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Pitiot Alain - One of the best experts on this subject based on the ideXlab platform.

  • Ratlas-LH: An MRI template of the Lister Hooded Rat brain with stereotaxic coordinates for neurosurgical implantations
    'Academy of Traumatology', 2021
    Co-Authors: Prior, Malcolm J.w., Bast Tobias, Mcgarrity Stephanie, Goldschmidt Jürgen, Vincenz Daniel, Seaton Adam, Hall Gerard, Pitiot Alain
    Abstract:

    There is currently no brain atlas available to specifically determine stereotaxic coordinates for neurosurgery in Lister Hooded Rats despite the popularity of this strain for behavioural neuroscience studies in the UK and elsewhere. We have created a dataset, which we refer to as 'Ratlas-LH' (for Lister Hooded). Ratlas-LH combines in vivo magnetic resonance images of the brain of young adult male Lister Hooded Rats with micro-computed tomography images of the ex vivo skull, as well as a set of delineations of brain regions, adapted from the Waxholm Space Atlas of the Sprague Dawley Rat Brain. Ratlas-LH was produced with an isotropic resolution of 0.15 mm. It has been labelled in such a way as to provide a stereotaxic coordinate system for the determination of distances relative to the skull landmark of bregma. We have demonstRated that the atlas can be used to determine stereotaxic coordinates to accuRately target brain regions in the Lister Hooded Rat brain. Ratlas-LH is freely available to facilitate neurosurgical procedures in the Lister Hooded Rat. https://mc.manuscriptcentral.com/bna Brain and Neuroscience Advance

  • Ratlas-LH: An MRI template of the Lister Hooded Rat brain with stereotaxic coordinates for neurosurgical implantations
    'SAGE Publications', 2021
    Co-Authors: Prior Malcolm, Bast Tobias, Mcgarrity Stephanie, Goldschmidt Jürgen, Vincenz Daniel, Seaton Adam, Hall Gerard, Pitiot Alain
    Abstract:

    There is currently no brain atlas available to specifically determine stereotaxic coordinates for neurosurgery in Lister Hooded Rats despite the popularity of this strain for behavioural neuroscience studies in the United Kingdom and elsewhere. We have created a dataset, which we refer to as 'Ratlas-LH' (for Lister Hooded). Ratlas-LH combines in vivo magnetic resonance images of the brain of young adult male Lister Hooded Rats with ex vivo micro-computed tomography images of the ex vivo skull, as well as a set of delineations of brain regions, adapted from the Waxholm Space Atlas of the Sprague Dawley Rat Brain. Ratlas-LH was produced with an isotropic resolution of 0.15 mm. It has been labelled in such a way as to provide a stereotaxic coordinate system for the determination of distances relative to the skull landmark of bregma. We have demonstRated that the atlas can be used to determine stereotaxic coordinates to accuRately target brain regions in the Lister Hooded Rat brain. Ratlas-LH is freely available to facilitate neurosurgical procedures in the Lister Hooded Rat

Alain Pitiot - One of the best experts on this subject based on the ideXlab platform.

Edward R Browne - One of the best experts on this subject based on the ideXlab platform.

  • pharmacokinetic and pharmacodynamic properties of cholinesterase inhibitors donepezil tacrine and galantamine in aged and young Lister Hooded Rats
    Drug Metabolism and Disposition, 2011
    Co-Authors: Catherine W Goh, Jasinda H Lee, Christopher P Chen, Edward R Browne
    Abstract:

    Physiological alteRations that may change pharmacological response accompany aging. Pharmacokinetic/pharmacodynamic properties of cholinesterase inhibitors (ChEIs) used in the treatment of Alzheimer's disease, donepezil, tacrine, and galantamine, were investigated in an aged Lister Hooded Rat model. Intravenous and oral 6-h blood sampling profiles in old (30 months old) and young (7 months old) Rats revealed pharmacokinetic changes similar to those in humans with an approximately 40% increase in C max of galantamine and prolonged t 1/2 (1.4-fold) and mean residence time (1.5-fold) of donepezil. Tacrine disposition was maintained with age, and area under the concentRation-time curve and clearance in old Rats were similar to those in young Rats for all drugs tested as was bioavailability. Old Rats showed a trend of increased pharmacodynamic sensitivity (<20%) to ChEIs in cholinesterase activity assays, which was attributed to pharmacokinetic effects because a trend of higher blood and brain concentRations was seen in the old Rats although brain/blood Ratios remained unaffected. Enhanced cholinergic-mediated behaviors such as tremor, hypothermia, salivation, and lacrimation were also observed in the old Rats, which could not be accounted for by a similar magnitude of change in pharmacokinetics. A decrease in expression of muscarinic acetylcholine receptor subtype 2 detected in old Rat brains was postulated to play a role. Greater age effects in both pharmacokinetics and pharmacodynamics of donepezil and tacrine were seen in previous studies with Fischer 344 Rats, indicating a potential risk in overreliance on this Rat strain for aging studies.

Bast Tobias - One of the best experts on this subject based on the ideXlab platform.

  • Ratlas-LH: An MRI template of the Lister Hooded Rat brain with stereotaxic coordinates for neurosurgical implantations
    'Academy of Traumatology', 2021
    Co-Authors: Prior, Malcolm J.w., Bast Tobias, Mcgarrity Stephanie, Goldschmidt Jürgen, Vincenz Daniel, Seaton Adam, Hall Gerard, Pitiot Alain
    Abstract:

    There is currently no brain atlas available to specifically determine stereotaxic coordinates for neurosurgery in Lister Hooded Rats despite the popularity of this strain for behavioural neuroscience studies in the UK and elsewhere. We have created a dataset, which we refer to as 'Ratlas-LH' (for Lister Hooded). Ratlas-LH combines in vivo magnetic resonance images of the brain of young adult male Lister Hooded Rats with micro-computed tomography images of the ex vivo skull, as well as a set of delineations of brain regions, adapted from the Waxholm Space Atlas of the Sprague Dawley Rat Brain. Ratlas-LH was produced with an isotropic resolution of 0.15 mm. It has been labelled in such a way as to provide a stereotaxic coordinate system for the determination of distances relative to the skull landmark of bregma. We have demonstRated that the atlas can be used to determine stereotaxic coordinates to accuRately target brain regions in the Lister Hooded Rat brain. Ratlas-LH is freely available to facilitate neurosurgical procedures in the Lister Hooded Rat. https://mc.manuscriptcentral.com/bna Brain and Neuroscience Advance

  • Ratlas-LH: An MRI template of the Lister Hooded Rat brain with stereotaxic coordinates for neurosurgical implantations
    'SAGE Publications', 2021
    Co-Authors: Prior Malcolm, Bast Tobias, Mcgarrity Stephanie, Goldschmidt Jürgen, Vincenz Daniel, Seaton Adam, Hall Gerard, Pitiot Alain
    Abstract:

    There is currently no brain atlas available to specifically determine stereotaxic coordinates for neurosurgery in Lister Hooded Rats despite the popularity of this strain for behavioural neuroscience studies in the United Kingdom and elsewhere. We have created a dataset, which we refer to as 'Ratlas-LH' (for Lister Hooded). Ratlas-LH combines in vivo magnetic resonance images of the brain of young adult male Lister Hooded Rats with ex vivo micro-computed tomography images of the ex vivo skull, as well as a set of delineations of brain regions, adapted from the Waxholm Space Atlas of the Sprague Dawley Rat Brain. Ratlas-LH was produced with an isotropic resolution of 0.15 mm. It has been labelled in such a way as to provide a stereotaxic coordinate system for the determination of distances relative to the skull landmark of bregma. We have demonstRated that the atlas can be used to determine stereotaxic coordinates to accuRately target brain regions in the Lister Hooded Rat brain. Ratlas-LH is freely available to facilitate neurosurgical procedures in the Lister Hooded Rat

Mcgarrity Stephanie - One of the best experts on this subject based on the ideXlab platform.

  • Ratlas-LH: An MRI template of the Lister Hooded Rat brain with stereotaxic coordinates for neurosurgical implantations
    'Academy of Traumatology', 2021
    Co-Authors: Prior, Malcolm J.w., Bast Tobias, Mcgarrity Stephanie, Goldschmidt Jürgen, Vincenz Daniel, Seaton Adam, Hall Gerard, Pitiot Alain
    Abstract:

    There is currently no brain atlas available to specifically determine stereotaxic coordinates for neurosurgery in Lister Hooded Rats despite the popularity of this strain for behavioural neuroscience studies in the UK and elsewhere. We have created a dataset, which we refer to as 'Ratlas-LH' (for Lister Hooded). Ratlas-LH combines in vivo magnetic resonance images of the brain of young adult male Lister Hooded Rats with micro-computed tomography images of the ex vivo skull, as well as a set of delineations of brain regions, adapted from the Waxholm Space Atlas of the Sprague Dawley Rat Brain. Ratlas-LH was produced with an isotropic resolution of 0.15 mm. It has been labelled in such a way as to provide a stereotaxic coordinate system for the determination of distances relative to the skull landmark of bregma. We have demonstRated that the atlas can be used to determine stereotaxic coordinates to accuRately target brain regions in the Lister Hooded Rat brain. Ratlas-LH is freely available to facilitate neurosurgical procedures in the Lister Hooded Rat. https://mc.manuscriptcentral.com/bna Brain and Neuroscience Advance

  • Ratlas-LH: An MRI template of the Lister Hooded Rat brain with stereotaxic coordinates for neurosurgical implantations
    'SAGE Publications', 2021
    Co-Authors: Prior Malcolm, Bast Tobias, Mcgarrity Stephanie, Goldschmidt Jürgen, Vincenz Daniel, Seaton Adam, Hall Gerard, Pitiot Alain
    Abstract:

    There is currently no brain atlas available to specifically determine stereotaxic coordinates for neurosurgery in Lister Hooded Rats despite the popularity of this strain for behavioural neuroscience studies in the United Kingdom and elsewhere. We have created a dataset, which we refer to as 'Ratlas-LH' (for Lister Hooded). Ratlas-LH combines in vivo magnetic resonance images of the brain of young adult male Lister Hooded Rats with ex vivo micro-computed tomography images of the ex vivo skull, as well as a set of delineations of brain regions, adapted from the Waxholm Space Atlas of the Sprague Dawley Rat Brain. Ratlas-LH was produced with an isotropic resolution of 0.15 mm. It has been labelled in such a way as to provide a stereotaxic coordinate system for the determination of distances relative to the skull landmark of bregma. We have demonstRated that the atlas can be used to determine stereotaxic coordinates to accuRately target brain regions in the Lister Hooded Rat brain. Ratlas-LH is freely available to facilitate neurosurgical procedures in the Lister Hooded Rat