The Experts below are selected from a list of 237 Experts worldwide ranked by ideXlab platform

J. R. Sutton - One of the best experts on this subject based on the ideXlab platform.

Michael P. Frenneaux - One of the best experts on this subject based on the ideXlab platform.

  • Forearm vascular responses during semierect dynamic Leg Exercise in patients following myocardial infarction
    Heart and vessels, 1998
    Co-Authors: H. L. Thomson, John Atherton, J. A. Morris-thurgood, Michael P. Frenneaux
    Abstract:

    We assessed forearm vascular and blood pressure responses to dynamic Leg Exercise in patients 7 and 28 days postmyocardial infarction. To determine a possible association between abnormal Exercise vascular responses and baroreflex dysfunction, integrated and carotid baroreflex sensitivity and forearm vascular responses (during application of subhypotensive lower body negative pressure) were assessed. On day 7, 42 patients were compared with 21 age- and sex-matched controls. All subjects were assessed for (1) forearm vascular resistance during semierect Exercise, (2) blood pressure measurements during erect treadmill Exercise, and (3) integrated, cardiopulmonary, and carotid baroreceptor sensitivity. These studies were repeated in 13 patients on day 28. Forearm vascular resistance increased during Exercise by 36% ± 63% in patients versus 121% ± 105% in controls (P = 0.0001), and fell in 15 patients, a response seen in none of the controls. Exercise hypotension was demonstrated in 5 patients, all of whom had abnormal vasodilator vascular responses. Those patients with vasodilator responses had a lower left ventricular ejection fraction (52% ± 12% vs 62% ± 9%;P = 0.007), and lower cardiopulmonary mechanoreceptor sensitivity (−6.6 ± 3.9 units vs +6.4 ± 10.4 units,P = 0.02) than those with constrictor responses, respectively. In the 13 patients studied on day 28, the change in forearm vascular resistance was similar to that observed on day 7 (36% ± 63% vs 46% ± 73%). Paradoxical vasodilation of forearm vessels during Leg Exercise is common in patients studied 7 and 28 days postmyocardial infarction, and is associated with lower left ventricular ejection fraction and abnormal vascular responses during subhypotensive lower body negative pressure.

  • Abnormal Forearm Vascular Responses During Dynamic Leg Exercise in Patients With Vasovagal Syncope
    Circulation, 1995
    Co-Authors: H. L. Thomson, S. S. Lele, John Atherton, K. Wright, Wayne J. Stafford, Michael P. Frenneaux
    Abstract:

    Background We have reported previously that in some patients with normal hearts who present with Exercise syncope, abnormal forearm vasodilation is seen during Leg Exercise and tilt table tests are positive. This suggests that Exercise syncope may be a variant of vasovagal syncope. In this study we tested the hypothesis that there is loss of the normal forearm vasoconstrictor response during dynamic Leg Exercise in an unselected population of patients with classic vasovagal syncope. Methods and Results We evaluated forearm vascular responses during maximal semierect cycle Exercise in 28 consecutive patients with vasovagal syncope and compared them with 30 age-matched control subjects. We also evaluated blood pressure responses during erect treadmill Exercise (Bruce protocol). While forearm vascular resistance at rest was similar in the patients with vasovagal syncope and the control group, forearm vascular resistance was markedly lower in the patients than in control subjects at peak Exercise (85±54 versus 149±94 units, P =.002). Forearm vascular resistance fell by 3±48% during Exercise in patients versus an increase of 135±103% in control subjects ( P

Andrew M. Jones - One of the best experts on this subject based on the ideXlab platform.

  • Contralateral fatigue during severe-intensity single-Leg Exercise: influence of acute acetaminophen ingestion.
    American journal of physiology. Regulatory integrative and comparative physiology, 2019
    Co-Authors: Paul T. Morgan, Stephen J. Bailey, Rhys Banks, Jonathan Fulford, Anni Vanhatalo, Andrew M. Jones
    Abstract:

    Exhaustive single-Leg Exercise has been suggested to reduce time to task failure (Tlim) during subsequent Exercise in the contralateral Leg by exacerbating central fatigue development. We investiga...

  • Oxygen uptake kinetics during high-intensity arm and Leg Exercise.
    Respiratory physiology & neurobiology, 2002
    Co-Authors: Katrien Koppo, Jacques Bouckaert, Andrew M. Jones
    Abstract:

    Abstract The purpose of the present study was to examine the oxygen uptake kinetics during heavy arm Exercise using appropriate modelling techniques, and to compare the responses to those observed during heavy Leg Exercise at the same relative intensity. We hypothesised that any differences in the response might be related to differences in muscle fibre composition that are known to exist between the upper and lower body musculature. To test this, ten subjects completed several bouts of constant-load cycling and arm cranking Exercise at 90% of the mode specific V O2 peak. There was no difference in plasma [lactate] at the end of arm and Leg Exercise. The time constant of the fast component response was significantly longer in arm Exercise compared to Leg Exercise (mean±S.D., 48±12 vs. 21±5 sec; P V O2 slow component emerged later in arm Exercise (126±27 vs. 95±20 sec; P

Yasuyoshi Wadano - One of the best experts on this subject based on the ideXlab platform.

  • NOVEL APPARATUS FOR VENOUS THROMBOEMBOLISM PROPHYLAXIS: Leg Exercise APPARATUS (LEX)
    Journal of Bone and Joint Surgery-british Volume, 2016
    Co-Authors: Yukiyo Shimizu, Hiroshi Kamada, Masataka Sakane, Shizu Aikawa, Kenta Tanaka, Hajime Mishima, Akihiro Kanamori, Kiyoshi Eguchi, Hirotaka Mutsuzaki, Yasuyoshi Wadano
    Abstract:

    Background Venous thromboembolisms are serious complications of arthroplasty of the lower extremities. Although early ambulation and active Leg Exercise is recommended, postoperative patients with surgical pain have difficulty in moving their Legs. Therefore, we developed a novel Leg Exercise apparatus (LEX) to facilitate active Leg movement even during the early postoperative period (Fig 1). LEX is a portable apparatus that allows patients to actively move their Legs while in the supine position. LEX enables dorsiflexion, plantar flexion, combined eversion and inversion of the ankle, and multi-joint movement of the Leg. Objectives To describe how LEX facilitates active movement of the Leg and thereby increases venous flow in the lower extremities. Participants and Methods The venous flow volume of the femoral vein of 8 healthy volunteers; 5 men and 3 women, with a mean age of 22.4 (range, 22–26) years, were measured by duplex ultrasonography. The measurements were repeated at 1, 3, 5, and 10 minutes after the completion of one-minute active ankle Exercise with LEX, and during the 10-minute use of an intermittent pneumatic compression (IPC) device. The same measurements were taken from 8 healthy volunteers; 5 men and 3 women, with a mean age of 21.6 (19–26) years, after three types of 1 minute LEX Exercise: rapid dorsiflexion-plantar flexion (60 reps/min), slow dorsiflexion-plantar flexion (30 reps/min) and combined motion of the Leg (30 reps/min). These measurements were repeated at 1, 10, 20, and 30 minutes after the 1 min-LEX Exercise. Statistical methods All data were analyzed in a two-way repeated measures analysis of variance. Post-hoc analyses were performed using the Bonferroni comparisons test. The probability level accepted for statistical significance was p Results Whereas the flow volume of the femoral vein after the 1 min-LEX Exercise increased 2.00-fold over the baseline level, the value at 1 minute after the start of IPC did 1.18-fold (p = 0.033). The flow volume at 10 minutes had increased 1.50-fold; the corresponding values during IPC use were the same as those during rest (Fig 2). The flow volume after the 1 min-LEX Exercise had increased for 30 minutes. After 30 minutes of rapid dorsiflexion-plantar flexion, it increased 1.63-fold over the baseline level. While 1 minute after slow flexion, the flow volume increased 1.38-fold and remained on the same level, this value was 1.53-fold at 30 minutes after combined Leg motion. The combined Leg Exercise made the flow volume higher than dorsiflexion-plantar flexion at equal speed (Fig 3). Discussion Short periods of LEX use improved the venous flow volume of the femoral vein more than continuous use of IPC. The 1-min LEX Exercise had improved the femoral venous flow volume for 30 minutes, and combined Leg Exercise was more effective than a single ankle Exercise. These results suggest that LEX Exercise can induce the lower-extremity venous flow greater than that achieved using IPC. Clinical Relevance: LEX might be effective for enabling postoperative patients to move their Legs and to improve venous flow of the lower extremities.

Connor J. Doherty - One of the best experts on this subject based on the ideXlab platform.