The Experts below are selected from a list of 699 Experts worldwide ranked by ideXlab platform
P. A. Kyriacou - One of the best experts on this subject based on the ideXlab platform.
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Optical analysis of Lithium carbonate: Towards the development of a portable Lithium Blood Level analyzer for bipolar disorder patients
2014 36th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, 2014Co-Authors: J. M. May, M Hickey, I. Triantis, E. Palazidou, P. A. KyriacouAbstract:Lithium medication is the gold standard of treatment in Bipolar Disorder patients, preventing and reducing mood swings and suicidality. However, despite its effectiveness, it is a potentially hazardous drug requiring regular monitoring of Blood Levels to ensure toxic Levels are not reached. This paper describes the first steps towards developing a new portable device that can be used by Bipolar Disorder patients to facilitate the analysis of Lithium Blood Levels at home. Solutions of Lithium carbonate have been optically fingerprinted using a high-end spectrophotometer. Preliminary measurements indicate that while the visible to near infrared region of the absorption spectra fall heavily within the water band, measurements in the Ultraviolet region show a strong distinction between different Lithium concentrations. The optical spectra of Lithium in the 220 nm to 230 nm region demonstrated the ability to differentiate between concentrations representing those found in patients.
E. Palazidou - One of the best experts on this subject based on the ideXlab platform.
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A Method for Rapid, Reliable, and Low-Volume Measurement of Lithium in Blood for Use in Bipolar Disorder Treatment Management
IEEE Transactions on Biomedical Engineering, 2019Co-Authors: M. Qassem, E. Palazidou, Loukas Constantinou, Iasonasi. F. Triantis, Michelle Hickey, Panayiotis A. KyriacouAbstract:Goal: Lithium preparations are considered the most reliable mood stabilizers for patients with Bipolar Disorder (BD), and are the most effective at reducing the risk of suicide. However, maintaining Blood Lithium concentration within the narrow therapeutic range of 0.4-1.2 mEq is crucial but extremely difficult. The aim of this work is to develop a personal Lithium Blood Level analyzer using a novel method of combined optical and electrical impedance spectroscopy to test micro volumes of spiked samples of human Blood. Results: Impedance measurements alone showed a limit of detection of less than 0.1 mEq within the therapeutic range, whereas optical measurements could verify the presence of Lithium and provide a degree of Lithium content. Optical specificity to Lithium was further verified in qualitative assessment of Lithium spiked Blood samples with varying concentrations of sodium. Moreover, analysis of multiple linear regression yielded a prediction model of R2 = 0.322716 and RMSEP = 0.223602 for optical measurements only using feature wavelengths, which were found to appear at minima 560 and 605 nm. Combined with impedance measurements, prediction of Lithium concentration in samples with unknown Lithium content was significantly increased to R2 = 0.876438 and RMSEP = 0.513554. Conclusion: The combination of optical and impedance modalities for determinations of Blood Lithium resulted in significant improvement to the sensitivity and accuracy of measurement. Significance: Results are complementary of the proposed opto-impedance method, and future work will now focus on the technical development of an integrated and miniaturized system for measurement of Lithium Levels in Blood with a high Level of accuracy and sensitivity.
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Optical analysis of Lithium carbonate: Towards the development of a portable Lithium Blood Level analyzer for bipolar disorder patients
2014 36th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, 2014Co-Authors: J. M. May, M Hickey, I. Triantis, E. Palazidou, P. A. KyriacouAbstract:Lithium medication is the gold standard of treatment in Bipolar Disorder patients, preventing and reducing mood swings and suicidality. However, despite its effectiveness, it is a potentially hazardous drug requiring regular monitoring of Blood Levels to ensure toxic Levels are not reached. This paper describes the first steps towards developing a new portable device that can be used by Bipolar Disorder patients to facilitate the analysis of Lithium Blood Levels at home. Solutions of Lithium carbonate have been optically fingerprinted using a high-end spectrophotometer. Preliminary measurements indicate that while the visible to near infrared region of the absorption spectra fall heavily within the water band, measurements in the Ultraviolet region show a strong distinction between different Lithium concentrations. The optical spectra of Lithium in the 220 nm to 230 nm region demonstrated the ability to differentiate between concentrations representing those found in patients.
J. M. May - One of the best experts on this subject based on the ideXlab platform.
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Optical analysis of Lithium carbonate: Towards the development of a portable Lithium Blood Level analyzer for bipolar disorder patients
2014 36th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, 2014Co-Authors: J. M. May, M Hickey, I. Triantis, E. Palazidou, P. A. KyriacouAbstract:Lithium medication is the gold standard of treatment in Bipolar Disorder patients, preventing and reducing mood swings and suicidality. However, despite its effectiveness, it is a potentially hazardous drug requiring regular monitoring of Blood Levels to ensure toxic Levels are not reached. This paper describes the first steps towards developing a new portable device that can be used by Bipolar Disorder patients to facilitate the analysis of Lithium Blood Levels at home. Solutions of Lithium carbonate have been optically fingerprinted using a high-end spectrophotometer. Preliminary measurements indicate that while the visible to near infrared region of the absorption spectra fall heavily within the water band, measurements in the Ultraviolet region show a strong distinction between different Lithium concentrations. The optical spectra of Lithium in the 220 nm to 230 nm region demonstrated the ability to differentiate between concentrations representing those found in patients.
M Hickey - One of the best experts on this subject based on the ideXlab platform.
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Colorimetric determinations of Lithium Levels in drop-volumes of human plasma for monitoring patients with bipolar mood disorder
2016 38th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC), 2016Co-Authors: M. Qassem, M Hickey, Panayiotis A. KyriacouAbstract:Lithium preparations are considered the most reliable form of mood stabilizing medication for patients with Bipolar disorder. Nevertheless, Lithium is a toxic element and its therapeutic range is extremely narrow, with Levels of 0.61.0 mEq considered normal, whereas Levels above 1.5 mEq are toxic. Thus unfortunately, many patients reach toxic Levels that lead to unnecessary complications. It is believed that personal monitoring of Blood Lithium Levels would benefit patients taking Lithium medication. Therefore, our aim is to develop a personal Lithium Blood Level analyzer for patients with bipolar mood disorder, and we report here our initial results of a colorimetric-based method used to test drop-volumes of human plasma that had been spiked with Lithium. It was possible to validate results with standard flame photometry readings. Applying the Partial Least Squares (PLS) method on preprocessed spectra, therapeutic concentrations of Lithium in a single drop can be predicted in a rapid manner, and furthermore, the calibration results were used to select effective wavelengths which were employed as inputs in Multiple Linear Regression (MLR). The simplified algorithms of this would prove useful when developing a personal Lithium analyzer. Overall, both calibration methods gave high correlation and small error outputs with a R2= 0.99036 and RMSEC = 0.03778, and R2= 0.994148 and RMSEC= 0.0294404, for PLS and MLR methods, respectively. The results show that the spectrophotometric determination of Blood Lithium Levels can be extended beyond laboratory applications and indicate the capability of this testing principle to be employed in a personal monitoring device. Future work will now focus on the technical development of a miniaturized system for measurement of Lithium Levels in Blood with an acceptable Level of accuracy and sensitivity.
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Optical analysis of Lithium carbonate: Towards the development of a portable Lithium Blood Level analyzer for bipolar disorder patients
2014 36th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, 2014Co-Authors: J. M. May, M Hickey, I. Triantis, E. Palazidou, P. A. KyriacouAbstract:Lithium medication is the gold standard of treatment in Bipolar Disorder patients, preventing and reducing mood swings and suicidality. However, despite its effectiveness, it is a potentially hazardous drug requiring regular monitoring of Blood Levels to ensure toxic Levels are not reached. This paper describes the first steps towards developing a new portable device that can be used by Bipolar Disorder patients to facilitate the analysis of Lithium Blood Levels at home. Solutions of Lithium carbonate have been optically fingerprinted using a high-end spectrophotometer. Preliminary measurements indicate that while the visible to near infrared region of the absorption spectra fall heavily within the water band, measurements in the Ultraviolet region show a strong distinction between different Lithium concentrations. The optical spectra of Lithium in the 220 nm to 230 nm region demonstrated the ability to differentiate between concentrations representing those found in patients.
I. Triantis - One of the best experts on this subject based on the ideXlab platform.
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Optical analysis of Lithium carbonate: Towards the development of a portable Lithium Blood Level analyzer for bipolar disorder patients
2014 36th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, 2014Co-Authors: J. M. May, M Hickey, I. Triantis, E. Palazidou, P. A. KyriacouAbstract:Lithium medication is the gold standard of treatment in Bipolar Disorder patients, preventing and reducing mood swings and suicidality. However, despite its effectiveness, it is a potentially hazardous drug requiring regular monitoring of Blood Levels to ensure toxic Levels are not reached. This paper describes the first steps towards developing a new portable device that can be used by Bipolar Disorder patients to facilitate the analysis of Lithium Blood Levels at home. Solutions of Lithium carbonate have been optically fingerprinted using a high-end spectrophotometer. Preliminary measurements indicate that while the visible to near infrared region of the absorption spectra fall heavily within the water band, measurements in the Ultraviolet region show a strong distinction between different Lithium concentrations. The optical spectra of Lithium in the 220 nm to 230 nm region demonstrated the ability to differentiate between concentrations representing those found in patients.