The Experts below are selected from a list of 9555 Experts worldwide ranked by ideXlab platform
Guillaume Bourque - One of the best experts on this subject based on the ideXlab platform.
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the retrovirus hervh is a Long Noncoding RNA required for human embryonic stem cell identity
Nature Structural & Molecular Biology, 2014Co-Authors: Xinyi Lu, Friedrich Sachs, Leeann Ramsay, Pierreetienne Jacques, Jonathan Goke, Guillaume Bourque, Huckhui NgAbstract:Human endogenous retrovirus subfamily H (HERVH) is a class of transposable elements expressed preferentially in human embryonic stem cells (hESCs). A new study now shows that the Long terminal repeats of HERVH function as enhancers and that HERVH is a nuclear Long Noncoding RNA required to maintain hESC identity.
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the retrovirus hervh is a Long Noncoding RNA required for human embryonic stem cell identity
Nature Structural & Molecular Biology, 2014Co-Authors: Friedrich Sachs, Leeann Ramsay, Pierreetienne Jacques, Jonathan Goke, Guillaume BourqueAbstract:Human endogenous retrovirus subfamily H (HERVH) is a class of transposable elements expressed preferentially in human embryonic stem cells (hESCs). Here, we report that the Long terminal repeats of HERVH function as enhancers and that HERVH is a nuclear Long Noncoding RNA required to maintain hESC identity. Furthermore, HERVH is associated with OCT4, coactivators and Mediator subunits. Together, these results uncover a new role of species-specific transposable elements in hESCs.
Yeye Chen - One of the best experts on this subject based on the ideXlab platform.
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downregulation of a novel Long Noncoding RNA trpm2 as promotes apoptosis in non small cell lung cancer
Tumor Biology, 2017Co-Authors: Cheng Huang, Yingzhi Qin, Hongsheng Liu, Naixin Liang, Yeye ChenAbstract:Non-small cell lung cancer is one of the most common types of cancer, and the prognosis of non-small cell lung cancer is still poor. Recent evidence has proved that Long Noncoding RNA is involved in tumorigenesis. For non-small cell lung cancer, the expression profile of Long Noncoding RNA has been studied. Here, we identified a novel Long Noncoding RNA TRPM2-AS from published dataset and found TRPM2-AS is widely upregulated in non-small cell lung cancer tissues compared with adjacent non-tumor tissues. Higher expression level of TRPM2-AS was correlated with higher TNM stages and larger tumor size. Patients with high TRPM2-AS expression level had poor survival than those with low TRPM2-AS level. We silenced TRPM2-AS by small interfering RNA and found that cell proliferation was significantly inhibited after knockdown of TRPM2-AS. Annexin V/propidium iodide staining and terminal deoxynucleotidyl transferase-mediated dUTP nick-end labeling assay confirmed that cell apoptosis increased after TRPM2-AS knockdown. Further experiments showed that silence of TRPM2-AS upregulated SHC1 and silence of SHC1 partially reversed cell apoptosis after TRPM2-AS knockdown. In summary, the novel Long Noncoding RNA TRPM2-AS upregulated in non-small cell lung cancer, and downregulation of TRPM2-AS promotes apoptosis in vitro.
Maria U Moreno - One of the best experts on this subject based on the ideXlab platform.
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circulating Long Noncoding RNA lipcar predicts heart failure outcomes in patients without chronic kidney disease
Hypertension, 2019Co-Authors: Laura Santer, Begona Lopez, Susana Ravassa, Christian Baer, Isabelle Riedel, Shambhabi Chatterjee, Maria U MorenoAbstract:The plasma levels of Long Noncoding RNA LIPCAR are elevated in heart failure (HF) patients with reduced ejection fraction and associated with left ventricular remodeling and poor outcomes. We studi...
Friedrich Sachs - One of the best experts on this subject based on the ideXlab platform.
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the retrovirus hervh is a Long Noncoding RNA required for human embryonic stem cell identity
Nature Structural & Molecular Biology, 2014Co-Authors: Xinyi Lu, Friedrich Sachs, Leeann Ramsay, Pierreetienne Jacques, Jonathan Goke, Guillaume Bourque, Huckhui NgAbstract:Human endogenous retrovirus subfamily H (HERVH) is a class of transposable elements expressed preferentially in human embryonic stem cells (hESCs). A new study now shows that the Long terminal repeats of HERVH function as enhancers and that HERVH is a nuclear Long Noncoding RNA required to maintain hESC identity.
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the retrovirus hervh is a Long Noncoding RNA required for human embryonic stem cell identity
Nature Structural & Molecular Biology, 2014Co-Authors: Friedrich Sachs, Leeann Ramsay, Pierreetienne Jacques, Jonathan Goke, Guillaume BourqueAbstract:Human endogenous retrovirus subfamily H (HERVH) is a class of transposable elements expressed preferentially in human embryonic stem cells (hESCs). Here, we report that the Long terminal repeats of HERVH function as enhancers and that HERVH is a nuclear Long Noncoding RNA required to maintain hESC identity. Furthermore, HERVH is associated with OCT4, coactivators and Mediator subunits. Together, these results uncover a new role of species-specific transposable elements in hESCs.
Huckhui Ng - One of the best experts on this subject based on the ideXlab platform.
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the retrovirus hervh is a Long Noncoding RNA required for human embryonic stem cell identity
Nature Structural & Molecular Biology, 2014Co-Authors: Xinyi Lu, Friedrich Sachs, Leeann Ramsay, Pierreetienne Jacques, Jonathan Goke, Guillaume Bourque, Huckhui NgAbstract:Human endogenous retrovirus subfamily H (HERVH) is a class of transposable elements expressed preferentially in human embryonic stem cells (hESCs). A new study now shows that the Long terminal repeats of HERVH function as enhancers and that HERVH is a nuclear Long Noncoding RNA required to maintain hESC identity.
