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Fumihiko Hayashi - One of the best experts on this subject based on the ideXlab platform.
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anterior capsule contraction and intraocular Lens Dislocation in eyes with pseudoexfoliation syndrome
British Journal of Ophthalmology, 1998Co-Authors: Hideyuki Hayashi, Ken Hayashi, Fuminori Nakao, Fumihiko HayashiAbstract:AIMS—To examine the extent of anterior capsule contraction as well as intraocular Lens (IOL) decentration and tilt following implant surgery in eyes with pseudoexfoliation syndrome (PE). METHODS—53 eyes from 53 patients with PE and 53 control eyes from 53 age matched patients, undergoing phacoemulsification and implant surgery, were recruited. The anterior capsule opening area and the amounts of IOL decentration and tilt after undergoing continuous curvilinear capsulorhexis were measured using the Scheimpflug videophotography system at 1 week and 1, 3, 6, 9, and 12 months postoperatively. RESULTS—The mean area of the anterior capsule opening in the PE group was significantly smaller than that in the control group at 1 month postoperatively and later. The percentage reductions in the PE group were approximately 25%, while they were less than 10% in the control group. The degree of IOL tilt was also larger in the PE group than in the control group. Five eyes (9.4%) in the PE group underwent a neodymium:YAG laser anterior capsulotomy, but none in the control group underwent a capsulotomy. CONCLUSIONS—The contraction of the anterior capsule opening was more extensive in the PE eyes than in the control eyes, thus resulting in a high Nd:YAG laser anterior capsulotomy rate. The IOL tilt was also greater in the PE eyes than in the control eyes. Keywords: anterior capsule contraction; intraocular Lens Dislocation; pseudoexfoliation syndrome; continuous curvilinear capsulorhexis
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anterior capsule contraction and intraocular Lens Dislocation after implant surgery in eyes with retinitis pigmentosa
Ophthalmology, 1998Co-Authors: Ken Hayashi, Hideyuki Hayashi, Fuminori Nakao, Keishi Matsuo, Fumihiko HayashiAbstract:Abstract Objective The purpose of the study was to investigate the extent of anterior capsule contraction, intraocular Lens (IOL) decentration, and tilt after implant surgery in eyes with retinitis pigmentosa (RP). Design A case-control study. Participants Forty-seven eyes from 47 patients with typical RP and 47 control eyes from 47 age-matched healthy patients were studied. Intervention Phacoemulsification surgery with polymethylmethacrylate IOL implantation with continuous curvilinear capsulorrhexis was performed. Main outcome measures The area of the anterior capsule opening obtained with capsulorrhexis and the amount of the decentration and tilt of the IOL were measured using a Scheimpflug photography system at 1 week and 1, 3, 6, 9, and 12 months after surgery. Results The mean area in the RP group was found to be significantly smaller than that in the control group at 1 month after surgery and later ( P Conclusions Anterior capsule contraction in the RP eyes was more extensive than in the control eyes, leading to a high Nd:YAG laser anterior capsulotomy rate. Both Lens decentration and tilt also were greater in the RP eyes than in the control eyes.
Iqbal Ike K. Ahmed - One of the best experts on this subject based on the ideXlab platform.
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inter eye differences in patients with pseudoexfoliation syndrome presenting with intraocular Lens Dislocation
Ophthalmology, 2015Co-Authors: Victoria C Leung, Iqbal Ike K. Ahmed, Harmanjit SinghAbstract:Purpose To analyze differences in glaucoma diagnosis and glaucoma severity between fellow eyes in patients with pseudoexfoliation syndrome (PXF) who present with intraocular Lens (IOL) Dislocation. Design Retrospective matched case-control study. Eyes presenting with IOL Dislocation (case group) were compared with fellow eyes (control group). Participants Patients from a tertiary referral practice in Mississauga, Ontario, Canada. Methods Consecutive patients with PXF and prior bilateral uneventful cataract surgeries with in-the-bag IOLs who presented with IOL Dislocation between 2008 and 2013 were identified (n = 71). Indicators of glaucoma severity were compared between fellow eyes using McNemar's test and Wilcoxon signed-rank tests. Indicators of glaucoma severity were also compared pre- and post-IOL exchange/repositioning in the eye with IOL Dislocation. Main Outcome Measures Glaucoma diagnosis, corrected distance visual acuity (CDVA), intraocular pressure (IOP), optic nerve cup-to-disc (C/D) ratio, mean deviation (MD) on visual field, retinal nerve fiber layer (RNFL) thickness, and glaucoma medication requirements (GMRs). Results Seventy-one participants were included. The affected eye was more likely to have glaucoma ( P P = 0.0001). In addition, the affected eye had worse mean CDVA (1.14±0.79 logarithm of the minimum angle of resolution [logMAR] vs. 0.35±0.46 logMAR, P P P = 0.006), greater mean number of glaucoma medication classes (1.4±1.4 vs. 0.5±1.1, P P P = 0.001). In the affected eye, there were early postoperative improvements in mean CDVA, IOP, and GMRs. Conclusions In patients with PXF, the eye presenting with IOL Dislocation was more likely than its fellow eye to have a diagnosis of glaucoma and to have glaucoma of greater severity.
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Cataract surgery in pseudoexfoliation syndrome.
Current opinion in ophthalmology, 2010Co-Authors: Graham W. Belovay, Devesh K. Varma, Iqbal Ike K. AhmedAbstract:PURPOSE OF REVIEW To discuss the preoperative, intraoperative and postoperative considerations and techniques for cataract surgery in pseudoexfoliation syndrome. RECENT FINDINGS Pseudoexfoliation syndrome is a common disorder worldwide that has been linked to the lysyl oxidase-like-one (LOXL1) gene. Its identification in patients undergoing cataract surgery has become important in preventing complications through proper preoperative planning. The management of the small pupil found in pseudoexfoliation can be achieved using various pharmacological and mechanical techniques. There are now several devices available to support the weak zonules that commonly accompany pseudoexfoliation. Postoperatively, pseudoexfoliation patients need to be followed closely to monitor for complications such as intraocular pressure spikes, inflammation and intraocular Lens Dislocation. SUMMARY With proper preoperative preparation, intraoperative use of appropriate adjunctive devices, and close postoperative follow-up, favorable outcomes can be achieved in cataract surgery in pseudoexfoliation syndrome.
Hideyuki Hayashi - One of the best experts on this subject based on the ideXlab platform.
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anterior capsule contraction and intraocular Lens Dislocation in eyes with pseudoexfoliation syndrome
British Journal of Ophthalmology, 1998Co-Authors: Hideyuki Hayashi, Ken Hayashi, Fuminori Nakao, Fumihiko HayashiAbstract:AIMS—To examine the extent of anterior capsule contraction as well as intraocular Lens (IOL) decentration and tilt following implant surgery in eyes with pseudoexfoliation syndrome (PE). METHODS—53 eyes from 53 patients with PE and 53 control eyes from 53 age matched patients, undergoing phacoemulsification and implant surgery, were recruited. The anterior capsule opening area and the amounts of IOL decentration and tilt after undergoing continuous curvilinear capsulorhexis were measured using the Scheimpflug videophotography system at 1 week and 1, 3, 6, 9, and 12 months postoperatively. RESULTS—The mean area of the anterior capsule opening in the PE group was significantly smaller than that in the control group at 1 month postoperatively and later. The percentage reductions in the PE group were approximately 25%, while they were less than 10% in the control group. The degree of IOL tilt was also larger in the PE group than in the control group. Five eyes (9.4%) in the PE group underwent a neodymium:YAG laser anterior capsulotomy, but none in the control group underwent a capsulotomy. CONCLUSIONS—The contraction of the anterior capsule opening was more extensive in the PE eyes than in the control eyes, thus resulting in a high Nd:YAG laser anterior capsulotomy rate. The IOL tilt was also greater in the PE eyes than in the control eyes. Keywords: anterior capsule contraction; intraocular Lens Dislocation; pseudoexfoliation syndrome; continuous curvilinear capsulorhexis
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anterior capsule contraction and intraocular Lens Dislocation after implant surgery in eyes with retinitis pigmentosa
Ophthalmology, 1998Co-Authors: Ken Hayashi, Hideyuki Hayashi, Fuminori Nakao, Keishi Matsuo, Fumihiko HayashiAbstract:Abstract Objective The purpose of the study was to investigate the extent of anterior capsule contraction, intraocular Lens (IOL) decentration, and tilt after implant surgery in eyes with retinitis pigmentosa (RP). Design A case-control study. Participants Forty-seven eyes from 47 patients with typical RP and 47 control eyes from 47 age-matched healthy patients were studied. Intervention Phacoemulsification surgery with polymethylmethacrylate IOL implantation with continuous curvilinear capsulorrhexis was performed. Main outcome measures The area of the anterior capsule opening obtained with capsulorrhexis and the amount of the decentration and tilt of the IOL were measured using a Scheimpflug photography system at 1 week and 1, 3, 6, 9, and 12 months after surgery. Results The mean area in the RP group was found to be significantly smaller than that in the control group at 1 month after surgery and later ( P Conclusions Anterior capsule contraction in the RP eyes was more extensive than in the control eyes, leading to a high Nd:YAG laser anterior capsulotomy rate. Both Lens decentration and tilt also were greater in the RP eyes than in the control eyes.
Ken Hayashi - One of the best experts on this subject based on the ideXlab platform.
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anterior capsule contraction and intraocular Lens Dislocation in eyes with pseudoexfoliation syndrome
British Journal of Ophthalmology, 1998Co-Authors: Hideyuki Hayashi, Ken Hayashi, Fuminori Nakao, Fumihiko HayashiAbstract:AIMS—To examine the extent of anterior capsule contraction as well as intraocular Lens (IOL) decentration and tilt following implant surgery in eyes with pseudoexfoliation syndrome (PE). METHODS—53 eyes from 53 patients with PE and 53 control eyes from 53 age matched patients, undergoing phacoemulsification and implant surgery, were recruited. The anterior capsule opening area and the amounts of IOL decentration and tilt after undergoing continuous curvilinear capsulorhexis were measured using the Scheimpflug videophotography system at 1 week and 1, 3, 6, 9, and 12 months postoperatively. RESULTS—The mean area of the anterior capsule opening in the PE group was significantly smaller than that in the control group at 1 month postoperatively and later. The percentage reductions in the PE group were approximately 25%, while they were less than 10% in the control group. The degree of IOL tilt was also larger in the PE group than in the control group. Five eyes (9.4%) in the PE group underwent a neodymium:YAG laser anterior capsulotomy, but none in the control group underwent a capsulotomy. CONCLUSIONS—The contraction of the anterior capsule opening was more extensive in the PE eyes than in the control eyes, thus resulting in a high Nd:YAG laser anterior capsulotomy rate. The IOL tilt was also greater in the PE eyes than in the control eyes. Keywords: anterior capsule contraction; intraocular Lens Dislocation; pseudoexfoliation syndrome; continuous curvilinear capsulorhexis
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anterior capsule contraction and intraocular Lens Dislocation after implant surgery in eyes with retinitis pigmentosa
Ophthalmology, 1998Co-Authors: Ken Hayashi, Hideyuki Hayashi, Fuminori Nakao, Keishi Matsuo, Fumihiko HayashiAbstract:Abstract Objective The purpose of the study was to investigate the extent of anterior capsule contraction, intraocular Lens (IOL) decentration, and tilt after implant surgery in eyes with retinitis pigmentosa (RP). Design A case-control study. Participants Forty-seven eyes from 47 patients with typical RP and 47 control eyes from 47 age-matched healthy patients were studied. Intervention Phacoemulsification surgery with polymethylmethacrylate IOL implantation with continuous curvilinear capsulorrhexis was performed. Main outcome measures The area of the anterior capsule opening obtained with capsulorrhexis and the amount of the decentration and tilt of the IOL were measured using a Scheimpflug photography system at 1 week and 1, 3, 6, 9, and 12 months after surgery. Results The mean area in the RP group was found to be significantly smaller than that in the control group at 1 month after surgery and later ( P Conclusions Anterior capsule contraction in the RP eyes was more extensive than in the control eyes, leading to a high Nd:YAG laser anterior capsulotomy rate. Both Lens decentration and tilt also were greater in the RP eyes than in the control eyes.
Liv Drolsum - One of the best experts on this subject based on the ideXlab platform.
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Long-term myofibroblast persistence in the capsular bag contributes to the late spontaneous in-the-bag intraocular Lens Dislocation
Scientific Reports, 2020Co-Authors: Jovana Bisevac, Liv Drolsum, Natalia S. Anisimova, Richárd Nagymihály, Olav Kristianslund, Kirankumar Katta, Agate Noer, Ilias H. Sharafetdinov, Morten C. Moe, Boris E. MalyuginAbstract:Late spontaneous in-the-bag intraocular Lens (IOL) Dislocation is a complication presenting 6 months or later after cataract surgery. We aimed to characterize the cells in the Lens capsules (LCs) of 18 patients with spontaneous late in-the-bag IOL Dislocation. Patients' average age was 82.6 ± 1.5 years (range 72–98), and most of them had pseudoexfoliation syndrome (PEX). Cells from the LCs were positive for myofibroblast (αSMA), proliferation (Ki-67, PCNA), early Lens development/Lens progenitor (SOX2, PAX6), chemokine receptor (CXCR4), and transmembrane (N-cadherin) markers, while negative for epithelial (E-cadherin) marker. Moreover, the cells produced abundant fibronectin, type I and type V collagen in the nearby extracellular matrix (ECM). During ex vivo cultivation of dislocated IOL-LCs in toto, the cells proliferated and likely migrated onto the IOL’s anterior side. EdU proliferation assay confirmed the proliferation potential of the myofibroblasts (MFBs) in dislocated IOL-LCs. Primary cultured Lens epithelial cells/MFBs isolated from the LC of dislocated IOLs could induce collagen matrix contraction and continuously proliferated, migrated, and induced ECM remodeling. Taken together, this indicates that long-lived MFBs of dislocated IOLs might contribute to the pathogenic mechanisms in late in-the-bag IOL Dislocation.
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late in the bag intraocular Lens Dislocation in eyes with pseudoexfoliation syndrome
Acta Ophthalmologica, 2014Co-Authors: Atle Einar Ostern, Gunhild Falleth Sandvik, Liv DrolsumAbstract:. Purpose: To assess preoperative features, frequency, surgical approaches and outcomes of late in-the-bag Dislocation of posterior chamber intraocular Lenses (IOLs) in eyes with pseudoexfoliation syndrome. Methods: Seventy-seven patients (81 eyes) were enrolled. Inclusion criteria were patients with pre-existing pseudoexfoliation syndrome who underwent surgery for late in-the-bag IOL Dislocation between March 2004 and April 2010. Medical records were reviewed. Data from before and after secondary surgery were analysed. Results: Mean time between cataract extraction and secondary surgery for late in-the-bag Dislocation of posterior chamber IOLs was 8.5 years. The increase in frequency within the reviewed period was statistically significant, ranging from six patients in the first year to 25 patients in the final year (p = 0.004). When surgical correction was performed within 1 month of referral, deterioration of the Dislocation occurred in only one of 23 patients (4.3%). Complications, especially vitreous loss, occurred significantly more frequently during exchange surgery (n = 23) when compared with scleral suturing (n = 50) (p < 0.0001). After surgery, however, no differences in complications (p = 0.98) or best-corrected visual acuity (p = 0.74) was found. In general, following secondary surgery, there was a statistically significant improvement in best-corrected visual acuity (p < 0.0001). Conclusion: The frequency of late in-the-bag Dislocation of posterior chamber IOLs in eyes with pseudoexfoliation syndrome increased during the observation period. Our study suggests that surgical repair should not be delayed beyond 1 month and that scleral suturing is preferable to exchange surgery, because of less intraoperative complications.