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Eun Bin Kwon - One of the best experts on this subject based on the ideXlab platform.

Takashi Tanaka - One of the best experts on this subject based on the ideXlab platform.

Takako Fujiwara - One of the best experts on this subject based on the ideXlab platform.

  • Treatment with Lindera strychnifolia reduces blood pressure by decreasing sympathetic nerve activity in spontaneously hypertensive rats.
    The American journal of Chinese medicine, 2010
    Co-Authors: Masayuki Shimomura, Genzou Takemura, Ichijiro Murata, Hiroaki Ushikoshi, Arihiro Hattori, Yasushi Ohno, Takuma Aoyama, Masanori Kawasaki, Kazuhiko Nishigaki, Takako Fujiwara
    Abstract:

    Lindera strychnifolia (Tendai-Uyaku), a medicinal plant, has long been used for the treatment of cardiac, renal and rheumatic diseases in Japan. We investigated the effect of Lindera strychnifolia on systolic blood pressure, cardiac function, and plasma noradrenaline levels in rats. Spontaneously hypertensive rats (SHR) were given free access to water or extract solution of Lindera strychnifolia, which was extracted with a ratio of 10 g Lindera strychnifolia roots/20 ml water. Systolic blood pressure was measured by using a tail-cuf sphygmomanometer twice a week from 10 to 30 weeks of age, and compared to the age-matched Wistar Kyoto rats (WKY) as a control group. At 30 weeks of age, heart function was measured by echocardiography and blood samples were taken for detection of plasma noradrenaline levels, and rats were then sacrificed. Systolic blood pressure gradually increased from 10 to 30 weeks of age in the SHR group, while it did not change in the WKY group. In the Lindera-treated SHR group, the increase in systolic blood pressure was significantly attenuated from 21 to 30 weeks of age. Echocardiography showed a significant increase in ejection fraction in the Lindera-treated SHR group (60.4 +/- 7.8%) as compared to the SHR group (39.7 +/- 23.4%). Plasma noradrenaline levels were significantly decreased in Lindera-treated SHR group compared to the SHR group. These results suggest that Lindera strychnifolia has an anti-hypertensive effect and improves cardiac function in spontaneous hypertensive rats. These effects may be related to the decrease in plasma noradrenaline levels by Lindera strychnifolia.

  • water extract of the root of Lindera strychnifolia slows down the progression of diabetic nephropathy in db db mice
    Life Sciences, 2005
    Co-Authors: Takamasa Ohno, Genzou Takemura, Ichijiro Murata, Tomoyo Kagawa, Seigo Akao, Shinya Minatoguchi, Takako Fujiwara, Hisayoshi Fujiwara
    Abstract:

    Abstract We examined a possible preventive effect of Linderae radix (LR), the root of Lindera strychnifolia , on the progression of diabetic nephropathy. Water extract of Linderae radix (LR extract) was orally administered to the C57BL/KsJ- db/db ( db/db ) mice, a model of genetic diabetes, at a dose of 730 mg/kg/day for 12 week. The LR extract treatment did not affect glucose metabolism and systolic pressure. However, it resulted in a better renal function as evaluated by creatinine clearance (Ccr) and serum creatinine than the control; Ccr and serum creatinine were progressively worsened in controls (0.13 ± 0.01 (l/day) and 0.69 ± 0.04 (mg/dl), respectively) whereas unchanged in the treated group (0.24 ± 0.03 (l/day), p p 1 expression was decreased in the LR extract-treated group. These findings suggest that the LR therapy can be a novel therapeutic approach against diabetic nephropathy.

Hye Jin Yang - One of the best experts on this subject based on the ideXlab platform.

Isao Kouno - One of the best experts on this subject based on the ideXlab platform.