The Experts below are selected from a list of 126 Experts worldwide ranked by ideXlab platform
A Goldman - One of the best experts on this subject based on the ideXlab platform.
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Open Lung biopsy in neonatal and paediatric patients referred for extracorporeal membrane oxygenation (ECMO)
Thorax, 2004Co-Authors: David Inwald, K Brown, F Gensini, M Malone, A GoldmanAbstract:This study was undertaken to determine the usefulness, safety, and most appropriate timing of open Lung biopsy in infants and children considered for and on extracorporeal membrane oxygenation (ECMO) for respiratory failure. A retrospective review of children referred for consideration of and placed on ECMO in our institution in the period 1996-2002. 506 patients were referred, 15 (3%) of whom underwent antemortem open Lung biopsy (eight neonatal, four paediatric, and three cardiac patients). In the neonatal group open Lung biopsy contributed to clinical decision making in all patients. Four neonates had a fatal Lung Dysplasia (three alveolar capillary Dysplasia and one surfactant protein B deficiency) and treatment was withdrawn. Of the other four neonates, two had pulmonary hypoplasia, one had pulmonary lymphangiectasia, and one had meconium aspiration with mild barotrauma. Treatment was continued in these four patients and two survived. In the paediatric group the biopsies were of clinical relevance in two infants with pertussis who had Lung infarction on biopsy in whom treatment was withdrawn. In the other two paediatric patients the biopsies were equivocal, treatment was continued, but both patients died. In the cardiac group, who presented perioperatively with pulmonary hypertension, the biopsies excluded a fatal Lung Dysplasia and severe pulmonary vascular disease but all three infants died. One patient had non-fatal bleeding complications. Open Lung biopsy is clinically most useful when performed to diagnose fatal Lung Dysplasias in neonates and to confirm the presence of viable Lung tissue in patients with acute Lung injury due to pertussis infection.
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Open Lung biopsy in neonatal and paediatric patients referred for extracorporeal membrane oxygenation (ECMO)
Thorax, 2004Co-Authors: David Inwald, F Gensini, M Malone, Katherine L. Brown, A GoldmanAbstract:Background: This study was undertaken to determine the usefulness, safety, and most appropriate timing of open Lung biopsy in infants and children considered for and on extracorporeal membrane oxygenation (ECMO) for respiratory failure. Methods: A retrospective review of children referred for consideration of and placed on ECMO in our institution in the period 1996–2002. Results: 506 patients were referred, 15 (3%) of whom underwent antemortem open Lung biopsy (eight neonatal, four paediatric, and three cardiac patients). In the neonatal group open Lung biopsy contributed to clinical decision making in all patients. Four neonates had a fatal Lung Dysplasia (three alveolar capillary Dysplasia and one surfactant protein B deficiency) and treatment was withdrawn. Of the other four neonates, two had pulmonary hypoplasia, one had pulmonary lymphangiectasia, and one had meconium aspiration with mild barotrauma. Treatment was continued in these four patients and two survived. In the paediatric group the biopsies were of clinical relevance in two infants with pertussis who had Lung infarction on biopsy in whom treatment was withdrawn. In the other two paediatric patients the biopsies were equivocal, treatment was continued, but both patients died. In the cardiac group, who presented perioperatively with pulmonary hypertension, the biopsies excluded a fatal Lung Dysplasia and severe pulmonary vascular disease but all three infants died. One patient had non-fatal bleeding complications. Conclusion: Open Lung biopsy is clinically most useful when performed to diagnose fatal Lung Dysplasias in neonates and to confirm the presence of viable Lung tissue in patients with acute Lung injury due to pertussis infection.
David Inwald - One of the best experts on this subject based on the ideXlab platform.
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Open Lung biopsy in neonatal and paediatric patients referred for extracorporeal membrane oxygenation (ECMO)
Thorax, 2004Co-Authors: David Inwald, K Brown, F Gensini, M Malone, A GoldmanAbstract:This study was undertaken to determine the usefulness, safety, and most appropriate timing of open Lung biopsy in infants and children considered for and on extracorporeal membrane oxygenation (ECMO) for respiratory failure. A retrospective review of children referred for consideration of and placed on ECMO in our institution in the period 1996-2002. 506 patients were referred, 15 (3%) of whom underwent antemortem open Lung biopsy (eight neonatal, four paediatric, and three cardiac patients). In the neonatal group open Lung biopsy contributed to clinical decision making in all patients. Four neonates had a fatal Lung Dysplasia (three alveolar capillary Dysplasia and one surfactant protein B deficiency) and treatment was withdrawn. Of the other four neonates, two had pulmonary hypoplasia, one had pulmonary lymphangiectasia, and one had meconium aspiration with mild barotrauma. Treatment was continued in these four patients and two survived. In the paediatric group the biopsies were of clinical relevance in two infants with pertussis who had Lung infarction on biopsy in whom treatment was withdrawn. In the other two paediatric patients the biopsies were equivocal, treatment was continued, but both patients died. In the cardiac group, who presented perioperatively with pulmonary hypertension, the biopsies excluded a fatal Lung Dysplasia and severe pulmonary vascular disease but all three infants died. One patient had non-fatal bleeding complications. Open Lung biopsy is clinically most useful when performed to diagnose fatal Lung Dysplasias in neonates and to confirm the presence of viable Lung tissue in patients with acute Lung injury due to pertussis infection.
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Open Lung biopsy in neonatal and paediatric patients referred for extracorporeal membrane oxygenation (ECMO)
Thorax, 2004Co-Authors: David Inwald, F Gensini, M Malone, Katherine L. Brown, A GoldmanAbstract:Background: This study was undertaken to determine the usefulness, safety, and most appropriate timing of open Lung biopsy in infants and children considered for and on extracorporeal membrane oxygenation (ECMO) for respiratory failure. Methods: A retrospective review of children referred for consideration of and placed on ECMO in our institution in the period 1996–2002. Results: 506 patients were referred, 15 (3%) of whom underwent antemortem open Lung biopsy (eight neonatal, four paediatric, and three cardiac patients). In the neonatal group open Lung biopsy contributed to clinical decision making in all patients. Four neonates had a fatal Lung Dysplasia (three alveolar capillary Dysplasia and one surfactant protein B deficiency) and treatment was withdrawn. Of the other four neonates, two had pulmonary hypoplasia, one had pulmonary lymphangiectasia, and one had meconium aspiration with mild barotrauma. Treatment was continued in these four patients and two survived. In the paediatric group the biopsies were of clinical relevance in two infants with pertussis who had Lung infarction on biopsy in whom treatment was withdrawn. In the other two paediatric patients the biopsies were equivocal, treatment was continued, but both patients died. In the cardiac group, who presented perioperatively with pulmonary hypertension, the biopsies excluded a fatal Lung Dysplasia and severe pulmonary vascular disease but all three infants died. One patient had non-fatal bleeding complications. Conclusion: Open Lung biopsy is clinically most useful when performed to diagnose fatal Lung Dysplasias in neonates and to confirm the presence of viable Lung tissue in patients with acute Lung injury due to pertussis infection.
Virender K. Rehan - One of the best experts on this subject based on the ideXlab platform.
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Effect of electroacupuncture at "Zusanli" (ST 36) and "Yanglingquan" (GB 34) on perinatal nicotine-exposure-induced Lung function and morphology of neonatal rats
Zhongguo zhen jiu = Chinese acupuncture & moxibustion, 2019Co-Authors: Guozhen Zhao, Yitian Liu, Jian Dai, Dan Wang, Sakurai Reiko, Virender K. RehanAbstract:OBJECTIVE To compare the effects of electroacupuncture (EA) at "Zusanli" (ST 36) versus "Yanglingquan" (GB 34) in the pregnant rats on perinatal nicotine-exposure-induced Lung function and morphology of newborn rats and explore the rule of acupoint effect in EA for the prevention from Lung Dysplasia in newborn rats. METHODS A total of 24 female SD rats were randomized into a normal saline group (S group), a nicotine group (N group), a nicotine-ST 36 group (N + ST 36 group) and a nicotine-GB 34 group (N+GB 34 group), 6 rats in each one. Starting at the 6th day of pregnancy, 0.9% sodium chloride solution was injected subcutaneously in the S group, 1 mg/kg; and in the rest 3 groups, nicotine of the same dose was injected through to the 21st postnatal day to establish the perinatal nicotine-exposure model. Simultaneously, during model preparation, EA was applied at "Zusanli" (ST 36) and "Yanglingquan" (GB 34) in the N+ST 36 group and the N+GB 34 group respectively, once a day, through to the 21st postnatal day. The Lung function analytic system for small animal was adopted to observe the changes in Lung function indicators in newborn rats, such as peak inspiratory flow (PIF), peak expiratory flow (PEF), expiratory resistance (RE), inspiratory resistance (RI) and dynamic compliance (Cdyn). HE staining was used to observe the morphological changes of Lung, such as alveolar fusion and rupture. RESULTS Compared with the S group, PEF and Cdyn were lower and PIF, RI and RE higher in the N group (all P 0.05). CONCLUSION Electroacupuncture at "Zusanli" (ST 36) in the pregnant rats significantly improves the perinatal nicotine-exposure-induced Lung function and morphology of newborn rats than electroacupuncture at "Yanglingquan" (GB 34).
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Protective effect of electro-acupuncture at maternal different points on perinatal nicotine exposure-induced pulmonary Dysplasia in offspring based on HPA axis and signal transduction pathway.
Biochemical and biophysical research communications, 2018Co-Authors: Yitian Liu, Guozhen Zhao, Jian Dai, Reiko Sakurai, Virender K. RehanAbstract:Perinatal nicotine exposure can not only lead to Lung Dysplasia in offspring, but also cause epigenetic changes and induce transgenerational asthma. Previous studies have shown that electro-acupuncture (EA) applied to "Zusanli" (ST 36) can improve the Lung morphology and correct abnormal expression of Lung development-related protein in perinatal nicotine exposure offspring. However, it is still unclear whether ST 36 has a specific therapeutic effect and how maternal acupuncture can protect the offspring from pulmonary Dysplasia. In this study, we compared the different effect of ST 36 and "Fenglong" (ST 40), which belong to the same meridian, in terms of Lung pulmonary function and morphology, PPARγ, β-catenin, GR levels in the Lung tissues and CORT in the serum of perinatal nicotine exposure offspring, and explored the mechanism of acupuncture based on the maternal hypothalamus-pituitary-adrenal (HPA) axis. It is shown that EA applied to ST 36 could restore the normal function of maternal HPA axis and alleviate maternal glucocorticoid overexposure in offspring, thereby it can up-regulate the PTHrP/PPARγ and down-regulate the Wnt/β-catenin signaling pathways, and protects perinatal nicotine exposure-induced pulmonary Dysplasia in offspring. Its effect is better than that of ST 40. These results are of great significance in preventing perinatal nicotine exposure-induced pulmonary Dysplasia in offspring.
M Malone - One of the best experts on this subject based on the ideXlab platform.
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Open Lung biopsy in neonatal and paediatric patients referred for extracorporeal membrane oxygenation (ECMO)
Thorax, 2004Co-Authors: David Inwald, K Brown, F Gensini, M Malone, A GoldmanAbstract:This study was undertaken to determine the usefulness, safety, and most appropriate timing of open Lung biopsy in infants and children considered for and on extracorporeal membrane oxygenation (ECMO) for respiratory failure. A retrospective review of children referred for consideration of and placed on ECMO in our institution in the period 1996-2002. 506 patients were referred, 15 (3%) of whom underwent antemortem open Lung biopsy (eight neonatal, four paediatric, and three cardiac patients). In the neonatal group open Lung biopsy contributed to clinical decision making in all patients. Four neonates had a fatal Lung Dysplasia (three alveolar capillary Dysplasia and one surfactant protein B deficiency) and treatment was withdrawn. Of the other four neonates, two had pulmonary hypoplasia, one had pulmonary lymphangiectasia, and one had meconium aspiration with mild barotrauma. Treatment was continued in these four patients and two survived. In the paediatric group the biopsies were of clinical relevance in two infants with pertussis who had Lung infarction on biopsy in whom treatment was withdrawn. In the other two paediatric patients the biopsies were equivocal, treatment was continued, but both patients died. In the cardiac group, who presented perioperatively with pulmonary hypertension, the biopsies excluded a fatal Lung Dysplasia and severe pulmonary vascular disease but all three infants died. One patient had non-fatal bleeding complications. Open Lung biopsy is clinically most useful when performed to diagnose fatal Lung Dysplasias in neonates and to confirm the presence of viable Lung tissue in patients with acute Lung injury due to pertussis infection.
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Open Lung biopsy in neonatal and paediatric patients referred for extracorporeal membrane oxygenation (ECMO)
Thorax, 2004Co-Authors: David Inwald, F Gensini, M Malone, Katherine L. Brown, A GoldmanAbstract:Background: This study was undertaken to determine the usefulness, safety, and most appropriate timing of open Lung biopsy in infants and children considered for and on extracorporeal membrane oxygenation (ECMO) for respiratory failure. Methods: A retrospective review of children referred for consideration of and placed on ECMO in our institution in the period 1996–2002. Results: 506 patients were referred, 15 (3%) of whom underwent antemortem open Lung biopsy (eight neonatal, four paediatric, and three cardiac patients). In the neonatal group open Lung biopsy contributed to clinical decision making in all patients. Four neonates had a fatal Lung Dysplasia (three alveolar capillary Dysplasia and one surfactant protein B deficiency) and treatment was withdrawn. Of the other four neonates, two had pulmonary hypoplasia, one had pulmonary lymphangiectasia, and one had meconium aspiration with mild barotrauma. Treatment was continued in these four patients and two survived. In the paediatric group the biopsies were of clinical relevance in two infants with pertussis who had Lung infarction on biopsy in whom treatment was withdrawn. In the other two paediatric patients the biopsies were equivocal, treatment was continued, but both patients died. In the cardiac group, who presented perioperatively with pulmonary hypertension, the biopsies excluded a fatal Lung Dysplasia and severe pulmonary vascular disease but all three infants died. One patient had non-fatal bleeding complications. Conclusion: Open Lung biopsy is clinically most useful when performed to diagnose fatal Lung Dysplasias in neonates and to confirm the presence of viable Lung tissue in patients with acute Lung injury due to pertussis infection.
F Gensini - One of the best experts on this subject based on the ideXlab platform.
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Open Lung biopsy in neonatal and paediatric patients referred for extracorporeal membrane oxygenation (ECMO)
Thorax, 2004Co-Authors: David Inwald, K Brown, F Gensini, M Malone, A GoldmanAbstract:This study was undertaken to determine the usefulness, safety, and most appropriate timing of open Lung biopsy in infants and children considered for and on extracorporeal membrane oxygenation (ECMO) for respiratory failure. A retrospective review of children referred for consideration of and placed on ECMO in our institution in the period 1996-2002. 506 patients were referred, 15 (3%) of whom underwent antemortem open Lung biopsy (eight neonatal, four paediatric, and three cardiac patients). In the neonatal group open Lung biopsy contributed to clinical decision making in all patients. Four neonates had a fatal Lung Dysplasia (three alveolar capillary Dysplasia and one surfactant protein B deficiency) and treatment was withdrawn. Of the other four neonates, two had pulmonary hypoplasia, one had pulmonary lymphangiectasia, and one had meconium aspiration with mild barotrauma. Treatment was continued in these four patients and two survived. In the paediatric group the biopsies were of clinical relevance in two infants with pertussis who had Lung infarction on biopsy in whom treatment was withdrawn. In the other two paediatric patients the biopsies were equivocal, treatment was continued, but both patients died. In the cardiac group, who presented perioperatively with pulmonary hypertension, the biopsies excluded a fatal Lung Dysplasia and severe pulmonary vascular disease but all three infants died. One patient had non-fatal bleeding complications. Open Lung biopsy is clinically most useful when performed to diagnose fatal Lung Dysplasias in neonates and to confirm the presence of viable Lung tissue in patients with acute Lung injury due to pertussis infection.
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Open Lung biopsy in neonatal and paediatric patients referred for extracorporeal membrane oxygenation (ECMO)
Thorax, 2004Co-Authors: David Inwald, F Gensini, M Malone, Katherine L. Brown, A GoldmanAbstract:Background: This study was undertaken to determine the usefulness, safety, and most appropriate timing of open Lung biopsy in infants and children considered for and on extracorporeal membrane oxygenation (ECMO) for respiratory failure. Methods: A retrospective review of children referred for consideration of and placed on ECMO in our institution in the period 1996–2002. Results: 506 patients were referred, 15 (3%) of whom underwent antemortem open Lung biopsy (eight neonatal, four paediatric, and three cardiac patients). In the neonatal group open Lung biopsy contributed to clinical decision making in all patients. Four neonates had a fatal Lung Dysplasia (three alveolar capillary Dysplasia and one surfactant protein B deficiency) and treatment was withdrawn. Of the other four neonates, two had pulmonary hypoplasia, one had pulmonary lymphangiectasia, and one had meconium aspiration with mild barotrauma. Treatment was continued in these four patients and two survived. In the paediatric group the biopsies were of clinical relevance in two infants with pertussis who had Lung infarction on biopsy in whom treatment was withdrawn. In the other two paediatric patients the biopsies were equivocal, treatment was continued, but both patients died. In the cardiac group, who presented perioperatively with pulmonary hypertension, the biopsies excluded a fatal Lung Dysplasia and severe pulmonary vascular disease but all three infants died. One patient had non-fatal bleeding complications. Conclusion: Open Lung biopsy is clinically most useful when performed to diagnose fatal Lung Dysplasias in neonates and to confirm the presence of viable Lung tissue in patients with acute Lung injury due to pertussis infection.
