The Experts below are selected from a list of 84 Experts worldwide ranked by ideXlab platform

Ole Jakob Elle - One of the best experts on this subject based on the ideXlab platform.

  • Portal and Hepatic Vein Segmentation with Leak Restriction: A Pilot Study
    EMBEC & NBC 2017, 2017
    Co-Authors: Rahul Prasanna Kumar, Leonid Barkhatov, Bjørn Edwin, Fritz Albregtsen, Ole Jakob Elle
    Abstract:

    A safe Liver resection requires an optimal resection line to be planned with good correlation between Blood inflow and outflow, and to avoid bleeding through large Vessels. The objective of our research is to conduct a pilot study on the development of a portal and hepatic Blood Vessel segmentation method that will help significantly in the planning and navigation of Liver resections. The proposed method is divided into two parts: pre-processing and Liver Blood Vessel segmentation with leak restriction. On evaluation of our results, 80% of Blood Vessels of radius 2.5mm and 100% Vessels from 3.0mm were detected by the proposed method. The time taken for processing was shown to be less than 2 minutes. We have developed a clinically valuable, semi-automatic portal and hepatic vein segmentation method that can be used for planning and intra-operative organ update in Liver resection surgery.

  • CVCS - Study on Liver Blood Vessel movement during breathing cycle
    2013 Colour and Visual Computing Symposium (CVCS), 2013
    Co-Authors: Rahul Prasanna Kumar, Erik-jan Rijkhorst, Oliver Geier, Dean Barratt, Ole Jakob Elle
    Abstract:

    Liver Blood Vessel movement information is important for improving the accuracy of minimally invasive therapies such as high intensity focused ultrasound and radio frequency ablation. In this paper, we present a rigid registration of centerlines obtained from multiscale Vessel enhanced Liver images to understand the movement of Liver during breathing cycle. The method uses modified Vesselness filter for finding Vessel-enhanced images. The Vesselness images are used for finding the centerlines of the Vessels and then used for registering rigidly using the iterative closest point algorithm. Our study has shown on volunteer magnetic resonance images, the Liver Blood Vessels move an average of approximately 3cms during the breathing cycle. Our method can potentially be used to correct for respiratory motion during image-guided Liver procedures.

  • Study on Liver Blood Vessel movement during breathing cycle
    2013 Colour and Visual Computing Symposium (CVCS), 2013
    Co-Authors: Rahul Prasanna Kumar, Erik-jan Rijkhorst, Oliver Geier, Dean Barratt, Ole Jakob Elle
    Abstract:

    Liver Blood Vessel movement information is important for improving the accuracy of minimally invasive therapies such as high intensity focused ultrasound and radio frequency ablation. In this paper, we present a rigid registration of centerlines obtained from multiscale Vessel enhanced Liver images to understand the movement of Liver during breathing cycle. The method uses modified Vesselness filter for finding Vessel-enhanced images. The Vesselness images are used for finding the centerlines of the Vessels and then used for registering rigidly using the iterative closest point algorithm. Our study has shown on volunteer magnetic resonance images, the Liver Blood Vessels move an average of approximately 3cms during the breathing cycle. Our method can potentially be used to correct for respiratory motion during image-guided Liver procedures.

Aaron Barchowsky - One of the best experts on this subject based on the ideXlab platform.

  • low level arsenic promotes progressive inflammatory angiogenesis and Liver Blood Vessel remodeling in mice
    Toxicology and Applied Pharmacology, 2007
    Co-Authors: Adam C Straub, Donna B Stolz, Mark A Ross, Nicole V Soucy, Linda R Klei, Aaron Barchowsky
    Abstract:

    Abstract The vascular effects of arsenic in drinking water are global health concerns contributing to human disease worldwide. Arsenic targets the endothelial cells lining Blood Vessels, and endothelial cell activation or dysfunction may underlie the pathogenesis of both arsenic-induced vascular diseases and arsenic-enhanced tumorigenesis. The purpose of the current studies was to demonstrate that exposing mice to drinking water containing environmentally relevant levels of arsenic promoted endothelial cell dysfunction and pathologic vascular remodeling. Increased angiogenesis, neovascularization, and inflammatory cell infiltration were observed in Matrigel plugs implanted in C57BL/6 mice following 5-week exposures to 5–500 ppb arsenic [Soucy, N.V., Mayka, D., Klei, L.R., Nemec, A.A., Bauer, J.A., Barchowsky, A., 2005. Neovascularization and angiogenic gene expression following chronic arsenic exposure in mice. Cardiovasc.Toxicol 5, 29–42]. Therefore, functional in vivo effects of arsenic on endothelial cell function and Vessel remodeling in an endogenous vascular bed were investigated in the Liver. Liver sinusoidal endothelial cells (LSEC) became progressively defenestrated and underwent capillarization to decrease Vessel porosity following exposure to 250 ppb arsenic for 2 weeks. Sinusoidal expression of PECAM-1 and laminin-1 proteins, a hallmark of capillarization, was also increased by 2 weeks of exposure. LSEC caveolin-1 protein and caveolae expression were induced after 2 weeks of exposure indicating a compensatory change. Likewise, CD45/CD68-positive inflammatory cells did not accumulate in the Livers until after LSEC porosity was decreased, indicating that inflammation is a consequence and not a cause of the arsenic-induced LSEC phenotype. The data demonstrate that the Liver vasculature is an early target of pathogenic arsenic effects and that the mouse Liver vasculature is a sensitive model for investigating vascular health effects of arsenic.

Rahul Prasanna Kumar - One of the best experts on this subject based on the ideXlab platform.

  • Portal and Hepatic Vein Segmentation with Leak Restriction: A Pilot Study
    EMBEC & NBC 2017, 2017
    Co-Authors: Rahul Prasanna Kumar, Leonid Barkhatov, Bjørn Edwin, Fritz Albregtsen, Ole Jakob Elle
    Abstract:

    A safe Liver resection requires an optimal resection line to be planned with good correlation between Blood inflow and outflow, and to avoid bleeding through large Vessels. The objective of our research is to conduct a pilot study on the development of a portal and hepatic Blood Vessel segmentation method that will help significantly in the planning and navigation of Liver resections. The proposed method is divided into two parts: pre-processing and Liver Blood Vessel segmentation with leak restriction. On evaluation of our results, 80% of Blood Vessels of radius 2.5mm and 100% Vessels from 3.0mm were detected by the proposed method. The time taken for processing was shown to be less than 2 minutes. We have developed a clinically valuable, semi-automatic portal and hepatic vein segmentation method that can be used for planning and intra-operative organ update in Liver resection surgery.

  • CVCS - Study on Liver Blood Vessel movement during breathing cycle
    2013 Colour and Visual Computing Symposium (CVCS), 2013
    Co-Authors: Rahul Prasanna Kumar, Erik-jan Rijkhorst, Oliver Geier, Dean Barratt, Ole Jakob Elle
    Abstract:

    Liver Blood Vessel movement information is important for improving the accuracy of minimally invasive therapies such as high intensity focused ultrasound and radio frequency ablation. In this paper, we present a rigid registration of centerlines obtained from multiscale Vessel enhanced Liver images to understand the movement of Liver during breathing cycle. The method uses modified Vesselness filter for finding Vessel-enhanced images. The Vesselness images are used for finding the centerlines of the Vessels and then used for registering rigidly using the iterative closest point algorithm. Our study has shown on volunteer magnetic resonance images, the Liver Blood Vessels move an average of approximately 3cms during the breathing cycle. Our method can potentially be used to correct for respiratory motion during image-guided Liver procedures.

  • Study on Liver Blood Vessel movement during breathing cycle
    2013 Colour and Visual Computing Symposium (CVCS), 2013
    Co-Authors: Rahul Prasanna Kumar, Erik-jan Rijkhorst, Oliver Geier, Dean Barratt, Ole Jakob Elle
    Abstract:

    Liver Blood Vessel movement information is important for improving the accuracy of minimally invasive therapies such as high intensity focused ultrasound and radio frequency ablation. In this paper, we present a rigid registration of centerlines obtained from multiscale Vessel enhanced Liver images to understand the movement of Liver during breathing cycle. The method uses modified Vesselness filter for finding Vessel-enhanced images. The Vesselness images are used for finding the centerlines of the Vessels and then used for registering rigidly using the iterative closest point algorithm. Our study has shown on volunteer magnetic resonance images, the Liver Blood Vessels move an average of approximately 3cms during the breathing cycle. Our method can potentially be used to correct for respiratory motion during image-guided Liver procedures.

Kou Guanju - One of the best experts on this subject based on the ideXlab platform.

  • preliminarily investigate the mechanism of Liver storing Blood controlling conveyance and dispersion based on the brain Liver Blood Vessel axis
    Tianjin Journal of Traditional Chinese Medicine, 2015
    Co-Authors: Kou Guanju
    Abstract:

    "The Liver storing Blood, controlling conveyance and dispersion" was an important content in tradition Chinese medicine doctrine of viscera state. This theory was widely used in many diseases which were treated by syndrome differentiation and treatment,especially in terms of hypertension treated from Liver. While, the exact mechanism was not clear, including regulate Blood pressure,regulate Blood flow, and the way, the position. This paper collected related literature at home and abroad, based on the Liver Blood Vessels and the physiological and innervation. Preliminary discussed the mechanism of "storing Blood, controlling conveyance and dispersion",and the relationship of them from the perspective of "brain-Liver-Blood Vessel"axis. To provide for the related mechanism of the basis of deep research in the future.

Kou Guan-ju - One of the best experts on this subject based on the ideXlab platform.

  • Preliminarily investigate the mechanism of Liver storing Blood, controlling conveyance and dispersion based on the“brain-Liver-Blood Vessel ”axis
    Tianjin Journal of Traditional Chinese Medicine, 2015
    Co-Authors: Kou Guan-ju
    Abstract:

    "The Liver storing Blood, controlling conveyance and dispersion" was an important content in tradition Chinese medicine doctrine of viscera state. This theory was widely used in many diseases which were treated by syndrome differentiation and treatment,especially in terms of hypertension treated from Liver. While, the exact mechanism was not clear, including regulate Blood pressure,regulate Blood flow, and the way, the position. This paper collected related literature at home and abroad, based on the Liver Blood Vessels and the physiological and innervation. Preliminary discussed the mechanism of "storing Blood, controlling conveyance and dispersion",and the relationship of them from the perspective of "brain-Liver-Blood Vessel"axis. To provide for the related mechanism of the basis of deep research in the future.