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Michael E Phelps - One of the best experts on this subject based on the ideXlab platform.
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dissociation of cerebral glucose metabolism and Level of Consciousness during the period of metabolic depression following human traumatic brain injury
Journal of Neurotrauma, 2000Co-Authors: Marvin Bergsneider, David A Hovda, Stefan M Lee, Daniel F Kelly, David L Mcarthur, Paul M Vespa, Jae Hong Lee, Sungcheng Huang, Neil A Martin, Michael E PhelpsAbstract:ABSTRACT Utilizing [18F]fluorodeoxyglucose positron emission tomography (FDG-PET), we studied the correlation between CMRglc and the Level of Consciousness within the first month following human tr...
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dissociation of cerebral glucose metabolism and Level of Consciousness during the period of metabolic depression following human traumatic brain injury
Journal of Neurotrauma, 2000Co-Authors: Marvin Bergsneider, David A Hovda, Stefan M Lee, Daniel F Kelly, David L Mcarthur, Paul M Vespa, Jae Hong Lee, Sungcheng Huang, Neil A Martin, Michael E PhelpsAbstract:Utilizing [18F]fluorodeoxyglucose positron emission tomography (FDG-PET), we studied the correlation between CMRglc and the Level of Consciousness within the first month following human traumatic brain injury. Forty-three FDG-PET scans obtained on 42 mild to severely head-injured patients were quantitatively analyzed for the determination of regional cerebral metabolic rate of glucose (CMRglc). Reduction of cerebral glucose utilization, defined as a CMRglc of < or =4.9 mg/100 g/min, was present regionally in 88% of the studies. The prevalence of global cortical CMRglc reduction was higher in severely head-injured patients (86% versus 67% mild-moderate), although the absolute magnitude was similar across the injury severity spectrum (mean CMRglc 3.9 +/- 0.6 mg/100 g/min). The Level of Consciousness, as measured by the Glasgow Coma Scale, correlated poorly with the global cortical CMRglc value (r = 0.08; p = 0.63). With regards to severity of head injury, this correlation was worst for the severely injured (r = -0.11; p = 0.58) and better for the mildly injured patients (r = 0.50; p = 0.07). In most cases, intraparenchymal hemorrhagic lesions were associated with either focal CMRglc reduction or elevation. It is concluded that the etiologies of CMRglc reduction are likely multifactorial given the complex nature of traumatic brain injury and that the reduction of CMRglc represents a fundamental pathobiologic state following head injury that is not tightly coupled to Level of Consciousness.
Marvin Bergsneider - One of the best experts on this subject based on the ideXlab platform.
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dissociation of cerebral glucose metabolism and Level of Consciousness during the period of metabolic depression following human traumatic brain injury
Journal of Neurotrauma, 2000Co-Authors: Marvin Bergsneider, David A Hovda, Stefan M Lee, Daniel F Kelly, David L Mcarthur, Paul M Vespa, Jae Hong Lee, Sungcheng Huang, Neil A Martin, Michael E PhelpsAbstract:ABSTRACT Utilizing [18F]fluorodeoxyglucose positron emission tomography (FDG-PET), we studied the correlation between CMRglc and the Level of Consciousness within the first month following human tr...
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dissociation of cerebral glucose metabolism and Level of Consciousness during the period of metabolic depression following human traumatic brain injury
Journal of Neurotrauma, 2000Co-Authors: Marvin Bergsneider, David A Hovda, Stefan M Lee, Daniel F Kelly, David L Mcarthur, Paul M Vespa, Jae Hong Lee, Sungcheng Huang, Neil A Martin, Michael E PhelpsAbstract:Utilizing [18F]fluorodeoxyglucose positron emission tomography (FDG-PET), we studied the correlation between CMRglc and the Level of Consciousness within the first month following human traumatic brain injury. Forty-three FDG-PET scans obtained on 42 mild to severely head-injured patients were quantitatively analyzed for the determination of regional cerebral metabolic rate of glucose (CMRglc). Reduction of cerebral glucose utilization, defined as a CMRglc of < or =4.9 mg/100 g/min, was present regionally in 88% of the studies. The prevalence of global cortical CMRglc reduction was higher in severely head-injured patients (86% versus 67% mild-moderate), although the absolute magnitude was similar across the injury severity spectrum (mean CMRglc 3.9 +/- 0.6 mg/100 g/min). The Level of Consciousness, as measured by the Glasgow Coma Scale, correlated poorly with the global cortical CMRglc value (r = 0.08; p = 0.63). With regards to severity of head injury, this correlation was worst for the severely injured (r = -0.11; p = 0.58) and better for the mildly injured patients (r = 0.50; p = 0.07). In most cases, intraparenchymal hemorrhagic lesions were associated with either focal CMRglc reduction or elevation. It is concluded that the etiologies of CMRglc reduction are likely multifactorial given the complex nature of traumatic brain injury and that the reduction of CMRglc represents a fundamental pathobiologic state following head injury that is not tightly coupled to Level of Consciousness.
Bo Mi Min - One of the best experts on this subject based on the ideXlab platform.
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Clinical Research Article
2016Co-Authors: Jin Yong Jung, Cheol Beom Cho, Bo Mi MinAbstract:Background: In general, measuring the Level of Consciousness in neurological patients is important. To assess the patient’s mental status, the Glasgow Coma Scale (GCS) and the Level of Consciousness (drowsiness, stupor, and coma) have been used in clinical situations. The aim of the present study was to identify the correlation between bispectral index (BIS) and Level of Consciousness in brain injured patients. Methods: Eighty-nine adult patients of both sexes were included in the study. A blinded observer evaluated the mental status (GCS and Level of Consciousness) of a patient who is admitted in intensive care unit with brain injury, while an investigator noted the patient’s BIS. The BIS was measured using a BIS monitor, Model A-3000 vistaTM with Sensor Bis quatroTM (Aspect Medical Systems, Norwood, USA). A Spearman’s rank correlation coefficient was used to determine if the Level of Consciousness correlated with the BIS. Results: In 89 patients, the BIS was found to be significantly correlated with the Level of Consciousness (r = 0.723, P < 0.01) and GCS (r = 0.646, P < 0.01). The BIS values increased with an increasing Level of Consciousness. Mean BIS values of coma, semicoma, stupor and drowsiness were 0.14 ± 0.23, 38.9 ± 18.0, 60.3 ± 14.5, and 73.6 ± 16.5, respectively. Conclusions: In the present study, a significant correlation existed between Level of Consciousness and BIS. These findings suggest that BIS may be used for assessing the Level of Consciousness in brain injured patients. However, th
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bispectral index monitoring correlates with the Level of Consciousness in brain injured patients
Korean Journal of Anesthesiology, 2013Co-Authors: Jin Yong Jung, Cheol Beom Cho, Bo Mi MinAbstract:BACKGROUND In general, measuring the Level of Consciousness in neurological patients is important. To assess the patient's mental status, the Glasgow Coma Scale (GCS) and the Level of Consciousness (drowsiness, stupor, and coma) have been used in clinical situations. The aim of the present study was to identify the correlation between bispectral index (BIS) and Level of Consciousness in brain injured patients. METHODS Eighty-nine adult patients of both sexes were included in the study. A blinded observer evaluated the mental status (GCS and Level of Consciousness) of a patient who is admitted in intensive care unit with brain injury, while an investigator noted the patient's BIS. The BIS was measured using a BIS monitor, Model A-3000 vista™ with Sensor Bis quatro™ (Aspect Medical Systems, Norwood, USA). A Spearman's rank correlation coefficient was used to determine if the Level of Consciousness correlated with the BIS. RESULTS In 89 patients, the BIS was found to be significantly correlated with the Level of Consciousness (r = 0.723, P < 0.01) and GCS (r = 0.646, P < 0.01). The BIS values increased with an increasing Level of Consciousness. Mean BIS values of coma, semicoma, stupor and drowsiness were 0.14 ± 0.23, 38.9 ± 18.0, 60.3 ± 14.5, and 73.6 ± 16.5, respectively. CONCLUSIONS In the present study, a significant correlation existed between Level of Consciousness and BIS. These findings suggest that BIS may be used for assessing the Level of Consciousness in brain injured patients. However, the scatter of BIS values for any Level of Consciousness limited the worth of BIS in predicting mentality except in coma patients.
Neil A Martin - One of the best experts on this subject based on the ideXlab platform.
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dissociation of cerebral glucose metabolism and Level of Consciousness during the period of metabolic depression following human traumatic brain injury
Journal of Neurotrauma, 2000Co-Authors: Marvin Bergsneider, David A Hovda, Stefan M Lee, Daniel F Kelly, David L Mcarthur, Paul M Vespa, Jae Hong Lee, Sungcheng Huang, Neil A Martin, Michael E PhelpsAbstract:ABSTRACT Utilizing [18F]fluorodeoxyglucose positron emission tomography (FDG-PET), we studied the correlation between CMRglc and the Level of Consciousness within the first month following human tr...
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dissociation of cerebral glucose metabolism and Level of Consciousness during the period of metabolic depression following human traumatic brain injury
Journal of Neurotrauma, 2000Co-Authors: Marvin Bergsneider, David A Hovda, Stefan M Lee, Daniel F Kelly, David L Mcarthur, Paul M Vespa, Jae Hong Lee, Sungcheng Huang, Neil A Martin, Michael E PhelpsAbstract:Utilizing [18F]fluorodeoxyglucose positron emission tomography (FDG-PET), we studied the correlation between CMRglc and the Level of Consciousness within the first month following human traumatic brain injury. Forty-three FDG-PET scans obtained on 42 mild to severely head-injured patients were quantitatively analyzed for the determination of regional cerebral metabolic rate of glucose (CMRglc). Reduction of cerebral glucose utilization, defined as a CMRglc of < or =4.9 mg/100 g/min, was present regionally in 88% of the studies. The prevalence of global cortical CMRglc reduction was higher in severely head-injured patients (86% versus 67% mild-moderate), although the absolute magnitude was similar across the injury severity spectrum (mean CMRglc 3.9 +/- 0.6 mg/100 g/min). The Level of Consciousness, as measured by the Glasgow Coma Scale, correlated poorly with the global cortical CMRglc value (r = 0.08; p = 0.63). With regards to severity of head injury, this correlation was worst for the severely injured (r = -0.11; p = 0.58) and better for the mildly injured patients (r = 0.50; p = 0.07). In most cases, intraparenchymal hemorrhagic lesions were associated with either focal CMRglc reduction or elevation. It is concluded that the etiologies of CMRglc reduction are likely multifactorial given the complex nature of traumatic brain injury and that the reduction of CMRglc represents a fundamental pathobiologic state following head injury that is not tightly coupled to Level of Consciousness.
Sungcheng Huang - One of the best experts on this subject based on the ideXlab platform.
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dissociation of cerebral glucose metabolism and Level of Consciousness during the period of metabolic depression following human traumatic brain injury
Journal of Neurotrauma, 2000Co-Authors: Marvin Bergsneider, David A Hovda, Stefan M Lee, Daniel F Kelly, David L Mcarthur, Paul M Vespa, Jae Hong Lee, Sungcheng Huang, Neil A Martin, Michael E PhelpsAbstract:ABSTRACT Utilizing [18F]fluorodeoxyglucose positron emission tomography (FDG-PET), we studied the correlation between CMRglc and the Level of Consciousness within the first month following human tr...
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dissociation of cerebral glucose metabolism and Level of Consciousness during the period of metabolic depression following human traumatic brain injury
Journal of Neurotrauma, 2000Co-Authors: Marvin Bergsneider, David A Hovda, Stefan M Lee, Daniel F Kelly, David L Mcarthur, Paul M Vespa, Jae Hong Lee, Sungcheng Huang, Neil A Martin, Michael E PhelpsAbstract:Utilizing [18F]fluorodeoxyglucose positron emission tomography (FDG-PET), we studied the correlation between CMRglc and the Level of Consciousness within the first month following human traumatic brain injury. Forty-three FDG-PET scans obtained on 42 mild to severely head-injured patients were quantitatively analyzed for the determination of regional cerebral metabolic rate of glucose (CMRglc). Reduction of cerebral glucose utilization, defined as a CMRglc of < or =4.9 mg/100 g/min, was present regionally in 88% of the studies. The prevalence of global cortical CMRglc reduction was higher in severely head-injured patients (86% versus 67% mild-moderate), although the absolute magnitude was similar across the injury severity spectrum (mean CMRglc 3.9 +/- 0.6 mg/100 g/min). The Level of Consciousness, as measured by the Glasgow Coma Scale, correlated poorly with the global cortical CMRglc value (r = 0.08; p = 0.63). With regards to severity of head injury, this correlation was worst for the severely injured (r = -0.11; p = 0.58) and better for the mildly injured patients (r = 0.50; p = 0.07). In most cases, intraparenchymal hemorrhagic lesions were associated with either focal CMRglc reduction or elevation. It is concluded that the etiologies of CMRglc reduction are likely multifactorial given the complex nature of traumatic brain injury and that the reduction of CMRglc represents a fundamental pathobiologic state following head injury that is not tightly coupled to Level of Consciousness.