The Experts below are selected from a list of 303 Experts worldwide ranked by ideXlab platform
Delcio Matos - One of the best experts on this subject based on the ideXlab platform.
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Intravenous versus inhalation anaesthesia for one-Lung ventilation.
The Cochrane database of systematic reviews, 2008Co-Authors: Adriana Bassi, Wilson Roberto Oliveira Milani, Delcio MatosAbstract:The technique called one-Lung ventilation can confine bleeding or infection to one Lung, prevent rupture of a Lung Cyst or, more commonly, facilitate surgical exposure of the unventilated Lung. During one-Lung ventilation, anaesthesia is maintained either by delivering a volatile anaesthetic to the ventilated Lung or by infusing an intravenous anaesthetic. It is possible that the method chosen to maintain anaesthesia may affect patient outcomes. The objective of this review was to evaluate the effectiveness and safety of intravenous versus inhalation anaesthesia for one-Lung ventilation. We searched the Cochrane Central Register of Controlled Trials (CENTRAL) (The Cochrane Library 2006, Issue 3), MEDLINE, LILACS, EMBASE (from inception to June 2006), ISI web of Science (1945 to June 2006), reference lists of identified trials, and bibliographies of published reviews. We also contacted researchers in the field. There were no language restrictions. We included randomized controlled trials and quasi-randomized controlled trials of intravenous versus inhalation anaesthesia for one-Lung ventilation. Two authors independently assessed trial quality and extracted data. We contacted study authors for additional information. We included nine studies that enrolled 291 participants. We could not perform meta-analyses as the included studies did not report the outcomes listed in the protocol for this review. There is no evidence from randomized controlled trials of differences in patient outcomes for anaesthesia maintained by intravenous versus inhalational anaesthesia during one-Lung ventilation. This review highlights the need for continued research into the use of intravenous versus inhalation anaesthesia for one-Lung ventilation. Future trials should have standardized outcome measures such as death, adverse postoperative outcomes and intraoperative awareness. Dropouts and losses to follow up should be reported.
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Intravenous versus inhalation anaesthesia for one-Lung ventilation
Cochrane Database of Systematic Reviews, 2008Co-Authors: Adriana Bassi, Wilson Roberto Oliveira Milani, Delcio MatosAbstract:Background the technique called one-Lung ventilation can confine bleeding or infection to one Lung, prevent rupture of a Lung Cyst or, more commonly, facilitate surgical exposure of the unventilated Lung. During one- Lung ventilation, anaesthesia is maintained either by delivering a volatile anaesthetic to the ventilated Lung or by infusing an intravenous anaesthetic. It is possible that the method chosen to maintain anaesthesia may affect patient outcomes.Objectives the objective of this review was to evaluate the effectiveness and safety of intravenous versus inhalation anaesthesia for one- Lung ventilation.Search strategy We searched the Cochrane Central Register of Controlled Trials (CENTRAL) ( the Cochrane Library 2006, Issue 3), MEDLINE, LILACS, EMBASE ( from inception to June 2006), ISI web of Science ( 1945 to June 2006), reference lists of identified trials, and bibliographies of published reviews. We also contacted researchers in the field. There were no language restrictions.Selection criteria We included randomized controlled trials and quasi- randomized controlled trials of intravenous versus inhalation anaesthesia for one-Lung ventilation.Data collection and analysis Two authors independently assessed trial quality and extracted data. We contacted study authors for additional information.Main results We included nine studies that enrolled 291 participants. We could not perform meta-analyses as the included studies did not report the outcomes listed in the protocol for this review.Authors' conclusions There is no evidence from randomized controlled trials of differences in patient outcomes for anaesthesia maintained by intravenous versus inhalational anaesthesia during one- Lung ventilation. This review highlights the need for continued research into the use of intravenous versus inhalation anaesthesia for one- Lung ventilation. Future trials should have standardized outcome measures such as death, adverse postoperative outcomes and intraoperative awareness. Dropouts and losses to follow up should be reported.Hosp Sirio Libanes, Dept Anesthesiol, BR-05011040 São Paulo, BrazilMcMaster Univ, Toronto, ON, CanadaUniversidade Federal de São Paulo, Brazilian Cochrane Ctr, São Paulo, BrazilUniversidade Federal de São Paulo, Brazilian Cochrane Ctr, São Paulo, BrazilWeb of Scienc
Adriana Bassi - One of the best experts on this subject based on the ideXlab platform.
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Intravenous versus inhalation anaesthesia for one-Lung ventilation.
The Cochrane database of systematic reviews, 2008Co-Authors: Adriana Bassi, Wilson Roberto Oliveira Milani, Delcio MatosAbstract:The technique called one-Lung ventilation can confine bleeding or infection to one Lung, prevent rupture of a Lung Cyst or, more commonly, facilitate surgical exposure of the unventilated Lung. During one-Lung ventilation, anaesthesia is maintained either by delivering a volatile anaesthetic to the ventilated Lung or by infusing an intravenous anaesthetic. It is possible that the method chosen to maintain anaesthesia may affect patient outcomes. The objective of this review was to evaluate the effectiveness and safety of intravenous versus inhalation anaesthesia for one-Lung ventilation. We searched the Cochrane Central Register of Controlled Trials (CENTRAL) (The Cochrane Library 2006, Issue 3), MEDLINE, LILACS, EMBASE (from inception to June 2006), ISI web of Science (1945 to June 2006), reference lists of identified trials, and bibliographies of published reviews. We also contacted researchers in the field. There were no language restrictions. We included randomized controlled trials and quasi-randomized controlled trials of intravenous versus inhalation anaesthesia for one-Lung ventilation. Two authors independently assessed trial quality and extracted data. We contacted study authors for additional information. We included nine studies that enrolled 291 participants. We could not perform meta-analyses as the included studies did not report the outcomes listed in the protocol for this review. There is no evidence from randomized controlled trials of differences in patient outcomes for anaesthesia maintained by intravenous versus inhalational anaesthesia during one-Lung ventilation. This review highlights the need for continued research into the use of intravenous versus inhalation anaesthesia for one-Lung ventilation. Future trials should have standardized outcome measures such as death, adverse postoperative outcomes and intraoperative awareness. Dropouts and losses to follow up should be reported.
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Intravenous versus inhalation anaesthesia for one-Lung ventilation
Cochrane Database of Systematic Reviews, 2008Co-Authors: Adriana Bassi, Wilson Roberto Oliveira Milani, Delcio MatosAbstract:Background the technique called one-Lung ventilation can confine bleeding or infection to one Lung, prevent rupture of a Lung Cyst or, more commonly, facilitate surgical exposure of the unventilated Lung. During one- Lung ventilation, anaesthesia is maintained either by delivering a volatile anaesthetic to the ventilated Lung or by infusing an intravenous anaesthetic. It is possible that the method chosen to maintain anaesthesia may affect patient outcomes.Objectives the objective of this review was to evaluate the effectiveness and safety of intravenous versus inhalation anaesthesia for one- Lung ventilation.Search strategy We searched the Cochrane Central Register of Controlled Trials (CENTRAL) ( the Cochrane Library 2006, Issue 3), MEDLINE, LILACS, EMBASE ( from inception to June 2006), ISI web of Science ( 1945 to June 2006), reference lists of identified trials, and bibliographies of published reviews. We also contacted researchers in the field. There were no language restrictions.Selection criteria We included randomized controlled trials and quasi- randomized controlled trials of intravenous versus inhalation anaesthesia for one-Lung ventilation.Data collection and analysis Two authors independently assessed trial quality and extracted data. We contacted study authors for additional information.Main results We included nine studies that enrolled 291 participants. We could not perform meta-analyses as the included studies did not report the outcomes listed in the protocol for this review.Authors' conclusions There is no evidence from randomized controlled trials of differences in patient outcomes for anaesthesia maintained by intravenous versus inhalational anaesthesia during one- Lung ventilation. This review highlights the need for continued research into the use of intravenous versus inhalation anaesthesia for one- Lung ventilation. Future trials should have standardized outcome measures such as death, adverse postoperative outcomes and intraoperative awareness. Dropouts and losses to follow up should be reported.Hosp Sirio Libanes, Dept Anesthesiol, BR-05011040 São Paulo, BrazilMcMaster Univ, Toronto, ON, CanadaUniversidade Federal de São Paulo, Brazilian Cochrane Ctr, São Paulo, BrazilUniversidade Federal de São Paulo, Brazilian Cochrane Ctr, São Paulo, BrazilWeb of Scienc
Tina Dalianis - One of the best experts on this subject based on the ideXlab platform.
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No association between Birt-Hogg-Dubé syndrome skin fibrofolliculomas and the first 10 described human polyomaviruses or human papillomaviruses.
Virology, 2014Co-Authors: Maria Bradley, Cecilia Nordfors, Andrea Vlastos, Giovanni Ferrara, Torbjörn Ramqvist, Tina DalianisAbstract:The rare autosomal dominant condition Birt-Hogg-Dubé syndrome (BHD) is attributed to mutations on chromosome 17 in the folliculin (FLCN) gene, but not always diagnosed due to lack of, or a variety of symptoms such as fibrofolliculomas, Lung Cystic lesions, spontaneous pneumothorax and renal cancer. We hypothesized that the lack of or variability in symptoms could be due to BHD patients potentially being abnormally susceptible to infections with human papillomavirus (HPV) or human polyomavirus (HPyV), which can be associated with skin lesions or latency in the kidneys. Seven fibrofolliculoma skin lesions, one renal cancer and one Lung Cyst from nine patients with BHD treated at the Karolinska University Hospital were therefore analyzed for cutaneous and mucosal HPV types and 10 HPyVs by bead based multiplex assays or by PCR. All samples were negative for viral DNA. In conclusion, the data suggest that HPV and HPyVs do not contribute to BHD pathology.
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No association between Birt-Hogg-Dubé syndrome skin fibrofolliculomas and the first 10 described human polyomaviruses or human papillomaviruses
Virology, 2014Co-Authors: Maria Bradley, Cecilia Nordfors, Andrea Vlastos, Giovanni Ferrara, Torbjörn Ramqvist, Tina DalianisAbstract:The rare autosomal dominant condition Birt–Hogg–Dube syndrome (BHD) is attributed to mutations on chromosome 17 in the folliculin (FLCN) gene, but not always diagnosed due to lack of, or a variety of symptoms such as fibrofolliculomas, Lung Cystic lesions, spontaneous pneumothorax and renal cancer. We hypothesized that the lack of or variability in symptoms could be due to BHD patients potentially being abnormally susceptible to infections with human papillomavirus (HPV) or human polyomavirus (HPyV), which can be associated with skin lesions or latency in the kidneys. Seven fibrofolliculoma skin lesions, one renal cancer and one Lung Cyst from nine patients with BHD treated at the Karolinska University Hospital were therefore analyzed for cutaneous and mucosal HPV types and 10 HPyVs by bead based multiplex assays or by PCR. All samples were negative for viral DNA. In conclusion, the data suggest that HPV and HPyVs do not contribute to BHD pathology
B Matthew - One of the best experts on this subject based on the ideXlab platform.
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Ultra-Small Lung Cysts Impair Diffusion Without Obstructing Air Flow in Lymphangioleiomyomatosis
Chest, 2021Co-Authors: B Matthew, A Hasani, Yunching Chen, Mehdi Pirooznia, Mario Stylianou, Shirley F Rollison, T Machado, Nora M Quade, Amanda M Jones, Patricia Julien-williamsAbstract:BACKGROUND Lymphangioleiomyomatosis (LAM) is a rare Lung disease found primarily in women of childbearing age, characterized by the formation of air-filled Cysts, which may be associated with reductions in Lung function. An experimental, regional ultra-high resolution CT scan identified an additional volume of Cysts relative to standard chest CT imaging, which consisted primarily of ultra-small Cysts. RESEARCH QUESTION What is the impact of these ultra-small Cysts on the pulmonary function of patients with LAM? STUDY DESIGN AND METHODS A group of 103 patients with LAM received pulmonary function tests and a CT examination in the same visit. Cyst score, the percentage Lung volume occupied by Cysts, was measured by using commercial software approved by the US Food and Drug Administration. The association between Cyst scores and pulmonary function tests of diffusing capacity of the Lungs for carbon monoxide (Dlco) (% predicted), FEV1 (% predicted), and FEV1/FVC (% predicted) was assessed with statistical analysis adjusted for demographic variables. The distributions of average Cyst size and ultra-small Cyst fraction among the patients were evaluated. RESULTS The additional Cyst volume identified by the experimental, higher resolution scan consisted of Cysts of 2.2 ± 0.8 mm diameter on average and are thus labeled the "ultra-small Cyst fraction." It accounted for 27.9 ± 19.0% of the total Cyst volume among the patients. The resulting adjusted, whole-Lung Cyst scores better explained the variance of Dlco (P < .001 adjusted for multiple comparisons) but not FEV1 and FEV1/FVC (P ≈ 1.000). The ultra-small Cyst fraction contributed to the reduction in Dlco (P < .001) but not to FEV1 and FEV1/FVC (P = .760 and .575, respectively). The ultra-small Cyst fraction and average Cyst size were correlated with Cyst burden, FEV1, and FEV1/FVC but less with Dlco. INTERPRETATION The ultra-small Cysts primarily contributed to the reduction in Dlco, with minimal effects on FEV1 and FEV1/FVC. Patients with lower Cyst burden and better FEV1 and FEV1/FVC tended to have smaller average Cyst size and higher ultra-small Cyst fraction. CLINICAL TRIAL REGISTRATION ClinicalTrials.gov; No.: NCT00001465; URL: www.clinicaltrials.govclinicaltrials.gov.
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ultra small Lung Cysts impair diffusion without obstructing air flow in lymphangioleiomyomatosis
Chest, 2021Co-Authors: B Matthew, A Hasani, Yunching Chen, Mehdi Pirooznia, Mario Stylianou, Shirley F Rollison, T Machado, Nora M Quade, Amanda M Jones, Patricia JulienwilliamsAbstract:Abstract Background Lymphangioleiomyomatosis (LAM) is a rare Lung disease found primarily in women of childbearing age, characterized by the formation of air-filled Cysts, which may be associated with reductions in Lung function. An experimental, regional, ultra-high resolution CT identified an additional volume of Cysts relative to standard chest CT, which consisted primarily of ultra-small Cysts. Research Question What is the impact of these ultra-small Cysts on the pulmonary function of LAM patients? Study Design and Methods: A group of 103 LAM patients received pulmonary function tests and a CT exam in the same visit. Cyst score, the percentage Lung volume occupied by Cysts, was measured using an FDA-approved commercial software. The association between Cyst scores and pulmonary function tests of DLco(%predicted), FEV1(%predicted) and FEV1/FVC(%predicted) was assessed with statistical analysis adjusted for demographic variables. The distributions of average Cyst size and ultra-small Cyst fraction among the patients were evaluated. Results The additional Cyst volume identified by the experimental, higher resolution scan consisted of Cysts of 2.2±0.8 mm diameter on average, and thus called the “ultra-small Cyst fraction”. It accounted for 27.9±19.0% of the total Cyst volume among the patients. The resulting adjusted, whole-Lung Cyst scores better explained the variance of DLco (p
Wilson Roberto Oliveira Milani - One of the best experts on this subject based on the ideXlab platform.
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Intravenous versus inhalation anaesthesia for one-Lung ventilation.
The Cochrane database of systematic reviews, 2008Co-Authors: Adriana Bassi, Wilson Roberto Oliveira Milani, Delcio MatosAbstract:The technique called one-Lung ventilation can confine bleeding or infection to one Lung, prevent rupture of a Lung Cyst or, more commonly, facilitate surgical exposure of the unventilated Lung. During one-Lung ventilation, anaesthesia is maintained either by delivering a volatile anaesthetic to the ventilated Lung or by infusing an intravenous anaesthetic. It is possible that the method chosen to maintain anaesthesia may affect patient outcomes. The objective of this review was to evaluate the effectiveness and safety of intravenous versus inhalation anaesthesia for one-Lung ventilation. We searched the Cochrane Central Register of Controlled Trials (CENTRAL) (The Cochrane Library 2006, Issue 3), MEDLINE, LILACS, EMBASE (from inception to June 2006), ISI web of Science (1945 to June 2006), reference lists of identified trials, and bibliographies of published reviews. We also contacted researchers in the field. There were no language restrictions. We included randomized controlled trials and quasi-randomized controlled trials of intravenous versus inhalation anaesthesia for one-Lung ventilation. Two authors independently assessed trial quality and extracted data. We contacted study authors for additional information. We included nine studies that enrolled 291 participants. We could not perform meta-analyses as the included studies did not report the outcomes listed in the protocol for this review. There is no evidence from randomized controlled trials of differences in patient outcomes for anaesthesia maintained by intravenous versus inhalational anaesthesia during one-Lung ventilation. This review highlights the need for continued research into the use of intravenous versus inhalation anaesthesia for one-Lung ventilation. Future trials should have standardized outcome measures such as death, adverse postoperative outcomes and intraoperative awareness. Dropouts and losses to follow up should be reported.
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Intravenous versus inhalation anaesthesia for one-Lung ventilation
Cochrane Database of Systematic Reviews, 2008Co-Authors: Adriana Bassi, Wilson Roberto Oliveira Milani, Delcio MatosAbstract:Background the technique called one-Lung ventilation can confine bleeding or infection to one Lung, prevent rupture of a Lung Cyst or, more commonly, facilitate surgical exposure of the unventilated Lung. During one- Lung ventilation, anaesthesia is maintained either by delivering a volatile anaesthetic to the ventilated Lung or by infusing an intravenous anaesthetic. It is possible that the method chosen to maintain anaesthesia may affect patient outcomes.Objectives the objective of this review was to evaluate the effectiveness and safety of intravenous versus inhalation anaesthesia for one- Lung ventilation.Search strategy We searched the Cochrane Central Register of Controlled Trials (CENTRAL) ( the Cochrane Library 2006, Issue 3), MEDLINE, LILACS, EMBASE ( from inception to June 2006), ISI web of Science ( 1945 to June 2006), reference lists of identified trials, and bibliographies of published reviews. We also contacted researchers in the field. There were no language restrictions.Selection criteria We included randomized controlled trials and quasi- randomized controlled trials of intravenous versus inhalation anaesthesia for one-Lung ventilation.Data collection and analysis Two authors independently assessed trial quality and extracted data. We contacted study authors for additional information.Main results We included nine studies that enrolled 291 participants. We could not perform meta-analyses as the included studies did not report the outcomes listed in the protocol for this review.Authors' conclusions There is no evidence from randomized controlled trials of differences in patient outcomes for anaesthesia maintained by intravenous versus inhalational anaesthesia during one- Lung ventilation. This review highlights the need for continued research into the use of intravenous versus inhalation anaesthesia for one- Lung ventilation. Future trials should have standardized outcome measures such as death, adverse postoperative outcomes and intraoperative awareness. Dropouts and losses to follow up should be reported.Hosp Sirio Libanes, Dept Anesthesiol, BR-05011040 São Paulo, BrazilMcMaster Univ, Toronto, ON, CanadaUniversidade Federal de São Paulo, Brazilian Cochrane Ctr, São Paulo, BrazilUniversidade Federal de São Paulo, Brazilian Cochrane Ctr, São Paulo, BrazilWeb of Scienc
