The Experts below are selected from a list of 327 Experts worldwide ranked by ideXlab platform
Bharat Guthikonda - One of the best experts on this subject based on the ideXlab platform.
-
jacques jean Lhermitte and the syndrome of peduncular hallucinosis
Neurosurgical Focus, 2019Co-Authors: Jennifer Kosty, Juan C Mejiamunne, Rimal H Dossani, Amey R Savardekar, Bharat GuthikondaAbstract:: Jacques Jean Lhermitte (1877-1959) was among the most accomplished neurologists of the 20th century. In addition to working as a clinician and instructor, he authored more than 800 papers and 16 books on neurology, neuropathology, psychiatry, and mystical phenomena. In addition to the well-known "Lhermitte's sign," an electrical shock-like sensation caused by spinal cord irritation in demyelinating disease, Lhermitte was a pioneer in the study of the relationship between the physical substance of the brain and the experience of the mind. A fascinating example of this is the syndrome of peduncular hallucinosis, characterized by vivid visual hallucinations occurring in fully lucid patients. This syndrome, which was initially described as the result of a midbrain insult, also may occur with injury to the thalamus or pons. It has been reported as a presenting symptom of various tumors and as a complication of neurosurgical procedures. Here, the authors review the life of Lhermitte and provide a historical review of the syndrome of peduncular hallucinosis.
Suzanne J. Baker - One of the best experts on this subject based on the ideXlab platform.
-
Pten regulates neuronal soma size: A mouse model of Lhermitte-Duclos disease
Nature Genetics, 2001Co-Authors: Chang Hyuk Kwon, Junyuan Zhang, Lori L. Knoop, Ruby Tharp, Xiaoyan Zhu, Richard J Smeyne, Peter C Burger, Charles G. Eberhart, Suzanne J. BakerAbstract:Somatic inactivation of PTEN occurs in different human tumors including glioblastoma, endometrial carcinoma and prostate carcinoma. Germline mutations in PTEN result in a range of phenotypic abnormalities that occur with variable penetrance, including neurological features such as macrocephaly, seizures, ataxia and Lhermitte-Duclos disease (also described as dysplastic gangliocytoma of the cerebellum). Homozygous deletion of Pten causes embryonic lethality in mice. To investigate function in the brain, we used Cre-loxP technology to selectively inactivate Pten in specific mouse neuronal populations. Loss of Pten resulted in progressive macrocephaly and seizures. Neurons lacking Pten expressed high levels of phosphorylated Akt and showed a progressive increase in soma size without evidence of abnormal proliferation. Cerebellar abnormalities closely resembled the histopathology of human Lhermitte-Duclos disease. These results indicate that Pten regulates neuronal size in vivo in a cell-autonomous manner and provide new insights into the etiology of Lhermitte-Duclos disease.
Kuniaki Ogasawara - One of the best experts on this subject based on the ideXlab platform.
-
biological characteristics of a cerebellar mass regrowing after removal in a patient with Lhermitte duclos disease emission tomography studies
Case Reports in Neurology, 2014Co-Authors: Hideo Saito, Kuniaki Ogasawara, Takaaki Beppu, Hideki Matsuura, Kazunori TerasakiAbstract:Lhermitte-Duclos disease is a rare disorder characterized by a slowly enlarging mass in the cerebellum. The exact nature of this lesion remains unclear, but it has been variously characterized as hypertrophy, hamartoma or benign neoplasm. Single-photon emission computed tomography (SPECT) with 123I-iomazenil and 99mTc-ethyl cysteinate dimer (ECD) display central benzodiazepine receptors that are widely distributed in the normal brain cortex, a combination of brain perfusion, enzymatic activity and blood-brain barrier function, respectively. This report describes the case of a 30-year-old man who developed Lhermitte-Duclos disease. The mass regrew after a subtotal removal 13 years earlier. The cerebellar lesion exhibited hyperperfusion and hypermetabolism on blood flow and a metabolic rate of oxygen imaging on 15O-gas positron emission tomography (PET), as well as a hyperactivity and a defect in the uptake on 99mTc-ECD and 123I-iomazenil SPECT imaging, respectively. The present Lhermitte-Duclos lesion might have the biological characteristics of both hypertrophy and neoplasm, from the perspective of results from 15O-gas PET, 99mTc-ECD and 123I-iomazenil SPECT.
-
brain pet and technetium 99m ecd spect imaging in Lhermitte duclos disease
Neuroradiology, 2001Co-Authors: Kuniaki Ogasawara, Shigeru Yasuda, Takaaki Beppu, Masakazu Kobayashi, Kiyoshi Kuroda, Akira OgawaAbstract:Two patients with Lhermitte-Duclos disease were evaluated by brain positron emission tomography (PET) and technetium-99m-ethyl cysteinate dimer (99mTc-ECD) single-photon emission computed tomography (SPECT). In the lesions in both patients, hyperperfusion was detected on cerebral blood flow images obtained by PET, and hyperactivity by standard 99mTc-ECD SPECT. Dynamic 99mTc-ECD SPECT images demonstrated a plateau of activity in each lesion. These findings suggest that lesions in Lhermitte-Duclos disease have a retention mechanism for 99mTc-ECD equivalent to that of normal neural tissue.
Akira Ogawa - One of the best experts on this subject based on the ideXlab platform.
-
brain pet and technetium 99m ecd spect imaging in Lhermitte duclos disease
Neuroradiology, 2001Co-Authors: Kuniaki Ogasawara, Shigeru Yasuda, Takaaki Beppu, Masakazu Kobayashi, Kiyoshi Kuroda, Akira OgawaAbstract:Two patients with Lhermitte-Duclos disease were evaluated by brain positron emission tomography (PET) and technetium-99m-ethyl cysteinate dimer (99mTc-ECD) single-photon emission computed tomography (SPECT). In the lesions in both patients, hyperperfusion was detected on cerebral blood flow images obtained by PET, and hyperactivity by standard 99mTc-ECD SPECT. Dynamic 99mTc-ECD SPECT images demonstrated a plateau of activity in each lesion. These findings suggest that lesions in Lhermitte-Duclos disease have a retention mechanism for 99mTc-ECD equivalent to that of normal neural tissue.
Jennifer Kosty - One of the best experts on this subject based on the ideXlab platform.
-
jacques jean Lhermitte and the syndrome of peduncular hallucinosis
Neurosurgical Focus, 2019Co-Authors: Jennifer Kosty, Juan C Mejiamunne, Rimal H Dossani, Amey R Savardekar, Bharat GuthikondaAbstract:: Jacques Jean Lhermitte (1877-1959) was among the most accomplished neurologists of the 20th century. In addition to working as a clinician and instructor, he authored more than 800 papers and 16 books on neurology, neuropathology, psychiatry, and mystical phenomena. In addition to the well-known "Lhermitte's sign," an electrical shock-like sensation caused by spinal cord irritation in demyelinating disease, Lhermitte was a pioneer in the study of the relationship between the physical substance of the brain and the experience of the mind. A fascinating example of this is the syndrome of peduncular hallucinosis, characterized by vivid visual hallucinations occurring in fully lucid patients. This syndrome, which was initially described as the result of a midbrain insult, also may occur with injury to the thalamus or pons. It has been reported as a presenting symptom of various tumors and as a complication of neurosurgical procedures. Here, the authors review the life of Lhermitte and provide a historical review of the syndrome of peduncular hallucinosis.