The Experts below are selected from a list of 3495 Experts worldwide ranked by ideXlab platform
R. S. Shinde - One of the best experts on this subject based on the ideXlab platform.
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CASE REPORT Pre- and Posttreatment MR Imaging Findings in Lead Encephalopathy
2015Co-Authors: A. L. Atre, P. R. Shinde, S. N. Shinde, R. S. Wadia, A. A. Nanivadekar, S. J. Vaid, R. S. ShindeAbstract:SUMMARY: A 41-year-old man suspected of having Lead poisoning was evaluated with MR imaging before and after British antilewisite therapy. The MR imaging findings showed bilateral symmetric involvement of the occipital lobe, affecting predominantly the gray-white matter junction and the subcortical white matter. A right cerebellar lesion was noted, with focal hyperintensities involving the gray-white matter. Similar lesions were seen in the temporal, parietal, and frontal regions. These lesions resolved after chelation therapy. Lead Encephalopathy is rare,1,2 but Lead Encephalopathy dueto ayurvedic medicines is even rarer. In this report, we dis-cuss the MR imaging findings in a patient with Lead encepha-lopathy due to ayurvedic medicines (Ayu-Life). Lead poison-ing affects multiple organs: specifically bones (Lead bands at the epiphyses of the long bones), blood (punctate basophilic stippling of erythrocytes and microcytic hypochromic hemo-lytic anemia), brain (brain edema and demyelination of the cerebral and cerebellar white matter), peripheral nervous sys-tem (demyelinating neuropathy), gingiva (Lead lines), an
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pre and posttreatment mr imaging findings in Lead Encephalopathy
American Journal of Neuroradiology, 2006Co-Authors: A. L. Atre, P. R. Shinde, S. N. Shinde, R. S. Wadia, A. A. Nanivadekar, S. J. Vaid, R. S. ShindeAbstract:A 41-year-old man suspected of having Lead poisoning was evaluated with MR imaging before and after British antilewisite therapy. The MR imaging findings showed bilateral symmetric involvement of the occipital lobe, affecting predominantly the gray-white matter junction and the subcortical white matter. A right cerebellar lesion was noted, with focal hyperintensities involving the gray-white matter. Similar lesions were seen in the temporal, parietal, and frontal regions. These lesions resolved after chelation therapy.
Maziar Shojaei - One of the best experts on this subject based on the ideXlab platform.
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Encephalopathy following ingestion of Lead contaminated opium magnetic resonance imaging findings
BMC Neurology, 2020Co-Authors: Maryam Haghighimorad, Nasim Zamani, Hossein Hassanianmoghaddam, Maziar ShojaeiAbstract:Encephalopathy is an uncommon but serious presentation of Lead toxicity. We aimed to determine and follow-up the brain magnetic resonance imaging (MRI) abnormalities in the patients with Lead Encephalopathy due to ingestion of Lead contaminated opium. In a cross-sectional study during Lead-contaminated opium outbreak, all Lead-poisoned patients with any signs/symptoms of Encephalopathy were included. Of 19 patients with Lead Encephalopathy, five died early and other five could not be sent to MRI during their hospitalization period. Mean age was 51 ± 11 years and males were dominant (89%). Median [IQR] blood Lead level (BLL) was 101 [81, 108] μg/dL (range; 50 to 200 μg/dL). There was no correlation between MRI findings and signs/symptoms. MRI was normal in six and abnormal in three. Bilateral symmetric involvement of parieto-occipital lobes was observed. Gray matter, gray-white matter junction, and subcortical white matter were also affected. Follow-up MRI was performed in two with abnormal MRI which showed complete and near complete resolution of the abnormalities after cessation of opium use and treatment. Conclusion: There was no correlation between MRI findings and BLL. Complete recovery of brain MRI lesions was detected after cessation of opium use.
P N Bennett - One of the best experts on this subject based on the ideXlab platform.
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Lead poisoning case studies
British Journal of Clinical Pharmacology, 2002Co-Authors: J N Gordon, A Taylor, P N BennettAbstract:Early clinical features of Lead toxicity are non-specific and an occupational history is particularly valuable. Lead in the body comprises 2% in the blood (t1/2 35 days) and 95% in bone and dentine (t1/2 20–30 years). Blood Lead may remain elevated for years after cessation from long exposure, due to redistribution from bone. Blood Lead concentration is the most widely used marker for inorganic Lead exposure. Zinc protoporphyrin (ZPP) concentration in blood usefully reflects Lead exposure over the prior 3 months. Symptomatic patients with blood Lead concentration >2.4 µmol l−1 (50 µg dl−1) or in any event >3.8 µmol l−1 (80 µg dl−1) should receive sodium calciumedetate i.v., followed by succimer by mouth for 19 days. Asymptomatic patients with blood Lead concentration >2.4 µmol l−1 (50 µg dl−1) may be treated with succimer alone. Sodium calciumedetate should be given with dimercaprol to treat Lead Encephalopathy.
Bart J Currie - One of the best experts on this subject based on the ideXlab platform.
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saccade dysfunction associated with chronic petrol sniffing and Lead Encephalopathy
Journal of Neurology Neurosurgery and Psychiatry, 2004Co-Authors: Sheree Cairney, Paul Maruff, Chris B Burns, Jon Currie, Bart J CurrieAbstract:Background: In chronic petrol sniffers, recent exposure to high levels of Leaded petrol may give rise to a Lead Encephalopathy characterised by tremor, chorea, ataxia, hyperreflexia, convulsive seizures, and death. Neurological abnormalities associated with Lead Encephalopathy involve the cortex, basal ganglia, cerebellum, and brain stem. Objective: To use saccadic eye movement tasks as an experimental tool to determine which CNS changes are associated with chronic petrol sniffing and which with a history of Lead Encephalopathy, and to what extent these changes are reversible. Methods: Saccade function was assessed in chronic petrol sniffers with a history of Lead Encephalopathy (encephalopathic sniffers), chronic petrol sniffers who had never suffered Lead Encephalopathy (chronic sniffers), individuals who had sniffed petrol in the past but had not done so for more than six months (ex-sniffers), and individuals who had never sniffed petrol (non-sniffers). Results: Chronic sniffers showed increased latency of visually guided saccades and antisaccades and increased antisaccade errors which suggested cortical and basal ganglia dysfunction. These abnormalities returned to normal in ex-sniffers. Encephalopathic sniffers showed the same abnormalities as chronic sniffers but with greater severity and additional saccadic signs including dysmetria, gaze evoked nystagmus, and saccade slowing which usually indicate cerebellar and brain stem dysfunction. Conclusions: Chronic petrol abuse is associated with cortical and basal ganglia abnormalities that are at least partially recoverable with abstinence. Additional long term cerebellar and brain stem abnormalities are associated with Lead Encephalopathy.
A. L. Atre - One of the best experts on this subject based on the ideXlab platform.
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CASE REPORT Pre- and Posttreatment MR Imaging Findings in Lead Encephalopathy
2015Co-Authors: A. L. Atre, P. R. Shinde, S. N. Shinde, R. S. Wadia, A. A. Nanivadekar, S. J. Vaid, R. S. ShindeAbstract:SUMMARY: A 41-year-old man suspected of having Lead poisoning was evaluated with MR imaging before and after British antilewisite therapy. The MR imaging findings showed bilateral symmetric involvement of the occipital lobe, affecting predominantly the gray-white matter junction and the subcortical white matter. A right cerebellar lesion was noted, with focal hyperintensities involving the gray-white matter. Similar lesions were seen in the temporal, parietal, and frontal regions. These lesions resolved after chelation therapy. Lead Encephalopathy is rare,1,2 but Lead Encephalopathy dueto ayurvedic medicines is even rarer. In this report, we dis-cuss the MR imaging findings in a patient with Lead encepha-lopathy due to ayurvedic medicines (Ayu-Life). Lead poison-ing affects multiple organs: specifically bones (Lead bands at the epiphyses of the long bones), blood (punctate basophilic stippling of erythrocytes and microcytic hypochromic hemo-lytic anemia), brain (brain edema and demyelination of the cerebral and cerebellar white matter), peripheral nervous sys-tem (demyelinating neuropathy), gingiva (Lead lines), an
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pre and posttreatment mr imaging findings in Lead Encephalopathy
American Journal of Neuroradiology, 2006Co-Authors: A. L. Atre, P. R. Shinde, S. N. Shinde, R. S. Wadia, A. A. Nanivadekar, S. J. Vaid, R. S. ShindeAbstract:A 41-year-old man suspected of having Lead poisoning was evaluated with MR imaging before and after British antilewisite therapy. The MR imaging findings showed bilateral symmetric involvement of the occipital lobe, affecting predominantly the gray-white matter junction and the subcortical white matter. A right cerebellar lesion was noted, with focal hyperintensities involving the gray-white matter. Similar lesions were seen in the temporal, parietal, and frontal regions. These lesions resolved after chelation therapy.