrically sensitive points are herein defined as positions, which allow Muscles stimulation with a minimum possible fatigue for a maximum amount of time. A multichannel array electrode was used which could be interesting to retain the function of Larynx Muscle after paralysis. Eight array electrodes were implanted in the triceps brachii Muscle of four rats. While being under anesthesia, the animals were intramuscularly stimulated at 16 different positions. Sihler’s staining technique was used to make visible the nerves routes and the intramuscular position of the individual electrode plate. The positions of the motor end plates were determined by means of multichannel-electromyography. The positions that allow longest stimulation periods are located close to the points where the nerves enter the Muscle. Stimulation at the position of the motor end plates does not result in stimulation periods above average. Locations initially causing strong Muscle contractions are not necessarily identical to the ones allowing long stimulation periods. The animal model identified the stimulation points for minimal possible Muscle fatigue stimulation as being located close to the points of entrance of the nerve into the Muscle. Stimulation causing an initially strong contraction response is no indication of optimal location of the stimulation electrode in terms of chronic stimulation. The array electrode of this study could be interesting as a stimulation electrode for a Larynx pacemaker.
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Development of a novel Larynx pacemaker multichannel array electrode: In vivo animal analysis
The Laryngoscope, 2015Co-Authors: Bernd Faenger, Dirk Arnold, Nikolaus P. Schumann, Orlando Guntinas-lichius, Roland Grassme, Hans-christoph ScholleAbstract:Objectives/Hypothesis Electrical stimulation of posterior cricoarytenoid Muscle offers a physiological approach to retain the function of the paralyzed Larynx Muscle after paralysis. The aim of this study was to develop and evaluate a durable, biocompatible, and atraumatic array electrode for inclusion in a Larynx pacemaker. In addition to developing the electrode array, an evaluation methodology using in vivo multichannel electromyography was assessed. Study Design In vivo test procedures for material evaluation: an animal model. Methods Over the research period, 42 array electrodes representing nine different prototypes were implanted in the triceps brachii Muscle of 21 rats. Biocompatibility and atraumatic functions were evaluated via observation. Electrode function and durability were determined by comparison of daily electromyographic measurements of the Muscle activity of the front leg (triceps brachii Muscle) during locomotion. Results The used animal model demonstrated electrode material problems that could not be material evaluation from in vitro tests alone. Through use of this in vivo method, it was found that an array tip that is durable, biocompatible, and atraumatic should consist of many small electrode plates cast in flexible silicone. The connecting wires to the individual electrode plates should be Litz wire, which consists of multiple strands. Conclusions The here demonstrated in vivo test method was a suitable animal model for designing and evaluating electrodes to be further developed for inclusion in human implants. Level of Evidence N/A. Laryngoscope, 2015
