The Experts below are selected from a list of 207546 Experts worldwide ranked by ideXlab platform
Yasuhiko Hashikura - One of the best experts on this subject based on the ideXlab platform.
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Living donor Liver Transplantation for patients with fulminant hepatic failure.
Hepatology Research, 2008Co-Authors: Yasuhiko HashikuraAbstract:The prognosis for patients with fulminant hepatic failure has improved since the introduction of Liver Transplantation. However, the death rate of patients awaiting Liver Transplantation is high, possibly because of the difficulty in obtaining grafts in a timely manner, given the relative shortage of cadaveric donors. Under these circumstances, living donor Liver Transplantation is an alternative therapeutic option for patients with fulminant hepatic failure. The present review provides recent updates on the clinical and therapeutic aspects of living donor Liver Transplantation for fulminant hepatic failure.
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Recent advances in living-related Liver Transplantation and in Liver Transplantation for patients with Liver cirrhosis and hepatocellular carcinoma
Nihon Geka Gakkai zasshi, 1998Co-Authors: Yasuhiko Hashikura, Kawasaki SAbstract:Living-related-donor Liver Transplantation has been performed in more than 700 patients in Japan. This article deals with recent advances in living-related-donor Liver Transplantation and the strategy for Liver Transplantation for patients with Liver cirrhosis and hepatocellular carcinoma. The indication for living-related-donor Liver Transplantation has gradually widened to include urgent cases as well as adult patients. In living-related-donor Liver Transplantation for adults, limitation of graft volume has led to the use of left hepatic lobe grafts including the caudate lobe, or right hepatic lobe grafts. The results of Liver Transplantation for patients with hepatitis B cirrhosis, hepatitis C cirrhosis and hepatocellular carcinoma have improved, due mainly to advances in patient selection and perioperative medical Care. The widespread use of Liver transplants from both living and cadaveric donors is necessary in Japan, where adult patients with viral hepatitis and hepatocellular carcinoma account for the majority of patients with end-stage Liver disease.
Jan Schmidt - One of the best experts on this subject based on the ideXlab platform.
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Partial Liver Transplantation-living donor Liver Transplantation and split Liver Transplantation
Nephrology Dialysis Transplantation, 2007Co-Authors: Sascha A. Müller, Arianeb Mehrabi, Bruno M. Schmied, Thilo Welsch, Hamidreza Fonouni, Guido Engelmann, Peter Schemmer, Jürgen Weitz, Jan SchmidtAbstract:In the last two decades, Liver Transplantation (LTx) has become the treatment of choice for several Liver diseases including hepatocellular carcinoma in selected cases. Improvements in surgical and anesthesiological procedures have increased patient survival after LTx, resulting in excellent 1-year survival rates. The ratelimiting factor to further increase the number of LTx is the extreme shortage of suitable organs with the consequence that pediatric and adult patients are dying on the waiting list. At present, mortality reported for pediatric and adult patients on the waiting list is 10 to 20%. Living-donor Liver Transplantation and split Liver Transplantation are measurements to reduce the severe lack of cadaveric grafts by expanding the donor pool. Major centers around the world now routinely perform partial LTx in infants and adults with survival success equivalent to that after full-size Liver Transplantation.
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Liver Transplantation for metabolic Liver diseases in adults: indications and outcome
Nephrology Dialysis Transplantation, 2007Co-Authors: Karl Heinz Weiss, Peter Schemmer, Jan Schmidt, Daniel Gotthardt, Jens Encke, Carina Riediger, Wolfgang Stremmel, Peter Sauer, Uta MerleAbstract:Orthotopic Liver Transplantation is the preferred treatment for many patients with complications of end-stage Liver disease. For metabolic Liver diseases Liver Transplantation does not only replace the diseased organ, but also can potentially correct the metabolic defect. Results of Liver Transplantation for metabolic diseases have been encouraging. In Wilson’s disease Liver Transplantation is considered an effective treatment for the fulminant form and for end-stage Liver disease, associated with an excellent long-term outcome. However, it is still a matter of controversy whether Liver Transplantation should be considered in Wilson’s disease patients with severe neurological impairment. Liver Transplantation for hereditary haemochromatosis is relatively uncommon and is associated with a decreased post-Transplantation patient survival, most likely due to infections and cardiac complications. Reduction of iron overload prior to Liver Transplantation in patients with hereditary haemochromatosis might be associated with a better outcome.
F J Schulte - One of the best experts on this subject based on the ideXlab platform.
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Living donor for Liver Transplantation
Hepatology, 1994Co-Authors: Christoph Erich Broelsch, Burdelski M, Xavier Rogiers, M. Gundlach, Wolfram T. Knoefel, T. E. Langwieler, Lutz Fischer, A. Latta, H H Hellwege, F J SchulteAbstract:Since living related Liver Transplantation was first performed in 1989, more than 150 cases have been performed worldwide, mostly in the United States and Japan. This paper reports the first series of living related Liver Transplantation in Europe. Twenty living related Liver Transplantation surgeries were performed over a 13-mo period, with an overall patient survival of 85%. For patients who underwent elective Transplantation (n = 13), the survival rate was 100%. Technical complications included one arterial thrombosis necessitating reTransplantation and five bile leaks requiring surgical revision. The technical improvements that permit avoidance of these complications are discussed. A detailed description of the living related Liver procurement is given. All procurements yielded grafts of excellent quality. No intraoperative complications occurred, and no reoperations were necessary. No heterologous blood transfusion was needed. In two patients, incisional hernias developed after wound infection. Living related Liver Transplantation does not absolve the transplant community of efforts to promote cadaveric organ procurement. Nevertheless, living related Liver Transplantation does have the advantage of a readily available graft of excellent quality, permitting Transplantation with optimal timing under elective conditions. Several centers are now preparing living related segmental Liver transplants, following the model of our protocol, for three reasons: (a) to obtain superior results compared with cadaveric Liver Transplantation; (b) to overcome cadaveric organ shortage and further reduce preTransplantation mortality and (c) to provide viable organs in countries where cadaveric organ procurement is not established. When performed by a team experienced in pediatric Liver Transplantation and in adult Liver resection, living related Liver Transplantation is an excellent modality for the treatment of end-stage Liver disease in children.
Isobel Leake - One of the best experts on this subject based on the ideXlab platform.
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Liver Transplantation: Liver Transplantation between an HIV-infected donor and HIV-infected recipient.
Nature reviews. Gastroenterology & hepatology, 2016Co-Authors: Isobel LeakeAbstract:Liver Transplantation: Liver Transplantation between an HIV-infected donor and HIV-infected recipient
Christoph Erich Broelsch - One of the best experts on this subject based on the ideXlab platform.
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Living donor for Liver Transplantation
Hepatology, 1994Co-Authors: Christoph Erich Broelsch, Burdelski M, Xavier Rogiers, M. Gundlach, Wolfram T. Knoefel, T. E. Langwieler, Lutz Fischer, A. Latta, H H Hellwege, F J SchulteAbstract:Since living related Liver Transplantation was first performed in 1989, more than 150 cases have been performed worldwide, mostly in the United States and Japan. This paper reports the first series of living related Liver Transplantation in Europe. Twenty living related Liver Transplantation surgeries were performed over a 13-mo period, with an overall patient survival of 85%. For patients who underwent elective Transplantation (n = 13), the survival rate was 100%. Technical complications included one arterial thrombosis necessitating reTransplantation and five bile leaks requiring surgical revision. The technical improvements that permit avoidance of these complications are discussed. A detailed description of the living related Liver procurement is given. All procurements yielded grafts of excellent quality. No intraoperative complications occurred, and no reoperations were necessary. No heterologous blood transfusion was needed. In two patients, incisional hernias developed after wound infection. Living related Liver Transplantation does not absolve the transplant community of efforts to promote cadaveric organ procurement. Nevertheless, living related Liver Transplantation does have the advantage of a readily available graft of excellent quality, permitting Transplantation with optimal timing under elective conditions. Several centers are now preparing living related segmental Liver transplants, following the model of our protocol, for three reasons: (a) to obtain superior results compared with cadaveric Liver Transplantation; (b) to overcome cadaveric organ shortage and further reduce preTransplantation mortality and (c) to provide viable organs in countries where cadaveric organ procurement is not established. When performed by a team experienced in pediatric Liver Transplantation and in adult Liver resection, living related Liver Transplantation is an excellent modality for the treatment of end-stage Liver disease in children.