The Experts below are selected from a list of 291 Experts worldwide ranked by ideXlab platform
Haran Burri - One of the best experts on this subject based on the ideXlab platform.
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Quantitative study of nerves of the human Left Atrium.
Heart Rhythm, 2005Co-Authors: Philippe Chevalier, Alain Tabib, David Meyronnet, Lara Chalabreysse, Lioara Restier, Valérie Ludman, Alexandre Aliès, Patrice Adeleine, Françoise Thivolet, Haran BurriAbstract:Objectives To quantify and study the distribution of innervation of the Left Atrium and the pulmonary veins in humans. Background Damage to cardiac nerves has been hypothesized as the explanation for successful radiofrequency ablation of atrial fibrillation. Methods From January 2003 to September 2003, histologic and quantitative studies of innervation of the Left Atrium and the pulmonary veins was performed in 43 consecutive necropsied adult hearts (30 men and 3 women; mean age 45.5 ± 12.4 years). The Left Atrium was sectioned in 1-cm slices from Left to right, with the plane of section perpendicular to the long axis of the heart. Sections of the pulmonary veins at their ostia and sections 1 cm away of this structure also were obtained. Nerve fiber density was counted manually for each case and expressed as the mean number per slice. Results Numerous epicardial nerve fibers and ganglia having distinct patterns of distribution in the Left Atrium were found. Nerve density was significantly higher at the ostia of the four pulmonary veins than in their distal part (7.1 ± 2.1 vs 5.2 ± 1.3 for Left upper pulmonary vein; 6.3 ± 1.5 vs 5.2 ± 1.7 for right upper pulmonary vein; 7.4 ± 2 vs 5.9 ± 2 for Left lower pulmonary vein; 6.7 ± 1.8 vs 3.9 ± 1.3 for right lower pulmonary vein). The Left superior vein was significantly more innervated than the right inferior vein (12.3 ± 3 vs 10.6 ± 1.4). Gradients of innervation were found from right to Left (9.8 ± 4.6 vs 18.5 ± 6.6, P P Conclusions The human Left Atrium exhibits several gradients of innervation at discrete sites. These findings may have clinical implications for radiofrequency ablation of atrial fibrillation.
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Quantitative study of nerves of the human Left Atrium
Heart Rhythm, 2005Co-Authors: Philippe Chevalier, Alain Tabib, David Meyronnet, Lara Chalabreysse, Lioara Restier, Valérie Ludman, Alexandre Aliès, Patrice Adeleine, Françoise Thivolet-bejui, Haran BurriAbstract:OBJECTIVES To quantify and study the distribution of innervation of the Left Atrium and the pulmonary veins in humans. BACKGROUND Damage to cardiac nerves has been hypothesized as the explanation for successful radioftequency ablation of atrial fibrillation. METHODS From January 2003 to September 2003, histologic and quantitative studies of innervation of the Left Atrium and the pulmonary veins was performed in 43 consecutive necropsied adult hearts (30 men and 3 women; mean age 45.5 +/- 12.4 years). The Left Atrium was sectioned in 1-cm slices from Left to right, with the plane of section perpendicular to the long axis of the heart. Sections of the pulmonary veins at their ostia and sections 1cm away of this structure also were obtained. Nerve fiber density was counted manually for each case and expressed as the mean number per slice. RESULTS Numerous epicardial nerve fibers and ganglia having distinct patterns of distribution in the Left Atrium were found. Nerve density was significantly higher at the ostia of the four pulmonary veins than in their distal part (7.1 +/- 2.1 vs 5.2 +/- 1.3 for Left upper pulmonary vein; 6.3 +/- 1.5 vs 5.2 +/- 1.7 for right upper pulmonary vein; 7.4 - 2 vs 5.9 +/- 2 for Left lower pulmonary vein; 6.7 +/- 1.8 vs 3.9 +/- 1.3 for right lower pulmonary vein). The Left superior vein was significantly more innervated than the right inferior vein (12.3 +/- 3 vs 10.6 +/- 1.4). Gradients of innervation were found from right to Left (9.8 +/- 4.6 vs 18.5 +/- 6.6, P < 05) and from the front to the rear of the Atrium (17.2 +/- 6.4 vs 20.7 +/- 6.5, P < 05). The same heterogeneous distribution was observed at the myocardial level but with thinner nerve fibers, making quantification difficult. Only very thin nerve fibers were present in the endocardium. CONCLUSIONS The human Left Atrium exhibits several gradients of innervation at discrete sites. These findings may have clinical implications for radiofrequency ablation of atrial fibrillation.
Hamdy El Sayed - One of the best experts on this subject based on the ideXlab platform.
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Giant Left Atrium associated with massive thrombus formation
Thrombosis Journal, 2013Co-Authors: Ahmad K Darwazah, Hamdy El SayedAbstract:Giant Left Atrium is a condition characterized by huge enlargement of the Left Atrium with a diameter exceeding 65mm. It is most commonly associated with long standing rheumatic mitral valve disease. We present a 45-year-old female patient with rheumatic mitral stenosis associated with giant Left Atrium occupied by an 11 × 10 × 5 cm thrombus weighing 500 gms. The patient underwent successful mitral valve replacement and thrombectomy through an inverted T-shaped biatrial incision.
Philippe Chevalier - One of the best experts on this subject based on the ideXlab platform.
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Quantitative study of nerves of the human Left Atrium.
Heart Rhythm, 2005Co-Authors: Philippe Chevalier, Alain Tabib, David Meyronnet, Lara Chalabreysse, Lioara Restier, Valérie Ludman, Alexandre Aliès, Patrice Adeleine, Françoise Thivolet, Haran BurriAbstract:Objectives To quantify and study the distribution of innervation of the Left Atrium and the pulmonary veins in humans. Background Damage to cardiac nerves has been hypothesized as the explanation for successful radiofrequency ablation of atrial fibrillation. Methods From January 2003 to September 2003, histologic and quantitative studies of innervation of the Left Atrium and the pulmonary veins was performed in 43 consecutive necropsied adult hearts (30 men and 3 women; mean age 45.5 ± 12.4 years). The Left Atrium was sectioned in 1-cm slices from Left to right, with the plane of section perpendicular to the long axis of the heart. Sections of the pulmonary veins at their ostia and sections 1 cm away of this structure also were obtained. Nerve fiber density was counted manually for each case and expressed as the mean number per slice. Results Numerous epicardial nerve fibers and ganglia having distinct patterns of distribution in the Left Atrium were found. Nerve density was significantly higher at the ostia of the four pulmonary veins than in their distal part (7.1 ± 2.1 vs 5.2 ± 1.3 for Left upper pulmonary vein; 6.3 ± 1.5 vs 5.2 ± 1.7 for right upper pulmonary vein; 7.4 ± 2 vs 5.9 ± 2 for Left lower pulmonary vein; 6.7 ± 1.8 vs 3.9 ± 1.3 for right lower pulmonary vein). The Left superior vein was significantly more innervated than the right inferior vein (12.3 ± 3 vs 10.6 ± 1.4). Gradients of innervation were found from right to Left (9.8 ± 4.6 vs 18.5 ± 6.6, P P Conclusions The human Left Atrium exhibits several gradients of innervation at discrete sites. These findings may have clinical implications for radiofrequency ablation of atrial fibrillation.
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Quantitative study of nerves of the human Left Atrium
Heart Rhythm, 2005Co-Authors: Philippe Chevalier, Alain Tabib, David Meyronnet, Lara Chalabreysse, Lioara Restier, Valérie Ludman, Alexandre Aliès, Patrice Adeleine, Françoise Thivolet-bejui, Haran BurriAbstract:OBJECTIVES To quantify and study the distribution of innervation of the Left Atrium and the pulmonary veins in humans. BACKGROUND Damage to cardiac nerves has been hypothesized as the explanation for successful radioftequency ablation of atrial fibrillation. METHODS From January 2003 to September 2003, histologic and quantitative studies of innervation of the Left Atrium and the pulmonary veins was performed in 43 consecutive necropsied adult hearts (30 men and 3 women; mean age 45.5 +/- 12.4 years). The Left Atrium was sectioned in 1-cm slices from Left to right, with the plane of section perpendicular to the long axis of the heart. Sections of the pulmonary veins at their ostia and sections 1cm away of this structure also were obtained. Nerve fiber density was counted manually for each case and expressed as the mean number per slice. RESULTS Numerous epicardial nerve fibers and ganglia having distinct patterns of distribution in the Left Atrium were found. Nerve density was significantly higher at the ostia of the four pulmonary veins than in their distal part (7.1 +/- 2.1 vs 5.2 +/- 1.3 for Left upper pulmonary vein; 6.3 +/- 1.5 vs 5.2 +/- 1.7 for right upper pulmonary vein; 7.4 - 2 vs 5.9 +/- 2 for Left lower pulmonary vein; 6.7 +/- 1.8 vs 3.9 +/- 1.3 for right lower pulmonary vein). The Left superior vein was significantly more innervated than the right inferior vein (12.3 +/- 3 vs 10.6 +/- 1.4). Gradients of innervation were found from right to Left (9.8 +/- 4.6 vs 18.5 +/- 6.6, P < 05) and from the front to the rear of the Atrium (17.2 +/- 6.4 vs 20.7 +/- 6.5, P < 05). The same heterogeneous distribution was observed at the myocardial level but with thinner nerve fibers, making quantification difficult. Only very thin nerve fibers were present in the endocardium. CONCLUSIONS The human Left Atrium exhibits several gradients of innervation at discrete sites. These findings may have clinical implications for radiofrequency ablation of atrial fibrillation.
Shinichi Takamoto - One of the best experts on this subject based on the ideXlab platform.
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Communication between the right pulmonary artery and Left Atrium with aneurysm formation
General Thoracic and Cardiovascular Surgery, 2008Co-Authors: Masahide Chikada, Arata Murakami, Kou Takeuchi, Shinichi TakamotoAbstract:Communication between the pulmonary artery and the Left Atrium is a rare congenital anomaly. A 7-year-old boy was referred to our hospital with a diagnosis of pulmonary arteriovenous fistula. Referral to a pediatric cardiologist had been delayed because he had only slight cyanosis and no heart murmur. Catheterization and computed tomography scans confirmed that the right pulmonary branches and pulmonary venous returns were normal and that an additional aneurysmal communication was located between the right pulmonary artery and the Left Atrium. Surgery proceeded uneventfully together with a cardiopulmonary bypass. The connection from the right pulmonary artery to the aneurysm was ligated, and the connection from the Left Atrium to the aneurysm was closed with a polytetrafluoroethylene patch. We describe this rare anomaly with cyanosis and no heart murmur.
Ann F Bolger - One of the best experts on this subject based on the ideXlab platform.
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three dimensional flow in the human Left Atrium
Heart, 2001Co-Authors: Anna Fyrenius, Lars Wigstrom, Tino Ebbers, Matts Karlsson, Jan Engvall, Ann F BolgerAbstract:BACKGROUND: Abnormal flow patterns in the Left Atrium in atrial fibrillation or mitral stenosis are associated with an increased risk of thrombosis and systemic embolisation; the characteristics of ...
