The Experts below are selected from a list of 111909 Experts worldwide ranked by ideXlab platform

Qiaozhen Guo - One of the best experts on this subject based on the ideXlab platform.

  • detection and identification of leachables in vaccine from plastic packaging materials using uplc qtof ms with self built polymer additives Library
    Analytical Chemistry, 2016
    Co-Authors: Yun Zhang, Shuqi Sun, Xuebin Xing, Zhenxia Du, Qiaozhen Guo, Wenlian Yu
    Abstract:

    The direct contact of plastic parts with the medical products raises the possibility that plastic-related contaminants (leachables) may be present in the finished medical product. The leachable components from plastic materials may impact the safety and efficacy of the final medical product, so identification and determination of the leachables are essential for the safety assessment of medical products. A method to identify main leachables-polymer additives in medical products was developed by ultraperformance liquid chromatography-quadrupole time-of-flight-mass spectrometry (UPLC-QTOF MS) and a self-built Library. The Library contains 174 additives and the information on their names, formulas, structures, retention times, fragments, classifications, origin, and corresponding MSE and MSMS spectra. The reliability of the construction process of the Library was guaranteed by the system stability and suitability test. Identification parameters of Library Application, such as mass error, retention times, fra...

  • detection and identification of leachables in vaccine from plastic packaging materials using uplc qtof ms with self built polymer additives Library
    Analytical Chemistry, 2016
    Co-Authors: Yun Zhang, Shuqi Sun, Xuebin Xing, Qiaozhen Guo
    Abstract:

    The direct contact of plastic parts with the medical products raises the possibility that plastic-related contaminants (leachables) may be present in the finished medical product. The leachable components from plastic materials may impact the safety and efficacy of the final medical product, so identification and determination of the leachables are essential for the safety assessment of medical products. A method to identify main leachables-polymer additives in medical products was developed by ultraperformance liquid chromatography-quadrupole time-of-flight-mass spectrometry (UPLC-QTOF MS) and a self-built Library. The Library contains 174 additives and the information on their names, formulas, structures, retention times, fragments, classifications, origin, and corresponding MS(E) and MSMS spectra. The reliability of the construction process of the Library was guaranteed by the system stability and suitability test. Identification parameters of Library Application, such as mass error, retention times, fragments, and isotope pattern, were evaluated. Leachables in real vaccine and the intermediates were identified using automatic Library searching. In vaccine, the peak m/z 239.0887 that could not be assigned by the Library was identified as dimethyl 2-hydroxy-1,3-cyclohexanedicarboxylate using a series of elucidation tools. As a result, the concentrations of leachables in vaccine and the intermediates ranged from 0.85 to 21.91 μg/L.

  • Detection and Identification of Leachables in Vaccine from Plastic Packaging Materials Using UPLC-QTOF MS with Self-Built Polymer Additives Library
    2016
    Co-Authors: Yun Zhang, Shuqi Sun, Xuebin Xing, Qiaozhen Guo
    Abstract:

    The direct contact of plastic parts with the medical products raises the possibility that plastic-related contaminants (leachables) may be present in the finished medical product. The leachable components from plastic materials may impact the safety and efficacy of the final medical product, so identification and determination of the leachables are essential for the safety assessment of medical products. A method to identify main leachables-polymer additives in medical products was developed by ultraperformance liquid chromatography-quadrupole time-of-flight-mass spectrometry (UPLC-QTOF MS) and a self-built Library. The Library contains 174 additives and the information on their names, formulas, structures, retention times, fragments, classifications, origin, and corresponding MSE and MSMS spectra. The reliability of the construction process of the Library was guaranteed by the system stability and suitability test. Identification parameters of Library Application, such as mass error, retention times, fragments, and isotope pattern, were evaluated. Leachables in real vaccine and the intermediates were identified using automatic Library searching. In vaccine, the peak m/z 239.0887 that could not be assigned by the Library was identified as dimethyl 2-hydroxy-1,3-cyclohexanedicarboxylate using a series of elucidation tools. As a result, the concentrations of leachables in vaccine and the intermediates ranged from 0.85 to 21.91 μg/L

Gilbert Pepin - One of the best experts on this subject based on the ideXlab platform.

  • use of high performance liquid chromatography with photodiode array uv detection for the creation of a 600 compound Library Application to forensic toxicology
    Journal of Chromatography A, 1997
    Co-Authors: Yvan Gaillard, Gilbert Pepin
    Abstract:

    A high-performance liquid chromatographic method is described with photodiode array detection for systematic toxicological analysis in human blood and urine. After a single step liquid-liquid extraction using Toxi-Tube A, drugs are analyzed with a multi step gradient (phosphate pH 3.8-acetonitrile) on a Symmetry C8 5-microns column (250 mm x 4.6 mm I.D.) (Waters), operated at 30 degrees C. The flow-rate is varied during the run from 1 ml/min to 1.5 ml/min. Full UV spectra are recorded on-line during the 28 min chromatographic run. Enhanced performances for drug detection are obtained with this method due to (a) reduction of peak-tailing for basic drugs, (b) lower identification limits, (c) more stable retention times and (d) larger number of referenced drugs (684 spectrum registered). Application of real samples has been demonstrated.

  • use of high performance liquid chromatography with photodiode array uv detection for the creation of a 600 compound Library Application to forensic toxicology
    Journal of Chromatography A, 1997
    Co-Authors: Yvan Gaillard, Gilbert Pepin
    Abstract:

    Abstract A high-performance liquid chromatographic method is described with photodiode array detection for systematic toxicological analysis in human blood and urine. After a single step liquid-liquid extraction using Toxi-Tube A, drugs are analyzed with a multi step gradient (phosphate pH 3.8-acetonitrile) on a Symmetry C 8 5-μm column (250 mm × 4.6 mm I.D.) (Waters), operated at 30°C. The flow-rate is varied during the run from 1 ml/min to 1.5 ml/min. Full UV spectra are recorded on-line during the 28 min chromatographic run. Enhanced performances for drug detection are obtained with this method due to (a) reduction of peak-tailing for basic drugs, (b) lower identification limits, (c) more stable retention times and (d) larger number of referenced drugs (684 spectrum registered). Application of real samples has been demonstrated.

Yvan Gaillard - One of the best experts on this subject based on the ideXlab platform.

  • use of high performance liquid chromatography with photodiode array uv detection for the creation of a 600 compound Library Application to forensic toxicology
    Journal of Chromatography A, 1997
    Co-Authors: Yvan Gaillard, Gilbert Pepin
    Abstract:

    A high-performance liquid chromatographic method is described with photodiode array detection for systematic toxicological analysis in human blood and urine. After a single step liquid-liquid extraction using Toxi-Tube A, drugs are analyzed with a multi step gradient (phosphate pH 3.8-acetonitrile) on a Symmetry C8 5-microns column (250 mm x 4.6 mm I.D.) (Waters), operated at 30 degrees C. The flow-rate is varied during the run from 1 ml/min to 1.5 ml/min. Full UV spectra are recorded on-line during the 28 min chromatographic run. Enhanced performances for drug detection are obtained with this method due to (a) reduction of peak-tailing for basic drugs, (b) lower identification limits, (c) more stable retention times and (d) larger number of referenced drugs (684 spectrum registered). Application of real samples has been demonstrated.

  • use of high performance liquid chromatography with photodiode array uv detection for the creation of a 600 compound Library Application to forensic toxicology
    Journal of Chromatography A, 1997
    Co-Authors: Yvan Gaillard, Gilbert Pepin
    Abstract:

    Abstract A high-performance liquid chromatographic method is described with photodiode array detection for systematic toxicological analysis in human blood and urine. After a single step liquid-liquid extraction using Toxi-Tube A, drugs are analyzed with a multi step gradient (phosphate pH 3.8-acetonitrile) on a Symmetry C 8 5-μm column (250 mm × 4.6 mm I.D.) (Waters), operated at 30°C. The flow-rate is varied during the run from 1 ml/min to 1.5 ml/min. Full UV spectra are recorded on-line during the 28 min chromatographic run. Enhanced performances for drug detection are obtained with this method due to (a) reduction of peak-tailing for basic drugs, (b) lower identification limits, (c) more stable retention times and (d) larger number of referenced drugs (684 spectrum registered). Application of real samples has been demonstrated.

Yun Zhang - One of the best experts on this subject based on the ideXlab platform.

  • detection and identification of leachables in vaccine from plastic packaging materials using uplc qtof ms with self built polymer additives Library
    Analytical Chemistry, 2016
    Co-Authors: Yun Zhang, Shuqi Sun, Xuebin Xing, Zhenxia Du, Qiaozhen Guo, Wenlian Yu
    Abstract:

    The direct contact of plastic parts with the medical products raises the possibility that plastic-related contaminants (leachables) may be present in the finished medical product. The leachable components from plastic materials may impact the safety and efficacy of the final medical product, so identification and determination of the leachables are essential for the safety assessment of medical products. A method to identify main leachables-polymer additives in medical products was developed by ultraperformance liquid chromatography-quadrupole time-of-flight-mass spectrometry (UPLC-QTOF MS) and a self-built Library. The Library contains 174 additives and the information on their names, formulas, structures, retention times, fragments, classifications, origin, and corresponding MSE and MSMS spectra. The reliability of the construction process of the Library was guaranteed by the system stability and suitability test. Identification parameters of Library Application, such as mass error, retention times, fra...

  • detection and identification of leachables in vaccine from plastic packaging materials using uplc qtof ms with self built polymer additives Library
    Analytical Chemistry, 2016
    Co-Authors: Yun Zhang, Shuqi Sun, Xuebin Xing, Qiaozhen Guo
    Abstract:

    The direct contact of plastic parts with the medical products raises the possibility that plastic-related contaminants (leachables) may be present in the finished medical product. The leachable components from plastic materials may impact the safety and efficacy of the final medical product, so identification and determination of the leachables are essential for the safety assessment of medical products. A method to identify main leachables-polymer additives in medical products was developed by ultraperformance liquid chromatography-quadrupole time-of-flight-mass spectrometry (UPLC-QTOF MS) and a self-built Library. The Library contains 174 additives and the information on their names, formulas, structures, retention times, fragments, classifications, origin, and corresponding MS(E) and MSMS spectra. The reliability of the construction process of the Library was guaranteed by the system stability and suitability test. Identification parameters of Library Application, such as mass error, retention times, fragments, and isotope pattern, were evaluated. Leachables in real vaccine and the intermediates were identified using automatic Library searching. In vaccine, the peak m/z 239.0887 that could not be assigned by the Library was identified as dimethyl 2-hydroxy-1,3-cyclohexanedicarboxylate using a series of elucidation tools. As a result, the concentrations of leachables in vaccine and the intermediates ranged from 0.85 to 21.91 μg/L.

  • Detection and Identification of Leachables in Vaccine from Plastic Packaging Materials Using UPLC-QTOF MS with Self-Built Polymer Additives Library
    2016
    Co-Authors: Yun Zhang, Shuqi Sun, Xuebin Xing, Qiaozhen Guo
    Abstract:

    The direct contact of plastic parts with the medical products raises the possibility that plastic-related contaminants (leachables) may be present in the finished medical product. The leachable components from plastic materials may impact the safety and efficacy of the final medical product, so identification and determination of the leachables are essential for the safety assessment of medical products. A method to identify main leachables-polymer additives in medical products was developed by ultraperformance liquid chromatography-quadrupole time-of-flight-mass spectrometry (UPLC-QTOF MS) and a self-built Library. The Library contains 174 additives and the information on their names, formulas, structures, retention times, fragments, classifications, origin, and corresponding MSE and MSMS spectra. The reliability of the construction process of the Library was guaranteed by the system stability and suitability test. Identification parameters of Library Application, such as mass error, retention times, fragments, and isotope pattern, were evaluated. Leachables in real vaccine and the intermediates were identified using automatic Library searching. In vaccine, the peak m/z 239.0887 that could not be assigned by the Library was identified as dimethyl 2-hydroxy-1,3-cyclohexanedicarboxylate using a series of elucidation tools. As a result, the concentrations of leachables in vaccine and the intermediates ranged from 0.85 to 21.91 μg/L

Xuebin Xing - One of the best experts on this subject based on the ideXlab platform.

  • detection and identification of leachables in vaccine from plastic packaging materials using uplc qtof ms with self built polymer additives Library
    Analytical Chemistry, 2016
    Co-Authors: Yun Zhang, Shuqi Sun, Xuebin Xing, Zhenxia Du, Qiaozhen Guo, Wenlian Yu
    Abstract:

    The direct contact of plastic parts with the medical products raises the possibility that plastic-related contaminants (leachables) may be present in the finished medical product. The leachable components from plastic materials may impact the safety and efficacy of the final medical product, so identification and determination of the leachables are essential for the safety assessment of medical products. A method to identify main leachables-polymer additives in medical products was developed by ultraperformance liquid chromatography-quadrupole time-of-flight-mass spectrometry (UPLC-QTOF MS) and a self-built Library. The Library contains 174 additives and the information on their names, formulas, structures, retention times, fragments, classifications, origin, and corresponding MSE and MSMS spectra. The reliability of the construction process of the Library was guaranteed by the system stability and suitability test. Identification parameters of Library Application, such as mass error, retention times, fra...

  • detection and identification of leachables in vaccine from plastic packaging materials using uplc qtof ms with self built polymer additives Library
    Analytical Chemistry, 2016
    Co-Authors: Yun Zhang, Shuqi Sun, Xuebin Xing, Qiaozhen Guo
    Abstract:

    The direct contact of plastic parts with the medical products raises the possibility that plastic-related contaminants (leachables) may be present in the finished medical product. The leachable components from plastic materials may impact the safety and efficacy of the final medical product, so identification and determination of the leachables are essential for the safety assessment of medical products. A method to identify main leachables-polymer additives in medical products was developed by ultraperformance liquid chromatography-quadrupole time-of-flight-mass spectrometry (UPLC-QTOF MS) and a self-built Library. The Library contains 174 additives and the information on their names, formulas, structures, retention times, fragments, classifications, origin, and corresponding MS(E) and MSMS spectra. The reliability of the construction process of the Library was guaranteed by the system stability and suitability test. Identification parameters of Library Application, such as mass error, retention times, fragments, and isotope pattern, were evaluated. Leachables in real vaccine and the intermediates were identified using automatic Library searching. In vaccine, the peak m/z 239.0887 that could not be assigned by the Library was identified as dimethyl 2-hydroxy-1,3-cyclohexanedicarboxylate using a series of elucidation tools. As a result, the concentrations of leachables in vaccine and the intermediates ranged from 0.85 to 21.91 μg/L.

  • Detection and Identification of Leachables in Vaccine from Plastic Packaging Materials Using UPLC-QTOF MS with Self-Built Polymer Additives Library
    2016
    Co-Authors: Yun Zhang, Shuqi Sun, Xuebin Xing, Qiaozhen Guo
    Abstract:

    The direct contact of plastic parts with the medical products raises the possibility that plastic-related contaminants (leachables) may be present in the finished medical product. The leachable components from plastic materials may impact the safety and efficacy of the final medical product, so identification and determination of the leachables are essential for the safety assessment of medical products. A method to identify main leachables-polymer additives in medical products was developed by ultraperformance liquid chromatography-quadrupole time-of-flight-mass spectrometry (UPLC-QTOF MS) and a self-built Library. The Library contains 174 additives and the information on their names, formulas, structures, retention times, fragments, classifications, origin, and corresponding MSE and MSMS spectra. The reliability of the construction process of the Library was guaranteed by the system stability and suitability test. Identification parameters of Library Application, such as mass error, retention times, fragments, and isotope pattern, were evaluated. Leachables in real vaccine and the intermediates were identified using automatic Library searching. In vaccine, the peak m/z 239.0887 that could not be assigned by the Library was identified as dimethyl 2-hydroxy-1,3-cyclohexanedicarboxylate using a series of elucidation tools. As a result, the concentrations of leachables in vaccine and the intermediates ranged from 0.85 to 21.91 μg/L