The Experts below are selected from a list of 204192 Experts worldwide ranked by ideXlab platform
Bing Rui - One of the best experts on this subject based on the ideXlab platform.
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Ultrasonic characterization of porcine Liver Tissue at frequency between 25 to 55 MHz.
World journal of gastroenterology, 2006Co-Authors: Xiaozhou Liu, Xiu-fen Gong, Dong Zhang, Bing RuiAbstract:AIM: To study the relation between acoustic parameters and histological structure of biological Tissue and to provide the basis for high-resolution image of biological Tissues and quantitative ultrasonic diagnosis of Liver disease. METHODS: Ultrasonic imaging and Tissue characterization of four normal porcine Liver and five cirrhotic Liver Tissue samples were performed using a high frequency imaging system. RESULTS: The acoustic parameters of cirrhotic Liver Tissue were larger than those of normal Liver Tissue. The sound velocity was 1577 m/s in normal Liver Tissue and 1631 m/s in cirrhotic Liver Tissue. At 35 MHz, the attenuation coefficient was 3.0 dB/mm in normal Liver Tissue and 4.1 dB/mm in cirrhotic Liver Tissue. The backscatter coefficient was 0.00431 dB/Srmm in cirrhotic Liver Tissue and 0.00303 dB/Srmm in normal Liver Tissue. The backscatter coefficient increased with the frequency. The high frequency images coincided with their histological features. CONCLUSION: The acoustic parameters, especially the sound backscatter coefficient, are sensitive to the changes of Liver Tissues and can be used to differentiate between the normal and pathological Liver Tissues. High frequency image system is a useful device for high-resolution image and Tissue characterization.
Huayong Yang - One of the best experts on this subject based on the ideXlab platform.
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Current Advances on 3D-Bioprinted Liver Tissue Models.
Advanced healthcare materials, 2020Co-Authors: Abdellah Aazmi, Hongzhao Zhou, Bin Zhang, Huayong YangAbstract:The Liver, the largest gland in the human body, plays a key role in metabolism, bile production, detoxification, and water and electrolyte regulation. The toxins or drugs that the gastrointestinal system absorbs reach the Liver first before entering the bloodstream. Liver disease is one of the leading causes of death worldwide. Therefore, an in vitro Liver Tissue model that reproduces the main functions of the Liver can be a reliable platform for investigating Liver diseases and developing new drugs. In addition, the limitations in traditional, planar monolayer cell cultures and animal tests for evaluating the toxicity and efficacy of drug candidates can be overcome. Currently, the newly emerging 3D bioprinting technologies have the ability to construct in vitro Liver Tissue models both in static scaffolds and dynamic Liver-on-chip manners. This review mainly focuses on the construction and applications of Liver Tissue models based on 3D bioprinting. Special attention is given to 3D bioprinting strategies and bioinks for constructing Liver Tissue models including the cell sources and hydrogel selection. In addition, the main advantages and limitations and the major challenges and future perspectives are discussed, paving the way for the next generation of in vitro Liver Tissue models.
Jörg C. Gerlach - One of the best experts on this subject based on the ideXlab platform.
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transport advances in disposable bioreactors for Liver Tissue engineering
Advances in Biochemical Engineering \ Biotechnology, 2009Co-Authors: Gerardo Catapano, John F Patzer, Jörg C. GerlachAbstract:Acute Liver failure (ALF) is a devastating diagnosis with an overall survival of approximately 60%. Liver transplantation is the therapy of choice for ALF patients but is limited by the scarce availability of donor organs. The prognosis of ALF patients may improve if essential Liver functions are restored during Liver failure by means of auxiliary methods because Liver Tissue has the capability to regenerate and heal. Bioartificial Liver (BAL) approaches use Liver Tissue or cells to provide ALF patients with Liver-specific metabolism and synthesis products necessary to relieve some of the symptoms and to promote Liver Tissue regeneration. The most promising BAL treatments are based on the culture of Tissue engineered (TE) Liver constructs, with mature Liver cells or cells that may differentiate into hepatocytes to perform Liver-specific functions, in disposable continuous-flow bioreactors. In fact, adult hepatocytes perform all essential Liver functions. Clinical evaluations of the proposed BALs show that they are safe but have not clearly proven the efficacy of treatment as compared to standard supportive treatments. Ambiguous clinical results, the time loss of cellular activity during treatment, and the presence of a necrotic core in the cell compartment of many bioreactors suggest that improvement of transport of nutrients, and metabolic wastes and products to or from the cells in the bioreactor is critical for the development of therapeutically effective BALs. In this chapter, advanced strategies that have been proposed over to improve mass transport in the bioreactors at the core of a BAL for the treatment of ALF patients are reviewed.
Ramille N. Shah - One of the best experts on this subject based on the ideXlab platform.
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3D Printing for Liver Tissue Engineering: Current Approaches and Future Challenges
Current Transplantation Reports, 2016Co-Authors: Phillip L. Lewis, Ramille N. ShahAbstract:Recent developments in 3D printing have greatly accelerated progress in the field of Liver Tissue engineering by enabling the fabrication of more Tissue-mimetic structures capable of restoring function. A variety of 3D printing and additive manufacturing techniques ranging from stereolithography to direct ink writing have shown great promise in Liver Tissue engineering and the study of cellular interactions. Despite these advances, however, there is significant room for improvement. Furthermore, because of the enormous capabilities of 3D printing, methods to analyze complex heterogeneous Tissues in vitro have yet to be perfected. Investigations into the ability of 3D printing to recreate the macro- and microstructural components of the Liver are still in their infancy. These specific issues need to be addressed in combination with massive scale up if 3D-printed Tissue-engineered Livers are to reach clinical relevance.
Hae-won Kim - One of the best experts on this subject based on the ideXlab platform.
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Biomaterials and Culture Technologies for Regenerative Therapy of Liver Tissue
Advanced healthcare materials, 2016Co-Authors: Roman A. Perez, Cho-rok Jung, Hae-won KimAbstract:Regenerative approach has emerged to substitute the current extracorporeal technologies for the treatment of diseased and damaged Liver Tissue. This is based on the use of biomaterials that modulate the responses of hepatic cells through the unique matrix properties tuned to recapitulate regenerative functions. Cells in Liver preserve their phenotype or differentiate through the interactions with extracellular matrix molecules. Therefore, the intrinsic properties of the engineered biomaterials, such as stiffness and surface topography, need to be tailored to induce appropriate cellular functions. The matrix physical stimuli can be combined with biochemical cues, such as immobilized functional groups or the deLivered actions of signaling molecules. Furthermore, the external modulation of cells, through cocultures with nonparenchymal cells (e.g., endothelial cells) that can signal bioactive molecules, is another promising avenue to regenerate Liver Tissue. This review disseminates the recent approaches of regenerating Liver Tissue, with a focus on the development of biomaterials and the related culture technologies.
