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Arja T Erkkila - One of the best experts on this subject based on the ideXlab platform.
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camelina sativa oil fatty Fish and Lean Fish do not markedly affect urinary prostanoids in subjects with impaired glucose metabolism
Lipids, 2019Co-Authors: Arja T Erkkila, Jetty Chungyung Lee, Maria Lankinen, Suvi Manninen, Ho Hang Leung, Camille Oger, Vanessa D De Mello, Ursula SchwabAbstract:Dietary fatty acids are suggested to affect oxidative stress; however, results from interventions have been inconclusive. The aim was to examine if fatty Fish, Lean Fish, and Camelina sativa oil (CSO) affect the urinary prostanoid levels in subjects with impaired glucose metabolism. Altogether 79 participants aged 43-72 years completed a randomized controlled study lasting 12 weeks. There were four parallel groups, fatty Fish, Lean Fish (four Fish meals/week in both), CSO providing 10 g/day alpha-linolenic acid (ALA), and control diet with limited Fish and ALA containing oil consumption. Urinary prostanoids (prostaglandin F2α , 5-F2t -isoprostanes and 15-F2t -isoprostane metabolites, isofuran, 8-F3t -isoprostanes, and 4-(RS)-4-F4t -neuroprostane) of 72 participants (age: mean (±SD) 58.9 ± 6.5 years; body mass index: 29.3 ± 2.5 kg/m2 ) collected over 12-h were measured using liquid chromatography tandem-mass spectrometry. Plasma phospholipid fatty acids were determined using gas chromatography. Our study showed that the proportion of ALA in plasma phospholipids increased in the CSO group (overall difference among the groups p-value <0.001). In the fatty Fish group, proportions of eicosapentaenoic and docosahexaenoic acids increased (overall p-value <0.001 for both). Prostaglandin F2α was higher in the CSO group than in the control group (p < 0.05), however, there were no other significant changes in urinary excretion of other prostanoids among the study groups. At baseline, arachidonic acid in plasma phospholipids was positively (r = 0.247, p < 0.05) and ALA negatively (r = -0.326, p < 0.05) associated with urinary total isoprostanes. In conclusion, CSO, fatty Fish, and Lean Fish consumption do not cause major changes in oxidative stress markers in subjects with impaired glucose tolerance.
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Camelina sativa Oil, Fatty Fish, and Lean Fish Do Not Markedly Affect Urinary Prostanoids in Subjects with Impaired Glucose Metabolism
Lipids, 2019Co-Authors: Arja T Erkkila, Jetty Chungyung Lee, Maria Lankinen, Suvi Manninen, Ho Hang Leung, Camille Oger, Vanessa De Mello, Ursula SchwabAbstract:Dietary fatty acids are suggested to affect oxidative stress; however, results from interventions have been inconclusive. The aim was to examine if fatty Fish, Lean Fish, and Camelina sativa oil (CSO) affect the urinary prostanoid levels in subjects with impaired glucose metabolism. Altogether 79 participants aged 43-72 years completed a randomized controlled study lasting 12 weeks. There were four parallel groups, fatty Fish, Lean Fish (four Fish meals/week in both), CSO providing 10 g/day alpha-linolenic acid (ALA), and control diet with limited Fish and ALA containing oil consumption. Urinary prostanoids (prostaglandin F2α , 5-F2t -isoprostanes and 15-F2t -isoprostane metabolites, isofuran, 8-F3t -isoprostanes, and 4-(RS)-4-F4t -neuroprostane) of 72 participants (age: mean (±SD) 58.9 ± 6.5 years; body mass index: 29.3 ± 2.5 kg/m2 ) collected over 12-h were measured using liquid chromatography tandem-mass spectrometry. Plasma phospholipid fatty acids were determined using gas chromatography. Our study showed that the proportion of ALA in plasma phospholipids increased in the CSO group (overall difference among the groups p-value
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Camelina Sativa Oil, but not Fatty Fish or Lean Fish, Improves Serum Lipid Profile in Subjects with Impaired Glucose Metabolism-A Randomized Controlled Trial.
Molecular nutrition & food research, 2018Co-Authors: Ursula Schwab, Maria Lankinen, Vanessa D De Mello, Suvi M. Manninen, Sudhir Kurl, Kari Pulkki, David E. Laaksonen, Arja T ErkkilaAbstract:SCOPE The aim of the study is to examine whether Lean Fish (LF), fatty Fish (FF), and camelina sativa oil (CSO), a plant-based source of alpha-linolenic acid (ALA), differ in their metabolic effects in subjects with impaired glucose metabolism. METHODS AND RESULTS Altogether 79 volunteers with impaired fasting glucose, BMI 25-36 kg m-2 , age 43-72 years, participated in a 12-week randomized controlled trial with four parallel groups, that is, the FF (four Fish meals/week), LF (four Fish meals/week), CSO (10 g d-1 ALA), and control (limited intakes of Fish and sources of ALA) groups. The proportions of eicosapentaenoic acid and DHA increase in plasma lipids in the FF group, and the proportion of ALA increase in the CSO group (p < 0.0001 for all). In the CSO group, total and LDL-cholesterol (C) concentrations decrease compared with the FF and LF groups; LDL-C/HDL-C and ApoB/ApoA-I ratios decrease compared with the LF group. There are no significant changes in glucose metabolism or markers of low-grade inflammation. CONCLUSIONS A diet enriched in CSO improves serum lipid profile as compared with a diet enriched in FF or LF in subjects with impaired fasting glucose, with no differences in glucose metabolism or concentrations of inflammatory markers.
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Effect of fatty and Lean Fish intake on lipoprotein subclasses in subjects with coronary heart disease: A controlled trial
Journal of clinical lipidology, 2013Co-Authors: Arja T Erkkila, Vanessa D De Mello, Ursula Schwab, Seppo Lehto, Antti J. Kangas, Pasi Soininen, Mika Ala-korpela, Matti UusitupaAbstract:Background Fish oil intake reduces serum triglycerides; however, little is known about the effects of dietary Fish intake on lipoprotein subclasses. Objective We aimed at assessing the effect of fatty and Lean Fish intake on the lipoprotein subclasses in an intervention study. Methods The intervention study included 33 patients with coronary heart disease, who were aged 61.0 ± 5.8 (mean ± SD) years. The subjects were randomly assigned to a fatty Fish (n = 11), Lean Fish (n = 12), or control (n = 10) diet for 8 weeks. Fish diets included at least 4 Fish meals per week. Subjects in the control group consumed Lean beef, pork, and chicken. Lipoprotein subclasses and their lipid components were determined by nuclear magnetic resonance spectroscopy. Results Concentrations of n-3 fatty acids and docosahexaenoic acid increased in the fatty Fish group. The concentrations of cholesterol, cholesterol esters, and total lipids in very large high-density lipoproteins (HDLs) increased in the fatty Fish group (overall difference P = .005, P = .002, and P = .007, respectively; false discovery rate P = .04, P = .04, and P = .05, respectively). The mean size of HDL particles increased in the fatty Fish group (9.8 ± 0.3 nm at baseline and 9.9 ± 0.4 nm at end of study; overall difference P = .004, false discovery rate P = .04). The Fish diets did not affect very-low-density lipoprotein or low-density lipoprotein size. Conclusion Fatty Fish intake at least 4 times per week increases HDL particle size which might have beneficial effect in patients with coronary heart disease.
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The effect of fatty or Lean Fish intake on inflammatory gene expression in peripheral blood mononuclear cells of patients with coronary heart disease
European Journal of Nutrition, 2009Co-Authors: Vanessa D. F. Mello, Arja T Erkkila, Maria Lankinen, Ursula S. Schwab, Hanna Mussalo, Leena Pulkkinen, Marjukka Kolehmainen, Mustafa Atalay, Matej Orešič, Seppo LehtoAbstract:Background Little is known about the effect of Fish consumption on gene expression of inflammation-related genes in immune cells in coronary heart disease (CHD). Aim of the study We sought to evaluate the effect of a fatty Fish (FF) or a Lean Fish (LF) diet on the modulation of inflammatory and endothelial function-related genes in peripheral blood mononuclear cells (PBMCs) of subjects with CHD, and its association with serum fatty acid (FA) profile and lipid metabolic compounds. Methods Data from 27 patients randomized into an 8-week FF ( n = 10; mean ± SD: 4.3 ± 0.4 portions of Fish per week), LF ( n = 11; 4.7 ± 1.1 portions of Fish per week), or control diet ( n = 6; 0.6 ± 0.4 portions of Fish per week) were analyzed. The mRNA expression was measured using real-time PCR. Results The effect of the intervention on the mRNA expression of the genes studied did not differ among groups. In the FF group, however, the decrease in arachidonic acid to eicosapentaenoic acid (AA:EPA) ratio in cholesterol ester and phospholipid fractions strongly correlated with the change in IL1B mRNA levels ( r _s = 0.60, P = 0.06 and r _s = 0.86, P = 0.002, respectively). In the LF group, the decrease in palmitic acid and total saturated FAs in cholesterol esters correlated with the change in intercellular cell adhesion molecule-1 (ICAM1) expression ( r _s = 0.64, P = 0.04 for both). Circulating levels of soluble ICAM-1 decreased only in the LF group ( P
I. Sluijs - One of the best experts on this subject based on the ideXlab platform.
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Fish consumption and risk of stroke, coronary heart disease, and cardiovascular mortality in a Dutch population with low Fish intake
European Journal of Clinical Nutrition, 2018Co-Authors: L. M. Hengeveld, J. Praagman, J. W. J. Beulens, I. A. Brouwer, Y. T. Schouw, I. SluijsAbstract:Background/objectives Fish consumption of at least 1 portion/week is related to lower cardiovascular disease (CVD) risk. It is uncertain whether a less frequent intake is also beneficial and whether the type of Fish matters. We investigated associations of very low intakes of total, fatty, and Lean Fish, compared with no Fish intake, with 18-year incidences of stroke, coronary heart disease (CHD), and CVD mortality. Methods Data were used from 34,033 participants, aged 20–70 years, of the EPIC-Netherlands cohort. Baseline (1993–1997) Fish consumption was estimated using a food frequency questionnaire. We compared any Fish consumption,
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Fish consumption and risk of stroke, coronary heart disease, and cardiovascular mortality in a Dutch population with low Fish intake
European journal of clinical nutrition, 2018Co-Authors: L. M. Hengeveld, J. Praagman, J. W. J. Beulens, I. A. Brouwer, Y. T. Van Der Schouw, I. SluijsAbstract:Fish consumption of at least 1 portion/week is related to lower cardiovascular disease (CVD) risk. It is uncertain whether a less frequent intake is also beneficial and whether the type of Fish matters. We investigated associations of very low intakes of total, fatty, and Lean Fish, compared with no Fish intake, with 18-year incidences of stroke, coronary heart disease (CHD), and CVD mortality. Data were used from 34,033 participants, aged 20–70 years, of the EPIC-Netherlands cohort. Baseline (1993–1997) Fish consumption was estimated using a food frequency questionnaire. We compared any Fish consumption,
Eiliv Lund - One of the best experts on this subject based on the ideXlab platform.
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Consumption of Lean Fish reduces the risk of type 2 diabetes mellitus: A prospective population based cohort study of Norwegian women
PloS one, 2014Co-Authors: Charlotta Rylander, Torkjel M. Sandanger, Dagrun Engeset, Eiliv LundAbstract:Background The effects of Fish consumption and n-3 fatty acids on type 2 diabetes mellitus (T2DM) have recently been debated. Objective We explored the risk of T2DM in relation to consumption of Lean Fish, fatty Fish, Fish products and total Fish as well as cod liver oil supplements in a representative sample of Norwegian women. Design This was a prospective population based cohort study in 33740 women free of T2DM, stroke, angina or heart attack and with detailed information on important co-variates and dietary intake at baseline. Risk ratios and corresponding 95% CI were estimated using Poisson regression with log-person time as offset. Results Lean Fish consumption was inversely associated with T2DM compared to zero intake. Risk ratios and 95% CI for intake of 75 and 100 g Lean Fish per day were 0.71 (0.51, 0.98) and 0.67 (0.46, 0.98), respectively. There was no effect of intake of fatty Fish, Fish products, total Fish or use of cod liver oil supplements on the risk of T2DM. Conclusion Lean Fish consumption of 75–100 g/d had a beneficial effect on T2DM. It remains unclear whether Lean Fish in itself has a protective effect on T2DM or that Lean Fish consumers have a protective life-style that we were not able to take into account in this study. Unfavorable effects of fatty Fish consumption or use of cod liver oil supplements on T2DM were not observed.
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Consumption of Fish and risk of colon cancer in the Norwegian Women and Cancer (NOWAC) study
The British journal of nutrition, 2007Co-Authors: Dagrun Engeset, Vegard Andersen, Anette Hjartåker, Eiliv LundAbstract:Recent studies have shown a decreased risk of colon cancer with consumption of Fish. However, most studies on Fish consumption do not distinguish between Lean and fatty Fish, or between poached and fried Fish. The aim of this study was to investigate any association between Fish consumption and colon cancer in The Norwegian Women and Cancer (NOWAC) study. We focused mainly on Lean Fish, which was further divided into poached and fried Fish. A total of 63 914 women were included in the analysis, 254 of whom were found to have colon cancer during follow-up. Since Fish consumption was one of the main topics of interest in the NOWAC study, there is a predominance of women from northern Norway due to higher Fish intake in this area; hence the study is not representative of the whole of Norway. The participants completed a semi-quantitative FFQ between 1996 and 1999, and were followed-up for incidence of colon cancer until 2004. No association between Fish consumption and risk of colon cancer was seen, except for the third tertile of poached Lean Fish consumption (relative risk (RR) 1.46, 95 % CI 1.04, 2.06). This association disappeared when excluding women with less than 1 year of follow-up. In conclusion, the present study does not support the hypothesis of a protective effect of Fish against colon cancer risk.
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Consumption of seafood—the influence of overweight and health beliefs
Food Quality and Preference, 2004Co-Authors: Torbjørn Trondsen, Eiliv Lund, Tonje Braaten, Anne Elise EggenAbstract:Abstract This study investigated the relationship between self reported body weight and health perceptions and choice of seafood in a region with a traditionally high-level of Fish consumption. A random sample of women aged 45–69 years who live in northern Norway answered a self-administrated questionnaire about eating habits, socioeconomic factors and questions related to health sent to them by mail; 7556 women answered the questionnaire (56.1% response rate) which was analyzed by logistic regression methods in which odds ratios (OR) were calculated. The mean frequency of consumption of seafood was 15 times a month. Some 46% of the respondents were overweight, 77% agreed that food is important for health and 55% had a desire to reduce weight. Overweight women consumed less Lean Fish than normal weight women (OR=0.8). Fish consumption was not associated with the desire to reduce weight. Fat and Lean Fish, but not processed Fish, consumption are associated with the perception that food is important for health. A generally healthy food consumption pattern was strongly associated with weekly Fish consumption, with normal weight and with the desire to reduce weight. Very high family income was associated with higher fat Fish consumption (OR=1.9) normal body weight and for the desire to reduce weight (OR=2.1). High Fish consumption in childhood and the belief that food is important for health were strongly associated with high Fish consumption (OR=2.1 and 1.4 respectively for Lean Fish). Kids 60 years compared with 45–49 years). It is concluded that the desire to reduce weight does not influence Fish consumption, but overweight women consume less Lean Fish than women of normal weight. Normal body weight and the desire to reduce overweight are associated with a broader healthy lifestyle pattern, in which seafood has a role in the diet. Higher Fish consumption is associated with increasing consumers’ belief and behavior according to food's importance to health, high Fish consumption in childhood and a higher level of education and income.
Maria Lankinen - One of the best experts on this subject based on the ideXlab platform.
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camelina sativa oil fatty Fish and Lean Fish do not markedly affect urinary prostanoids in subjects with impaired glucose metabolism
Lipids, 2019Co-Authors: Arja T Erkkila, Jetty Chungyung Lee, Maria Lankinen, Suvi Manninen, Ho Hang Leung, Camille Oger, Vanessa D De Mello, Ursula SchwabAbstract:Dietary fatty acids are suggested to affect oxidative stress; however, results from interventions have been inconclusive. The aim was to examine if fatty Fish, Lean Fish, and Camelina sativa oil (CSO) affect the urinary prostanoid levels in subjects with impaired glucose metabolism. Altogether 79 participants aged 43-72 years completed a randomized controlled study lasting 12 weeks. There were four parallel groups, fatty Fish, Lean Fish (four Fish meals/week in both), CSO providing 10 g/day alpha-linolenic acid (ALA), and control diet with limited Fish and ALA containing oil consumption. Urinary prostanoids (prostaglandin F2α , 5-F2t -isoprostanes and 15-F2t -isoprostane metabolites, isofuran, 8-F3t -isoprostanes, and 4-(RS)-4-F4t -neuroprostane) of 72 participants (age: mean (±SD) 58.9 ± 6.5 years; body mass index: 29.3 ± 2.5 kg/m2 ) collected over 12-h were measured using liquid chromatography tandem-mass spectrometry. Plasma phospholipid fatty acids were determined using gas chromatography. Our study showed that the proportion of ALA in plasma phospholipids increased in the CSO group (overall difference among the groups p-value <0.001). In the fatty Fish group, proportions of eicosapentaenoic and docosahexaenoic acids increased (overall p-value <0.001 for both). Prostaglandin F2α was higher in the CSO group than in the control group (p < 0.05), however, there were no other significant changes in urinary excretion of other prostanoids among the study groups. At baseline, arachidonic acid in plasma phospholipids was positively (r = 0.247, p < 0.05) and ALA negatively (r = -0.326, p < 0.05) associated with urinary total isoprostanes. In conclusion, CSO, fatty Fish, and Lean Fish consumption do not cause major changes in oxidative stress markers in subjects with impaired glucose tolerance.
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Camelina sativa Oil, Fatty Fish, and Lean Fish Do Not Markedly Affect Urinary Prostanoids in Subjects with Impaired Glucose Metabolism
Lipids, 2019Co-Authors: Arja T Erkkila, Jetty Chungyung Lee, Maria Lankinen, Suvi Manninen, Ho Hang Leung, Camille Oger, Vanessa De Mello, Ursula SchwabAbstract:Dietary fatty acids are suggested to affect oxidative stress; however, results from interventions have been inconclusive. The aim was to examine if fatty Fish, Lean Fish, and Camelina sativa oil (CSO) affect the urinary prostanoid levels in subjects with impaired glucose metabolism. Altogether 79 participants aged 43-72 years completed a randomized controlled study lasting 12 weeks. There were four parallel groups, fatty Fish, Lean Fish (four Fish meals/week in both), CSO providing 10 g/day alpha-linolenic acid (ALA), and control diet with limited Fish and ALA containing oil consumption. Urinary prostanoids (prostaglandin F2α , 5-F2t -isoprostanes and 15-F2t -isoprostane metabolites, isofuran, 8-F3t -isoprostanes, and 4-(RS)-4-F4t -neuroprostane) of 72 participants (age: mean (±SD) 58.9 ± 6.5 years; body mass index: 29.3 ± 2.5 kg/m2 ) collected over 12-h were measured using liquid chromatography tandem-mass spectrometry. Plasma phospholipid fatty acids were determined using gas chromatography. Our study showed that the proportion of ALA in plasma phospholipids increased in the CSO group (overall difference among the groups p-value
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Camelina Sativa Oil, but not Fatty Fish or Lean Fish, Improves Serum Lipid Profile in Subjects with Impaired Glucose Metabolism-A Randomized Controlled Trial.
Molecular nutrition & food research, 2018Co-Authors: Ursula Schwab, Maria Lankinen, Vanessa D De Mello, Suvi M. Manninen, Sudhir Kurl, Kari Pulkki, David E. Laaksonen, Arja T ErkkilaAbstract:SCOPE The aim of the study is to examine whether Lean Fish (LF), fatty Fish (FF), and camelina sativa oil (CSO), a plant-based source of alpha-linolenic acid (ALA), differ in their metabolic effects in subjects with impaired glucose metabolism. METHODS AND RESULTS Altogether 79 volunteers with impaired fasting glucose, BMI 25-36 kg m-2 , age 43-72 years, participated in a 12-week randomized controlled trial with four parallel groups, that is, the FF (four Fish meals/week), LF (four Fish meals/week), CSO (10 g d-1 ALA), and control (limited intakes of Fish and sources of ALA) groups. The proportions of eicosapentaenoic acid and DHA increase in plasma lipids in the FF group, and the proportion of ALA increase in the CSO group (p < 0.0001 for all). In the CSO group, total and LDL-cholesterol (C) concentrations decrease compared with the FF and LF groups; LDL-C/HDL-C and ApoB/ApoA-I ratios decrease compared with the LF group. There are no significant changes in glucose metabolism or markers of low-grade inflammation. CONCLUSIONS A diet enriched in CSO improves serum lipid profile as compared with a diet enriched in FF or LF in subjects with impaired fasting glucose, with no differences in glucose metabolism or concentrations of inflammatory markers.
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The effect of fatty or Lean Fish intake on inflammatory gene expression in peripheral blood mononuclear cells of patients with coronary heart disease
European Journal of Nutrition, 2009Co-Authors: Vanessa D. F. Mello, Arja T Erkkila, Maria Lankinen, Ursula S. Schwab, Hanna Mussalo, Leena Pulkkinen, Marjukka Kolehmainen, Mustafa Atalay, Matej Orešič, Seppo LehtoAbstract:Background Little is known about the effect of Fish consumption on gene expression of inflammation-related genes in immune cells in coronary heart disease (CHD). Aim of the study We sought to evaluate the effect of a fatty Fish (FF) or a Lean Fish (LF) diet on the modulation of inflammatory and endothelial function-related genes in peripheral blood mononuclear cells (PBMCs) of subjects with CHD, and its association with serum fatty acid (FA) profile and lipid metabolic compounds. Methods Data from 27 patients randomized into an 8-week FF ( n = 10; mean ± SD: 4.3 ± 0.4 portions of Fish per week), LF ( n = 11; 4.7 ± 1.1 portions of Fish per week), or control diet ( n = 6; 0.6 ± 0.4 portions of Fish per week) were analyzed. The mRNA expression was measured using real-time PCR. Results The effect of the intervention on the mRNA expression of the genes studied did not differ among groups. In the FF group, however, the decrease in arachidonic acid to eicosapentaenoic acid (AA:EPA) ratio in cholesterol ester and phospholipid fractions strongly correlated with the change in IL1B mRNA levels ( r _s = 0.60, P = 0.06 and r _s = 0.86, P = 0.002, respectively). In the LF group, the decrease in palmitic acid and total saturated FAs in cholesterol esters correlated with the change in intercellular cell adhesion molecule-1 (ICAM1) expression ( r _s = 0.64, P = 0.04 for both). Circulating levels of soluble ICAM-1 decreased only in the LF group ( P
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Fatty Fish intake decreases lipids related to inflammation and insulin signaling--a lipidomics approach.
PloS one, 2009Co-Authors: Maria Lankinen, Arja T Erkkila, Ursula Schwab, Seppo Lehto, Hanna Mussalo, Tuulikki Seppänen-laakso, Marja-leena Hannila, Matti Uusitupa, Helena Gylling, Matej OrešičAbstract:Background The evidence of the multiple beneficial health effects of Fish consumption is strong, but physiological mechanisms behind these effects are not completely known. Little information is available on the effects of consumption of different type of Fish. The aim of this study was to investigate how fatty Fish or Lean Fish in a diet affect serum lipidomic profiles in subjects with coronary heart disease. Methodology and Principal Findings A pilot study was designed which included altogether 33 subjects with myocardial infarction or unstable ischemic attack in an 8-week parallel controlled intervention. The subjects were randomized to either fatty Fish (n = 11), Lean Fish (n = 12) or control (n = 10) groups. Subjects in the Fish groups had 4 Fish meals per week and subjects in the control group consumed Lean beef, pork and chicken. A Fish meal was allowed once a week maximum. Lipidomics analyses were performed using ultra performance liquid chromatography coupled to electrospray ionization mass spectrometry and gas chromatography. Multiple bioactive lipid species, including ceramides, lysophosphatidylcholines and diacylglycerols, decreased significantly in the fatty Fish group, whereas in the Lean Fish group cholesterol esters and specific long-chain triacylglycerols increased significantly (False Discovery Rate q-value
Ursula Schwab - One of the best experts on this subject based on the ideXlab platform.
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camelina sativa oil fatty Fish and Lean Fish do not markedly affect urinary prostanoids in subjects with impaired glucose metabolism
Lipids, 2019Co-Authors: Arja T Erkkila, Jetty Chungyung Lee, Maria Lankinen, Suvi Manninen, Ho Hang Leung, Camille Oger, Vanessa D De Mello, Ursula SchwabAbstract:Dietary fatty acids are suggested to affect oxidative stress; however, results from interventions have been inconclusive. The aim was to examine if fatty Fish, Lean Fish, and Camelina sativa oil (CSO) affect the urinary prostanoid levels in subjects with impaired glucose metabolism. Altogether 79 participants aged 43-72 years completed a randomized controlled study lasting 12 weeks. There were four parallel groups, fatty Fish, Lean Fish (four Fish meals/week in both), CSO providing 10 g/day alpha-linolenic acid (ALA), and control diet with limited Fish and ALA containing oil consumption. Urinary prostanoids (prostaglandin F2α , 5-F2t -isoprostanes and 15-F2t -isoprostane metabolites, isofuran, 8-F3t -isoprostanes, and 4-(RS)-4-F4t -neuroprostane) of 72 participants (age: mean (±SD) 58.9 ± 6.5 years; body mass index: 29.3 ± 2.5 kg/m2 ) collected over 12-h were measured using liquid chromatography tandem-mass spectrometry. Plasma phospholipid fatty acids were determined using gas chromatography. Our study showed that the proportion of ALA in plasma phospholipids increased in the CSO group (overall difference among the groups p-value <0.001). In the fatty Fish group, proportions of eicosapentaenoic and docosahexaenoic acids increased (overall p-value <0.001 for both). Prostaglandin F2α was higher in the CSO group than in the control group (p < 0.05), however, there were no other significant changes in urinary excretion of other prostanoids among the study groups. At baseline, arachidonic acid in plasma phospholipids was positively (r = 0.247, p < 0.05) and ALA negatively (r = -0.326, p < 0.05) associated with urinary total isoprostanes. In conclusion, CSO, fatty Fish, and Lean Fish consumption do not cause major changes in oxidative stress markers in subjects with impaired glucose tolerance.
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Camelina sativa Oil, Fatty Fish, and Lean Fish Do Not Markedly Affect Urinary Prostanoids in Subjects with Impaired Glucose Metabolism
Lipids, 2019Co-Authors: Arja T Erkkila, Jetty Chungyung Lee, Maria Lankinen, Suvi Manninen, Ho Hang Leung, Camille Oger, Vanessa De Mello, Ursula SchwabAbstract:Dietary fatty acids are suggested to affect oxidative stress; however, results from interventions have been inconclusive. The aim was to examine if fatty Fish, Lean Fish, and Camelina sativa oil (CSO) affect the urinary prostanoid levels in subjects with impaired glucose metabolism. Altogether 79 participants aged 43-72 years completed a randomized controlled study lasting 12 weeks. There were four parallel groups, fatty Fish, Lean Fish (four Fish meals/week in both), CSO providing 10 g/day alpha-linolenic acid (ALA), and control diet with limited Fish and ALA containing oil consumption. Urinary prostanoids (prostaglandin F2α , 5-F2t -isoprostanes and 15-F2t -isoprostane metabolites, isofuran, 8-F3t -isoprostanes, and 4-(RS)-4-F4t -neuroprostane) of 72 participants (age: mean (±SD) 58.9 ± 6.5 years; body mass index: 29.3 ± 2.5 kg/m2 ) collected over 12-h were measured using liquid chromatography tandem-mass spectrometry. Plasma phospholipid fatty acids were determined using gas chromatography. Our study showed that the proportion of ALA in plasma phospholipids increased in the CSO group (overall difference among the groups p-value
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Camelina Sativa Oil, but not Fatty Fish or Lean Fish, Improves Serum Lipid Profile in Subjects with Impaired Glucose Metabolism-A Randomized Controlled Trial.
Molecular nutrition & food research, 2018Co-Authors: Ursula Schwab, Maria Lankinen, Vanessa D De Mello, Suvi M. Manninen, Sudhir Kurl, Kari Pulkki, David E. Laaksonen, Arja T ErkkilaAbstract:SCOPE The aim of the study is to examine whether Lean Fish (LF), fatty Fish (FF), and camelina sativa oil (CSO), a plant-based source of alpha-linolenic acid (ALA), differ in their metabolic effects in subjects with impaired glucose metabolism. METHODS AND RESULTS Altogether 79 volunteers with impaired fasting glucose, BMI 25-36 kg m-2 , age 43-72 years, participated in a 12-week randomized controlled trial with four parallel groups, that is, the FF (four Fish meals/week), LF (four Fish meals/week), CSO (10 g d-1 ALA), and control (limited intakes of Fish and sources of ALA) groups. The proportions of eicosapentaenoic acid and DHA increase in plasma lipids in the FF group, and the proportion of ALA increase in the CSO group (p < 0.0001 for all). In the CSO group, total and LDL-cholesterol (C) concentrations decrease compared with the FF and LF groups; LDL-C/HDL-C and ApoB/ApoA-I ratios decrease compared with the LF group. There are no significant changes in glucose metabolism or markers of low-grade inflammation. CONCLUSIONS A diet enriched in CSO improves serum lipid profile as compared with a diet enriched in FF or LF in subjects with impaired fasting glucose, with no differences in glucose metabolism or concentrations of inflammatory markers.
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Effect of fatty and Lean Fish intake on lipoprotein subclasses in subjects with coronary heart disease: A controlled trial
Journal of clinical lipidology, 2013Co-Authors: Arja T Erkkila, Vanessa D De Mello, Ursula Schwab, Seppo Lehto, Antti J. Kangas, Pasi Soininen, Mika Ala-korpela, Matti UusitupaAbstract:Background Fish oil intake reduces serum triglycerides; however, little is known about the effects of dietary Fish intake on lipoprotein subclasses. Objective We aimed at assessing the effect of fatty and Lean Fish intake on the lipoprotein subclasses in an intervention study. Methods The intervention study included 33 patients with coronary heart disease, who were aged 61.0 ± 5.8 (mean ± SD) years. The subjects were randomly assigned to a fatty Fish (n = 11), Lean Fish (n = 12), or control (n = 10) diet for 8 weeks. Fish diets included at least 4 Fish meals per week. Subjects in the control group consumed Lean beef, pork, and chicken. Lipoprotein subclasses and their lipid components were determined by nuclear magnetic resonance spectroscopy. Results Concentrations of n-3 fatty acids and docosahexaenoic acid increased in the fatty Fish group. The concentrations of cholesterol, cholesterol esters, and total lipids in very large high-density lipoproteins (HDLs) increased in the fatty Fish group (overall difference P = .005, P = .002, and P = .007, respectively; false discovery rate P = .04, P = .04, and P = .05, respectively). The mean size of HDL particles increased in the fatty Fish group (9.8 ± 0.3 nm at baseline and 9.9 ± 0.4 nm at end of study; overall difference P = .004, false discovery rate P = .04). The Fish diets did not affect very-low-density lipoprotein or low-density lipoprotein size. Conclusion Fatty Fish intake at least 4 times per week increases HDL particle size which might have beneficial effect in patients with coronary heart disease.
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Fatty Fish intake decreases lipids related to inflammation and insulin signaling--a lipidomics approach.
PloS one, 2009Co-Authors: Maria Lankinen, Arja T Erkkila, Ursula Schwab, Seppo Lehto, Hanna Mussalo, Tuulikki Seppänen-laakso, Marja-leena Hannila, Matti Uusitupa, Helena Gylling, Matej OrešičAbstract:Background The evidence of the multiple beneficial health effects of Fish consumption is strong, but physiological mechanisms behind these effects are not completely known. Little information is available on the effects of consumption of different type of Fish. The aim of this study was to investigate how fatty Fish or Lean Fish in a diet affect serum lipidomic profiles in subjects with coronary heart disease. Methodology and Principal Findings A pilot study was designed which included altogether 33 subjects with myocardial infarction or unstable ischemic attack in an 8-week parallel controlled intervention. The subjects were randomized to either fatty Fish (n = 11), Lean Fish (n = 12) or control (n = 10) groups. Subjects in the Fish groups had 4 Fish meals per week and subjects in the control group consumed Lean beef, pork and chicken. A Fish meal was allowed once a week maximum. Lipidomics analyses were performed using ultra performance liquid chromatography coupled to electrospray ionization mass spectrometry and gas chromatography. Multiple bioactive lipid species, including ceramides, lysophosphatidylcholines and diacylglycerols, decreased significantly in the fatty Fish group, whereas in the Lean Fish group cholesterol esters and specific long-chain triacylglycerols increased significantly (False Discovery Rate q-value
