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Ilkka Porsti - One of the best experts on this subject based on the ideXlab platform.

  • Liquorice ingestion attenuates vasodilatation via exogenous nitric oxide donor but not via β2 adrenoceptor stimulation
    PLOS ONE, 2019
    Co-Authors: Elina J Hautaniemi, Antti Tikkakoski, Arttu Eraranta, Mika Kahone, Esa Hamalaine, Ursula Turpeine, Heini Huhtala, Jukka Mustone, Ilkka Porsti
    Abstract:

    We examined the effect of Liquorice ingestion on haemodynamic responses to exogenous nitric oxide donor (nitroglycerin) and β2-adrenoceptor agonist (salbutamol), and 11β-hydroxysteroid dehydrogenase activity, in 21 volunteers and 21 reference subjects. Haemodynamic data was captured before and after sublingual nitroglycerin (0.25 mg) and inhaled salbutamol (400 μg) during orthostatic challenge utilising radial pulse wave analysis and whole-body impedance cardiography. The recordings were performed at baseline and following two weeks of Liquorice intake (290–370 mg/d glycyrrhizin). Urinary cortisone and cortisol metabolites were examined. Liquorice intake elevated aortic systolic and diastolic blood pressure and systemic vascular resistance when compared with the reference group. Following research drug administration the Liquorice-induced increase in systemic vascular resistance was observed in the presence of nitroglycerin (p<0.05) but no longer in the presence of salbutamol. Liquorice ingestion decreased cardiac chronotropic response to upright posture (p = 0.032) in unadjusted analysis, but when adjusted for age and sex the difference in the upright change in heart rate was no longer significant. The urinary cortisone to cortisol metabolite ratio decreased from 0.70 to 0.31 (p<0.001) after Liquorice intake indicating significant inhibition of the 11β-hydroxysteroid dehydrogenase type 2. In the reference group the haemodynamic variables remained virtually unchanged. These results suggest that Liquorice exposure impaired vasodilatation in vivo that was induced by exogenous nitric oxide donor but not that induced by β2-adrenoceptor stimulation. Trial registration: EU Clinical Trials Register 2006-002065-39 ClinicalTrials.gov NCT01742702.

  • voluntary Liquorice ingestion increases blood pressure via increased volume load elevated peripheral arterial resistance and decreased aortic compliance
    Scientific Reports, 2017
    Co-Authors: Elina J Hautaniemi, Antti Tikkakoski, Anna Tahvanainen, Jenni Koskela, Mika Kahonen, Marko Uitto, Kalle Sipila, Onni Niemela, Jukka Mustonen, Ilkka Porsti
    Abstract:

    We investigated the haemodynamic effects of two-week Liquorice exposure (glycyrrhizin dose 290–370 mg/day) in 22 healthy volunteers during orthostatic challenge. Haemodynamics were recorded during passive 10-minute head-up tilt using radial pulse wave analysis, whole-body impedance cardiography, and spectral analysis of heart rate variability. Thirty age-matched healthy subjects served as controls. Liquorice ingestion elevated radial systolic (p < 0.001) and diastolic (p = 0.018) blood pressure and systemic vascular resistance (p = 0.037). During orthostatic challenge, heart rate increased less after the Liquorice versus control diet (p = 0.003) and low frequency power of heart rate variability decreased within the Liquorice group (p = 0.034). Liquorice intake increased central pulse pressure (p < 0.001) and augmentation index (p = 0.002) supine and upright, but in the upright position the elevation of augmentation index was accentuated (p = 0.007). Liquorice diet also increased extracellular fluid volume (p = 0.024) and aortic to popliteal pulse wave velocity (p = 0.027), and aortic characteristic impedance in the upright position (p = 0.002). To conclude, in addition to increased extracellular fluid volume and large arterial stiffness, two weeks of Liquorice ingestion elevated systemic vascular resistance and augmentation index. Measurements performed at rest may underestimate the haemodynamic effects of Liquorice ingestion, as enhanced central wave reflection and reduced chronotropic response were especially observed in the upright position.

  • Voluntary Liquorice ingestion increases blood pressure via increased volume load, elevated peripheral arterial resistance, and decreased aortic compliance
    Nature Publishing Group, 2017
    Co-Authors: Elina J Hautaniemi, Antti Tikkakoski, Mika Kahonen, Marko Uitto, Kalle Sipila, Onni Niemela, Jukka Mustonen, Anna M. Tahvanainen, Jenni K. Koskela, Ilkka Porsti
    Abstract:

    Abstract We investigated the haemodynamic effects of two-week Liquorice exposure (glycyrrhizin dose 290–370 mg/day) in 22 healthy volunteers during orthostatic challenge. Haemodynamics were recorded during passive 10-minute head-up tilt using radial pulse wave analysis, whole-body impedance cardiography, and spectral analysis of heart rate variability. Thirty age-matched healthy subjects served as controls. Liquorice ingestion elevated radial systolic (p 

Elina J Hautaniemi - One of the best experts on this subject based on the ideXlab platform.

  • Liquorice ingestion attenuates vasodilatation via exogenous nitric oxide donor but not via β2 adrenoceptor stimulation
    PLOS ONE, 2019
    Co-Authors: Elina J Hautaniemi, Antti Tikkakoski, Arttu Eraranta, Mika Kahone, Esa Hamalaine, Ursula Turpeine, Heini Huhtala, Jukka Mustone, Ilkka Porsti
    Abstract:

    We examined the effect of Liquorice ingestion on haemodynamic responses to exogenous nitric oxide donor (nitroglycerin) and β2-adrenoceptor agonist (salbutamol), and 11β-hydroxysteroid dehydrogenase activity, in 21 volunteers and 21 reference subjects. Haemodynamic data was captured before and after sublingual nitroglycerin (0.25 mg) and inhaled salbutamol (400 μg) during orthostatic challenge utilising radial pulse wave analysis and whole-body impedance cardiography. The recordings were performed at baseline and following two weeks of Liquorice intake (290–370 mg/d glycyrrhizin). Urinary cortisone and cortisol metabolites were examined. Liquorice intake elevated aortic systolic and diastolic blood pressure and systemic vascular resistance when compared with the reference group. Following research drug administration the Liquorice-induced increase in systemic vascular resistance was observed in the presence of nitroglycerin (p<0.05) but no longer in the presence of salbutamol. Liquorice ingestion decreased cardiac chronotropic response to upright posture (p = 0.032) in unadjusted analysis, but when adjusted for age and sex the difference in the upright change in heart rate was no longer significant. The urinary cortisone to cortisol metabolite ratio decreased from 0.70 to 0.31 (p<0.001) after Liquorice intake indicating significant inhibition of the 11β-hydroxysteroid dehydrogenase type 2. In the reference group the haemodynamic variables remained virtually unchanged. These results suggest that Liquorice exposure impaired vasodilatation in vivo that was induced by exogenous nitric oxide donor but not that induced by β2-adrenoceptor stimulation. Trial registration: EU Clinical Trials Register 2006-002065-39 ClinicalTrials.gov NCT01742702.

  • voluntary Liquorice ingestion increases blood pressure via increased volume load elevated peripheral arterial resistance and decreased aortic compliance
    Scientific Reports, 2017
    Co-Authors: Elina J Hautaniemi, Antti Tikkakoski, Anna Tahvanainen, Jenni Koskela, Mika Kahonen, Marko Uitto, Kalle Sipila, Onni Niemela, Jukka Mustonen, Ilkka Porsti
    Abstract:

    We investigated the haemodynamic effects of two-week Liquorice exposure (glycyrrhizin dose 290–370 mg/day) in 22 healthy volunteers during orthostatic challenge. Haemodynamics were recorded during passive 10-minute head-up tilt using radial pulse wave analysis, whole-body impedance cardiography, and spectral analysis of heart rate variability. Thirty age-matched healthy subjects served as controls. Liquorice ingestion elevated radial systolic (p < 0.001) and diastolic (p = 0.018) blood pressure and systemic vascular resistance (p = 0.037). During orthostatic challenge, heart rate increased less after the Liquorice versus control diet (p = 0.003) and low frequency power of heart rate variability decreased within the Liquorice group (p = 0.034). Liquorice intake increased central pulse pressure (p < 0.001) and augmentation index (p = 0.002) supine and upright, but in the upright position the elevation of augmentation index was accentuated (p = 0.007). Liquorice diet also increased extracellular fluid volume (p = 0.024) and aortic to popliteal pulse wave velocity (p = 0.027), and aortic characteristic impedance in the upright position (p = 0.002). To conclude, in addition to increased extracellular fluid volume and large arterial stiffness, two weeks of Liquorice ingestion elevated systemic vascular resistance and augmentation index. Measurements performed at rest may underestimate the haemodynamic effects of Liquorice ingestion, as enhanced central wave reflection and reduced chronotropic response were especially observed in the upright position.

  • Voluntary Liquorice ingestion increases blood pressure via increased volume load, elevated peripheral arterial resistance, and decreased aortic compliance
    Nature Publishing Group, 2017
    Co-Authors: Elina J Hautaniemi, Antti Tikkakoski, Mika Kahonen, Marko Uitto, Kalle Sipila, Onni Niemela, Jukka Mustonen, Anna M. Tahvanainen, Jenni K. Koskela, Ilkka Porsti
    Abstract:

    Abstract We investigated the haemodynamic effects of two-week Liquorice exposure (glycyrrhizin dose 290–370 mg/day) in 22 healthy volunteers during orthostatic challenge. Haemodynamics were recorded during passive 10-minute head-up tilt using radial pulse wave analysis, whole-body impedance cardiography, and spectral analysis of heart rate variability. Thirty age-matched healthy subjects served as controls. Liquorice ingestion elevated radial systolic (p 

  • daily Liquorice consumption for two weeks increases augmentation index and central systolic and diastolic blood pressure
    PLOS ONE, 2014
    Co-Authors: Miia H Leskinen, Elina J Hautaniemi, Antti Tikkakoski, Anna Tahvanainen, Jenni Koskela, Mika Kahonen, Onni Niemela, Marika Paallysaho, Tiit Koobi, Jukka Mustonen
    Abstract:

    Background Liquorice ingestion often elevates blood pressure, but the detailed haemodynamic alterations are unknown. We studied haemodynamic changes induced by Liquorice consumption in 20 subjects versus 30 controls with average blood pressures of 120/68 and 116/64 mmHg, respectively.

Antti Tikkakoski - One of the best experts on this subject based on the ideXlab platform.

  • Liquorice ingestion attenuates vasodilatation via exogenous nitric oxide donor but not via β2 adrenoceptor stimulation
    PLOS ONE, 2019
    Co-Authors: Elina J Hautaniemi, Antti Tikkakoski, Arttu Eraranta, Mika Kahone, Esa Hamalaine, Ursula Turpeine, Heini Huhtala, Jukka Mustone, Ilkka Porsti
    Abstract:

    We examined the effect of Liquorice ingestion on haemodynamic responses to exogenous nitric oxide donor (nitroglycerin) and β2-adrenoceptor agonist (salbutamol), and 11β-hydroxysteroid dehydrogenase activity, in 21 volunteers and 21 reference subjects. Haemodynamic data was captured before and after sublingual nitroglycerin (0.25 mg) and inhaled salbutamol (400 μg) during orthostatic challenge utilising radial pulse wave analysis and whole-body impedance cardiography. The recordings were performed at baseline and following two weeks of Liquorice intake (290–370 mg/d glycyrrhizin). Urinary cortisone and cortisol metabolites were examined. Liquorice intake elevated aortic systolic and diastolic blood pressure and systemic vascular resistance when compared with the reference group. Following research drug administration the Liquorice-induced increase in systemic vascular resistance was observed in the presence of nitroglycerin (p<0.05) but no longer in the presence of salbutamol. Liquorice ingestion decreased cardiac chronotropic response to upright posture (p = 0.032) in unadjusted analysis, but when adjusted for age and sex the difference in the upright change in heart rate was no longer significant. The urinary cortisone to cortisol metabolite ratio decreased from 0.70 to 0.31 (p<0.001) after Liquorice intake indicating significant inhibition of the 11β-hydroxysteroid dehydrogenase type 2. In the reference group the haemodynamic variables remained virtually unchanged. These results suggest that Liquorice exposure impaired vasodilatation in vivo that was induced by exogenous nitric oxide donor but not that induced by β2-adrenoceptor stimulation. Trial registration: EU Clinical Trials Register 2006-002065-39 ClinicalTrials.gov NCT01742702.

  • voluntary Liquorice ingestion increases blood pressure via increased volume load elevated peripheral arterial resistance and decreased aortic compliance
    Scientific Reports, 2017
    Co-Authors: Elina J Hautaniemi, Antti Tikkakoski, Anna Tahvanainen, Jenni Koskela, Mika Kahonen, Marko Uitto, Kalle Sipila, Onni Niemela, Jukka Mustonen, Ilkka Porsti
    Abstract:

    We investigated the haemodynamic effects of two-week Liquorice exposure (glycyrrhizin dose 290–370 mg/day) in 22 healthy volunteers during orthostatic challenge. Haemodynamics were recorded during passive 10-minute head-up tilt using radial pulse wave analysis, whole-body impedance cardiography, and spectral analysis of heart rate variability. Thirty age-matched healthy subjects served as controls. Liquorice ingestion elevated radial systolic (p < 0.001) and diastolic (p = 0.018) blood pressure and systemic vascular resistance (p = 0.037). During orthostatic challenge, heart rate increased less after the Liquorice versus control diet (p = 0.003) and low frequency power of heart rate variability decreased within the Liquorice group (p = 0.034). Liquorice intake increased central pulse pressure (p < 0.001) and augmentation index (p = 0.002) supine and upright, but in the upright position the elevation of augmentation index was accentuated (p = 0.007). Liquorice diet also increased extracellular fluid volume (p = 0.024) and aortic to popliteal pulse wave velocity (p = 0.027), and aortic characteristic impedance in the upright position (p = 0.002). To conclude, in addition to increased extracellular fluid volume and large arterial stiffness, two weeks of Liquorice ingestion elevated systemic vascular resistance and augmentation index. Measurements performed at rest may underestimate the haemodynamic effects of Liquorice ingestion, as enhanced central wave reflection and reduced chronotropic response were especially observed in the upright position.

  • Voluntary Liquorice ingestion increases blood pressure via increased volume load, elevated peripheral arterial resistance, and decreased aortic compliance
    Nature Publishing Group, 2017
    Co-Authors: Elina J Hautaniemi, Antti Tikkakoski, Mika Kahonen, Marko Uitto, Kalle Sipila, Onni Niemela, Jukka Mustonen, Anna M. Tahvanainen, Jenni K. Koskela, Ilkka Porsti
    Abstract:

    Abstract We investigated the haemodynamic effects of two-week Liquorice exposure (glycyrrhizin dose 290–370 mg/day) in 22 healthy volunteers during orthostatic challenge. Haemodynamics were recorded during passive 10-minute head-up tilt using radial pulse wave analysis, whole-body impedance cardiography, and spectral analysis of heart rate variability. Thirty age-matched healthy subjects served as controls. Liquorice ingestion elevated radial systolic (p 

  • daily Liquorice consumption for two weeks increases augmentation index and central systolic and diastolic blood pressure
    PLOS ONE, 2014
    Co-Authors: Miia H Leskinen, Elina J Hautaniemi, Antti Tikkakoski, Anna Tahvanainen, Jenni Koskela, Mika Kahonen, Onni Niemela, Marika Paallysaho, Tiit Koobi, Jukka Mustonen
    Abstract:

    Background Liquorice ingestion often elevates blood pressure, but the detailed haemodynamic alterations are unknown. We studied haemodynamic changes induced by Liquorice consumption in 20 subjects versus 30 controls with average blood pressures of 120/68 and 116/64 mmHg, respectively.

Jukka Mustonen - One of the best experts on this subject based on the ideXlab platform.

  • voluntary Liquorice ingestion increases blood pressure via increased volume load elevated peripheral arterial resistance and decreased aortic compliance
    Scientific Reports, 2017
    Co-Authors: Elina J Hautaniemi, Antti Tikkakoski, Anna Tahvanainen, Jenni Koskela, Mika Kahonen, Marko Uitto, Kalle Sipila, Onni Niemela, Jukka Mustonen, Ilkka Porsti
    Abstract:

    We investigated the haemodynamic effects of two-week Liquorice exposure (glycyrrhizin dose 290–370 mg/day) in 22 healthy volunteers during orthostatic challenge. Haemodynamics were recorded during passive 10-minute head-up tilt using radial pulse wave analysis, whole-body impedance cardiography, and spectral analysis of heart rate variability. Thirty age-matched healthy subjects served as controls. Liquorice ingestion elevated radial systolic (p < 0.001) and diastolic (p = 0.018) blood pressure and systemic vascular resistance (p = 0.037). During orthostatic challenge, heart rate increased less after the Liquorice versus control diet (p = 0.003) and low frequency power of heart rate variability decreased within the Liquorice group (p = 0.034). Liquorice intake increased central pulse pressure (p < 0.001) and augmentation index (p = 0.002) supine and upright, but in the upright position the elevation of augmentation index was accentuated (p = 0.007). Liquorice diet also increased extracellular fluid volume (p = 0.024) and aortic to popliteal pulse wave velocity (p = 0.027), and aortic characteristic impedance in the upright position (p = 0.002). To conclude, in addition to increased extracellular fluid volume and large arterial stiffness, two weeks of Liquorice ingestion elevated systemic vascular resistance and augmentation index. Measurements performed at rest may underestimate the haemodynamic effects of Liquorice ingestion, as enhanced central wave reflection and reduced chronotropic response were especially observed in the upright position.

  • Voluntary Liquorice ingestion increases blood pressure via increased volume load, elevated peripheral arterial resistance, and decreased aortic compliance
    Nature Publishing Group, 2017
    Co-Authors: Elina J Hautaniemi, Antti Tikkakoski, Mika Kahonen, Marko Uitto, Kalle Sipila, Onni Niemela, Jukka Mustonen, Anna M. Tahvanainen, Jenni K. Koskela, Ilkka Porsti
    Abstract:

    Abstract We investigated the haemodynamic effects of two-week Liquorice exposure (glycyrrhizin dose 290–370 mg/day) in 22 healthy volunteers during orthostatic challenge. Haemodynamics were recorded during passive 10-minute head-up tilt using radial pulse wave analysis, whole-body impedance cardiography, and spectral analysis of heart rate variability. Thirty age-matched healthy subjects served as controls. Liquorice ingestion elevated radial systolic (p 

  • daily Liquorice consumption for two weeks increases augmentation index and central systolic and diastolic blood pressure
    PLOS ONE, 2014
    Co-Authors: Miia H Leskinen, Elina J Hautaniemi, Antti Tikkakoski, Anna Tahvanainen, Jenni Koskela, Mika Kahonen, Onni Niemela, Marika Paallysaho, Tiit Koobi, Jukka Mustonen
    Abstract:

    Background Liquorice ingestion often elevates blood pressure, but the detailed haemodynamic alterations are unknown. We studied haemodynamic changes induced by Liquorice consumption in 20 subjects versus 30 controls with average blood pressures of 120/68 and 116/64 mmHg, respectively.

Cosimo Pizza - One of the best experts on this subject based on the ideXlab platform.

  • metabolic profiling of roots of Liquorice glycyrrhiza glabra from different geographical areas by esi ms ms and determination of major metabolites by lc esi ms and lc esi ms ms
    Journal of Pharmaceutical and Biomedical Analysis, 2011
    Co-Authors: Paola Montoro, Mariateresa Maldini, Mariateresa Russo, S Postorino, Sonia Piacente, Cosimo Pizza
    Abstract:

    Abstract Liquid chromatography electrospray mass spectrometry (LC-ESI/MS) has been applied to the full characterization of saponins and phenolics in hydroalcoholic extracts of roots of Liquorice (Glycyrrhiza glabra). Relative quantitative analyses of the samples with respect to the phenolic constituents and to a group of saponins related to glycyrrhizic acid were performed using LC-ESI/MS. For the saponin constituents, full scan LC–MS/MS fragmentation of the protonated (positive ion mode) or deprotonated (negative ion mode) molecular species generated diagnostic fragment ions that provided information concerning the triterpene skeleton and the number and nature of the substituents. On the basis of the specific fragmentation of glycyrrhizic acid, an LC–MS/MS method was developed in order to quantify the analyte in the Liquorice root samples. Chinese G. glabra roots contained the highest levels of glycyrrhizic acid, followed by those from Italy (Calabria).