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Diana Navikienė - One of the best experts on this subject based on the ideXlab platform.
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processing of Lovage into high value components using supercritical co2 and pressurized liquid extraction
Chemical Engineering & Technology, 2014Co-Authors: Aurelija Kemzūraitė, Petras Rimantas Venskutonis, Diana NavikienėAbstract:Lovage roots, leaves, and stems were extracted by supercritical carbon dioxide (SFE-CO2), while the residues of SFE-CO2 were further extracted by pressurized liquid extraction with acetone and methanol. Optimization of SFE-CO2 parameters resulted in enhanced extract yields from all Lovage parts. The antioxidant potential of solid material and extracts was assessed by Trolox-equivalent antioxidant capacity (TEAC) in two different assays and by the total phenolic content (TPC). TEAC and TPC values of SFE-CO2 residues were distinctly lower than those of the initial Lovage material which indicates that Lovage antioxidants are distributed both in lipophilic and fat-insoluble fractions.
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Processing of Lovage into High‐Value Components Using Supercritical CO2 and Pressurized Liquid Extraction
Chemical Engineering & Technology, 2014Co-Authors: Aurelija Kemzūraitė, Petras Rimantas Venskutonis, Diana NavikienėAbstract:Lovage roots, leaves, and stems were extracted by supercritical carbon dioxide (SFE-CO2), while the residues of SFE-CO2 were further extracted by pressurized liquid extraction with acetone and methanol. Optimization of SFE-CO2 parameters resulted in enhanced extract yields from all Lovage parts. The antioxidant potential of solid material and extracts was assessed by Trolox-equivalent antioxidant capacity (TEAC) in two different assays and by the total phenolic content (TPC). TEAC and TPC values of SFE-CO2 residues were distinctly lower than those of the initial Lovage material which indicates that Lovage antioxidants are distributed both in lipophilic and fat-insoluble fractions.
Sanjib Bhakta - One of the best experts on this subject based on the ideXlab platform.
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antimycobacterials from Lovage root ligusticum officinale koch
Phytotherapy Research, 2013Co-Authors: Juan D Guzman, Dimitrios Evangelopoulos, Antima Gupta, Jose M Prieto, Simon Gibbons, Sanjib BhaktaAbstract:The n-hexane extract of Lovage root was found to significantly inhibit the growth of both Mycobacterium smegmatis mc2155 and Mycobacterium bovis BCG, and therefore a bioassay-guided isolation strategy was undertaken. (Z)-Ligustilide, (Z)-3-butylidenephthalide, (E)-3-butylidenephthalide, 3-butylphthalide, α-prethapsenol, falcarindiol, levistolide A, psoralen and bergapten were isolated by chromatographic techniques, characterized by NMR spectroscopy and MS, and evaluated for their growth inhibition activity against Mycobacterium tuberculosis H37Rv using the whole-cell phenotypic spot culture growth inhibition assay (SPOTi). Cytotoxicity against RAW 264.7 murine macrophage cells was employed for assessing their degree of selectivity. Falcarindiol was the most potent compound with a minimum inhibitory concentration (MIC) value of 20 mg/L against the virulent H37Rv strain; however, it was found to be cytotoxic with a half-growth inhibitory concentration (GIC50) in the same order of magnitude (SI < 1). Interestingly the sesquiterpene alcohol α-prethapsenol was found to inhibit the growth of the pathogenic mycobacteria with an MIC value of 60 mg/L, being more specific towards mycobacteria than mammalian cells (SI ~ 2). Colony forming unit analysis at different concentrations of this phytochemical showed mycobacteriostatic mode of action.
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Antimycobacterials from Lovage Root (Ligusticum officinale Koch)
Phytotherapy research : PTR, 2012Co-Authors: Juan D Guzman, Dimitrios Evangelopoulos, Antima Gupta, Jose M Prieto, Simon Gibbons, Sanjib BhaktaAbstract:The n-hexane extract of Lovage root was found to significantly inhibit the growth of both Mycobacterium smegmatis mc2155 and Mycobacterium bovis BCG, and therefore a bioassay-guided isolation strategy was undertaken. (Z)-Ligustilide, (Z)-3-butylidenephthalide, (E)-3-butylidenephthalide, 3-butylphthalide, α-prethapsenol, falcarindiol, levistolide A, psoralen and bergapten were isolated by chromatographic techniques, characterized by NMR spectroscopy and MS, and evaluated for their growth inhibition activity against Mycobacterium tuberculosis H37Rv using the whole-cell phenotypic spot culture growth inhibition assay (SPOTi). Cytotoxicity against RAW 264.7 murine macrophage cells was employed for assessing their degree of selectivity. Falcarindiol was the most potent compound with a minimum inhibitory concentration (MIC) value of 20 mg/L against the virulent H37Rv strain; however, it was found to be cytotoxic with a half-growth inhibitory concentration (GIC50) in the same order of magnitude (SI
Juan D Guzman - One of the best experts on this subject based on the ideXlab platform.
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antimycobacterials from Lovage root ligusticum officinale koch
Phytotherapy Research, 2013Co-Authors: Juan D Guzman, Dimitrios Evangelopoulos, Antima Gupta, Jose M Prieto, Simon Gibbons, Sanjib BhaktaAbstract:The n-hexane extract of Lovage root was found to significantly inhibit the growth of both Mycobacterium smegmatis mc2155 and Mycobacterium bovis BCG, and therefore a bioassay-guided isolation strategy was undertaken. (Z)-Ligustilide, (Z)-3-butylidenephthalide, (E)-3-butylidenephthalide, 3-butylphthalide, α-prethapsenol, falcarindiol, levistolide A, psoralen and bergapten were isolated by chromatographic techniques, characterized by NMR spectroscopy and MS, and evaluated for their growth inhibition activity against Mycobacterium tuberculosis H37Rv using the whole-cell phenotypic spot culture growth inhibition assay (SPOTi). Cytotoxicity against RAW 264.7 murine macrophage cells was employed for assessing their degree of selectivity. Falcarindiol was the most potent compound with a minimum inhibitory concentration (MIC) value of 20 mg/L against the virulent H37Rv strain; however, it was found to be cytotoxic with a half-growth inhibitory concentration (GIC50) in the same order of magnitude (SI < 1). Interestingly the sesquiterpene alcohol α-prethapsenol was found to inhibit the growth of the pathogenic mycobacteria with an MIC value of 60 mg/L, being more specific towards mycobacteria than mammalian cells (SI ~ 2). Colony forming unit analysis at different concentrations of this phytochemical showed mycobacteriostatic mode of action.
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Antimycobacterials from Lovage Root (Ligusticum officinale Koch)
Phytotherapy research : PTR, 2012Co-Authors: Juan D Guzman, Dimitrios Evangelopoulos, Antima Gupta, Jose M Prieto, Simon Gibbons, Sanjib BhaktaAbstract:The n-hexane extract of Lovage root was found to significantly inhibit the growth of both Mycobacterium smegmatis mc2155 and Mycobacterium bovis BCG, and therefore a bioassay-guided isolation strategy was undertaken. (Z)-Ligustilide, (Z)-3-butylidenephthalide, (E)-3-butylidenephthalide, 3-butylphthalide, α-prethapsenol, falcarindiol, levistolide A, psoralen and bergapten were isolated by chromatographic techniques, characterized by NMR spectroscopy and MS, and evaluated for their growth inhibition activity against Mycobacterium tuberculosis H37Rv using the whole-cell phenotypic spot culture growth inhibition assay (SPOTi). Cytotoxicity against RAW 264.7 murine macrophage cells was employed for assessing their degree of selectivity. Falcarindiol was the most potent compound with a minimum inhibitory concentration (MIC) value of 20 mg/L against the virulent H37Rv strain; however, it was found to be cytotoxic with a half-growth inhibitory concentration (GIC50) in the same order of magnitude (SI
Petras Rimantas Venskutonis - One of the best experts on this subject based on the ideXlab platform.
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Lovage (Levisticum officinale Koch.) Oils
Essential Oils in Food Preservation Flavor and Safety, 2016Co-Authors: Petras Rimantas VenskutonisAbstract:Abstract Lovage (Levisticum officinale Koch.) is a well-known aromatic plant that has been commonly used in foods, flavorings, and medicinal preparations. Essential oil (EO) is an aromatic liquid that may be isolated from Lovage roots, aerial parts, and seeds by distillation and extraction. The main components of Lovage EO are terpenes and phthalides, β-phellandrene, α-terpinyl acetate, and Z-ligustilide, the main constituents being present in different proportions in the different plant anatomical organs. Although the bioactivity of the integral Lovage oils have not been widely studied, its components have been shown to possess antimicrobial, antioxidant, and other activities. Z-ligustilide was reported to demonstrate various health effects such as antiinflammatory, antitumor, antithrombotic activity, and a positive effect against neurological disorders. This chapter provides an overview of the current knowledge about the EOs of Lovage and their useful properties, which might find broader applications in foods and nutraceuticals as natural additives and functional health promoting ingredients.
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processing of Lovage into high value components using supercritical co2 and pressurized liquid extraction
Chemical Engineering & Technology, 2014Co-Authors: Aurelija Kemzūraitė, Petras Rimantas Venskutonis, Diana NavikienėAbstract:Lovage roots, leaves, and stems were extracted by supercritical carbon dioxide (SFE-CO2), while the residues of SFE-CO2 were further extracted by pressurized liquid extraction with acetone and methanol. Optimization of SFE-CO2 parameters resulted in enhanced extract yields from all Lovage parts. The antioxidant potential of solid material and extracts was assessed by Trolox-equivalent antioxidant capacity (TEAC) in two different assays and by the total phenolic content (TPC). TEAC and TPC values of SFE-CO2 residues were distinctly lower than those of the initial Lovage material which indicates that Lovage antioxidants are distributed both in lipophilic and fat-insoluble fractions.
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Processing of Lovage into High‐Value Components Using Supercritical CO2 and Pressurized Liquid Extraction
Chemical Engineering & Technology, 2014Co-Authors: Aurelija Kemzūraitė, Petras Rimantas Venskutonis, Diana NavikienėAbstract:Lovage roots, leaves, and stems were extracted by supercritical carbon dioxide (SFE-CO2), while the residues of SFE-CO2 were further extracted by pressurized liquid extraction with acetone and methanol. Optimization of SFE-CO2 parameters resulted in enhanced extract yields from all Lovage parts. The antioxidant potential of solid material and extracts was assessed by Trolox-equivalent antioxidant capacity (TEAC) in two different assays and by the total phenolic content (TPC). TEAC and TPC values of SFE-CO2 residues were distinctly lower than those of the initial Lovage material which indicates that Lovage antioxidants are distributed both in lipophilic and fat-insoluble fractions.
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Effect of fast CO2 pressure changes on the yield of Lovage (Levisticum officinale Koch.) and celery (Apium graveolens L.) extracts
The Journal of Supercritical Fluids, 2002Co-Authors: Egidijus Daukšas, Petras Rimantas Venskutonis, Björn Sivik, Tobias NillsonAbstract:The effect of pressure alterations on the yield of CO2, extracts from different anatomical parts of Lovage (Levisticum officinale Koch.) and celery (Apium graveolens L.) was studied. It was found that by applying frequent pressure changes in the extraction vessel it is possible to increase the rate of the isolation of CO2 soluble materials from Lovage seeds and leaves, Lovage and celery roots. However, after passing a sufficient amount of the supercritical solvent, the yields were similar both for constant and pulsing extraction pressures. The composition of the extracts was analyzed by gas chromatography and mass spectrometry and it was found that the phthalides were very important constituents in the extracts from all the anatomical parts of Lovage, while linoleic acid was the most abundant component in the celery root extracts. (C) 2002 Elsevier Science B.V. All rights reserved. (Less)
Aurelija Kemzūraitė - One of the best experts on this subject based on the ideXlab platform.
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processing of Lovage into high value components using supercritical co2 and pressurized liquid extraction
Chemical Engineering & Technology, 2014Co-Authors: Aurelija Kemzūraitė, Petras Rimantas Venskutonis, Diana NavikienėAbstract:Lovage roots, leaves, and stems were extracted by supercritical carbon dioxide (SFE-CO2), while the residues of SFE-CO2 were further extracted by pressurized liquid extraction with acetone and methanol. Optimization of SFE-CO2 parameters resulted in enhanced extract yields from all Lovage parts. The antioxidant potential of solid material and extracts was assessed by Trolox-equivalent antioxidant capacity (TEAC) in two different assays and by the total phenolic content (TPC). TEAC and TPC values of SFE-CO2 residues were distinctly lower than those of the initial Lovage material which indicates that Lovage antioxidants are distributed both in lipophilic and fat-insoluble fractions.
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Processing of Lovage into High‐Value Components Using Supercritical CO2 and Pressurized Liquid Extraction
Chemical Engineering & Technology, 2014Co-Authors: Aurelija Kemzūraitė, Petras Rimantas Venskutonis, Diana NavikienėAbstract:Lovage roots, leaves, and stems were extracted by supercritical carbon dioxide (SFE-CO2), while the residues of SFE-CO2 were further extracted by pressurized liquid extraction with acetone and methanol. Optimization of SFE-CO2 parameters resulted in enhanced extract yields from all Lovage parts. The antioxidant potential of solid material and extracts was assessed by Trolox-equivalent antioxidant capacity (TEAC) in two different assays and by the total phenolic content (TPC). TEAC and TPC values of SFE-CO2 residues were distinctly lower than those of the initial Lovage material which indicates that Lovage antioxidants are distributed both in lipophilic and fat-insoluble fractions.
