Loop Diuretic Agent

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Akio Ebihara - One of the best experts on this subject based on the ideXlab platform.

  • Decrease in the time-dependent difference in urinary excretion of furosemide with age.
    Chronobiology International, 1994
    Co-Authors: Akio Fujimura, Toshiaki Sudoh, Akio Ebihara
    Abstract:

    The influence of age on the time-dependent difference in urinary excretion of furosemide, a Loop Diuretic Agent, was examined in this longitudinal study. Male Wistar rats were maintained under conditions of light from 07:00 to 19:00 h and dark from 19:00 to 07:00 h. Furosemide (30 mg/kg) was given orally at 12:00 h (day trial) or 00:00 h (night trial) to rats at 3 months of age, and urine was collected for 8 h after dosage. Thereafter, the identical protocol was repeated using the same animals at 6, 9, 12, 15, 18, and 21 months of age. The urinary excretion of furosemide was significantly greater in the day than in the night trial at 3 months of age. Such a time-dependent difference was observed for up to 15 months, but disappeared at 18 and 21 months of age. The time-dependent difference in urinary excretion of furosemide (day trial — night trial) decreased gradually throughout the observation period of the study. These results suggest that the time-dependent difference in the urinary excretion of furose...

  • Influence of alpha-receptor blockade on the time-dependent change in the effect of furosemide.
    Japanese journal of pharmacology, 1993
    Co-Authors: Akio Fujimura, Toshiaki Sudoh, Tsuyoshi Shiga, Kyoichi Ohashi, Akio Ebihara
    Abstract:

    Influence of alpha-receptor blockade on the time-dependent change in the effect of furosemide (a Loop Diuretic Agent) was examined. Furosemide (30 mg/kg) was given orally to the doxazosin (an alpha 1-blocker)- or vehicle-treated rats at 12 AM or 12 PM. Urine volume and urinary excretions of of sodium and furosemide for 8 hr were significantly greater at 12 AM than at 12 PM in the vehicle-treated animals. However, such time-dependent changes in these parameters disappeared in the doxazosin-treated rats. These results suggest that the alpha 1-receptor-mediated stimuli are involved in the mechanism of the time-dependent change in the effect of furosemide.

  • Influence of clorgyline treatment on chronopharmacology of furosemide in rats
    Life sciences, 1993
    Co-Authors: Akio Fujimura, Toshiaki Sudoh, Tsuyoshi Shiga, Kyoichi Ohashi, Akio Ebihara
    Abstract:

    Abstract Circadian variations in the adrenergic nervous system have been reported to be altered by chronic treatment with clorgyline, a monoamine-oxidase inhibitor. In the present study, the influence of clorgyline on the chronopharmacology of furosemide, a Loop Diuretic Agent, was examined in rats maintained under conditions of light from 7 am to 7 pm and dark from 7 pm to 7 am. Clorgyline (4 mg/kg/day) or its vehicle alone was infused subcutaneously by osmotic minipumps for 14 days. Furosemide (30 mg/kg) was given orally at 12 am [noon (N)] or 12 pm [midnight (M)]. Urine was collected for 8 hours after the Agent, and urinary exretions of sodium and furosemide were determined. Urine volume and urinary excretions of sodium and furosemide were significantly greater at 12 N than at 12 M in the vehicle-infused group of rats. However these administration time-dependent changes in the effects of furosemide and its urinary excretion disappeared in the clorgyline-infused animals. These results suggest that the mode of the diurnal variation in the effects of furosemide is altered by chronic treatment with clorgyline. As chronic clorgyline is considered to disturb the adrenergic nervous system, the present findings are compatible with the hypothesis that this system is involved in the mechanism responsible for the time-dependent change in the effects of furosemide.

  • Daily variation in the effects of furosemide in rats.
    Japanese journal of pharmacology, 1992
    Co-Authors: Akio Fujimura, Toshiaki Sudoh, Tsuyoshi Shiga, Kyoichi Ohashi, Akio Ebihara
    Abstract:

    Daily variation in the effects of furosemide, a Loop Diuretic Agent, was examined in Wistar rats maintained under conditions of light from 7 a.m. to 7 p.m. and dark from 7 p.m. to 7 a.m. Furosemide (30 mg/kg) was given orally at 12 p.m., 4 a.m., 8 a.m., 12 a.m., 4 p.m. or 8 p.m. Urine was collected for 8 hr after furosemide administration, and urinary excretions of sodium and furosemide were determined. There were significant daily variations in the urine volume and urinary excretions of sodium and furosemide with a peak at 8 a.m. and a trough at 12 p.m. Significant correlations were observed between the urinary amount of furosemide and its Diuretic effects (urine volume and urinary sodium excretion). These results suggest that the Diuretic effects of furosemide show daily variations which are, at least in part, caused by the daily variation in the urinary excretion of furosemide.

  • Chronopharmacology of Furosemide in the Elderly
    Journal of clinical pharmacology, 1992
    Co-Authors: Akio Fujimura, Tsuyoshi Shiga, Kyoichi Ohashi, Hiroshi Ohira, Akio Ebihara
    Abstract:

    The authors have previously reported the time-dependent change in the Diuretic effects of Furosemide, a Loop Diuretic Agent, in young and middle-aged subjects. The current study was undertaken to examine an influence of aging on this chronopharmacologic phenomenon. Ten milligrams furosemide was given intravenously to 12 elderly subjects (>70 years of age) at 9:00 am (day trial) or at 9:00 pm (night trial) by a cross-over design. One-hour urine samples were collected for 3 hours after each administration, and urine volume and urinary excretions of sodium and furosemide were determined. Urine volume and urinary sodium excretion increased after furosemide administration. Contrary to the findings in the young and middle-aged subjects, no significant differences were observed in these parameters at any observation period between the day and night trials in the elderly subjects. Urinary furosemide excretion of the day and night trials did not significantly differ. These results suggest that the chronopharmacologic profiles of furosemide are altered in the elderly.

Akio Fujimura - One of the best experts on this subject based on the ideXlab platform.

  • Decrease in the time-dependent difference in urinary excretion of furosemide with age.
    Chronobiology International, 1994
    Co-Authors: Akio Fujimura, Toshiaki Sudoh, Akio Ebihara
    Abstract:

    The influence of age on the time-dependent difference in urinary excretion of furosemide, a Loop Diuretic Agent, was examined in this longitudinal study. Male Wistar rats were maintained under conditions of light from 07:00 to 19:00 h and dark from 19:00 to 07:00 h. Furosemide (30 mg/kg) was given orally at 12:00 h (day trial) or 00:00 h (night trial) to rats at 3 months of age, and urine was collected for 8 h after dosage. Thereafter, the identical protocol was repeated using the same animals at 6, 9, 12, 15, 18, and 21 months of age. The urinary excretion of furosemide was significantly greater in the day than in the night trial at 3 months of age. Such a time-dependent difference was observed for up to 15 months, but disappeared at 18 and 21 months of age. The time-dependent difference in urinary excretion of furosemide (day trial — night trial) decreased gradually throughout the observation period of the study. These results suggest that the time-dependent difference in the urinary excretion of furose...

  • Influence of alpha-receptor blockade on the time-dependent change in the effect of furosemide.
    Japanese journal of pharmacology, 1993
    Co-Authors: Akio Fujimura, Toshiaki Sudoh, Tsuyoshi Shiga, Kyoichi Ohashi, Akio Ebihara
    Abstract:

    Influence of alpha-receptor blockade on the time-dependent change in the effect of furosemide (a Loop Diuretic Agent) was examined. Furosemide (30 mg/kg) was given orally to the doxazosin (an alpha 1-blocker)- or vehicle-treated rats at 12 AM or 12 PM. Urine volume and urinary excretions of of sodium and furosemide for 8 hr were significantly greater at 12 AM than at 12 PM in the vehicle-treated animals. However, such time-dependent changes in these parameters disappeared in the doxazosin-treated rats. These results suggest that the alpha 1-receptor-mediated stimuli are involved in the mechanism of the time-dependent change in the effect of furosemide.

  • Influence of clorgyline treatment on chronopharmacology of furosemide in rats
    Life sciences, 1993
    Co-Authors: Akio Fujimura, Toshiaki Sudoh, Tsuyoshi Shiga, Kyoichi Ohashi, Akio Ebihara
    Abstract:

    Abstract Circadian variations in the adrenergic nervous system have been reported to be altered by chronic treatment with clorgyline, a monoamine-oxidase inhibitor. In the present study, the influence of clorgyline on the chronopharmacology of furosemide, a Loop Diuretic Agent, was examined in rats maintained under conditions of light from 7 am to 7 pm and dark from 7 pm to 7 am. Clorgyline (4 mg/kg/day) or its vehicle alone was infused subcutaneously by osmotic minipumps for 14 days. Furosemide (30 mg/kg) was given orally at 12 am [noon (N)] or 12 pm [midnight (M)]. Urine was collected for 8 hours after the Agent, and urinary exretions of sodium and furosemide were determined. Urine volume and urinary excretions of sodium and furosemide were significantly greater at 12 N than at 12 M in the vehicle-infused group of rats. However these administration time-dependent changes in the effects of furosemide and its urinary excretion disappeared in the clorgyline-infused animals. These results suggest that the mode of the diurnal variation in the effects of furosemide is altered by chronic treatment with clorgyline. As chronic clorgyline is considered to disturb the adrenergic nervous system, the present findings are compatible with the hypothesis that this system is involved in the mechanism responsible for the time-dependent change in the effects of furosemide.

  • Daily variation in the effects of furosemide in rats.
    Japanese journal of pharmacology, 1992
    Co-Authors: Akio Fujimura, Toshiaki Sudoh, Tsuyoshi Shiga, Kyoichi Ohashi, Akio Ebihara
    Abstract:

    Daily variation in the effects of furosemide, a Loop Diuretic Agent, was examined in Wistar rats maintained under conditions of light from 7 a.m. to 7 p.m. and dark from 7 p.m. to 7 a.m. Furosemide (30 mg/kg) was given orally at 12 p.m., 4 a.m., 8 a.m., 12 a.m., 4 p.m. or 8 p.m. Urine was collected for 8 hr after furosemide administration, and urinary excretions of sodium and furosemide were determined. There were significant daily variations in the urine volume and urinary excretions of sodium and furosemide with a peak at 8 a.m. and a trough at 12 p.m. Significant correlations were observed between the urinary amount of furosemide and its Diuretic effects (urine volume and urinary sodium excretion). These results suggest that the Diuretic effects of furosemide show daily variations which are, at least in part, caused by the daily variation in the urinary excretion of furosemide.

  • Chronopharmacology of Furosemide in the Elderly
    Journal of clinical pharmacology, 1992
    Co-Authors: Akio Fujimura, Tsuyoshi Shiga, Kyoichi Ohashi, Hiroshi Ohira, Akio Ebihara
    Abstract:

    The authors have previously reported the time-dependent change in the Diuretic effects of Furosemide, a Loop Diuretic Agent, in young and middle-aged subjects. The current study was undertaken to examine an influence of aging on this chronopharmacologic phenomenon. Ten milligrams furosemide was given intravenously to 12 elderly subjects (>70 years of age) at 9:00 am (day trial) or at 9:00 pm (night trial) by a cross-over design. One-hour urine samples were collected for 3 hours after each administration, and urine volume and urinary excretions of sodium and furosemide were determined. Urine volume and urinary sodium excretion increased after furosemide administration. Contrary to the findings in the young and middle-aged subjects, no significant differences were observed in these parameters at any observation period between the day and night trials in the elderly subjects. Urinary furosemide excretion of the day and night trials did not significantly differ. These results suggest that the chronopharmacologic profiles of furosemide are altered in the elderly.

Kyoichi Ohashi - One of the best experts on this subject based on the ideXlab platform.

  • Influence of alpha-receptor blockade on the time-dependent change in the effect of furosemide.
    Japanese journal of pharmacology, 1993
    Co-Authors: Akio Fujimura, Toshiaki Sudoh, Tsuyoshi Shiga, Kyoichi Ohashi, Akio Ebihara
    Abstract:

    Influence of alpha-receptor blockade on the time-dependent change in the effect of furosemide (a Loop Diuretic Agent) was examined. Furosemide (30 mg/kg) was given orally to the doxazosin (an alpha 1-blocker)- or vehicle-treated rats at 12 AM or 12 PM. Urine volume and urinary excretions of of sodium and furosemide for 8 hr were significantly greater at 12 AM than at 12 PM in the vehicle-treated animals. However, such time-dependent changes in these parameters disappeared in the doxazosin-treated rats. These results suggest that the alpha 1-receptor-mediated stimuli are involved in the mechanism of the time-dependent change in the effect of furosemide.

  • Influence of clorgyline treatment on chronopharmacology of furosemide in rats
    Life sciences, 1993
    Co-Authors: Akio Fujimura, Toshiaki Sudoh, Tsuyoshi Shiga, Kyoichi Ohashi, Akio Ebihara
    Abstract:

    Abstract Circadian variations in the adrenergic nervous system have been reported to be altered by chronic treatment with clorgyline, a monoamine-oxidase inhibitor. In the present study, the influence of clorgyline on the chronopharmacology of furosemide, a Loop Diuretic Agent, was examined in rats maintained under conditions of light from 7 am to 7 pm and dark from 7 pm to 7 am. Clorgyline (4 mg/kg/day) or its vehicle alone was infused subcutaneously by osmotic minipumps for 14 days. Furosemide (30 mg/kg) was given orally at 12 am [noon (N)] or 12 pm [midnight (M)]. Urine was collected for 8 hours after the Agent, and urinary exretions of sodium and furosemide were determined. Urine volume and urinary excretions of sodium and furosemide were significantly greater at 12 N than at 12 M in the vehicle-infused group of rats. However these administration time-dependent changes in the effects of furosemide and its urinary excretion disappeared in the clorgyline-infused animals. These results suggest that the mode of the diurnal variation in the effects of furosemide is altered by chronic treatment with clorgyline. As chronic clorgyline is considered to disturb the adrenergic nervous system, the present findings are compatible with the hypothesis that this system is involved in the mechanism responsible for the time-dependent change in the effects of furosemide.

  • Daily variation in the effects of furosemide in rats.
    Japanese journal of pharmacology, 1992
    Co-Authors: Akio Fujimura, Toshiaki Sudoh, Tsuyoshi Shiga, Kyoichi Ohashi, Akio Ebihara
    Abstract:

    Daily variation in the effects of furosemide, a Loop Diuretic Agent, was examined in Wistar rats maintained under conditions of light from 7 a.m. to 7 p.m. and dark from 7 p.m. to 7 a.m. Furosemide (30 mg/kg) was given orally at 12 p.m., 4 a.m., 8 a.m., 12 a.m., 4 p.m. or 8 p.m. Urine was collected for 8 hr after furosemide administration, and urinary excretions of sodium and furosemide were determined. There were significant daily variations in the urine volume and urinary excretions of sodium and furosemide with a peak at 8 a.m. and a trough at 12 p.m. Significant correlations were observed between the urinary amount of furosemide and its Diuretic effects (urine volume and urinary sodium excretion). These results suggest that the Diuretic effects of furosemide show daily variations which are, at least in part, caused by the daily variation in the urinary excretion of furosemide.

  • Chronopharmacology of Furosemide in the Elderly
    Journal of clinical pharmacology, 1992
    Co-Authors: Akio Fujimura, Tsuyoshi Shiga, Kyoichi Ohashi, Hiroshi Ohira, Akio Ebihara
    Abstract:

    The authors have previously reported the time-dependent change in the Diuretic effects of Furosemide, a Loop Diuretic Agent, in young and middle-aged subjects. The current study was undertaken to examine an influence of aging on this chronopharmacologic phenomenon. Ten milligrams furosemide was given intravenously to 12 elderly subjects (>70 years of age) at 9:00 am (day trial) or at 9:00 pm (night trial) by a cross-over design. One-hour urine samples were collected for 3 hours after each administration, and urine volume and urinary excretions of sodium and furosemide were determined. Urine volume and urinary sodium excretion increased after furosemide administration. Contrary to the findings in the young and middle-aged subjects, no significant differences were observed in these parameters at any observation period between the day and night trials in the elderly subjects. Urinary furosemide excretion of the day and night trials did not significantly differ. These results suggest that the chronopharmacologic profiles of furosemide are altered in the elderly.

  • Influence of DOCA treatment on administration-time-dependent changes in the effects of furosemide in saline-loaded rats.
    Japanese journal of pharmacology, 1992
    Co-Authors: Akio Fujimura, Toshiaki Sudoh, Tsuyoshi Shiga, Kyoichi Ohashi, Akio Ebihara
    Abstract:

    We have previously found that the administration-time-dependent change in the effects of furosemide, a Loop Diuretic Agent, is observed in normal rats. The present study was undertaken to examine whether an alteration in this phenomenon occurs in rats with DOCA-saline hypertension. Unilateral nephrectomized rats were divided into three groups. The first group (DOCA-saline) received a 50 mg DOCA tablet intraperitoneally and drank 1% NaCl solution. The other two groups were given sham operations. A 1% NaCl solution was given as drinking water to the second group (control-saline), while tap water was given to the third group (control-water). Furosemide (30 mg/kg) was given orally to each group at 12 a.m. or 12 p.m. Urine was collected for 8 hours after the Agent, and urinary excretion of sodium and furosemide were determined. Urine volume and urinary excretion of sodium and furosemide following the Agent were significantly greater at 12 a.m. than at 12 p.m. in the control-water and control-saline groups. However, the administration-time-dependent changes in these parameters disappeared in the DOCA-saline rats. These results suggest that the mode of the administration-time-dependent changes in the effects of furosemide is altered in the DOCA-saline hypertensive rats.

Tsuyoshi Shiga - One of the best experts on this subject based on the ideXlab platform.

  • Influence of alpha-receptor blockade on the time-dependent change in the effect of furosemide.
    Japanese journal of pharmacology, 1993
    Co-Authors: Akio Fujimura, Toshiaki Sudoh, Tsuyoshi Shiga, Kyoichi Ohashi, Akio Ebihara
    Abstract:

    Influence of alpha-receptor blockade on the time-dependent change in the effect of furosemide (a Loop Diuretic Agent) was examined. Furosemide (30 mg/kg) was given orally to the doxazosin (an alpha 1-blocker)- or vehicle-treated rats at 12 AM or 12 PM. Urine volume and urinary excretions of of sodium and furosemide for 8 hr were significantly greater at 12 AM than at 12 PM in the vehicle-treated animals. However, such time-dependent changes in these parameters disappeared in the doxazosin-treated rats. These results suggest that the alpha 1-receptor-mediated stimuli are involved in the mechanism of the time-dependent change in the effect of furosemide.

  • Influence of clorgyline treatment on chronopharmacology of furosemide in rats
    Life sciences, 1993
    Co-Authors: Akio Fujimura, Toshiaki Sudoh, Tsuyoshi Shiga, Kyoichi Ohashi, Akio Ebihara
    Abstract:

    Abstract Circadian variations in the adrenergic nervous system have been reported to be altered by chronic treatment with clorgyline, a monoamine-oxidase inhibitor. In the present study, the influence of clorgyline on the chronopharmacology of furosemide, a Loop Diuretic Agent, was examined in rats maintained under conditions of light from 7 am to 7 pm and dark from 7 pm to 7 am. Clorgyline (4 mg/kg/day) or its vehicle alone was infused subcutaneously by osmotic minipumps for 14 days. Furosemide (30 mg/kg) was given orally at 12 am [noon (N)] or 12 pm [midnight (M)]. Urine was collected for 8 hours after the Agent, and urinary exretions of sodium and furosemide were determined. Urine volume and urinary excretions of sodium and furosemide were significantly greater at 12 N than at 12 M in the vehicle-infused group of rats. However these administration time-dependent changes in the effects of furosemide and its urinary excretion disappeared in the clorgyline-infused animals. These results suggest that the mode of the diurnal variation in the effects of furosemide is altered by chronic treatment with clorgyline. As chronic clorgyline is considered to disturb the adrenergic nervous system, the present findings are compatible with the hypothesis that this system is involved in the mechanism responsible for the time-dependent change in the effects of furosemide.

  • Daily variation in the effects of furosemide in rats.
    Japanese journal of pharmacology, 1992
    Co-Authors: Akio Fujimura, Toshiaki Sudoh, Tsuyoshi Shiga, Kyoichi Ohashi, Akio Ebihara
    Abstract:

    Daily variation in the effects of furosemide, a Loop Diuretic Agent, was examined in Wistar rats maintained under conditions of light from 7 a.m. to 7 p.m. and dark from 7 p.m. to 7 a.m. Furosemide (30 mg/kg) was given orally at 12 p.m., 4 a.m., 8 a.m., 12 a.m., 4 p.m. or 8 p.m. Urine was collected for 8 hr after furosemide administration, and urinary excretions of sodium and furosemide were determined. There were significant daily variations in the urine volume and urinary excretions of sodium and furosemide with a peak at 8 a.m. and a trough at 12 p.m. Significant correlations were observed between the urinary amount of furosemide and its Diuretic effects (urine volume and urinary sodium excretion). These results suggest that the Diuretic effects of furosemide show daily variations which are, at least in part, caused by the daily variation in the urinary excretion of furosemide.

  • Chronopharmacology of Furosemide in the Elderly
    Journal of clinical pharmacology, 1992
    Co-Authors: Akio Fujimura, Tsuyoshi Shiga, Kyoichi Ohashi, Hiroshi Ohira, Akio Ebihara
    Abstract:

    The authors have previously reported the time-dependent change in the Diuretic effects of Furosemide, a Loop Diuretic Agent, in young and middle-aged subjects. The current study was undertaken to examine an influence of aging on this chronopharmacologic phenomenon. Ten milligrams furosemide was given intravenously to 12 elderly subjects (>70 years of age) at 9:00 am (day trial) or at 9:00 pm (night trial) by a cross-over design. One-hour urine samples were collected for 3 hours after each administration, and urine volume and urinary excretions of sodium and furosemide were determined. Urine volume and urinary sodium excretion increased after furosemide administration. Contrary to the findings in the young and middle-aged subjects, no significant differences were observed in these parameters at any observation period between the day and night trials in the elderly subjects. Urinary furosemide excretion of the day and night trials did not significantly differ. These results suggest that the chronopharmacologic profiles of furosemide are altered in the elderly.

  • Influence of DOCA treatment on administration-time-dependent changes in the effects of furosemide in saline-loaded rats.
    Japanese journal of pharmacology, 1992
    Co-Authors: Akio Fujimura, Toshiaki Sudoh, Tsuyoshi Shiga, Kyoichi Ohashi, Akio Ebihara
    Abstract:

    We have previously found that the administration-time-dependent change in the effects of furosemide, a Loop Diuretic Agent, is observed in normal rats. The present study was undertaken to examine whether an alteration in this phenomenon occurs in rats with DOCA-saline hypertension. Unilateral nephrectomized rats were divided into three groups. The first group (DOCA-saline) received a 50 mg DOCA tablet intraperitoneally and drank 1% NaCl solution. The other two groups were given sham operations. A 1% NaCl solution was given as drinking water to the second group (control-saline), while tap water was given to the third group (control-water). Furosemide (30 mg/kg) was given orally to each group at 12 a.m. or 12 p.m. Urine was collected for 8 hours after the Agent, and urinary excretion of sodium and furosemide were determined. Urine volume and urinary excretion of sodium and furosemide following the Agent were significantly greater at 12 a.m. than at 12 p.m. in the control-water and control-saline groups. However, the administration-time-dependent changes in these parameters disappeared in the DOCA-saline rats. These results suggest that the mode of the administration-time-dependent changes in the effects of furosemide is altered in the DOCA-saline hypertensive rats.

Toshiaki Sudoh - One of the best experts on this subject based on the ideXlab platform.

  • Decrease in the time-dependent difference in urinary excretion of furosemide with age.
    Chronobiology International, 1994
    Co-Authors: Akio Fujimura, Toshiaki Sudoh, Akio Ebihara
    Abstract:

    The influence of age on the time-dependent difference in urinary excretion of furosemide, a Loop Diuretic Agent, was examined in this longitudinal study. Male Wistar rats were maintained under conditions of light from 07:00 to 19:00 h and dark from 19:00 to 07:00 h. Furosemide (30 mg/kg) was given orally at 12:00 h (day trial) or 00:00 h (night trial) to rats at 3 months of age, and urine was collected for 8 h after dosage. Thereafter, the identical protocol was repeated using the same animals at 6, 9, 12, 15, 18, and 21 months of age. The urinary excretion of furosemide was significantly greater in the day than in the night trial at 3 months of age. Such a time-dependent difference was observed for up to 15 months, but disappeared at 18 and 21 months of age. The time-dependent difference in urinary excretion of furosemide (day trial — night trial) decreased gradually throughout the observation period of the study. These results suggest that the time-dependent difference in the urinary excretion of furose...

  • Influence of alpha-receptor blockade on the time-dependent change in the effect of furosemide.
    Japanese journal of pharmacology, 1993
    Co-Authors: Akio Fujimura, Toshiaki Sudoh, Tsuyoshi Shiga, Kyoichi Ohashi, Akio Ebihara
    Abstract:

    Influence of alpha-receptor blockade on the time-dependent change in the effect of furosemide (a Loop Diuretic Agent) was examined. Furosemide (30 mg/kg) was given orally to the doxazosin (an alpha 1-blocker)- or vehicle-treated rats at 12 AM or 12 PM. Urine volume and urinary excretions of of sodium and furosemide for 8 hr were significantly greater at 12 AM than at 12 PM in the vehicle-treated animals. However, such time-dependent changes in these parameters disappeared in the doxazosin-treated rats. These results suggest that the alpha 1-receptor-mediated stimuli are involved in the mechanism of the time-dependent change in the effect of furosemide.

  • Influence of clorgyline treatment on chronopharmacology of furosemide in rats
    Life sciences, 1993
    Co-Authors: Akio Fujimura, Toshiaki Sudoh, Tsuyoshi Shiga, Kyoichi Ohashi, Akio Ebihara
    Abstract:

    Abstract Circadian variations in the adrenergic nervous system have been reported to be altered by chronic treatment with clorgyline, a monoamine-oxidase inhibitor. In the present study, the influence of clorgyline on the chronopharmacology of furosemide, a Loop Diuretic Agent, was examined in rats maintained under conditions of light from 7 am to 7 pm and dark from 7 pm to 7 am. Clorgyline (4 mg/kg/day) or its vehicle alone was infused subcutaneously by osmotic minipumps for 14 days. Furosemide (30 mg/kg) was given orally at 12 am [noon (N)] or 12 pm [midnight (M)]. Urine was collected for 8 hours after the Agent, and urinary exretions of sodium and furosemide were determined. Urine volume and urinary excretions of sodium and furosemide were significantly greater at 12 N than at 12 M in the vehicle-infused group of rats. However these administration time-dependent changes in the effects of furosemide and its urinary excretion disappeared in the clorgyline-infused animals. These results suggest that the mode of the diurnal variation in the effects of furosemide is altered by chronic treatment with clorgyline. As chronic clorgyline is considered to disturb the adrenergic nervous system, the present findings are compatible with the hypothesis that this system is involved in the mechanism responsible for the time-dependent change in the effects of furosemide.

  • Daily variation in the effects of furosemide in rats.
    Japanese journal of pharmacology, 1992
    Co-Authors: Akio Fujimura, Toshiaki Sudoh, Tsuyoshi Shiga, Kyoichi Ohashi, Akio Ebihara
    Abstract:

    Daily variation in the effects of furosemide, a Loop Diuretic Agent, was examined in Wistar rats maintained under conditions of light from 7 a.m. to 7 p.m. and dark from 7 p.m. to 7 a.m. Furosemide (30 mg/kg) was given orally at 12 p.m., 4 a.m., 8 a.m., 12 a.m., 4 p.m. or 8 p.m. Urine was collected for 8 hr after furosemide administration, and urinary excretions of sodium and furosemide were determined. There were significant daily variations in the urine volume and urinary excretions of sodium and furosemide with a peak at 8 a.m. and a trough at 12 p.m. Significant correlations were observed between the urinary amount of furosemide and its Diuretic effects (urine volume and urinary sodium excretion). These results suggest that the Diuretic effects of furosemide show daily variations which are, at least in part, caused by the daily variation in the urinary excretion of furosemide.

  • Influence of DOCA treatment on administration-time-dependent changes in the effects of furosemide in saline-loaded rats.
    Japanese journal of pharmacology, 1992
    Co-Authors: Akio Fujimura, Toshiaki Sudoh, Tsuyoshi Shiga, Kyoichi Ohashi, Akio Ebihara
    Abstract:

    We have previously found that the administration-time-dependent change in the effects of furosemide, a Loop Diuretic Agent, is observed in normal rats. The present study was undertaken to examine whether an alteration in this phenomenon occurs in rats with DOCA-saline hypertension. Unilateral nephrectomized rats were divided into three groups. The first group (DOCA-saline) received a 50 mg DOCA tablet intraperitoneally and drank 1% NaCl solution. The other two groups were given sham operations. A 1% NaCl solution was given as drinking water to the second group (control-saline), while tap water was given to the third group (control-water). Furosemide (30 mg/kg) was given orally to each group at 12 a.m. or 12 p.m. Urine was collected for 8 hours after the Agent, and urinary excretion of sodium and furosemide were determined. Urine volume and urinary excretion of sodium and furosemide following the Agent were significantly greater at 12 a.m. than at 12 p.m. in the control-water and control-saline groups. However, the administration-time-dependent changes in these parameters disappeared in the DOCA-saline rats. These results suggest that the mode of the administration-time-dependent changes in the effects of furosemide is altered in the DOCA-saline hypertensive rats.

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