The Experts below are selected from a list of 16980 Experts worldwide ranked by ideXlab platform

Rolland Schwarting - One of the best experts on this subject based on the ideXlab platform.

Gene Gulati - One of the best experts on this subject based on the ideXlab platform.

  • changes in automated complete blood cell Count and differential Leukocyte Count results induced by storage of blood at room temperature
    Archives of Pathology & Laboratory Medicine, 2009
    Co-Authors: Gene Gulati, Lawrence J Hyland, William Kocher, Rolland Schwarting
    Abstract:

    Abstract Objective.—To delineate changes that occur in various parameters of automated complete blood cell Count (CBC) and differential Leukocyte Count (differential) on prolonged storage of blood ...

  • changes in automated complete blood cell Count and differential Leukocyte Count results induced by storage of blood at room temperature
    Archives of Pathology & Laboratory Medicine, 2002
    Co-Authors: Gene Gulati, Lawrence J Hyland, William Kocher, Rolland Schwarting
    Abstract:

    Abstract Objective.—To delineate changes that occur in various parameters of automated complete blood cell Count (CBC) and differential Leukocyte Count (differential) on prolonged storage of blood at room temperature. Design.—A CBC and an automated differential were performed on the Coulter Gen.S on 40 K3 (tripotassium ethylenediamine-tetraacetate) EDTA-anticoagulated blood specimens once daily, specimen volume permitting, for 3 to 7 days. Specimens were kept at room temperature throughout the study. The results were tabulated using a personal computer with Excel software. Percent change or absolute difference from the initial value for each parameter for each subsequent day of the study period was calculated. Results.—Among the CBC parameters, hemoglobin, red blood cell Count, and mean corpuscular hemoglobin were stable for the duration of the study (7 days), white blood cell Count was stable for at least 3 days (up to 7 days, if the Count was within or above the normal range), and platelet Count was sta...

  • differential Leukocyte Count manual or automated what should it be
    Yonsei Medical Journal, 1991
    Co-Authors: Bong H Hyun, Gene Gulati, John K Ashton
    Abstract:

    Today's automated hematology analyzers capable of performing a full CBC and a differential Leukocyte Count (DLC) on whole blood, particularly in a closed tube system, using cytochemistry or impedance-based flow cytometry technology coupled with laser light scattering, conductivity and/or differential cell lysis, are here to stay. Their need and popularity among at least the large, cost and quality-conscious clinical laboratories have been growing for the past few years and will continue to do so in the years ahead. The efficiency and reliability of several of these analyzers in performing complete CBCD (CBC and DLC) and in flagging significant abnormalities have been tested and found acceptable with the need to review a stained blood smear or perform a manual DLC to confirm or obtain additional information on selected cases.

Earl S Ford - One of the best experts on this subject based on the ideXlab platform.

  • the metabolic syndrome and c reactive protein fibrinogen and Leukocyte Count findings from the third national health and nutrition examination survey
    Atherosclerosis, 2003
    Co-Authors: Earl S Ford
    Abstract:

    Abstract To examine the association between the metabolic syndrome and C-reactive protein, fibrinogen, and Leukocyte Count, the author did a cross-sectional analysis of data from 8570 participants aged ≥20 years from the Third National Health and Nutrition Examination Survey (1988–1994). The metabolic syndrome was defined using criteria established by the Third Report of the National Cholesterol Education Program Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults. The age-adjusted prevalence of having an elevated C-reactive protein concentration was 29.0% (S.E.: 1.6%) for participants with the metabolic syndrome and 12.1% (S.E.: 0.6%) for participants without the metabolic syndrome (adjusted odds ratio (OR), 2.80; 95% confidence interval (CI): 2.36, 3.33). Compared with participants who had no abnormalities, the corresponding adjusted ORs were 1.91 (95% CI: 1.27, 2.87), 3.00 (95% CI: 1.96, 4.60), 5.01 (95% CI: 3.39, 7.41), 5.97 (95% CI: 3.83, 9.31), and 6.79 (95% CI: 3.55, 12.99) for participants with 1, 2, 3, 4, and 5 metabolic abnormalities, respectively. Participants with the metabolic syndrome had higher fibrinogen concentrations and white blood cell Counts than those without this syndrome. Many people with the metabolic syndrome have a low-grade inflammation, which may increase their risk for future adverse events. A better understanding of the potential consequences of the high prevalence of low-grade inflammation among people with the metabolic syndrome is needed.

  • Leukocyte Count erythrocyte sedimentation rate and diabetes incidence in a national sample of us adults
    American Journal of Epidemiology, 2002
    Co-Authors: Earl S Ford
    Abstract:

    Emerging data suggest that inflammation may play a role in the etiology of diabetes mellitus. Because few prospective studies have addressed this issue, the author examined the relation between Leukocyte Count and erythrocyte sedimentation rate and diabetes incidence using data from the National Health and Nutrition Examination Survey Epidemiologic Follow-up Study (from 1971-1975 to 1992-1993). Of 8,352 participants included in the analysis, 878 developed incident diabetes during the approximately 20-year follow-up. After adjustment for age, smoking status, systolic blood pressure, cholesterol concentration, use of antihypertensive medication, recreational exercise, nonrecreational activity, alcohol use, and body mass index, the hazard ratios from proportional hazards for participants with a Leukocyte Count of ≥9.1 x 109/liter compared with participants with a Leukocyte Count of < 5.7 x 109/liter were 1.33 (95% confidence interval (Cl): 0.81, 2.19) for men and 1.68 (95% Cl: 1.21, 2.34) for women. The adjusted hazard ratios for participants with an erythrocyte sedimentation rate of ≥26 mm/hour compared with participants with an erythrocyte sedimentation rate of ≤ 5 mm/hour were 1.85 (95% CI: 0.97, 3.54) for men and 0.83 (95% CI: 0.47, 1.44) for women. These results provide limited support to the hypothesis that inflammation is an etiologic factor for diabetes.

Ward S Casscells - One of the best experts on this subject based on the ideXlab platform.

  • Leukocyte Count and coronary heart disease implications for risk assessment
    Journal of the American College of Cardiology, 2004
    Co-Authors: Mohammad Madjid, Imran Awan, James T Willerson, Ward S Casscells
    Abstract:

    Inflammation is a key feature of atherosclerosis and its clinical manifestations. The Leukocyte Count is a marker of inflammation that is widely available in clinical practice. This paper reviews the available epidemiologic evidence for a relationship between the Leukocyte Count and coronary heart disease (CHD). Numerous epidemiologic and clinical studies have shown leukocytosis to be an independent predictor of future cardiovascular events, both in healthy individuals free of CHD at baseline and in patients with stable angina, unstable angina, or a history of myocardial infarction. This relationship has been observed in prospective and retrospective cohort studies, as well as in case-control studies. It is strong, consistent, temporal, dose-dependent, and biologically plausible. The relationship persists after adjustment for multiple CHD risk factors, including smoking. Elevated differential cell Counts, including eosinophil, neutrophil, and monocyte Counts, also predict the future incidence of CHD. Leukocytosis affects CHD through multiple pathologic mechanisms that mediate inflammation, cause proteolytic and oxidative damage to the endothelial cells, plug the microvasculature, induce hypercoagulability, and promote infarct expansion. In summary, leukocytosis has been consistently shown to be an independent risk factor and prognostic indicator of future cardiovascular outcomes, regardless of disease status. The Leukocyte Count is inexpensive, reliable, easy to interpret, and ordered routinely in inpatient and outpatient settings. However, its diagnostic and prognostic utility in CHD is widely unappreciated. Further studies are needed to assess the true impact of leukocytosis on CHD, compare it with other inflammatory markers such as C-reactive protein and lipoprotein phospholipase A2levels, and promote its use in CHD prediction.

William Kocher - One of the best experts on this subject based on the ideXlab platform.