The Experts below are selected from a list of 201 Experts worldwide ranked by ideXlab platform
Torvid Kiserud - One of the best experts on this subject based on the ideXlab platform.
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redistribution pattern of fetal Liver Circulation in intrauterine growth restriction
Acta Obstetricia et Gynecologica Scandinavica, 2009Co-Authors: Cathrine Ebbing, Svein Rasmussen, Keith M Godfrey, Mark A Hanson, Torvid KiserudAbstract:Objective. Fetal Liver blood supply is an important determinant of fetal growth and adaptation. Most fetal Liver blood supply is from the umbilical vein, but the portal vein contributes 14–20% and studies of low-risk pregnancies suggest the splanchnic arteries are also involved in the homeostasis of fetal Liver perfusion. Here we determine the circulatory pattern of the fetal Liver in intrauterine growth restriction (IUGR). Design. Cross-sectional study. Population. Thirty-one IUGR fetuses (estimated fetal weight 97.5 centile and 13 showed a middle cerebr...
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fetal superior mesenteric artery longitudinal reference ranges and evidence of regulatory link to portal Liver Circulation
Early Human Development, 2009Co-Authors: Svein Rasmussen, Keith M Godfrey, Mark A Hanson, Torvid Kiserud, Catherine EbbingAbstract:Objective: To establish longitudinal reference ranges for the fetal superior mesenteric artery (SMA) flow velocity and pulsatility index (PISMA). Also to examine the hemodynamic relationship to venous Liver perfusion and umbilical flow distribution in the Liver, to other splanchnic arteries, and more generally to the middle cerebral and umbilical artery. Methods: Prospective longitudinal study of 161 low-risk pregnancies using Doppler recordings including the SMA, repeated on 3–5 occasions at 3–5 weekly intervals. Umbilical venous flow was estimated, blood velocity in the shunt ductus venosus represented umbilico-caval (i.e. porto-caval) pressure gradient, and left portal vein blood velocity represented umbilical distribution within the Liver. The correlation between PISMA and the splenic and hepatic artery PI were analysed (PISA and PIHA), and the association to middle cerebral and umbilical artery PI (PIMCA and PIUA) assessed. Results: Reference ranges for the SMA for gestational weeks 21–39 were based on 589 observations. Low impedance in the SMA (i.e. low PISMA) was associated with low umbilical flow and porto-caval pressure gradient (i.e. b10th centile), and high distribution of umbilical flow to the right lobe (i.e. left portal vein blood velocity N90th centile). PISMA correlated weakly with PISA and PIHA (r=0.30, 95%CI 0.22–0.37, and r=0.39, 95% CI 0.27–0.51, respectively). PISMA was positively associated with PIMCA and PIUA. Conclusion: We have provided longitudinal reference ranges for fetal SMA flow velocity and PI, and shown that the SMA, which perfuses the fetal gut, is also involved in the regulation of the Liver perfusion.
Jiro Fujimoto - One of the best experts on this subject based on the ideXlab platform.
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a novel 3d hepatectomy simulation based on Liver Circulation application to Liver resection and transplantation
Hepatology, 2005Co-Authors: Shinichi Saito, Junichi Yamanaka, K Miura, Norio Nakao, Tomohiro Nagao, Takaaki Sugimoto, Tadamichi Hirano, Nobukazu Kuroda, Yuji Iimuro, Jiro FujimotoAbstract:Hepatectomy is a complicated operative procedure because of its anatomical complexity, vascular variability, and impaired hepatic function due to associated hepatitis or cirrhosis. Thus preoperative detailed topography and precise Liver resection volume measurements should be obtained for a curative hepatectomy. The aim of this study was to assess the feasibility and accuracy of a novel three-dimensional (3D) virtual hepatectomy simulation software in patients who underwent Liver resection or living donor Liver transplantation. We developed the hepatectomy simulation software, which was programmed to analyze detailed 3D vascular structure and to predict Liver resection volume and margins. In 72 patients receiving hepatectomy, the predicted Liver resection volumes and margins revealed a significant correlation with the actual value with a mean difference of 9.3 mL (P < .0001) and 1.6 mm (P < .01), respectively. The drainage area by hepatic veins was quantified to achieve reconstruction of the corresponding venous branch. In conclusion, this hepatectomy simulation software reliably predicted an accurate Liver resection volume, the cancer-free margin, and the drainage volume of hepatic vein branches. This software may promote curative hepatectomy and may be used for other interventional therapies in the treatment of Liver disease. (HEPATOLOGY 2005.)
Takao Ayuse - One of the best experts on this subject based on the ideXlab platform.
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protective effect of nitric oxide on Liver Circulation from ischemia reperfusion injury
Journal of Investigative Surgery, 2015Co-Authors: Watanabe Toshihiro, Shinji Kurata, Sanuki Takuro, Okayasu Ichiro, Shibata Yasuaki, Toru Ikeda, Hiroyuki Ureshino, Takao AyuseAbstract:ABSTRACTIntroduction: The reduction of endogenous nitric oxide (NO) production during hepatic ischemia-reperfusion injury, generally via a reduction in endothelial NO synthase activity, leads to Liver injury. We hypothesized that administration of an exogenous NO donor into the portal vein may ameliorate hepatic blood flow reduction after a period of ischemia.Material and Methods: A total of 90 min of ischemia (portal vein and hepatic artery) was applied in 15 anesthetized pigs, using the Pringle method under sevoflurane anesthesia. All animals were administered either saline (control group, n = 8) or sodium nitroprusside (SNP, n = 7) as exogenous NO donor drugs into the portal vein, 30 min before and after ischemia. The portal venous blood flow and hepatic artery blood flow were measured continuously using transonic flow probes attached to each vessel. Endogenous NO (NOx = NO2− + NO3−) production was measured every 10 min using a microdialysis probe placed in the left lobe of the Liver.Results: In the SN...
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role of nitric oxide in porcine Liver Circulation under normal and endotoxemic conditions
Journal of Applied Physiology, 1995Co-Authors: Takao Ayuse, Nicola Brienza, Jeanpierre Revelly, J K Boitnott, James L RobothamAbstract:The role of nitric oxide (NO) in the Liver vasculature during baseline and endotoxic shock states was evaluated in 17 anesthetized pigs. Mean systemic arterial pressure, pulmonary arterial pressure...
Svein Rasmussen - One of the best experts on this subject based on the ideXlab platform.
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redistribution pattern of fetal Liver Circulation in intrauterine growth restriction
Acta Obstetricia et Gynecologica Scandinavica, 2009Co-Authors: Cathrine Ebbing, Svein Rasmussen, Keith M Godfrey, Mark A Hanson, Torvid KiserudAbstract:Objective. Fetal Liver blood supply is an important determinant of fetal growth and adaptation. Most fetal Liver blood supply is from the umbilical vein, but the portal vein contributes 14–20% and studies of low-risk pregnancies suggest the splanchnic arteries are also involved in the homeostasis of fetal Liver perfusion. Here we determine the circulatory pattern of the fetal Liver in intrauterine growth restriction (IUGR). Design. Cross-sectional study. Population. Thirty-one IUGR fetuses (estimated fetal weight 97.5 centile and 13 showed a middle cerebr...
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fetal superior mesenteric artery longitudinal reference ranges and evidence of regulatory link to portal Liver Circulation
Early Human Development, 2009Co-Authors: Svein Rasmussen, Keith M Godfrey, Mark A Hanson, Torvid Kiserud, Catherine EbbingAbstract:Objective: To establish longitudinal reference ranges for the fetal superior mesenteric artery (SMA) flow velocity and pulsatility index (PISMA). Also to examine the hemodynamic relationship to venous Liver perfusion and umbilical flow distribution in the Liver, to other splanchnic arteries, and more generally to the middle cerebral and umbilical artery. Methods: Prospective longitudinal study of 161 low-risk pregnancies using Doppler recordings including the SMA, repeated on 3–5 occasions at 3–5 weekly intervals. Umbilical venous flow was estimated, blood velocity in the shunt ductus venosus represented umbilico-caval (i.e. porto-caval) pressure gradient, and left portal vein blood velocity represented umbilical distribution within the Liver. The correlation between PISMA and the splenic and hepatic artery PI were analysed (PISA and PIHA), and the association to middle cerebral and umbilical artery PI (PIMCA and PIUA) assessed. Results: Reference ranges for the SMA for gestational weeks 21–39 were based on 589 observations. Low impedance in the SMA (i.e. low PISMA) was associated with low umbilical flow and porto-caval pressure gradient (i.e. b10th centile), and high distribution of umbilical flow to the right lobe (i.e. left portal vein blood velocity N90th centile). PISMA correlated weakly with PISA and PIHA (r=0.30, 95%CI 0.22–0.37, and r=0.39, 95% CI 0.27–0.51, respectively). PISMA was positively associated with PIMCA and PIUA. Conclusion: We have provided longitudinal reference ranges for fetal SMA flow velocity and PI, and shown that the SMA, which perfuses the fetal gut, is also involved in the regulation of the Liver perfusion.
Shinichi Saito - One of the best experts on this subject based on the ideXlab platform.
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a novel 3d hepatectomy simulation based on Liver Circulation application to Liver resection and transplantation
Hepatology, 2005Co-Authors: Shinichi Saito, Junichi Yamanaka, K Miura, Norio Nakao, Tomohiro Nagao, Takaaki Sugimoto, Tadamichi Hirano, Nobukazu Kuroda, Yuji Iimuro, Jiro FujimotoAbstract:Hepatectomy is a complicated operative procedure because of its anatomical complexity, vascular variability, and impaired hepatic function due to associated hepatitis or cirrhosis. Thus preoperative detailed topography and precise Liver resection volume measurements should be obtained for a curative hepatectomy. The aim of this study was to assess the feasibility and accuracy of a novel three-dimensional (3D) virtual hepatectomy simulation software in patients who underwent Liver resection or living donor Liver transplantation. We developed the hepatectomy simulation software, which was programmed to analyze detailed 3D vascular structure and to predict Liver resection volume and margins. In 72 patients receiving hepatectomy, the predicted Liver resection volumes and margins revealed a significant correlation with the actual value with a mean difference of 9.3 mL (P < .0001) and 1.6 mm (P < .01), respectively. The drainage area by hepatic veins was quantified to achieve reconstruction of the corresponding venous branch. In conclusion, this hepatectomy simulation software reliably predicted an accurate Liver resection volume, the cancer-free margin, and the drainage volume of hepatic vein branches. This software may promote curative hepatectomy and may be used for other interventional therapies in the treatment of Liver disease. (HEPATOLOGY 2005.)