The Experts below are selected from a list of 228 Experts worldwide ranked by ideXlab platform
Karl-georg Schmidt - One of the best experts on this subject based on the ideXlab platform.
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Reduced ocular pulse amplitude in Low Tension Glaucoma is independent of vasospasm.
Eye, 1997Co-Authors: Karl-georg Schmidt, Andrea Von Ruckmann, Thomas W. Mittag, V. Hessemer, Lutz E. PillunatAbstract:Purpose: A vascular basis for the pathogenesis of primary open angle Glaucoma has been postulated for many years. Defects in the regulation of ocular blood fLow may be the initiating factor in this group of multifactorial diseases. This study was designed to evaluate the effect of vasospasm on ocular pulse amplitude (OPA) in Low Tension Glaucoma (LTG) patients. Methods: OPA, using the Langham Ocular Blood FLow (OBF) System, applanation intraocular pressure (IOP), systemic blood pressure and heart rate were measured and vasospasm was determined by a fingernail capillary blood fLow test. Results: OPA (mmHg) in the LTG patients with a vasospastic reaction (LTG-V, 1.4 ± 0.1, n= 17) was not significantly (p>0.09) different when compared with non-vasospastic LTG patients (LTG-NV, 1.5 ± 0.2, n= 15) but was significantly (p 0.05) different when compared with each other, but was significantly (p
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Reduced ocular pulse amplitude in Low Tension Glaucoma is independent of vasospasm.
Eye (London England), 1997Co-Authors: Karl-georg Schmidt, Andrea Von Ruckmann, Thomas W. Mittag, V. Hessemer, L E PillunatAbstract:A vascular basis for the pathogenesis of primary open angle Glaucoma has been postulated for many years. Defects in the regulation of ocular blood fLow may be the initiating factor in this group of multifactorial diseases. This study was designed to evaluate the effect of vasospasm on ocular pulse amplitude (OPA) in Low Tension Glaucoma (LTG) patients. OPA, using the Langham Ocular Blood FLow (OBF) System, applanation intraocular pressure (IOP), systemic blood pressure and heart rate were measured and vasospasm was determined by a fingernail capillary blood fLow test. OPA (mmHg) in the LTG patients with a vasospastic reaction (LTG-V, 1.4 +/- 0.1, n = 17) was not significantly (p > 0.09) different when compared with non-vasospastic LTG patients (LTG-NV, 1.5 +/- 0.2, n = 15) but was significantly (p < 0.001) reduced in LTG-V and LTG-NV patients when compared with matched healthy control subgroups (2.3 +/- 0.2 and 2.4 +/- 0.3, respectively). IOP (mmHg) in LTG-V (13.3 +/- 0.4) and LTG-NV (13.2 +/- 0.5) patient groups was not significantly (p > 0.05) different when compared with each other, but was significantly (p < 0.05) Lower when compared with matched control subgroups (15.0 +/- 0.3 and 15.2 +/- 0.4, respectively). Haemodynamic parameters were not significantly different from controls. The abnormality in choroidal perfusion indicated by a reduction in OPA in all LTG patients is unrelated to the presence or absence of vasospasm.
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reduced ocular pulse amplitude in Low Tension Glaucoma is independent of vasospasm
Eye, 1997Co-Authors: Karl-georg Schmidt, Andrea Von Ruckmann, Thomas W. Mittag, V. Hessemer, Lutz E. PillunatAbstract:Purpose: A vascular basis for the pathogenesis of primary open angle Glaucoma has been postulated for many years. Defects in the regulation of ocular blood fLow may be the initiating factor in this group of multifactorial diseases. This study was designed to evaluate the effect of vasospasm on ocular pulse amplitude (OPA) in Low Tension Glaucoma (LTG) patients. Methods: OPA, using the Langham Ocular Blood FLow (OBF) System, applanation intraocular pressure (IOP), systemic blood pressure and heart rate were measured and vasospasm was determined by a fingernail capillary blood fLow test. Results: OPA (mmHg) in the LTG patients with a vasospastic reaction (LTG-V, 1.4 ± 0.1, n= 17) was not significantly (p>0.09) different when compared with non-vasospastic LTG patients (LTG-NV, 1.5 ± 0.2, n= 15) but was significantly (p 0.05) different when compared with each other, but was significantly (p<0.05) Lower when compared with matched control subgroups (15.0 ± 0.3 and 15.2 ± 0.4, respectively). Haemodynamic parameters were not significantly different from controls. Conclusion: The abnormality in choroidal perfusion indicated by a reduction in OPA in all LTG patients is unrelated to the presence or absence of vasospasm.
Markku Teräsvirta - One of the best experts on this subject based on the ideXlab platform.
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Co-existence of empty sella syndrome and Low Tension Glaucoma.
Acta Ophthalmologica, 2009Co-Authors: Harri Rouhiainen, Markku TeräsvirtaAbstract:Abstract In 15 Low-Tension Glaucoma patients computed tomography of the head was re-evaluated in order to find the possible empty-sella syndrome. Fourteen CT-scans were normal, and empty sella was found in one patient with progressive Low Tension Glaucoma. The possible role of empty sella syndrome in Glaucomatous visual field defects is discussed.
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hemodynamic variables in progressive and non progressive Low Tension Glaucoma
Acta Ophthalmologica, 2009Co-Authors: Harri Rouhiainen, Markku TeräsvirtaAbstract:Abstract. Systemic blood pressure and medications for different general diseases were retrospectively examined in 30 Low-Tension Glaucoma patients. Thirty patients with POAG were used as controls. LTG was divided into a progressive and non-progressive form on basis of the course of the disease. Systemic blood pressure was higher in POAG and the progressive form of LTG than in the nonprogressive LTG. There was twice as much antihypertensive medication in LTG than POAG patients.
Vikas Chopra - One of the best experts on this subject based on the ideXlab platform.
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Comparison and Correlation of Retinal Sensitivity between Microperimetry and Standard Automated Perimetry in Low-Tension Glaucoma.
Journal of Glaucoma, 2020Co-Authors: Tudor Tepelus, Sheena Song, Muneeswar Gupta Nittala, Srinivas R Sadda, Marco Nassisi, Vikas ChopraAbstract:PReCIS:: Our study demonstrated that in Low-Tension Glaucoma patients, MP3- and HFA- derived retinal sensitivities were similar and strongly correlated, alLowing the respective data to be interrelated. PURPOSE To compare and correlate retinal sensitivities obtained by Nidek Microperimetry-3 (MP-3) with those obtained from the Humphrey Field Analyzer (HFA) in eyes with Low-Tension Glaucoma (LTG). METHODS In this prospective comparative study, 45 eyes of 24 LTG patients underwent retinal sensitivity assessments using the MP-3 (Nidek Technologies) and the HFA (Carl Zeiss Meditec) at the UCLA-Doheny Eye Center. Global and pointwise retinal sensitivity measurements were compared and correlated between the two devices. RESULTS No statistically significant differences (P=0.85) were noted between the mean retinal sensitivities determined by each device (MP-3: 26.33±4.31▒dB; range 13.05-31.60 vs. HFA: 26.42±3.98▒dB; range 17.17-30.96), and a strong correlation (r=0.66, P < 0.001) was noted for retinal sensitivity measurements. In addition, moderate to strong correlations were observed between the mean retinal sensitivity derived by MP3 versus HFA-derived mean deviation (MD, r=0.57, P
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comparison and correlation of retinal sensitivity between microperimetry and standard automated perimetry in Low Tension Glaucoma
Journal of Glaucoma, 2020Co-Authors: Tudor Tepelus, Sheena Song, Muneeswar Gupta Nittala, Srinivas R Sadda, Marco Nassisi, Vikas ChopraAbstract:PReCIS:: Our study demonstrated that in Low-Tension Glaucoma patients, MP3- and HFA- derived retinal sensitivities were similar and strongly correlated, alLowing the respective data to be interrelated. PURPOSE To compare and correlate retinal sensitivities obtained by Nidek Microperimetry-3 (MP-3) with those obtained from the Humphrey Field Analyzer (HFA) in eyes with Low-Tension Glaucoma (LTG). METHODS In this prospective comparative study, 45 eyes of 24 LTG patients underwent retinal sensitivity assessments using the MP-3 (Nidek Technologies) and the HFA (Carl Zeiss Meditec) at the UCLA-Doheny Eye Center. Global and pointwise retinal sensitivity measurements were compared and correlated between the two devices. RESULTS No statistically significant differences (P=0.85) were noted between the mean retinal sensitivities determined by each device (MP-3: 26.33±4.31▒dB; range 13.05-31.60 vs. HFA: 26.42±3.98▒dB; range 17.17-30.96), and a strong correlation (r=0.66, P < 0.001) was noted for retinal sensitivity measurements. In addition, moderate to strong correlations were observed between the mean retinal sensitivity derived by MP3 versus HFA-derived mean deviation (MD, r=0.57, P<0.001), as well as, the pattern standard deviation (PSD, r=0.67, P<0.001). The intraclass correlation coefficient was excellent (ICC=0.80, 95% CI 0.63 to 0.89), while the Bland-Altman analysis showed good agreement between the two devices with respect to retinal sensitivity. CONCLUSION Retinal sensitivity measurements obtained by the MP-3 microperimetry instrument and the standard automated HFA perimeter were similar and highly correlated in patients with Low Tension Glaucoma. Given the potential benefits of microperimetry technology such as auto-eye-tracking and potentially more precise structure-function correlations, the use of microperimetry to monitor visual function in Glaucoma management warrants further consideration.
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quantitative analysis of retinal and choroidal vascular parameters in patients with Low Tension Glaucoma
Journal of Glaucoma, 2019Co-Authors: Tudor Tepelus, Sheena Song, Enrico Borrelli, Muneeswar Gupta Nittala, Elmira Baghdasaryan, Srinivas R Sadda, Vikas ChopraAbstract:PReCIS:: By using OCT-A, we observed a reduction of the superficial macular, peripapillary, and optic nerve, as well as the choriocapillaris in eyes with Low Tension Glaucoma, compared with normal controls. PURPOSE The purpose of this study was to investigate macular and optic disc vascular parameters in patients with Low Tension Glaucoma (LTG) using optical coherence tomography angiography (OCTA). METHODS In this cross-sectional study, images were prospectively acquired from both eyes of 26 patients with clinically diagnosed LTG and 22 age-matched volunteers with normal healthy eyes using the Zeiss swept-source (SS) OCTA (Plex Elite 9000, Carl Zeiss Meditec). Perfusion density (PD) and vessel length density (VLD) within a 5 mm diameter circle centered over the macula and optic nerve head were analyzed. RESULTS The final analysis cohort included 49 eyes with LTG and 40 healthy control eyes. Mean age was 60±10 years in the LTG group and 60±17 years in the control group. The LTG group had a statistically significant reduction in PD of the choriocapillaris (CC) compared with normal controls (71.74±8.37% vs. 80.48±3.84%; P 0.05). The LTG group did show statistically significant reductions in VLD compared with normal controls for the SVP (2083.64±153.76 mm/mm vs. 2154.63±144.18 mm/mm; P=0.03) and ONH + PP (1813.76±271.69 mm/mm vs. 1950.23±169.33 mm/mm; P=0.03), whereas the DCP VD was similar between the 2 groups (P>0.05). CONCLUSIONS Eyes with Low Tension Glaucoma seems to show a Lower CC perfusion density, as well as a Lower SVP and ONH+PP vessel length density compared to normal eyes.
Lutz E. Pillunat - One of the best experts on this subject based on the ideXlab platform.
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Reduced ocular pulse amplitude in Low Tension Glaucoma is independent of vasospasm.
Eye, 1997Co-Authors: Karl-georg Schmidt, Andrea Von Ruckmann, Thomas W. Mittag, V. Hessemer, Lutz E. PillunatAbstract:Purpose: A vascular basis for the pathogenesis of primary open angle Glaucoma has been postulated for many years. Defects in the regulation of ocular blood fLow may be the initiating factor in this group of multifactorial diseases. This study was designed to evaluate the effect of vasospasm on ocular pulse amplitude (OPA) in Low Tension Glaucoma (LTG) patients. Methods: OPA, using the Langham Ocular Blood FLow (OBF) System, applanation intraocular pressure (IOP), systemic blood pressure and heart rate were measured and vasospasm was determined by a fingernail capillary blood fLow test. Results: OPA (mmHg) in the LTG patients with a vasospastic reaction (LTG-V, 1.4 ± 0.1, n= 17) was not significantly (p>0.09) different when compared with non-vasospastic LTG patients (LTG-NV, 1.5 ± 0.2, n= 15) but was significantly (p 0.05) different when compared with each other, but was significantly (p
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reduced ocular pulse amplitude in Low Tension Glaucoma is independent of vasospasm
Eye, 1997Co-Authors: Karl-georg Schmidt, Andrea Von Ruckmann, Thomas W. Mittag, V. Hessemer, Lutz E. PillunatAbstract:Purpose: A vascular basis for the pathogenesis of primary open angle Glaucoma has been postulated for many years. Defects in the regulation of ocular blood fLow may be the initiating factor in this group of multifactorial diseases. This study was designed to evaluate the effect of vasospasm on ocular pulse amplitude (OPA) in Low Tension Glaucoma (LTG) patients. Methods: OPA, using the Langham Ocular Blood FLow (OBF) System, applanation intraocular pressure (IOP), systemic blood pressure and heart rate were measured and vasospasm was determined by a fingernail capillary blood fLow test. Results: OPA (mmHg) in the LTG patients with a vasospastic reaction (LTG-V, 1.4 ± 0.1, n= 17) was not significantly (p>0.09) different when compared with non-vasospastic LTG patients (LTG-NV, 1.5 ± 0.2, n= 15) but was significantly (p 0.05) different when compared with each other, but was significantly (p<0.05) Lower when compared with matched control subgroups (15.0 ± 0.3 and 15.2 ± 0.4, respectively). Haemodynamic parameters were not significantly different from controls. Conclusion: The abnormality in choroidal perfusion indicated by a reduction in OPA in all LTG patients is unrelated to the presence or absence of vasospasm.
Peter Aspinall - One of the best experts on this subject based on the ideXlab platform.
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measurement of ocular blood fLow velocity using colour doppler imaging in Low Tension Glaucoma
Eye, 1995Co-Authors: Z Butt, G Mckillop, Colm Obrien, Paul Allan, Peter AspinallAbstract:Measurement of ocular blood fLow velocity using colour doppler imaging in Low Tension Glaucoma
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Measurement of ocular blood fLow velocity using colour doppler imaging in Low Tension Glaucoma
Eye, 1995Co-Authors: Z Butt, G Mckillop, Paul Allan, Colm O'brien, Peter AspinallAbstract:The purpose of this study was to compare the velocity of blood fLow and vascular resistance measured by colour Doppler imaging in the ophthalmic and central retinal arteries in 34 eyes of 34 patients (mean age 68.1 years) with Low Tension Glaucoma (LTG) and 17 eyes of 17 agematched normal controls (mean age 65.2 years). The Acuson 128 machine (using a 7.5 MHz probe) was used to measure peak systolic velocity (PSV), end-diastolic velocity (EDV) and resistive index (RI). The EDV of the ophthalmic artery (OA) in the LTG was significantly (p = 0.04) less than in the normal control group. There was a significant ( p = 0.02) increase in the vascular RI of both the OA and central retinal artery in the LTG group compared with the normal controls. The OA RI increased with age ( r = 0.61, p = 0.0001), and the OA EDV decreased with age (r = −0.50, p = 0.003), in the LTG group but not in the normal control group. The results suggest an increased resistance to blood fLow in the ophthalmic and central retinal arteries of LTG patients.
