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Marco R Di Tullio - One of the best experts on this subject based on the ideXlab platform.
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race ethnic differences in subclinical left ventricular systolic dysfunction by global Longitudinal Strain a community based cohort study
American Heart Journal, 2015Co-Authors: Cesare Russo, Mitchell S V Elkind, Tatjana Rundek, Shunichi Homma, Ralph L Sacco, Marco R Di TullioAbstract:Background Race-ethnic differences exist in the epidemiology of heart failure, with blacks experiencing higher incidence and worse prognosis. Left ventricular (LV) systolic dysfunction (LVSD) detected by speckle-tracking global Longitudinal Strain (GLS) is a predictor of cardiovascular events including heart failure. It is not known whether race-ethnic differences in GLS-LVSD exist in subjects without overt LV dysfunction. Methods Participants from a triethnic community-based study underwent 2-dimensional echocardiography with assessment of LV ejection fraction (LVEF) and GLS by speckle-tracking. Participants with LVEF 95% percentile in a healthy sample (−14.7%). Results Of the 678 study participants (mean age 71 ± 9 years, 61% women), 114 were blacks; 464, Hispanics; and 100, whites. Global Longitudinal Strain was significantly lower in blacks (−16.5% ± 3.5%) than in whites (−17.5% ± 3.0%) and Hispanics (−17.3% ± 2.9%) in both univariate ( P = .015) and multivariate analyses ( P = .011), whereas LVEF was not significantly different between the 3 groups (64.3% ± 4.6%, 63.4% ± 4.9%, 64.7% ± 4.9%, respectively, univariate P = .064, multivariate P = .291). Left ventricular systolic dysfunction by GLS was more frequent in blacks (27.2%) than in whites (19.0%) and Hispanics (14.9%, P = .008). In multivariate analysis adjusted for confounders and cardiovascular risk factors, blacks were significantly more likely to have GLS-LVSD (adjusted odds ratio 2.6, 95% CIs 1.4-4.7, P = .002) compared to the other groups. Conclusions Among participants from a triethnic community cohort, black race was associated with greater degree of subclinical LVSD by GLS than other race-ethnic groups. This difference was independent of confounders and cardiovascular risk factors.
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prevalence and prognostic value of subclinical left ventricular systolic dysfunction by global Longitudinal Strain in a community based cohort
European Journal of Heart Failure, 2014Co-Authors: Cesare Russo, Zhezhen Jin, Mitchell S V Elkind, Tatjana Rundek, Shunichi Homma, Ralph L Sacco, Marco R Di TullioAbstract:Aims Global Longitudinal Strain (GLS) assessed by speckle-tracking echocardiography has been proposed as a parameter able to reflect early changes in left ventricular (LV) systolic function at a stage when LV ejection fraction (LVEF) is still normal. This study aimed at assessing prevalence and prognostic value of LV systolic dysfunction (LVSD) assessed by echocardiographic speckle-tracking GLS in a community-based cohort.
Victoria Delgado - One of the best experts on this subject based on the ideXlab platform.
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feature tracking multi detector row computed tomography derived left ventricular global Longitudinal Strain in a large cohort of tavr patients and association with all cause mortality
Journal of the American College of Cardiology, 2020Co-Authors: Tea Gegenava, Pieter Van Der Bijl, Nina Ajmone Marsan, Jeroen J Bax, E M Vollema, Frank Van Der Kley, Arend De Weger, David Hautemann, Johan H C Reiber, Victoria DelgadoAbstract:Recent developments in multidetector row computed tomography (MDCT) permits assessment of left ventricular global Longitudinal Strain (LV GLS) with feature tracking (FT) and may play an important role in the risk-stratification of patients undergoing transcatheter aortic valve replacement (TAVR).
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prognostic implications of right ventricular free wall Longitudinal Strain in patients with significant functional tricuspid regurgitation
Circulation-cardiovascular Imaging, 2019Co-Authors: Edgard A Prihadi, Victoria Delgado, Pieter Van Der Bijl, Marlieke F Dietz, Rachid Abou, Mara E Vollema, Nina Ajmone Marsan, Jeroen J BaxAbstract:Background In patients with significant functional tricuspid regurgitation, timely detection of right ventricular (RV) dysfunction with conventional 2-dimensional echocardiography is challenging, whereas speckle-tracking echocardiography RV free wall Longitudinal Strain has been proposed as better prognosticator. We evaluated the prevalence and prognostic value of impaired RV free wall Longitudinal Strain in patients with significant functional tricuspid regurgitation, in comparison with tricuspid annular plane systolic excursion (TAPSE) and fractional area change (FAC). Methods Eight hundred ninety-six patients (51.3% men, 71 years [62-78 years]) with significant functional tricuspid regurgitation were divided according to the presence of RV dysfunction (defined as TAPSE -23%) and were followed for the occurrence of all-cause mortality. Results RV free wall Longitudinal Strain identified the highest percentage of RV dysfunction (84.9%), in comparison to FAC (48.5%) and TAPSE (71.7%). During a median follow-up of 2.8 years (1.3-5.4 years), 443 (49.4%) patients died. Compared with survivors, nonsurvivors showed worse RV systolic dysfunction (FAC=36.5±12.7% versus 33.9±11.8%, P=0.001; TAPSE=15.4±5.0 versus 14.0±4.5 mm, P<0.001; RV free wall Longitudinal Strain=-15.9±7.5% versus -12.9±6.8%, P<0.001). Cumulative event-free survival was significantly worse in patients with decreased FAC, decreased TAPSE, and impaired RV free wall Longitudinal Strain. On multivariate analysis, RV free wall Longitudinal Strain was independently associated with all-cause mortality and incremental to FAC and TAPSE. Conclusions In significant tricuspid regurgitation, impaired RV free wall Longitudinal Strain identifies higher rates of RV dysfunction and is associated with worse outcome beyond conventional echocardiographic parameters of RV systolic function.
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Left Ventricular Mechanical Dispersion and Global Longitudinal Strain and Ventricular Arrhythmias in Predialysis and Dialysis Patients
Journal of The American Society of Echocardiography, 2018Co-Authors: Liselotte C.r. Hensen, Kathleen Goossens, Tomaz Podlesnikar, J. Wouter Jukema, Joris I. Rotmans, Victoria DelgadoAbstract:Background Patients with advanced chronic kidney disease (CKD) have high risk for sudden cardiac death (SCD) and may benefit from implantable cardioverter-defibrillators (ICDs). However, the risk for ICD-related complications is also high in this population. Therefore, there is an unmet need for accurate risk stratification tools to identify patients with CKD at risk for ventricular arrhythmias (VAs), who may benefit from ICD implantation. The aim of this hypothesis-generating study was to investigate the association between left ventricular (LV) mechanical dispersion and LV global Longitudinal Strain (GLS) measured using two-dimensional speckle-tracking echocardiography and VA and SCD in patients with CKD. Methods Patients with CKD stages 3b to 5 (estimated glomerular filtration rate 2 or on dialysis) were included and were divided into two groups according to the occurrence of VA or SCD during follow-up. LV mechanical dispersion, as a measure of the temporal heterogeneity of the LV deformation, was measured as the SD of time to peak Longitudinal Strain of 17 LV segments. The ability of LV mechanical dispersion, LV ejection fraction, and LV GLS to discriminate patients with VA or SCD during follow-up was evaluated using receiver operating characteristic curve analysis. Results Of 250 patients (66% men; mean age, 61 ± 14 years), 16 (6%) experienced VA or SCD during a median follow-up duration of 28 months (interquartile range, 16–53 months). Using receiver operating characteristic curve analyses, LV GLS (area under the curve = 0.79; 95% CI, 0.68–0.89) and LV mechanical dispersion (area under the curve = 0.71; 95% CI, 0.61–0.82) showed modest discrimination to identify patients at risk for VA or SCD. In contrast, LV ejection fraction showed poor discrimination (area under the curve = 0.60; 95% CI, 0.41–0.78). Conclusions LV mechanical dispersion along with LV GLS may be an additional valuable risk marker of VA and SCD in predialysis and dialysis patients.
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global Longitudinal Strain predicts left ventricular dysfunction after mitral valve repair
European Journal of Echocardiography, 2013Co-Authors: Tomasz Witkowski, Victoria Delgado, James D Thomas, Philippe Debonnaire, Ulas Hoke, See Hooi Ewe, Michel I M Versteegh, Eduard R Holman, Martin J Schalij, Jeroen J BaxAbstract:Aims Despite a successful surgical procedure and adherence to current recommendations, postoperative left ventricular (LV) dysfunction after mitral valve repair (MVr) for organic mitral regurgitation (MR) may still occur. New approaches are therefore needed to detect subclinical preoperative LV dysfunction. LV global Longitudinal Strain (GLS), assessed with speckle-tracking echocardiographic analysis, has been proposed as a novel measure to better depict latent LV dysfunction. The aim of this study was to investigate the value of GLS to predict long-term LV dysfunction after MVr. Methods and results A total of 233 patients (61% men, 61 ± 12 years) with moderate–severe organic MR who underwent successful MVr between 2000 and 2009 were included. Echocardiography was performed at baseline and long-term follow-up (34 ± 20 months) after MVr. LV dysfunction at follow-up was defined as LV ejection fraction (EF) −19.9% were predictors of long-term LV dysfunction. By multivariate analysis, GLS remained an independent predictor of LV dysfunction (odds ratio 23.16, 95% confidence interval: 6.53–82.10, P < 0.001), together with LVESD. Conclusion In a large series of patients operated within the last decade, MVr resulted in a low incidence of long-term LV dysfunction. A GLS of >−19.9% demonstrated to be a major independent predictor of long-term LV dysfunction after adjustment for parameters currently implemented into guidelines.
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relation between global left ventricular Longitudinal Strain assessed with novel automated function imaging and biplane left ventricular ejection fraction in patients with coronary artery disease
Journal of The American Society of Echocardiography, 2008Co-Authors: Victoria Delgado, Sjoerd A Mollema, Claudia Ypenburg, Laurens F Tops, Ernst E Van Der Wall, Martin J SchalijAbstract:Objective Automated function imaging (AFI) is a novel algorithm based on speckle-tracking imaging that can be used for assessment of global Longitudinal Strain of the left ventricle. The purpose of this study was to evaluate the relation between global Longitudinal peak systolic Strain average (GLPSS Avg) assessed by AFI and left ventricular ejection fraction (LVEF). Methods The study population consisted of 222 consecutive patients with coronary artery disease (99 patients with acute ST-segment elevation myocardial infarction [STEMI] and 123 patients with advanced ischemic heart failure) and 20 age-matched controls. LVEF was calculated by Simpson's rule. The GLPSS Avg was obtained by AFI. Results In the overall study group (65 ± 10 years, 77% were men), mean GLPSS Avg was 11.1% ± 4.8% and mean LVEF was 37% ± 14%. Linear regression analysis showed a good correlation between GLPSS Avg and biplane LVEF for the overall study population ( r = 0.83; P r = 0.42 and r = 0.62, both P Conclusion Systolic global Longitudinal Strain assessed by AFI was linearly related to biplane LVEF. In patients with STEMI or heart failure, less strong correlations were observed, suggesting that these 2 parameters reflect different aspects of systolic left ventricular function.
Cesare Russo - One of the best experts on this subject based on the ideXlab platform.
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race ethnic differences in subclinical left ventricular systolic dysfunction by global Longitudinal Strain a community based cohort study
American Heart Journal, 2015Co-Authors: Cesare Russo, Mitchell S V Elkind, Tatjana Rundek, Shunichi Homma, Ralph L Sacco, Marco R Di TullioAbstract:Background Race-ethnic differences exist in the epidemiology of heart failure, with blacks experiencing higher incidence and worse prognosis. Left ventricular (LV) systolic dysfunction (LVSD) detected by speckle-tracking global Longitudinal Strain (GLS) is a predictor of cardiovascular events including heart failure. It is not known whether race-ethnic differences in GLS-LVSD exist in subjects without overt LV dysfunction. Methods Participants from a triethnic community-based study underwent 2-dimensional echocardiography with assessment of LV ejection fraction (LVEF) and GLS by speckle-tracking. Participants with LVEF 95% percentile in a healthy sample (−14.7%). Results Of the 678 study participants (mean age 71 ± 9 years, 61% women), 114 were blacks; 464, Hispanics; and 100, whites. Global Longitudinal Strain was significantly lower in blacks (−16.5% ± 3.5%) than in whites (−17.5% ± 3.0%) and Hispanics (−17.3% ± 2.9%) in both univariate ( P = .015) and multivariate analyses ( P = .011), whereas LVEF was not significantly different between the 3 groups (64.3% ± 4.6%, 63.4% ± 4.9%, 64.7% ± 4.9%, respectively, univariate P = .064, multivariate P = .291). Left ventricular systolic dysfunction by GLS was more frequent in blacks (27.2%) than in whites (19.0%) and Hispanics (14.9%, P = .008). In multivariate analysis adjusted for confounders and cardiovascular risk factors, blacks were significantly more likely to have GLS-LVSD (adjusted odds ratio 2.6, 95% CIs 1.4-4.7, P = .002) compared to the other groups. Conclusions Among participants from a triethnic community cohort, black race was associated with greater degree of subclinical LVSD by GLS than other race-ethnic groups. This difference was independent of confounders and cardiovascular risk factors.
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prevalence and prognostic value of subclinical left ventricular systolic dysfunction by global Longitudinal Strain in a community based cohort
European Journal of Heart Failure, 2014Co-Authors: Cesare Russo, Zhezhen Jin, Mitchell S V Elkind, Tatjana Rundek, Shunichi Homma, Ralph L Sacco, Marco R Di TullioAbstract:Aims Global Longitudinal Strain (GLS) assessed by speckle-tracking echocardiography has been proposed as a parameter able to reflect early changes in left ventricular (LV) systolic function at a stage when LV ejection fraction (LVEF) is still normal. This study aimed at assessing prevalence and prognostic value of LV systolic dysfunction (LVSD) assessed by echocardiographic speckle-tracking GLS in a community-based cohort.
Mitchell S V Elkind - One of the best experts on this subject based on the ideXlab platform.
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race ethnic differences in subclinical left ventricular systolic dysfunction by global Longitudinal Strain a community based cohort study
American Heart Journal, 2015Co-Authors: Cesare Russo, Mitchell S V Elkind, Tatjana Rundek, Shunichi Homma, Ralph L Sacco, Marco R Di TullioAbstract:Background Race-ethnic differences exist in the epidemiology of heart failure, with blacks experiencing higher incidence and worse prognosis. Left ventricular (LV) systolic dysfunction (LVSD) detected by speckle-tracking global Longitudinal Strain (GLS) is a predictor of cardiovascular events including heart failure. It is not known whether race-ethnic differences in GLS-LVSD exist in subjects without overt LV dysfunction. Methods Participants from a triethnic community-based study underwent 2-dimensional echocardiography with assessment of LV ejection fraction (LVEF) and GLS by speckle-tracking. Participants with LVEF 95% percentile in a healthy sample (−14.7%). Results Of the 678 study participants (mean age 71 ± 9 years, 61% women), 114 were blacks; 464, Hispanics; and 100, whites. Global Longitudinal Strain was significantly lower in blacks (−16.5% ± 3.5%) than in whites (−17.5% ± 3.0%) and Hispanics (−17.3% ± 2.9%) in both univariate ( P = .015) and multivariate analyses ( P = .011), whereas LVEF was not significantly different between the 3 groups (64.3% ± 4.6%, 63.4% ± 4.9%, 64.7% ± 4.9%, respectively, univariate P = .064, multivariate P = .291). Left ventricular systolic dysfunction by GLS was more frequent in blacks (27.2%) than in whites (19.0%) and Hispanics (14.9%, P = .008). In multivariate analysis adjusted for confounders and cardiovascular risk factors, blacks were significantly more likely to have GLS-LVSD (adjusted odds ratio 2.6, 95% CIs 1.4-4.7, P = .002) compared to the other groups. Conclusions Among participants from a triethnic community cohort, black race was associated with greater degree of subclinical LVSD by GLS than other race-ethnic groups. This difference was independent of confounders and cardiovascular risk factors.
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prevalence and prognostic value of subclinical left ventricular systolic dysfunction by global Longitudinal Strain in a community based cohort
European Journal of Heart Failure, 2014Co-Authors: Cesare Russo, Zhezhen Jin, Mitchell S V Elkind, Tatjana Rundek, Shunichi Homma, Ralph L Sacco, Marco R Di TullioAbstract:Aims Global Longitudinal Strain (GLS) assessed by speckle-tracking echocardiography has been proposed as a parameter able to reflect early changes in left ventricular (LV) systolic function at a stage when LV ejection fraction (LVEF) is still normal. This study aimed at assessing prevalence and prognostic value of LV systolic dysfunction (LVSD) assessed by echocardiographic speckle-tracking GLS in a community-based cohort.
Tatjana Rundek - One of the best experts on this subject based on the ideXlab platform.
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race ethnic differences in subclinical left ventricular systolic dysfunction by global Longitudinal Strain a community based cohort study
American Heart Journal, 2015Co-Authors: Cesare Russo, Mitchell S V Elkind, Tatjana Rundek, Shunichi Homma, Ralph L Sacco, Marco R Di TullioAbstract:Background Race-ethnic differences exist in the epidemiology of heart failure, with blacks experiencing higher incidence and worse prognosis. Left ventricular (LV) systolic dysfunction (LVSD) detected by speckle-tracking global Longitudinal Strain (GLS) is a predictor of cardiovascular events including heart failure. It is not known whether race-ethnic differences in GLS-LVSD exist in subjects without overt LV dysfunction. Methods Participants from a triethnic community-based study underwent 2-dimensional echocardiography with assessment of LV ejection fraction (LVEF) and GLS by speckle-tracking. Participants with LVEF 95% percentile in a healthy sample (−14.7%). Results Of the 678 study participants (mean age 71 ± 9 years, 61% women), 114 were blacks; 464, Hispanics; and 100, whites. Global Longitudinal Strain was significantly lower in blacks (−16.5% ± 3.5%) than in whites (−17.5% ± 3.0%) and Hispanics (−17.3% ± 2.9%) in both univariate ( P = .015) and multivariate analyses ( P = .011), whereas LVEF was not significantly different between the 3 groups (64.3% ± 4.6%, 63.4% ± 4.9%, 64.7% ± 4.9%, respectively, univariate P = .064, multivariate P = .291). Left ventricular systolic dysfunction by GLS was more frequent in blacks (27.2%) than in whites (19.0%) and Hispanics (14.9%, P = .008). In multivariate analysis adjusted for confounders and cardiovascular risk factors, blacks were significantly more likely to have GLS-LVSD (adjusted odds ratio 2.6, 95% CIs 1.4-4.7, P = .002) compared to the other groups. Conclusions Among participants from a triethnic community cohort, black race was associated with greater degree of subclinical LVSD by GLS than other race-ethnic groups. This difference was independent of confounders and cardiovascular risk factors.
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prevalence and prognostic value of subclinical left ventricular systolic dysfunction by global Longitudinal Strain in a community based cohort
European Journal of Heart Failure, 2014Co-Authors: Cesare Russo, Zhezhen Jin, Mitchell S V Elkind, Tatjana Rundek, Shunichi Homma, Ralph L Sacco, Marco R Di TullioAbstract:Aims Global Longitudinal Strain (GLS) assessed by speckle-tracking echocardiography has been proposed as a parameter able to reflect early changes in left ventricular (LV) systolic function at a stage when LV ejection fraction (LVEF) is still normal. This study aimed at assessing prevalence and prognostic value of LV systolic dysfunction (LVSD) assessed by echocardiographic speckle-tracking GLS in a community-based cohort.
