The Experts below are selected from a list of 291 Experts worldwide ranked by ideXlab platform
Salvador Gonzalezb - One of the best experts on this subject based on the ideXlab platform.
-
in vivo examination of Lentigo maligna and malignant melanoma in situ Lentigo maligna type by near infrared reflectance confocal microscopy comparison of in vivo confocal images with histologic sections
Journal of The American Academy of Dermatology, 2002Co-Authors: Zeina B S Tannousa, Martin C Mihma, Thomas J Flottea, Salvador GonzalezbAbstract:In vivo confocal microscopy can noninvasively image thin en face sections within living intact human tissue with high resolution and contrast. This evolving technique may provide clinicians with tools to help detect Lentigo maligna lesion progression in vivo and may be important in defining tumor margins, thus providing a more definitive surgical eradication of Lentigo maligna and malignant melanoma in situ, Lentigo maligna type. We present a case of malignant melanoma in situ, Lentigo maligna type, and we describe the images seen with confocal microscopy in correlation with routine histopathology.
-
in vivo examination of Lentigo maligna and malignant melanoma in situ Lentigo maligna type by near infrared reflectance confocal microscopy comparison of in vivo confocal images with histologic sections
Journal of The American Academy of Dermatology, 2002Co-Authors: Zeina B S Tannousa, Martin C Mihma, Thomas J Flottea, Salvador GonzalezbAbstract:Abstract In vivo confocal microscopy can noninvasively image thin en face sections within living intact human tissue with high resolution and contrast. This evolving technique may provide clinicians with tools to help detect Lentigo maligna lesion progression in vivo and may be important in defining tumor margins, thus providing a more definitive surgical eradication of Lentigo maligna and malignant melanoma in situ, Lentigo maligna type. We present a case of malignant melanoma in situ, Lentigo maligna type, and we describe the images seen with confocal microscopy in correlation with routine histopathology. (J Am Acad Dermatol 2002;46:260-3.)
Zeina B S Tannousa - One of the best experts on this subject based on the ideXlab platform.
-
in vivo examination of Lentigo maligna and malignant melanoma in situ Lentigo maligna type by near infrared reflectance confocal microscopy comparison of in vivo confocal images with histologic sections
Journal of The American Academy of Dermatology, 2002Co-Authors: Zeina B S Tannousa, Martin C Mihma, Thomas J Flottea, Salvador GonzalezbAbstract:In vivo confocal microscopy can noninvasively image thin en face sections within living intact human tissue with high resolution and contrast. This evolving technique may provide clinicians with tools to help detect Lentigo maligna lesion progression in vivo and may be important in defining tumor margins, thus providing a more definitive surgical eradication of Lentigo maligna and malignant melanoma in situ, Lentigo maligna type. We present a case of malignant melanoma in situ, Lentigo maligna type, and we describe the images seen with confocal microscopy in correlation with routine histopathology.
-
in vivo examination of Lentigo maligna and malignant melanoma in situ Lentigo maligna type by near infrared reflectance confocal microscopy comparison of in vivo confocal images with histologic sections
Journal of The American Academy of Dermatology, 2002Co-Authors: Zeina B S Tannousa, Martin C Mihma, Thomas J Flottea, Salvador GonzalezbAbstract:Abstract In vivo confocal microscopy can noninvasively image thin en face sections within living intact human tissue with high resolution and contrast. This evolving technique may provide clinicians with tools to help detect Lentigo maligna lesion progression in vivo and may be important in defining tumor margins, thus providing a more definitive surgical eradication of Lentigo maligna and malignant melanoma in situ, Lentigo maligna type. We present a case of malignant melanoma in situ, Lentigo maligna type, and we describe the images seen with confocal microscopy in correlation with routine histopathology. (J Am Acad Dermatol 2002;46:260-3.)
Thomas J Flotte - One of the best experts on this subject based on the ideXlab platform.
-
progression to invasive melanoma from malignant melanoma in situ Lentigo maligna type
Human Pathology, 2000Co-Authors: Zeina Tannous, Martin C Mihm, Lisa H Lerner, Lyn M Duncan, Thomas J FlotteAbstract:We have previously hypothesized that lesions that have been termed Lentigo maligna can be divided into 2 categories: 1 represents a pigmented lesion that is a precursor to melanoma, and the other melanoma in situ. We and others have hypothesized that there is a progressive acquisition of attributes in pigmented lesions that results in malignant melanoma. Based on these 2 hypotheses, we have predicted that the intraepidermal component of invasive malignant melanomas, Lentigo maligna type, should be similar to those lesions that we have termed malignant melanoma in situ, Lentigo maligna type rather than Lentigo maligna. The intraepidermal component of 42 consecutive cases of invasive malignant melanoma, Lentigo maligna type was evaluated by all of the authors. Malignant melanoma in situ, Lentigo maligna type is characterized by pagetoid spread, confluence, and nesting of atypical melanocytes. All of the cases evaluated showed features diagnostic of malignant melanoma in situ, Lentigo maligna type, in the epidermis overlying the invasive dermal component. We conclude that invasive Lentigo maligna melanoma arises in association with those lesions that we have termed malignant melanoma in situ, Lentigo maligna type, which may represent a step in the progression between atypical melanocytic hyperplasia (Lentigo maligna) and invasive melanoma. This finding supports the distinction of these entities and may have therapeutic implications.
-
Lentigo maligna and malignant melanoma in situ Lentigo maligna type
Human Pathology, 1999Co-Authors: Thomas J Flotte, Martin C MihmAbstract:Some authors have considered Lentigo maligna to be an atypical melanocytic proliferation, whereas others have considered it to be melanoma in situ. We reviewed 50 cases of Lentigo maligna. We have identified two subsets of lesions. The first has atypical melanocytic hyperplasia, which we postulate to be correctly designated Lentigo maligna. The second subset has the following features in addition to the melanocytic hyperplasia: individual and nests of cells at varying layers of the epidermis, confluence of the melanocytes replacing the basilar region, uniformity of the cytological atypia, and nesting of uniformly atypical melanocytes. These lesions we designate as malignant melanoma in situ, Lentigo maligna type. We are proposing that the lesions that have been termed Lentigo maligna represent a spectrum of atypia and that the application of some of the traditional features for the diagnosis melanoma may permit the segregation of more and less aggressive lesions.
Martin C Mihm - One of the best experts on this subject based on the ideXlab platform.
-
Lentigo, Other Melanosis, and the Acquired Nevus
Melanocytic Lesions, 2014Co-Authors: Mai P. Hoang, Martin C MihmAbstract:In this chapter, benign pigmented lesions associated with increased melanin pigment in basal keratinocytes and mild increase in the number of melanocytes such as Lentigo, psoralen and ultraviolet A Lentigo, solar Lentigo, cafe au lait macule, ink-spot Lentigo, mucosal melanotic macule, vulvar melanosis, and nevus spilus/speckled lentiginous nevus are discussed. In addition, the common acquired nevi are a phenomenon of the epidermis and papillary dermis, and they can present as junctional nevus, compound nevus, and dermal nevus.
-
progression to invasive melanoma from malignant melanoma in situ Lentigo maligna type
Human Pathology, 2000Co-Authors: Zeina Tannous, Martin C Mihm, Lisa H Lerner, Lyn M Duncan, Thomas J FlotteAbstract:We have previously hypothesized that lesions that have been termed Lentigo maligna can be divided into 2 categories: 1 represents a pigmented lesion that is a precursor to melanoma, and the other melanoma in situ. We and others have hypothesized that there is a progressive acquisition of attributes in pigmented lesions that results in malignant melanoma. Based on these 2 hypotheses, we have predicted that the intraepidermal component of invasive malignant melanomas, Lentigo maligna type, should be similar to those lesions that we have termed malignant melanoma in situ, Lentigo maligna type rather than Lentigo maligna. The intraepidermal component of 42 consecutive cases of invasive malignant melanoma, Lentigo maligna type was evaluated by all of the authors. Malignant melanoma in situ, Lentigo maligna type is characterized by pagetoid spread, confluence, and nesting of atypical melanocytes. All of the cases evaluated showed features diagnostic of malignant melanoma in situ, Lentigo maligna type, in the epidermis overlying the invasive dermal component. We conclude that invasive Lentigo maligna melanoma arises in association with those lesions that we have termed malignant melanoma in situ, Lentigo maligna type, which may represent a step in the progression between atypical melanocytic hyperplasia (Lentigo maligna) and invasive melanoma. This finding supports the distinction of these entities and may have therapeutic implications.
-
Lentigo maligna and malignant melanoma in situ Lentigo maligna type
Human Pathology, 1999Co-Authors: Thomas J Flotte, Martin C MihmAbstract:Some authors have considered Lentigo maligna to be an atypical melanocytic proliferation, whereas others have considered it to be melanoma in situ. We reviewed 50 cases of Lentigo maligna. We have identified two subsets of lesions. The first has atypical melanocytic hyperplasia, which we postulate to be correctly designated Lentigo maligna. The second subset has the following features in addition to the melanocytic hyperplasia: individual and nests of cells at varying layers of the epidermis, confluence of the melanocytes replacing the basilar region, uniformity of the cytological atypia, and nesting of uniformly atypical melanocytes. These lesions we designate as malignant melanoma in situ, Lentigo maligna type. We are proposing that the lesions that have been termed Lentigo maligna represent a spectrum of atypia and that the application of some of the traditional features for the diagnosis melanoma may permit the segregation of more and less aggressive lesions.
Artur Zembowicz - One of the best experts on this subject based on the ideXlab platform.
-
Expression of Soluble Adenylyl Cyclase in Lentigo Maligna: Use of Immunohistochemistry With Anti–Soluble Adenylyl Cyclase Antibody (R21) in Diagnosis of Lentigo Maligna and Assessment of Margins
Archives of pathology & laboratory medicine, 2012Co-Authors: Cynthia M. Magro, Sung-eun Yang, Jonathan H. Zippin, Artur ZembowiczAbstract:Context.—Soluble adenylyl cyclase (sAC) is an enzyme that generates cyclic adenosine monophosphate, a signaling molecule involved in regulating melanocyte functions. R21, a mouse monoclonal antibody against sAC, shows a striking pan-nuclear staining in Lentigo maligna, indicating possible utility for diagnosis and margin assessment. Objective.—To evaluate R21 in the diagnosis and evaluation of margins in Lentigo maligna. Design.—Thirty one re-excision specimens for Lentigo maligna were evaluated for R21 expression using previously published protocol. In addition, 153 cases including 41 Lentigo malignas, 30 non–Lentigo maligna-type melanomas, 38 Lentigos, and 44 nevi were evaluated using a modified stringent protocol to eliminate all nonmelanocyte staining. Results.—The sensitivity of nuclear staining with R21 in Lentigo maligna was 87.8%. Nuclear expression of sAC was observed in 40% of other melanomas and 2.3% of benign nevi. R21 did not stain nuclei of resting melanocytes but was observed in 28.9% of me...
