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Kaweh Mansouri - One of the best experts on this subject based on the ideXlab platform.
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Nocturnal Variability of Intraocular Pressure Monitored with Contact Lens Sensor is associated with Visual Field Loss in Glaucoma.
Journal of glaucoma, 2020Co-Authors: Zhiyong Yang, Kaweh Mansouri, Sasan Moghimi, Robert N WeinrebAbstract:Purpose To determine whether 24-hour recording of intraocular pressure (IOP)-related ocular dimensional changes with a contact Lens Sensor (CLS, Triggerfish, Sensimed) is associated with the rate of visual field progression in primary open-angle glaucoma (POAG) patients. Design Retrospective, observational cohort study. Participants Patients with POAG were included from the Glaucoma Clinic and Diagnostic Innovations in Glaucoma Study at the Hamilton Glaucoma Center at University of California San Diego. Methods A session of 24-hour CLS recording was acquired for one eye from each patient. The mean follow-up time was 9.9±4.0 years. The association between CLS variables and rate of change of mean deviation (MD) was determined by univariate and multivariate mixed linear regression models. Results Thirty-two patients, aged 69.8±13.6 years were included, 50% were female. An average of 11.6±5.6 SAP examinations was available with a mean rate of MD progression of -0.2±0.4▒dB/year. Mean IOP was 17.8±4.2▒mmHg. The mean number of IOP-lowering medications were 1.2±1.0. Each 10-unit larger nocturnal variability of IOP-related ocular dimensional changes measured by CLS recording was significantly associated with -0.25±0.11▒dB faster visual field loss in POAG patients (P = 0.035). Conclusions 24-hour CLS recording of IOP-related ocular dimensional change was associated with faster visual field progression. Such CLS recordings are useful to assess the risk of in progression in POAG patients.
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Intereye Symmetry of 24-Hour Intraocular Pressure-related Patterns in Untreated Glaucoma Patients Using a Contact Lens Sensor.
Journal of glaucoma, 2020Co-Authors: Kaweh Mansouri, Kevin GillmannAbstract:PURPOSE Scarce data are available on the symmetry of 24-hour intraocular pressure (IOP) variations between fellow eyes of glaucoma patients, and such evidence could have profound consequences on the interpretation of monocular therapeutic trials. The objective is to evaluate the intereye correlation of continuously measured circadian IOP-related patterns in untreated glaucoma patients. METHODS In this single-center prospective study, a total of 29 untreated patients with open-angle glaucoma underwent bilateral ambulatory 24-hour monitoring of IOP-related patterns using a contact Lens Sensor (CLS; SENSIMED Triggerfish). IOP was measured before and after CLS monitoring using Goldmann applanation tonometry. Intereye agreement of 24-hour patterns was calculated using Spearman correlation (r) of raw data and after cosinor rhythmometry modeling. RESULTS Complete bilateral CLS data could be obtained in 20 patients (mean age: 55.5±15.7 y; 51.7% women). On average, intereye correlation was r=0.76±0.19 (range: 0.16 to 0.95) and r=0.77±0.15 (range: 0.49 to 0.91), after excluding 8 patients with lower quality recordings. Cosine rhythmometry modeling showed mean acrophases occurring at 4:21±2:20 AM in left eyes and 3:39±1:50 AM in right eyes (r=0.48; P=0.034). Mean acrophase amplitude was 110.9±51.9 for left eyes and 107.8±46.2 for right eyes (r=0.79; P
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Using 24-hr ocular dimensional profile recorded with a sensing contact Lens to identify primary open-angle glaucoma patients with intraocular pressure constantly below the diagnostic threshold.
Acta ophthalmologica, 2020Co-Authors: Satomi Shioya, Kaweh Mansouri, Sonja Simon-zoula, Tomomi Higashide, Shunsuke Tsuchiya, Thierry Varidel, Sacha Cerboni, Kazuhisa SugiyamaAbstract:PURPOSE To evaluate the use of a 24-hr ocular dimensional profile recorded with a contact Lens Sensor (CLS) combined with a single tonometric intraocular pressure (IOP) reading to indicate the potential for exceeding the diagnostic threshold for normal tension glaucoma (NTG) in Japanese patients. METHODS Intraocular pressure (IOP) of untreated Japanese NTG patients was measured with tonometry every 3 hr from 9:00 to 24:00. The subsequent day a 24-hr CLS (SENSIMED Triggerfish, Sensimed AG, Lausanne, Switzerland) profile was recorded on the same eye. Patients initially diagnosed as NTG were reclassified as NTG when the measured IOP values were consistently
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Relationship Between Contact Lens Sensor Output Parameters and Visual Field Progression in Open-angle Glaucoma: Assessment of a Practical Tool to Guide Clinical Risk-assessment.
Journal of glaucoma, 2020Co-Authors: Kevin Gillmann, Cara E. Capitena Young, Jordan Stanley, Leonard K. Seibold, Kirsten Hoskens, Neha Midha, Malik Y. Kahook, Kaweh MansouriAbstract:PURPOSE In recent years, new technologies have emerged to better analyze and interpret intraocular pressure (IOP) fluctuations. Among them is the progression report (PR), an algorithm based on continuous contact Lens Sensor (CLS) readings to estimate the likelihood of fast visual field (VF) glaucomatous progression. The objective of this study is to validate the PR. METHODS In this retrospective study, 30 open-angle glaucoma patients were enrolled. Twenty-four hours IOP-related variations were recorded using a CLS. Recordings were used to generate PR. The likelihood of fast VF progression (
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First-in-human continuous 24-hour measurement of intraocular pressure and ocular pulsation using a novel contact Lens Sensor.
The British journal of ophthalmology, 2020Co-Authors: Robert Wasilewicz, Sonja Simon-zoula, Thierry Varidel, Sacha Cerboni, Mario Schlund, Kaweh MansouriAbstract:Background/Aims This study assessed the feasibility of a novel contact Lens device for intraocular pressure (IOP) and ocular pulse amplitude (OPA) continuous measurements over 24 hours. Methods This prospective, open-label, single-centre, non-randomised study included glaucoma and healthy subjects. IOP and OPA values acquired by the pressure-measuring contact Lens (PMCL) device in one patient’s eye at the beginning of the measurement were compared with tonometry values (Goldman applanation tonometry (GAT) and dynamic contour tonometry (DCT)) in the same eye just before PMCL placement. Furthermore, IOP and OPA values measured with PMCL on the study eye during a water drinking test (WDT) were compared with DCT values in the fellow eye. Comparisons were performed using t-tests with 95% Confidence Intervals. Results Twenty-four-hour IOP and OPA curves were obtained for eight subjects. The mean IOP difference between PMCL and tonometry on the same eye was within ±5 mm Hg in 75% (GAT) and 87.5% (DCT) of subjects. IOP variations due to WDT were detected by PMCL and DCT, showing an average increase of 2.43 and 1.85 mm Hg, respectively. Differences between PMCL and DCT for IOP variations in fellow eyes were within ±5 mm Hg for 97.2% of time points. The difference between OPA in fellow eyes was within ±5 mm Hg for 85.5% of the time points. Conclusions This first-in-human study is a proof-of-concept for 24-hour continuous measurements of IOP and OPA with the PMCL. This device is non-invasive and has good comparability with standard tonometry.
Atsushi Hayashi - One of the best experts on this subject based on the ideXlab platform.
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Questionnaire survey on complications during 24-h measurement of intraocular pressure-related patterns with a contact Lens Sensor
International Ophthalmology, 2020Co-Authors: Mitsuya Otsuka, Atsushi Hayashi, Naoki TojoAbstract:Purpose We investigated glaucoma patients' complications, subjective symptoms, and side effects of continuous 24-h measurement of intraocular pressure (IOP)-related patterns with a contact Lens Sensor (CLS). We asked the patients to complete a questionnaire about their subjective symptoms after wearing the CLS. Materials and methods This was an observational single-facility study. We analyzed 56 patients (35 men, 21 women) who underwent 24-h continuous measurement of their IOP-related patterns with a Triggerfish^® CLS. The four questionnaire items asked whether blurred vision, ocular pain, conjunctival hyperemia, and sleep disorder were present/absent. All questionnaire items were answered subjectively. We examined the relationship between the patients' questionnaire results and their visual acuity and visual field. Results The rate of blurred vision was 55%; ocular pain, 30%; conjunctival hyperemia, 14%; sleeping disorder, 29%. Patients with good visual acuity tended to report experiencing blurred vision. Conclusions When 24-h continuous measurement of IOP-related patterns with a CLS is considered, clinicians should tell the patient about the possibility of blurred vision, ocular pain, conjunctival hyperemia, and/or sleeping disorder.
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Can a contact Lens Sensor predict the success of trabectome surgery?
Graefe's Archive for Clinical and Experimental Ophthalmology, 2020Co-Authors: Naoki Tojo, Atsushi HayashiAbstract:Purpose We examined whether a contact Lens Sensor (CLS) is useful for the postoperative evaluation of trabectome surgery. We investigated the correlations between the outcomes of trabectome surgery and the output of a CLS. Methods We examined 24 consecutive eyes of patients with pseudo-exfoliation glaucoma. In each eye, the intraocular pressure (IOP) fluctuations over 24 h were measured with the SENSIMED Triggerfish CLS before and at 3 months after the trabectome surgery. We divided the patients into success ( n = 12 eyes) and failure ( n = 12 eyes) groups; success was defined as a postoperative IOP level ≤ 21 mmHg plus an IOP reduction ≥ 20% relative to the preoperative IOP value with or without anti-glaucoma medications. We investigated CLS parameters that correlate with surgical outcomes by performing a Cox hazard regression analysis. We determined the maximum value, minimum value, and range of IOP fluctuation as CLS parameters. Results The mean follow-up period was 38.0 ± 3.0 months. The success rate was 50%. The postoperative range of IOP fluctuation during the nocturnal period with the CLS was significantly correlated with the surgical results ( p = 0.024). Conclusions A smaller range of IOP fluctuation was significantly correlated with better surgical outcomes. We were able to predict the surgical success after trabectome surgery at 3 months using the CLS. Thus, CLS results could be a new surgical evaluation parameter.
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Can a contact Lens Sensor predict the success of trabectome surgery
Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie, 2020Co-Authors: Naoki Tojo, Atsushi HayashiAbstract:We examined whether a contact Lens Sensor (CLS) is useful for the postoperative evaluation of trabectome surgery. We investigated the correlations between the outcomes of trabectome surgery and the output of a CLS. We examined 24 consecutive eyes of patients with pseudo-exfoliation glaucoma. In each eye, the intraocular pressure (IOP) fluctuations over 24 h were measured with the SENSIMED Triggerfish CLS before and at 3 months after the trabectome surgery. We divided the patients into success (n = 12 eyes) and failure (n = 12 eyes) groups; success was defined as a postoperative IOP level ≤ 21 mmHg plus an IOP reduction ≥ 20% relative to the preoperative IOP value with or without anti-glaucoma medications. We investigated CLS parameters that correlate with surgical outcomes by performing a Cox hazard regression analysis. We determined the maximum value, minimum value, and range of IOP fluctuation as CLS parameters. The mean follow-up period was 38.0 ± 3.0 months. The success rate was 50%. The postoperative range of IOP fluctuation during the nocturnal period with the CLS was significantly correlated with the surgical results (p = 0.024). A smaller range of IOP fluctuation was significantly correlated with better surgical outcomes. We were able to predict the surgical success after trabectome surgery at 3 months using the CLS. Thus, CLS results could be a new surgical evaluation parameter.
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Correlation between 24-h continuous intraocular pressure measurement with a contact Lens Sensor and visual field progression
Graefe's Archive for Clinical and Experimental Ophthalmology, 2020Co-Authors: Naoki Tojo, Atsushi Hayashi, Mitsuya OtsukaAbstract:Purpose We investigated the correlations between 24-h continuous intraocular pressure (IOP) measurement with a contact Lens Sensor (CLS) and visual field (VF) progression. Methods We examined 69 eyes of glaucoma patients who were followed > 2 years after the measurement of IOP fluctuation with a CLS. All patients underwent VF examinations > 4 times. VF progression was defined as a deterioration of the mean deviation (MD). We evaluated the original 17 parameters from the data obtained from the CLS output and attempted to identify which of them contributed to the VF progression. We then performed multivariate analyses to identify risk factors for rapid VF progression. Results The mean follow-up period was 4.0 ± 1.6 years. The mean VF progression rate was − 0.37 ± 0.53 dB/year. The multivariate analysis identified the following as-risk factors for VF progression: more advanced baseline MD value ( p = 0.0269); high maximum values during the 24-h ( p = 0.0131) and nocturnal ( p = 0.0466) periods; large standard deviation of IOP fluctuation during the 24-h ( p = 0.0404), diurnal ( p = 0.0330), and nocturnal ( p = 0.0027) periods; and large range of IOP fluctuation during the nocturnal period (0.0431). Conclusions Our results suggested that the above CLS parameters might be correlated with rapid progression of VF disorder. These CLS parameters could be used to evaluate the results of CLS in the future. Examination with a CLS could be useful for predicting the VF progression rate within a mere 24-h period.
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Influence of Ocular Dimensional Change on 24-Hour Intraocular Pressure Measurement With Contact Lens Sensor.
Journal of glaucoma, 2019Co-Authors: Naoki Tojo, Atsushi HayashiAbstract:PURPOSE We measured changes in the corneal morphology and intraocular pressure (IOP) before and after the use of contact Lens Sensor (CLS). Then, we investigated whether the ocular dimensional change affected the measured IOP value with CLS. MATERIAL AND METHODS In this prospective study, we examined 112 eyes of glaucoma patients. We measured the IOP fluctuation using a Sensimed Triggerfish CLS. We measured the corneal morphology before and after making measurements using a CLS in anterior segment optic coherent optical coherence tomography and measured the IOP with a Goldmann applanation tonometer. We investigated the correlation between these ocular dimensional changes and the last IOP value with CLS. RESULTS Measurement with the CLS significantly increased the IOP (P=0.0305), made the corneal thickness (CT) significantly thicker (P
Robert N Weinreb - One of the best experts on this subject based on the ideXlab platform.
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Nocturnal Variability of Intraocular Pressure Monitored with Contact Lens Sensor is associated with Visual Field Loss in Glaucoma.
Journal of glaucoma, 2020Co-Authors: Zhiyong Yang, Kaweh Mansouri, Sasan Moghimi, Robert N WeinrebAbstract:Purpose To determine whether 24-hour recording of intraocular pressure (IOP)-related ocular dimensional changes with a contact Lens Sensor (CLS, Triggerfish, Sensimed) is associated with the rate of visual field progression in primary open-angle glaucoma (POAG) patients. Design Retrospective, observational cohort study. Participants Patients with POAG were included from the Glaucoma Clinic and Diagnostic Innovations in Glaucoma Study at the Hamilton Glaucoma Center at University of California San Diego. Methods A session of 24-hour CLS recording was acquired for one eye from each patient. The mean follow-up time was 9.9±4.0 years. The association between CLS variables and rate of change of mean deviation (MD) was determined by univariate and multivariate mixed linear regression models. Results Thirty-two patients, aged 69.8±13.6 years were included, 50% were female. An average of 11.6±5.6 SAP examinations was available with a mean rate of MD progression of -0.2±0.4▒dB/year. Mean IOP was 17.8±4.2▒mmHg. The mean number of IOP-lowering medications were 1.2±1.0. Each 10-unit larger nocturnal variability of IOP-related ocular dimensional changes measured by CLS recording was significantly associated with -0.25±0.11▒dB faster visual field loss in POAG patients (P = 0.035). Conclusions 24-hour CLS recording of IOP-related ocular dimensional change was associated with faster visual field progression. Such CLS recordings are useful to assess the risk of in progression in POAG patients.
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use of machine learning on contact Lens Sensor derived parameters for the diagnosis of primary open angle glaucoma
American Journal of Ophthalmology, 2018Co-Authors: Keith R Martin, Kaweh Mansouri, Robert N Weinreb, Christophe Gisler, Jean Hennebert, Robert Wasilewicz, Dominique GenoudAbstract:Purpose To test the hypothesis that contact Lens Sensor (CLS)-based 24-hour profiles of ocular volume changes contain information complementary to intraocular pressure (IOP) to discriminate between primary open-angle glaucoma (POAG) and healthy (H) eyes. Design Development and evaluation of a diagnostic test with machine learning. Methods Subjects : From 435 subjects (193 healthy and 242 POAG), 136 POAG and 136 age-matched healthy subjects were selected. Subjects with contraindications for CLS wear were excluded. Procedure : This is a pooled analysis of data from 24 prospective clinical studies and a registry. All subjects underwent 24-hour CLS recording on 1 eye. Statistical and physiological CLS parameters were derived from the signal recorded. CLS parameters frequently associated with the presence of POAG were identified using a random forest modeling approach. Main Outcome Measures : Area under the receiver operating characteristic curve (ROC AUC) for feature sets including CLS parameters and Start IOP, as well as a feature set with CLS parameters and Start IOP combined. Results The CLS parameters feature set discriminated POAG from H eyes with mean ROC AUCs of 0.611, confidence interval (CI) 0.493–0.722. Larger values of a given CLS parameter were in general associated with a diagnosis of POAG. The Start IOP feature set discriminated between POAG and H eyes with a mean ROC AUC of 0.681, CI 0.603–0.765. The combined feature set was the best indicator of POAG with an ROC AUC of 0.759, CI 0.654–0.855. This ROC AUC was statistically higher than for CLS parameters or Start IOP feature sets alone (both P Conclusions CLS recordings contain information complementary to IOP that enable discrimination between H and POAG. The feature set combining CLS parameters and Start IOP provide a better indication of the presence of POAG than each of the feature sets separately. As such, the CLS may be a new biomarker for POAG.
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Use of Machine Learning on Contact Lens Sensor–Derived Parameters for the Diagnosis of Primary Open-angle Glaucoma
American journal of ophthalmology, 2018Co-Authors: Keith R Martin, Kaweh Mansouri, Robert N Weinreb, Christophe Gisler, Jean Hennebert, Robert Wasilewicz, Dominique GenoudAbstract:Purpose To test the hypothesis that contact Lens Sensor (CLS)-based 24-hour profiles of ocular volume changes contain information complementary to intraocular pressure (IOP) to discriminate between primary open-angle glaucoma (POAG) and healthy (H) eyes. Design Development and evaluation of a diagnostic test with machine learning. Methods Subjects : From 435 subjects (193 healthy and 242 POAG), 136 POAG and 136 age-matched healthy subjects were selected. Subjects with contraindications for CLS wear were excluded. Procedure : This is a pooled analysis of data from 24 prospective clinical studies and a registry. All subjects underwent 24-hour CLS recording on 1 eye. Statistical and physiological CLS parameters were derived from the signal recorded. CLS parameters frequently associated with the presence of POAG were identified using a random forest modeling approach. Main Outcome Measures : Area under the receiver operating characteristic curve (ROC AUC) for feature sets including CLS parameters and Start IOP, as well as a feature set with CLS parameters and Start IOP combined. Results The CLS parameters feature set discriminated POAG from H eyes with mean ROC AUCs of 0.611, confidence interval (CI) 0.493–0.722. Larger values of a given CLS parameter were in general associated with a diagnosis of POAG. The Start IOP feature set discriminated between POAG and H eyes with a mean ROC AUC of 0.681, CI 0.603–0.765. The combined feature set was the best indicator of POAG with an ROC AUC of 0.759, CI 0.654–0.855. This ROC AUC was statistically higher than for CLS parameters or Start IOP feature sets alone (both P Conclusions CLS recordings contain information complementary to IOP that enable discrimination between H and POAG. The feature set combining CLS parameters and Start IOP provide a better indication of the presence of POAG than each of the feature sets separately. As such, the CLS may be a new biomarker for POAG.
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effect of glaucoma medications on 24 hour intraocular pressure related patterns using a contact Lens Sensor
Clinical and Experimental Ophthalmology, 2015Co-Authors: Kaweh Mansouri, Felipe A Medeiros, Robert N WeinrebAbstract:© 2015 Royal Australian and New Zealand College of Ophthalmologists. Background: The aim of this article was to study the circadian intraocular pressure (IOP)-related effects of ocular hypotensive medications using a contact Lens Sensor (CLS). Design: This is a university-based prospective, randomized, crossover trial. Participants: A total of 23 patients with primary open-angle glaucoma participated. Methods: Patients underwent ambulatory recording of IOP-related patterns for 24h in one eye during 3 monthly sessions using a CLS. Patients were untreated in session 1 (S1), were randomized to one of four classes of glaucoma drops for S2 and had a prostaglandin analogue add-on for S3. Main Outcome Measures: Changes in IOP-related patterns were defined using (i) slopes from wake/sitting to sleep/supine; (ii) cosinor rhythmometry modelling; and (iii) area under receiver operating curve (AUC) of sleep period. Results: Mean patient age was 63.8±11.8 years. Positive linear slopes were seen from wake/sitting to sleep/supine at S1 (17.1±14.2mVeq/h) and S2 (5.5±23.9mVeq/h) and negative slopes at S3 (-1.9±29.4mVeq/h) (S1-S2, P=0.01; S1-S3, P=0.02). In the prostaglandin group, slopes changed significantly with introduction of drops (S1-S2, P<0.024), whereas they did not in a mixed group combining the three other classes (S1-S2, P=0.060). Overall, cosinor amplitudes were 98.4±46.5mVeq (S1), 113.0±35.6mVeq (S2) and 109.6±58.3mVeq (S3) (S1-S2, P=0.23; S1-S3, P=0.66; S2-S3, P=0.93). AUC were 91.8±63.0mVeq (S1), 76.3±102.7mVeq (S2) and 19.9±135.8mVeq (S3). Differences between sessions were not statistically significant (S1-S2, P=0.541; S1-S3, P=0.083; S2-S3, P=0.092). Conclusions: Prostaglandin analogues, but not other medications, seem to flatten the IOP-related increase at transition of the wake/sitting to the sleep/supine period, but do not seem to have an effect on acrophase and amplitude.
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Effect of glaucoma medications on 24-hour intraocular pressure-related patterns using a contact Lens Sensor.
Clinical & experimental ophthalmology, 2015Co-Authors: Kaweh Mansouri, Felipe A Medeiros, Robert N WeinrebAbstract:© 2015 Royal Australian and New Zealand College of Ophthalmologists. Background: The aim of this article was to study the circadian intraocular pressure (IOP)-related effects of ocular hypotensive medications using a contact Lens Sensor (CLS). Design: This is a university-based prospective, randomized, crossover trial. Participants: A total of 23 patients with primary open-angle glaucoma participated. Methods: Patients underwent ambulatory recording of IOP-related patterns for 24h in one eye during 3 monthly sessions using a CLS. Patients were untreated in session 1 (S1), were randomized to one of four classes of glaucoma drops for S2 and had a prostaglandin analogue add-on for S3. Main Outcome Measures: Changes in IOP-related patterns were defined using (i) slopes from wake/sitting to sleep/supine; (ii) cosinor rhythmometry modelling; and (iii) area under receiver operating curve (AUC) of sleep period. Results: Mean patient age was 63.8±11.8 years. Positive linear slopes were seen from wake/sitting to sleep/supine at S1 (17.1±14.2mVeq/h) and S2 (5.5±23.9mVeq/h) and negative slopes at S3 (-1.9±29.4mVeq/h) (S1-S2, P=0.01; S1-S3, P=0.02). In the prostaglandin group, slopes changed significantly with introduction of drops (S1-S2, P
Naoki Tojo - One of the best experts on this subject based on the ideXlab platform.
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Questionnaire survey on complications during 24-h measurement of intraocular pressure-related patterns with a contact Lens Sensor
International Ophthalmology, 2020Co-Authors: Mitsuya Otsuka, Atsushi Hayashi, Naoki TojoAbstract:Purpose We investigated glaucoma patients' complications, subjective symptoms, and side effects of continuous 24-h measurement of intraocular pressure (IOP)-related patterns with a contact Lens Sensor (CLS). We asked the patients to complete a questionnaire about their subjective symptoms after wearing the CLS. Materials and methods This was an observational single-facility study. We analyzed 56 patients (35 men, 21 women) who underwent 24-h continuous measurement of their IOP-related patterns with a Triggerfish^® CLS. The four questionnaire items asked whether blurred vision, ocular pain, conjunctival hyperemia, and sleep disorder were present/absent. All questionnaire items were answered subjectively. We examined the relationship between the patients' questionnaire results and their visual acuity and visual field. Results The rate of blurred vision was 55%; ocular pain, 30%; conjunctival hyperemia, 14%; sleeping disorder, 29%. Patients with good visual acuity tended to report experiencing blurred vision. Conclusions When 24-h continuous measurement of IOP-related patterns with a CLS is considered, clinicians should tell the patient about the possibility of blurred vision, ocular pain, conjunctival hyperemia, and/or sleeping disorder.
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Can a contact Lens Sensor predict the success of trabectome surgery?
Graefe's Archive for Clinical and Experimental Ophthalmology, 2020Co-Authors: Naoki Tojo, Atsushi HayashiAbstract:Purpose We examined whether a contact Lens Sensor (CLS) is useful for the postoperative evaluation of trabectome surgery. We investigated the correlations between the outcomes of trabectome surgery and the output of a CLS. Methods We examined 24 consecutive eyes of patients with pseudo-exfoliation glaucoma. In each eye, the intraocular pressure (IOP) fluctuations over 24 h were measured with the SENSIMED Triggerfish CLS before and at 3 months after the trabectome surgery. We divided the patients into success ( n = 12 eyes) and failure ( n = 12 eyes) groups; success was defined as a postoperative IOP level ≤ 21 mmHg plus an IOP reduction ≥ 20% relative to the preoperative IOP value with or without anti-glaucoma medications. We investigated CLS parameters that correlate with surgical outcomes by performing a Cox hazard regression analysis. We determined the maximum value, minimum value, and range of IOP fluctuation as CLS parameters. Results The mean follow-up period was 38.0 ± 3.0 months. The success rate was 50%. The postoperative range of IOP fluctuation during the nocturnal period with the CLS was significantly correlated with the surgical results ( p = 0.024). Conclusions A smaller range of IOP fluctuation was significantly correlated with better surgical outcomes. We were able to predict the surgical success after trabectome surgery at 3 months using the CLS. Thus, CLS results could be a new surgical evaluation parameter.
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Can a contact Lens Sensor predict the success of trabectome surgery
Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie, 2020Co-Authors: Naoki Tojo, Atsushi HayashiAbstract:We examined whether a contact Lens Sensor (CLS) is useful for the postoperative evaluation of trabectome surgery. We investigated the correlations between the outcomes of trabectome surgery and the output of a CLS. We examined 24 consecutive eyes of patients with pseudo-exfoliation glaucoma. In each eye, the intraocular pressure (IOP) fluctuations over 24 h were measured with the SENSIMED Triggerfish CLS before and at 3 months after the trabectome surgery. We divided the patients into success (n = 12 eyes) and failure (n = 12 eyes) groups; success was defined as a postoperative IOP level ≤ 21 mmHg plus an IOP reduction ≥ 20% relative to the preoperative IOP value with or without anti-glaucoma medications. We investigated CLS parameters that correlate with surgical outcomes by performing a Cox hazard regression analysis. We determined the maximum value, minimum value, and range of IOP fluctuation as CLS parameters. The mean follow-up period was 38.0 ± 3.0 months. The success rate was 50%. The postoperative range of IOP fluctuation during the nocturnal period with the CLS was significantly correlated with the surgical results (p = 0.024). A smaller range of IOP fluctuation was significantly correlated with better surgical outcomes. We were able to predict the surgical success after trabectome surgery at 3 months using the CLS. Thus, CLS results could be a new surgical evaluation parameter.
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Correlation between 24-h continuous intraocular pressure measurement with a contact Lens Sensor and visual field progression
Graefe's Archive for Clinical and Experimental Ophthalmology, 2020Co-Authors: Naoki Tojo, Atsushi Hayashi, Mitsuya OtsukaAbstract:Purpose We investigated the correlations between 24-h continuous intraocular pressure (IOP) measurement with a contact Lens Sensor (CLS) and visual field (VF) progression. Methods We examined 69 eyes of glaucoma patients who were followed > 2 years after the measurement of IOP fluctuation with a CLS. All patients underwent VF examinations > 4 times. VF progression was defined as a deterioration of the mean deviation (MD). We evaluated the original 17 parameters from the data obtained from the CLS output and attempted to identify which of them contributed to the VF progression. We then performed multivariate analyses to identify risk factors for rapid VF progression. Results The mean follow-up period was 4.0 ± 1.6 years. The mean VF progression rate was − 0.37 ± 0.53 dB/year. The multivariate analysis identified the following as-risk factors for VF progression: more advanced baseline MD value ( p = 0.0269); high maximum values during the 24-h ( p = 0.0131) and nocturnal ( p = 0.0466) periods; large standard deviation of IOP fluctuation during the 24-h ( p = 0.0404), diurnal ( p = 0.0330), and nocturnal ( p = 0.0027) periods; and large range of IOP fluctuation during the nocturnal period (0.0431). Conclusions Our results suggested that the above CLS parameters might be correlated with rapid progression of VF disorder. These CLS parameters could be used to evaluate the results of CLS in the future. Examination with a CLS could be useful for predicting the VF progression rate within a mere 24-h period.
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Influence of Ocular Dimensional Change on 24-Hour Intraocular Pressure Measurement With Contact Lens Sensor.
Journal of glaucoma, 2019Co-Authors: Naoki Tojo, Atsushi HayashiAbstract:PURPOSE We measured changes in the corneal morphology and intraocular pressure (IOP) before and after the use of contact Lens Sensor (CLS). Then, we investigated whether the ocular dimensional change affected the measured IOP value with CLS. MATERIAL AND METHODS In this prospective study, we examined 112 eyes of glaucoma patients. We measured the IOP fluctuation using a Sensimed Triggerfish CLS. We measured the corneal morphology before and after making measurements using a CLS in anterior segment optic coherent optical coherence tomography and measured the IOP with a Goldmann applanation tonometer. We investigated the correlation between these ocular dimensional changes and the last IOP value with CLS. RESULTS Measurement with the CLS significantly increased the IOP (P=0.0305), made the corneal thickness (CT) significantly thicker (P
Christophe Chiquet - One of the best experts on this subject based on the ideXlab platform.
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24 hour intraocular pressure rhythm in patients with untreated primary open angle glaucoma and effects of selective laser trabeculoplasty
Journal of Glaucoma, 2017Co-Authors: Florent Aptel, Cecile Musson, Thierry Zhou, Antoine Lesoin, Christophe ChiquetAbstract:Purpose of the Study:The purpose of the study was to evaluate the 24-hour nyctohemeral rhythm of intraocular pressure (IOP) in patients with untreated primary open angle glaucoma using a contact Lens Sensor. To evaluate the effect of selective laser trabeculoplasty (SLT) on the 24-hour rhythm of IOP
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Hourly Awakening vs Continuous Contact Lens Sensor Measurements of 24-Hour Intraocular Pressure: Effect on Sleep Macrostructure and Intraocular Pressure Rhythm
JAMA ophthalmology, 2014Co-Authors: Florent Aptel, B Mottet, Jp Romanet, Ralitsa Hubanova, J.-l. Pépin, Renaud Tamisier, Christophe ChiquetAbstract:Importance All studies of 24-hour intraocular pressure (IOP) rhythm conducted to date have used repeated IOP measurements requiring nocturnal awakenings, potentially disturbing sleep macrostructure. Objective To evaluate the effects on sleep architecture and IOP rhythm of hourly awakening vs a contact Lens Sensor (CLS) to continuously monitor IOP without awakening. Design, Setting, and Participants Cross-sectional study at a referral center of chronobiology among 12 young healthy volunteers, with a mean (SD) age of 22.3 (2.3) years. Interventions Volunteers underwent two 24-hour IOP measurement sessions during a 2-month period. The eye order and session order were randomized. During one session, the IOP of the first eye was continuously monitored using a CLS, and the IOP of the fellow eye was measured hourly using a portable noncontact tonometer (session with nocturnal hourly awakening). During the other session, the IOP of the first eye was continuously monitored using a CLS, and the IOP of the fellow eye was not measured (session without nocturnal awakening). Overnight polysomnography was performed during the 2 sessions. Main Outcomes and Measures A nonlinear least squares, dual-harmonic regression analysis was used to model the 24-hour IOP rhythm from the CLS data. Comparisons of acrophase, bathyphase, amplitude, and the midline estimating statistic of rhythm were used to evaluate the effect of hourly awakening on IOP rhythm. To evaluate the effects of hourly awakening on sleep architecture, comparisons of sleep structure were used, including total sleep period, rapid eye movement, wake after sleep onset, absolute and relative total sleep time, and non–rapid eye movement sleep (N1, N2, and N3). Results A 24-hour IOP rhythm was found in all individuals for the sessions with and without awakening ( P P = .04) but did not seem to change total sleep time, total sleep period, sleep efficiency, or slow-wave and rapid eye movement sleep stage duration ( P > .30). Hourly awakening during noncontact tonometer IOP measurements did not seem to alter the mean variables of the 24-hour IOP pattern evaluated using CLS, including signal, maximum signal, minimum signal, acrophase, and bathyphase ( P > .15). Conclusion and Relevance The 24-hour IOP rhythms seem to be unaffected by hourly nocturnal awakening for IOP measurements in young healthy individuals.
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24-Hour Intraocular Pressure Rhythm in Young Healthy Subjects Evaluated With Continuous Monitoring Using a Contact Lens Sensor
JAMA ophthalmology, 2013Co-Authors: B Mottet, Florent Aptel, Jp Romanet, Ralitsa Hubanova, J.-l. Pépin, Christophe ChiquetAbstract:Importance This study evaluates a new device that has been proposed to continuously monitor intraocular pressure (IOP) over 24 hours. Objective To evaluate 24-hour IOP rhythm reproducibility during repeated continuous 24-hour IOP monitoring with noncontact tonometry (NCT) and a contact Lens Sensor (CLS) in healthy participants. Design, Setting, and Participants Cross-sectional study of 12 young healthy volunteers at a referral center of chronobiology. Interventions Participants were housed in a sleep laboratory and underwent four 24-hour sessions of IOP measurements over a 6-month period. After initial randomized attribution, the IOP of the first eye was continuously monitored using a CLS and the IOP of the fellow eye was measured hourly using NCT. Two sessions with NCT measurements in 1 eye and CLS measurements in the fellow eye, 1 session with CLS measurements in only 1 eye, and 1 session with NCT measurements in both eyes were performed. Main Outcomes and Measures A nonlinear least squares, dual-harmonic regression analysis was used to model the 24-hour IOP rhythm. Comparison of acrophase, bathyphase, amplitude, midline estimating statistic of rhythm, IOP values, IOP changes, and agreement were evaluated in the 3 tonometry methods. Results A significant nyctohemeral IOP rhythm was found in 31 of 36 sessions (86%) using NCT and in all sessions (100%) using CLS. Hourly awakening during NCT IOP measurements did not significantly change the mean phases of the 24-hour IOP pattern evaluated using CLS in the contralateral eye. Throughout the sessions, intraclass correlation coefficients of the CLS acrophase (0.6 [95% CI, 0.0 to 0.9]; P = .03), CLS bathyphase (0.7 [95% CI, 0.1 to 0.9]; P = .01), NCT amplitude (0.7 [95% CI, 0.1 to 0.9]; P = .01), and NCT midline estimating statistic of rhythm (0.9 [95% CI, 0.9 to 1.0]; P Conclusions and Relevance The CLS is an accurate and reproducible method to characterize the nyctohemeral IOP rhythm in healthy participants but does not allow for estimating the IOP value in millimeters of mercury corresponding to the relative variation of the electrical signal measured.
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24-hour intraocular pressure rhythm in young healthy subjects evaluated with continuous monitoring using contact Lens Sensor
Acta Ophthalmologica, 2013Co-Authors: B Mottet, Florent Aptel, Jp Romanet, Ralitsa Hubanova, J.-l. Pépin, Christophe ChiquetAbstract:Purpose To evaluate 24-h intraocular pressure (IOP) rhythm reproducibility during repeated continuous 24-h IOP monitoring with non-contact tonometry (NCT) and a contact Lens Sensor (CLS) in healthy subjects. Methods Twelve young healthy subjects were housed in a sleep laboratory and underwent four 24-h sessions of IOP measurements over a 6-month period. After randomized attribution, the IOP of the first eye was continuously monitored using the CLS Sensimed TriggerFish® and the IOP of the fellow eye was measured hourly using the Pulsair Intellipuff® non-contact tonometer. A nonlinear least-squares dual harmonic regression analysis was used to model the 24-h IOP rhythm. Comparison of acrophase, bathyphase, amplitude, the midline estimating statistic of rhythm (MESOR), IOP values, IOP changes and agreement were evaluated in the two tonometry methods. Results A significant nyctohemeral IOP rhythm was found in 31 out of 36 sessions (86%) using NCT and in all sessions (100%) using CLS. Hourly awakening during NCT IOP measurements did not significantly change the mean phases of the 24-h IOP pattern evaluated using CLS in the contralateral eye. Throughout the sessions, intraclass correlation coefficients (ICCs) of the CLS acrophase (0.6 [0–0.9]; p=0.03), CLS bathyphase (0.7 [0.1–0.9]; p=0.01), NCT amplitude (0.7 [0.1–0.9]; p=0.01) and NCT MESOR (0.9 [0.9–1]; p