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Jae Hoon Chung - One of the best experts on this subject based on the ideXlab platform.
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Low Iodine Diet for Preparation for Radioactive Iodine Therapy in Differentiated Thyroid Carcinoma in Korea
Endocrinology and metabolism (Seoul Korea), 2013Co-Authors: Jae Hoon ChungAbstract:Preparation for radioactive Iodine (RAI) therapy includes an increased serum thyroid stimulating hormone level and a Low Iodine Diet (LID). Because of extremely high Iodine intake, some physicians have advocated a more stringent LID for greater than 2 weeks in Korean patients with thyroid cancer prior to RAI therapy; however, it is very difficult to maintain a stringent LID for a longer period of time. According to recent reports in Korea, a nonstringent, simple LID for only 1 week might be enough prior to RAI therapy, if the patients can be educated intensively by specially trained staff. The measurement of simple urinary Iodine concentration (UIC; µg/L) may underestimate daily Iodine excretion in patients with a urinary volume of more than 1 L/day and can also be affected by dilution status. Simple UIC had a weaker correlation than the Iodine/creatinine (I/Cr) ratio. Therefore, the urinary I/Cr ratio can replace 24-hour urine Iodine excretion instead of simple UIC, although it may overestimate Iodine intake in patients with malnutrition or poor muscle mass. The measurement of serum Iodine level might be useful as an adjunct parameter for assessing LID preparation, but its sensitivity and specificity were relatively Low compared to the urinary I/Cr ratio.
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daily urine Iodine excretion while consuming a Low Iodine Diet in preparation for radioactive Iodine therapy in a high Iodine intake area
Clinical Endocrinology, 2011Co-Authors: Hee Kyung Kim, Soo-youn Lee, Ji In Lee, Hye Won Jang, Soo Kyoung Kim, Hye Soo Chung, Alice Hyun Kyung Tan, Kyu Yeon Hur, Jae Hyeon Kim, Jae Hoon ChungAbstract:Summary Objective Recommended durations of Low-Iodine Diet (LID) in preparation for radioactive Iodine therapy (RAIT) vary among major guidelines and are important for patients in areas where Iodine intake is high. The aim of this study was to investigate daily changes in urine Iodine excretion after starting a LID. Design The daily Iodine/creatinine (I/Cr) ratios and simple Iodine concentration (simple I) of morning spot urine from 19 patients with differentiated thyroid carcinoma were measured for 2 weeks from the start of LID for RAIT preparation. We set the cut-off of I/Cr and simple I for poor LID preparation at >66·2 μg/gCr and >150 μg/l, respectively. The day when daily I/Cr or simple I became equal to or beLow the cut-off both by 95% CI and 90th percentile was defined as the end-point for the appropriate duration of LID for RAIT. Results On day 6 of LID, the I/Cr ratio decreased beLow the cut-off (≤66·2 μg/gCr) both by 95% CI (0–60·8) and by 90th percentile (51·9). Simple I reached the cut-off (≤150 μg/l) on day 3 by both parameters (95%CI: 2·3–90·5; 90th percentile: 126·5). The morning spot-urine I/Cr and simple I on day 7 and day 14 were significantly Lower than on day 0 (P < 0·05). Conclusions One week of a strict LID is enough to decrease the level of urine Iodine excretion in preparation for RAIT even in high Iodine intake areas. These results provide essential data for future outcome studies regarding LID preparation for RAIT.
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Daily urine Iodine excretion while consuming a Low‐Iodine Diet in preparation for radioactive Iodine therapy in a high Iodine intake area
Clinical endocrinology, 2011Co-Authors: Hee Kyung Kim, Soo-youn Lee, Ji In Lee, Hye Won Jang, Soo Kyoung Kim, Hye Soo Chung, Alice Hyun Kyung Tan, Kyu Yeon Hur, Jae Hyeon Kim, Jae Hoon ChungAbstract:Summary Objective Recommended durations of Low-Iodine Diet (LID) in preparation for radioactive Iodine therapy (RAIT) vary among major guidelines and are important for patients in areas where Iodine intake is high. The aim of this study was to investigate daily changes in urine Iodine excretion after starting a LID. Design The daily Iodine/creatinine (I/Cr) ratios and simple Iodine concentration (simple I) of morning spot urine from 19 patients with differentiated thyroid carcinoma were measured for 2 weeks from the start of LID for RAIT preparation. We set the cut-off of I/Cr and simple I for poor LID preparation at >66·2 μg/gCr and >150 μg/l, respectively. The day when daily I/Cr or simple I became equal to or beLow the cut-off both by 95% CI and 90th percentile was defined as the end-point for the appropriate duration of LID for RAIT. Results On day 6 of LID, the I/Cr ratio decreased beLow the cut-off (≤66·2 μg/gCr) both by 95% CI (0–60·8) and by 90th percentile (51·9). Simple I reached the cut-off (≤150 μg/l) on day 3 by both parameters (95%CI: 2·3–90·5; 90th percentile: 126·5). The morning spot-urine I/Cr and simple I on day 7 and day 14 were significantly Lower than on day 0 (P
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Determination of Urinary Iodine Concentration by Inductively Coupled Plasma-mass Spectrometry in Thyroid Cancer Patients on Low-Iodine Diet
The Korean journal of laboratory medicine, 2010Co-Authors: Ji-hyun Lee, Jae Hoon Chung, Hee Kyung Kim, Min Jung Song, Hyung Doo Park, Sun Wook Kim, Soo-youn LeeAbstract:Thyroid cancer patients should be on Low-Iodine Diet (LID) before radioactive Iodine therapy (RAIT) to maximize the effect of RAIT. Urinary Iodine excretion is the most accurate marker of very recent Dietary Iodine intake. We developed and evaluated the analytical performance of inductively coupled plasma-mass spectrometry (ICP-MS) to determine urinary Iodine concentration. We evaluated the linearity, precision, accuracy, and Lower limit of quantification (LLOQ) of an ICP-MS method (Agilent 7500ce) to determine urinary Iodine concentration in accordance with the Food and Drug Administration (FDA) guidelines for bioanalytical method validation. This method was used to determine and compare the Iodine concentration in random urine samples of 120 thyroid cancer patients on LID for 1 week and 80 healthy adults on normal Diet. Our ICP-MS method showed good linearity (1.0-1,913 microg/L; R(2)>0.999). Both intra-day and inter-day precision CV were within 20% for the LLOQ (1 microg/L) and within 15% for the other concentrations. Accuracy was 110-120% for the LLOQ and 95-115% for the other concentrations. The median concentration of Iodine in random urine samples from thyroid cancer patients on LID (38.7 microg/L) was significantly Lower than that of healthy subjects (238.8 microg/L) (P<0.0001). Urinary Iodine analysis by ICP-MS showed good linearity, precision, accuracy, wide measuring range of detection, and Lower LLOQ. This method will be very useful to evaluate the status of Dietary Iodine intake and the appropriateness of LID in thyroid cancer patients, thereby maximizing the effect of RAIT.
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determination of urinary Iodine concentration by inductively coupled plasma mass spectrometry in thyroid cancer patients on Low Iodine Diet
Korean Journal of Laboratory Medicine, 2010Co-Authors: Ji-hyun Lee, Jae Hoon Chung, Hee Kyung Kim, Min Jung Song, Hyung Doo Park, Sun Wook Kim, Soo-youn LeeAbstract:Background : Thyroid cancer patients should be on Low-Iodine Diet (LID) before radioactive Iodine therapy (RAIT) to maximize the effect of RAIT. Urinary Iodine excretion is the most accurate marker of very recent Dietary Iodine intake. We developed and evaluated the analytical performance of inductively coupled plasma-mass spectrometry (ICP-MS) to determine urinary Iodine concentration. Methods : We evaluated the linearity, precision, accuracy, and Lower limit of quantification (LLOQ) of an ICP-MS method (Agilent 7500ce) to determine urinary Iodine concentration in accordance with the Food and Drug Administration (FDA) guidelines for bioanalytical method validation. This method was used to determine and compare the Iodine concentration in random urine samples of 120 thyroid cancer patients on LID for 1 week and 80 healthy adults on normal Diet. Results : Our ICP-MS method showed good linearity (1.0-1,913 mg/L; R 2 >0.999). Both intra-day and inter-day precision CV were within 20% for the LLOQ (1 mg/L) and within 15% for the other concentrations. Accuracy was 110-120% for the LLOQ and 95-115% for the other concentrations. The median concentration of Iodine in random urine samples from thyroid cancer patients on LID (38.7 mg/L) was significantly Lower than that of healthy subjects (238.8 mg/L) (P<0.0001). Conclusions : Urinary Iodine analysis by ICP-MS showed good linearity, precision, accuracy, wide measuring range of detection, and Lower LLOQ. This method will be very useful to evaluate the status of Dietary Iodine intake and the appropriateness of LID in thyroid cancer patients, thereby maximizing the effect of RAIT. (Korean J Lab Med 2010;30:351-6)
Ayhan Karakoc - One of the best experts on this subject based on the ideXlab platform.
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effects of diuretics on Iodine uptake in non toxic goitre comparison with Low Iodine Diet
European Journal of Nuclear Medicine and Molecular Imaging, 2003Co-Authors: Ozlem L Kapucu, Firat Azizoglu, Goksun Ayvaz, Ayhan KarakocAbstract:Low-Iodine Diet has been employed to achieve Iodine depletion prior to radioIodine (RI) therapy. However, treatment with diuretics may be more effective than Low-Iodine Diet in causing Iodine depletion and subsequent increase in RI uptake by the thyroid. Fifty-five patients with non-toxic goitre were given 0.20 MBq RI p.o. on the first day of the study and thyroid uptake was measured. In 15 patients, a Low-Iodine Diet was started and continued for 14 days. The remaining 40 patients received furosemide 40 mg/day orally for 5 days with an unrestricted Diet. On the 15th day of the study, all patients were given 0.20 MBq RI p.o. and thyroid RI uptake was measured again. Additionally, 24-h urinary Iodine excretion and RI clearance were measured on the 1st and 6th days in 21 patients from the furosemide group and on the 1st and 15th days in eight patients from the Diet group. Furosemide administration led to a 58.40% increase in Iodine uptake over the baseline value, which was significantly higher than the increase caused by Low-Iodine Diet (17.22%) (P<0.0001). Urinary excretion of RI decreased in both groups similarly (furosemide, 29.45%; Low-Iodine Diet, 21.06%; P=0.33). Iodine clearance also decreased in each group similarly (10.61% vs 7.53%, P=0.53). Treatment with furosemide prior to administration of RI increases the uptake of RI by the thyroid more effectively than does Low-Iodine Diet.
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Effects of diuretics on Iodine uptake in non-toxic goitre: comparison with Low-Iodine Diet
European journal of nuclear medicine and molecular imaging, 2003Co-Authors: L. Özlem Kapucu, Firat Azizoglu, Goksun Ayvaz, Ayhan KarakocAbstract:Low-Iodine Diet has been employed to achieve Iodine depletion prior to radioIodine (RI) therapy. However, treatment with diuretics may be more effective than Low-Iodine Diet in causing Iodine depletion and subsequent increase in RI uptake by the thyroid. Fifty-five patients with non-toxic goitre were given 0.20 MBq RI p.o. on the first day of the study and thyroid uptake was measured. In 15 patients, a Low-Iodine Diet was started and continued for 14 days. The remaining 40 patients received furosemide 40 mg/day orally for 5 days with an unrestricted Diet. On the 15th day of the study, all patients were given 0.20 MBq RI p.o. and thyroid RI uptake was measured again. Additionally, 24-h urinary Iodine excretion and RI clearance were measured on the 1st and 6th days in 21 patients from the furosemide group and on the 1st and 15th days in eight patients from the Diet group. Furosemide administration led to a 58.40% increase in Iodine uptake over the baseline value, which was significantly higher than the increase caused by Low-Iodine Diet (17.22%) ( P
Hee Kyung Kim - One of the best experts on this subject based on the ideXlab platform.
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daily urine Iodine excretion while consuming a Low Iodine Diet in preparation for radioactive Iodine therapy in a high Iodine intake area
Clinical Endocrinology, 2011Co-Authors: Hee Kyung Kim, Soo-youn Lee, Ji In Lee, Hye Won Jang, Soo Kyoung Kim, Hye Soo Chung, Alice Hyun Kyung Tan, Kyu Yeon Hur, Jae Hyeon Kim, Jae Hoon ChungAbstract:Summary Objective Recommended durations of Low-Iodine Diet (LID) in preparation for radioactive Iodine therapy (RAIT) vary among major guidelines and are important for patients in areas where Iodine intake is high. The aim of this study was to investigate daily changes in urine Iodine excretion after starting a LID. Design The daily Iodine/creatinine (I/Cr) ratios and simple Iodine concentration (simple I) of morning spot urine from 19 patients with differentiated thyroid carcinoma were measured for 2 weeks from the start of LID for RAIT preparation. We set the cut-off of I/Cr and simple I for poor LID preparation at >66·2 μg/gCr and >150 μg/l, respectively. The day when daily I/Cr or simple I became equal to or beLow the cut-off both by 95% CI and 90th percentile was defined as the end-point for the appropriate duration of LID for RAIT. Results On day 6 of LID, the I/Cr ratio decreased beLow the cut-off (≤66·2 μg/gCr) both by 95% CI (0–60·8) and by 90th percentile (51·9). Simple I reached the cut-off (≤150 μg/l) on day 3 by both parameters (95%CI: 2·3–90·5; 90th percentile: 126·5). The morning spot-urine I/Cr and simple I on day 7 and day 14 were significantly Lower than on day 0 (P < 0·05). Conclusions One week of a strict LID is enough to decrease the level of urine Iodine excretion in preparation for RAIT even in high Iodine intake areas. These results provide essential data for future outcome studies regarding LID preparation for RAIT.
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Daily urine Iodine excretion while consuming a Low‐Iodine Diet in preparation for radioactive Iodine therapy in a high Iodine intake area
Clinical endocrinology, 2011Co-Authors: Hee Kyung Kim, Soo-youn Lee, Ji In Lee, Hye Won Jang, Soo Kyoung Kim, Hye Soo Chung, Alice Hyun Kyung Tan, Kyu Yeon Hur, Jae Hyeon Kim, Jae Hoon ChungAbstract:Summary Objective Recommended durations of Low-Iodine Diet (LID) in preparation for radioactive Iodine therapy (RAIT) vary among major guidelines and are important for patients in areas where Iodine intake is high. The aim of this study was to investigate daily changes in urine Iodine excretion after starting a LID. Design The daily Iodine/creatinine (I/Cr) ratios and simple Iodine concentration (simple I) of morning spot urine from 19 patients with differentiated thyroid carcinoma were measured for 2 weeks from the start of LID for RAIT preparation. We set the cut-off of I/Cr and simple I for poor LID preparation at >66·2 μg/gCr and >150 μg/l, respectively. The day when daily I/Cr or simple I became equal to or beLow the cut-off both by 95% CI and 90th percentile was defined as the end-point for the appropriate duration of LID for RAIT. Results On day 6 of LID, the I/Cr ratio decreased beLow the cut-off (≤66·2 μg/gCr) both by 95% CI (0–60·8) and by 90th percentile (51·9). Simple I reached the cut-off (≤150 μg/l) on day 3 by both parameters (95%CI: 2·3–90·5; 90th percentile: 126·5). The morning spot-urine I/Cr and simple I on day 7 and day 14 were significantly Lower than on day 0 (P
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Determination of Urinary Iodine Concentration by Inductively Coupled Plasma-mass Spectrometry in Thyroid Cancer Patients on Low-Iodine Diet
The Korean journal of laboratory medicine, 2010Co-Authors: Ji-hyun Lee, Jae Hoon Chung, Hee Kyung Kim, Min Jung Song, Hyung Doo Park, Sun Wook Kim, Soo-youn LeeAbstract:Thyroid cancer patients should be on Low-Iodine Diet (LID) before radioactive Iodine therapy (RAIT) to maximize the effect of RAIT. Urinary Iodine excretion is the most accurate marker of very recent Dietary Iodine intake. We developed and evaluated the analytical performance of inductively coupled plasma-mass spectrometry (ICP-MS) to determine urinary Iodine concentration. We evaluated the linearity, precision, accuracy, and Lower limit of quantification (LLOQ) of an ICP-MS method (Agilent 7500ce) to determine urinary Iodine concentration in accordance with the Food and Drug Administration (FDA) guidelines for bioanalytical method validation. This method was used to determine and compare the Iodine concentration in random urine samples of 120 thyroid cancer patients on LID for 1 week and 80 healthy adults on normal Diet. Our ICP-MS method showed good linearity (1.0-1,913 microg/L; R(2)>0.999). Both intra-day and inter-day precision CV were within 20% for the LLOQ (1 microg/L) and within 15% for the other concentrations. Accuracy was 110-120% for the LLOQ and 95-115% for the other concentrations. The median concentration of Iodine in random urine samples from thyroid cancer patients on LID (38.7 microg/L) was significantly Lower than that of healthy subjects (238.8 microg/L) (P<0.0001). Urinary Iodine analysis by ICP-MS showed good linearity, precision, accuracy, wide measuring range of detection, and Lower LLOQ. This method will be very useful to evaluate the status of Dietary Iodine intake and the appropriateness of LID in thyroid cancer patients, thereby maximizing the effect of RAIT.
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determination of urinary Iodine concentration by inductively coupled plasma mass spectrometry in thyroid cancer patients on Low Iodine Diet
Korean Journal of Laboratory Medicine, 2010Co-Authors: Ji-hyun Lee, Jae Hoon Chung, Hee Kyung Kim, Min Jung Song, Hyung Doo Park, Sun Wook Kim, Soo-youn LeeAbstract:Background : Thyroid cancer patients should be on Low-Iodine Diet (LID) before radioactive Iodine therapy (RAIT) to maximize the effect of RAIT. Urinary Iodine excretion is the most accurate marker of very recent Dietary Iodine intake. We developed and evaluated the analytical performance of inductively coupled plasma-mass spectrometry (ICP-MS) to determine urinary Iodine concentration. Methods : We evaluated the linearity, precision, accuracy, and Lower limit of quantification (LLOQ) of an ICP-MS method (Agilent 7500ce) to determine urinary Iodine concentration in accordance with the Food and Drug Administration (FDA) guidelines for bioanalytical method validation. This method was used to determine and compare the Iodine concentration in random urine samples of 120 thyroid cancer patients on LID for 1 week and 80 healthy adults on normal Diet. Results : Our ICP-MS method showed good linearity (1.0-1,913 mg/L; R 2 >0.999). Both intra-day and inter-day precision CV were within 20% for the LLOQ (1 mg/L) and within 15% for the other concentrations. Accuracy was 110-120% for the LLOQ and 95-115% for the other concentrations. The median concentration of Iodine in random urine samples from thyroid cancer patients on LID (38.7 mg/L) was significantly Lower than that of healthy subjects (238.8 mg/L) (P<0.0001). Conclusions : Urinary Iodine analysis by ICP-MS showed good linearity, precision, accuracy, wide measuring range of detection, and Lower LLOQ. This method will be very useful to evaluate the status of Dietary Iodine intake and the appropriateness of LID in thyroid cancer patients, thereby maximizing the effect of RAIT. (Korean J Lab Med 2010;30:351-6)
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Usefulness of Iodine/creatinine ratio from spot-urine samples to evaluate the effectiveness of Low-Iodine Diet preparation for radioIodine therapy.
Clinical endocrinology, 2009Co-Authors: Hee Kyung Kim, Soo-youn Lee, Ji In Lee, Hye Won Jang, Soo Kyoung Kim, Hye Soo Chung, Alice Hyun Kyung Tan, Kyu Yeon Hur, Jae Hyeon Kim, Jae Hoon ChungAbstract:Summary Objective The success of a Low-Iodine Diet (LID) is best determined by measurement of 24-h urine Iodine (U-I) excretion. The aim of this study was to determine reliable estimates for 24-h U-I based on spot-urine samples and to provide cut-offs to determine the effectiveness of LID preparation. Design We prospectively measured Iodine levels in 193 patients based on 24-h- and spot-urine samples before radioactive Iodine therapy. The Iodine was expressed as the 24-h U-I excretion (μg/day) and as two different indices from spot urine, simple Iodine concentration (simple I) and the Iodine/creatinine (I/Cr) ratio. Poor LID preparation was defined as I excretion of >150 μg/day according to the 24-h U-I measurement. Results The measured 24-h U-I was significantly higher than the two indices from spot urine (P 66·2 μg/g Cr (sensitivity 96·4%, specificity 83·6%, positive predictive value 50·0% and negative predictive value 99·3%). Conclusions We demonstrated that the I/Cr ratio from spot urine could serve as a useful and reliable alternative to 24-h urine collection as it has acceptable diagnostic values for detecting poor LID preparation.
Byung Il Kim - One of the best experts on this subject based on the ideXlab platform.
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analysis of urine Iodine excretion decrease by two week stringent Low Iodine Diet for remnant thyroid ablation with radioactive Iodine in korean patients with thyroid cancer prospective study
Nuclear Medicine and Molecular Imaging, 2008Co-Authors: Joon Hyuk Choi, Hoon Il Kim, Jang Won Park, Eun Hoon Song, Gi Jeong Cheon, Byung Il KimAbstract:A Low Iodine Diet (LID) is the recommended preparation for radioactive Iodine treatment. However, the recommended duration and stringency of LID are different among each recommendation. More stringent LID is expected in Korea because Korea is a Iodine-rich region. We investigated the decrement of urine Iodine excretion by two-week stringent LID for remnant thyroid ablation with radioactive Iodine in Korean patients with thyroid cancer, prospectively. Material and Method: From November 2006, patients who referred to our hospital for remnant ablation after total thyroidectomy were included in this study. To decrease total body Iodine, our protocol included three strategies. First, we checked medication which could inhibit the radioactive Iodine uptake. Second, the date of 1-131 treatment was scheduled at least 3 months later if contrast agent had been used. The last strategy was two-week stringent LID education by specialized nutritionist. Before and after two-week stringent LID, 24hr-urine Iodine was analyzed respectively. 24hr-urine creatinine was also analyzed for determining more valid 24hr urine sampling subgroup. Results: Total 51 patients were finally enrolled. Average of 24hr-urine Iodine excretion was significantly Lowered (, p=0.03) after LID and 74.4% of patients reached beLow the recommended urine Iodine excretion level (). In subgroup (n=14), similar results was showed (, p=0.05) and 78.6% of patients met the criteria. Conclusion: Most patients could reach beLow the recommended urine Iodine level after two-week stringent LID. Therefore, in our opinion, at least two-week stringent LID should be recommended in Korea.
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comparison of urine Iodine creatinine ratio between patients folLowing stringent and less stringent Low Iodine Diet for radioIodine remnant ablation of thyroid cancer
Nuclear Medicine and Molecular Imaging, 2006Co-Authors: Jeeho Roh, Joon Hyuk Choi, Byung Il Kim, Seijoong Chang, Hyeyoung Shin, Domin Kim, Chongsoon KimAbstract:목적: 갑상선암 방사성요오드 치료를 위한 전처치로 1주 ${\sim}$ 2주간 저요오드식이를 시행하는 것이 국제 권고안에서 권고되고 있으나 각 병원마다 저요오드식이를 자체적인 교육방법에 따라 시행하고 있으며 저요오드식이를 통해 체내 요오드량을 효과적으로 낮추었는지에 대한 측정도 대부분의 병원에서 시행되지 않고 있어, 연구자들의 병원에 의뢰된 환자들의 소변 내 I/Cr비를 측정하여 고전적인 엄격한 저요오드식 이를 1주일간 시 행하는 방법과 덜 엄격한 저요오드식이를 2주일간 시행하는 방법을 비교하여 그 적절성을 평가하고자 하였다. 대상 및 방법: 2006년 4월 10일부터 6월 19일까지 본원에 의뢰된 27명의 환자를 대상으로 제한 및 허용식품 목록, 영양사 교육 유무, 예시 식단 유무, 저요오드식이 기간을 비교하여 가장 빈도가 높은 2가지 방법, 즉 관용적인 기준을 채택하는 군과 엄격한 제한식품을 설명한 군으로 나누어 두 군의 아침 소변을 채집, iodide selective electrode method를 사용하여 소변 내 요오드량을 측정하고 이를 소변 내 크레아티닌으로 나누어 I/Cr비를 구하였다. 두 군의 결과는 t-test를 이용하여 검정하였다. 결과: 두 군간의 특성에는 유의한 차이가 없었으며 각 군에서의 소변 내 I/Cr 비는 2주간 덜 엄격한 저요오드식이 군에서 $289.75{\pm}188.24{\mu}g/g$ , 1주간 엄격한 저요오드식이를 시행한 군에서는 $127.87{\pm}78.52{\mu}g/g$ 으로 측정되었으며 1주간 엄격하게 시행한 군에서 유의하게 낮았다 (p=0.008). 2주간 덜 엄격한 저요오드식이를 시행한 군에서는 14명중 3명(21.42%), 1주간 엄격한 저요오드식이를 시행한 군에서는 13명중 6명(46.15%)이 방사성요오드치료를 위한 적정한 수준으로 제시된 소변 내 요오드배설량 $100{\mu}g/g$ 이하를 만족했다. 결론: 2주간 덜 엄격한 저요오드식이를 시행한 군에서 1주간 엄격한 교육을 시행한 군보다 높은 소변 내 I/Cr비가 나온 것을 볼 때 교육 방법을 엄격하게 시행하지 않고 간단하게 변형된 방법을 사용할 경우 기간을 길게 하더라도 치료에 필요한 적정 수준의 체내 요오드량 감소를 달성하기 어려울 것으로 판단된다. 그러나 1주간 엄격한 저요오드식이를 시행한 군에서도 체내 요오드량의 감소가 충분히 감소하는 비율이 여전히 낮기 때문에 엄격한 저요오드식이 방법을 2주간 시행하는 것이 더바람직하리라 기대된다. 【A Low Iodine Diet (LID) for $1{\sim}2$ weeks is recommended for patients who undergoing radioIodine remnant ablation. However, the LID educations for patients are different among centers because there is no concrete recommendation for protocol of LID. In this investigation, we compared two representative types of LID protocols performed in several centers in Korea using urine Iodine to creatinine ratio (urine I/Cr). Methods: From 2006, April to June, patients referred to our center for radioIodine remnant ablation of thyroid cancer from several local hospitals which had different LID protocols were included. We divided into two groups, stringent LID for 1week and less stringent LID for 2 weeks, then measured their urine I/Cr ratio with spot urine when patients were admitted to the hospital. Results: Total 27 patients were included in this investigation (M:F=1:26; 13 in one-week stringent LID; 14 in two-week less stringent LID. Average of urine I/Cr ratio was $127.87{\pm}78.52{\mu}g/g$ in stringent LID for 1 week, and $289.75{\pm}188.24{\mu}g/g$ in less stringent LID for 2 weeks. It was significantly Lower in stringent LID for 1 week group (p=0.008). The number of patients whose urine I/Cr ratios were beLow $100{\mu}g/g$ was 6 of 13 in stringent LID for 1 week group, and 3 of 14 in less stringent LID for 2 weeks group. Conclusion: Stringent LID for 1 week resulted in better urinary I/Cr ratio in our investigation compared with the other protocol. However it still resulted in plenty of inadequate range of I/Cr ratio, so more stringent protocol such as stringent LID for 2 weeks is expected more desirable.】
Curtis D. Klaassen - One of the best experts on this subject based on the ideXlab platform.
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Inhibition of gap-junctional-intercellular communication in thyroid-follicular cells by propylthiouracil and Low Iodine Diet.
Toxicology, 2000Co-Authors: Kyle L. Kolaja, Jay S. Petrick, Curtis D. KlaassenAbstract:Propylthiouracil (PTU) or Low-Iodine Diet (LID) treatment increases thyroid-follicular-cell proliferation, possibly by disrupting the movement of small molecules (
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inhibition of gap junctional intercellular communication in thyroid follicular cells by propylthiouracil and Low Iodine Diet
Toxicology, 2000Co-Authors: Kyle L. Kolaja, Jay S. Petrick, Curtis D. KlaassenAbstract:Propylthiouracil (PTU) or Low-Iodine Diet (LID) treatment increases thyroid-follicular-cell proliferation, possibly by disrupting the movement of small molecules (<1.2 kD) through membrane channels called gap junctions. Numerous tumor promoters and proliferative disease states exhibit inhibited gap-junctional-intercellular communication (GJIC) prior to the induction of cell proliferation, yet the association between GJIC and apoptosis is unclear. In the present study, we used an ex vivo method to examine whether GJIC is inhibited in the thyroid of PTU- or LID-treated rats. In addition, the effect of these models of hypothyroidism on thyroid-follicular-cell proliferation and apoptosis was examined to determine the association between GJIC and cell homeostasis. After 14 days of treatment of either PTU or LID (plus 1% KClO4 in the drinking water), serum tri-iodothyronine (T3) and thyroxine, (T4) was decreased to nearly undetectable levels and serum TSH was increased in PTU- and LID-treated rats. At the same time point, GJIC was decreased 30–35% in PTU- and LID-treated rats while thyroid-follicular-cell proliferation increased nearly threefold in both treatment groups. Interestingly, apoptosis increased twofold in both hypothyroid treatment groups. These data suggest that PTU or LID treatment inhibit thyroid GJIC during a state of increased thyroid-follicular-cell proliferation and apoptosis. While the increase in proliferation was anticipated, the paradoxical increase in apoptosis during decreased GJIC in thyroid-follicular cells warrants further examination.
