The Experts below are selected from a list of 300 Experts worldwide ranked by ideXlab platform
Salvador Gonzalezb - One of the best experts on this subject based on the ideXlab platform.
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in vivo examination of Lentigo Maligna and Malignant melanoma in situ Lentigo Maligna type by near infrared reflectance confocal microscopy comparison of in vivo confocal images with histologic sections
Journal of The American Academy of Dermatology, 2002Co-Authors: Zeina B S Tannousa, Martin C Mihma, Thomas J Flottea, Salvador GonzalezbAbstract:In vivo confocal microscopy can noninvasively image thin en face sections within living intact human tissue with high resolution and contrast. This evolving technique may provide clinicians with tools to help detect Lentigo Maligna lesion progression in vivo and may be important in defining tumor margins, thus providing a more definitive surgical eradication of Lentigo Maligna and Malignant melanoma in situ, Lentigo Maligna type. We present a case of Malignant melanoma in situ, Lentigo Maligna type, and we describe the images seen with confocal microscopy in correlation with routine histopathology.
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in vivo examination of Lentigo Maligna and Malignant melanoma in situ Lentigo Maligna type by near infrared reflectance confocal microscopy comparison of in vivo confocal images with histologic sections
Journal of The American Academy of Dermatology, 2002Co-Authors: Zeina B S Tannousa, Martin C Mihma, Thomas J Flottea, Salvador GonzalezbAbstract:Abstract In vivo confocal microscopy can noninvasively image thin en face sections within living intact human tissue with high resolution and contrast. This evolving technique may provide clinicians with tools to help detect Lentigo Maligna lesion progression in vivo and may be important in defining tumor margins, thus providing a more definitive surgical eradication of Lentigo Maligna and Malignant melanoma in situ, Lentigo Maligna type. We present a case of Malignant melanoma in situ, Lentigo Maligna type, and we describe the images seen with confocal microscopy in correlation with routine histopathology. (J Am Acad Dermatol 2002;46:260-3.)
Artur Zembowicz - One of the best experts on this subject based on the ideXlab platform.
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Expression of Soluble Adenylyl Cyclase in Lentigo Maligna: Use of Immunohistochemistry With Anti–Soluble Adenylyl Cyclase Antibody (R21) in Diagnosis of Lentigo Maligna and Assessment of Margins
Archives of pathology & laboratory medicine, 2012Co-Authors: Cynthia M. Magro, Sung-eun Yang, Jonathan H. Zippin, Artur ZembowiczAbstract:Context.—Soluble adenylyl cyclase (sAC) is an enzyme that generates cyclic adenosine monophosphate, a signaling molecule involved in regulating melanocyte functions. R21, a mouse monoclonal antibody against sAC, shows a striking pan-nuclear staining in Lentigo Maligna, indicating possible utility for diagnosis and margin assessment. Objective.—To evaluate R21 in the diagnosis and evaluation of margins in Lentigo Maligna. Design.—Thirty one re-excision specimens for Lentigo Maligna were evaluated for R21 expression using previously published protocol. In addition, 153 cases including 41 Lentigo Malignas, 30 non–Lentigo Maligna-type melanomas, 38 Lentigos, and 44 nevi were evaluated using a modified stringent protocol to eliminate all nonmelanocyte staining. Results.—The sensitivity of nuclear staining with R21 in Lentigo Maligna was 87.8%. Nuclear expression of sAC was observed in 40% of other melanomas and 2.3% of benign nevi. R21 did not stain nuclei of resting melanocytes but was observed in 28.9% of me...
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expression of soluble adenylyl cyclase in Lentigo Maligna use of immunohistochemistry with anti soluble adenylyl cyclase antibody r21 in diagnosis of Lentigo Maligna and assessment of margins
Archives of Pathology & Laboratory Medicine, 2012Co-Authors: Cynthia M. Magro, Sung-eun Yang, Jonathan H. Zippin, Artur ZembowiczAbstract:Context.—Soluble adenylyl cyclase (sAC) is an enzyme that generates cyclic adenosine monophosphate, a signaling molecule involved in regulating melanocyte functions. R21, a mouse monoclonal antibody against sAC, shows a striking pan-nuclear staining in Lentigo Maligna, indicating possible utility for diagnosis and margin assessment. Objective.—To evaluate R21 in the diagnosis and evaluation of margins in Lentigo Maligna. Design.—Thirty one re-excision specimens for Lentigo Maligna were evaluated for R21 expression using previously published protocol. In addition, 153 cases including 41 Lentigo Malignas, 30 non–Lentigo Maligna-type melanomas, 38 Lentigos, and 44 nevi were evaluated using a modified stringent protocol to eliminate all nonmelanocyte staining. Results.—The sensitivity of nuclear staining with R21 in Lentigo Maligna was 87.8%. Nuclear expression of sAC was observed in 40% of other melanomas and 2.3% of benign nevi. R21 did not stain nuclei of resting melanocytes but was observed in 28.9% of me...
Zeina B S Tannousa - One of the best experts on this subject based on the ideXlab platform.
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in vivo examination of Lentigo Maligna and Malignant melanoma in situ Lentigo Maligna type by near infrared reflectance confocal microscopy comparison of in vivo confocal images with histologic sections
Journal of The American Academy of Dermatology, 2002Co-Authors: Zeina B S Tannousa, Martin C Mihma, Thomas J Flottea, Salvador GonzalezbAbstract:In vivo confocal microscopy can noninvasively image thin en face sections within living intact human tissue with high resolution and contrast. This evolving technique may provide clinicians with tools to help detect Lentigo Maligna lesion progression in vivo and may be important in defining tumor margins, thus providing a more definitive surgical eradication of Lentigo Maligna and Malignant melanoma in situ, Lentigo Maligna type. We present a case of Malignant melanoma in situ, Lentigo Maligna type, and we describe the images seen with confocal microscopy in correlation with routine histopathology.
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in vivo examination of Lentigo Maligna and Malignant melanoma in situ Lentigo Maligna type by near infrared reflectance confocal microscopy comparison of in vivo confocal images with histologic sections
Journal of The American Academy of Dermatology, 2002Co-Authors: Zeina B S Tannousa, Martin C Mihma, Thomas J Flottea, Salvador GonzalezbAbstract:Abstract In vivo confocal microscopy can noninvasively image thin en face sections within living intact human tissue with high resolution and contrast. This evolving technique may provide clinicians with tools to help detect Lentigo Maligna lesion progression in vivo and may be important in defining tumor margins, thus providing a more definitive surgical eradication of Lentigo Maligna and Malignant melanoma in situ, Lentigo Maligna type. We present a case of Malignant melanoma in situ, Lentigo Maligna type, and we describe the images seen with confocal microscopy in correlation with routine histopathology. (J Am Acad Dermatol 2002;46:260-3.)
Martin C Mihma - One of the best experts on this subject based on the ideXlab platform.
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in vivo examination of Lentigo Maligna and Malignant melanoma in situ Lentigo Maligna type by near infrared reflectance confocal microscopy comparison of in vivo confocal images with histologic sections
Journal of The American Academy of Dermatology, 2002Co-Authors: Zeina B S Tannousa, Martin C Mihma, Thomas J Flottea, Salvador GonzalezbAbstract:In vivo confocal microscopy can noninvasively image thin en face sections within living intact human tissue with high resolution and contrast. This evolving technique may provide clinicians with tools to help detect Lentigo Maligna lesion progression in vivo and may be important in defining tumor margins, thus providing a more definitive surgical eradication of Lentigo Maligna and Malignant melanoma in situ, Lentigo Maligna type. We present a case of Malignant melanoma in situ, Lentigo Maligna type, and we describe the images seen with confocal microscopy in correlation with routine histopathology.
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in vivo examination of Lentigo Maligna and Malignant melanoma in situ Lentigo Maligna type by near infrared reflectance confocal microscopy comparison of in vivo confocal images with histologic sections
Journal of The American Academy of Dermatology, 2002Co-Authors: Zeina B S Tannousa, Martin C Mihma, Thomas J Flottea, Salvador GonzalezbAbstract:Abstract In vivo confocal microscopy can noninvasively image thin en face sections within living intact human tissue with high resolution and contrast. This evolving technique may provide clinicians with tools to help detect Lentigo Maligna lesion progression in vivo and may be important in defining tumor margins, thus providing a more definitive surgical eradication of Lentigo Maligna and Malignant melanoma in situ, Lentigo Maligna type. We present a case of Malignant melanoma in situ, Lentigo Maligna type, and we describe the images seen with confocal microscopy in correlation with routine histopathology. (J Am Acad Dermatol 2002;46:260-3.)
Thomas J Flottea - One of the best experts on this subject based on the ideXlab platform.
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in vivo examination of Lentigo Maligna and Malignant melanoma in situ Lentigo Maligna type by near infrared reflectance confocal microscopy comparison of in vivo confocal images with histologic sections
Journal of The American Academy of Dermatology, 2002Co-Authors: Zeina B S Tannousa, Martin C Mihma, Thomas J Flottea, Salvador GonzalezbAbstract:In vivo confocal microscopy can noninvasively image thin en face sections within living intact human tissue with high resolution and contrast. This evolving technique may provide clinicians with tools to help detect Lentigo Maligna lesion progression in vivo and may be important in defining tumor margins, thus providing a more definitive surgical eradication of Lentigo Maligna and Malignant melanoma in situ, Lentigo Maligna type. We present a case of Malignant melanoma in situ, Lentigo Maligna type, and we describe the images seen with confocal microscopy in correlation with routine histopathology.
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in vivo examination of Lentigo Maligna and Malignant melanoma in situ Lentigo Maligna type by near infrared reflectance confocal microscopy comparison of in vivo confocal images with histologic sections
Journal of The American Academy of Dermatology, 2002Co-Authors: Zeina B S Tannousa, Martin C Mihma, Thomas J Flottea, Salvador GonzalezbAbstract:Abstract In vivo confocal microscopy can noninvasively image thin en face sections within living intact human tissue with high resolution and contrast. This evolving technique may provide clinicians with tools to help detect Lentigo Maligna lesion progression in vivo and may be important in defining tumor margins, thus providing a more definitive surgical eradication of Lentigo Maligna and Malignant melanoma in situ, Lentigo Maligna type. We present a case of Malignant melanoma in situ, Lentigo Maligna type, and we describe the images seen with confocal microscopy in correlation with routine histopathology. (J Am Acad Dermatol 2002;46:260-3.)