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Alexander Chuchalin - One of the best experts on this subject based on the ideXlab platform.
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the influence of carboxyhemoglobin cohb generation on measured total Lung diffusion capacity
European Respiratory Journal, 2012Co-Authors: Evgeny Babarskov, Evgeny Stepanov, Yury Shulagin, Alexander Cherniak, Zaurbek Aisanov, Alexander ChuchalinAbstract:Background . We found earlier that as a result of single breath diffusion capacity test for CO and NO mean relative current COHb concentration in Lung capillary volume (Vc) reaches to 10% [Babarskov E. et al. ERJ 2009. v.34. suppl.53:391s]. Aim . To determine the influence of COHb generation on measured value of total Lung diffusion capacity (DLco) and calculated Vc. Methods . Dynamic balance equations of CO and COHb in alveolar and capillary volumes were solved by numerical method. Results . The dependence of average relative COHb concentration on breathholding time and initial CO alveolar concentration was determined, as well as relationship between measured DLco and COHb concentration. It was demonstrated, that using of gas mixtures with usually recommended CO content (0.28%) results in COHb concentration increase to about 10%, that in turn leads to reducing of DLco about by 5% and Vc by 10%. If initial CO content in gas mixture is increased three fold (0.84%), then COHb concentration reaches to about 30%, that in turn leads to reducing of DLco about by 15% and Vc by 30%. Conclusion . Our findings confirm possibility of experimental measurment of the difference between DLco values, which may be used for noninvasive investigating of Lung Hemodynamics. Particularly this allows to determine important diagnostic parameter - capillar blood flow rate across ventilated alveoli and correctly to calculate Vc.
Popková Michaela - One of the best experts on this subject based on the ideXlab platform.
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Pulmonary pathophysiology during circulatory support.
2020Co-Authors: Popková MichaelaAbstract:Introduction: Left-ventricular (LV) distension and consequent pulmonary congestion are complications frequently discussed in patients with severe LV dysfunction treated with veno- arterial extracorporeal membrane oxygenation (VA ECMO). The goal of this study was to describe the influence of high VA ECMO flows to LV distension, Lung Hemodynamics, and Lung fluid accumulation. Methods of LV decompression were studied to prevent Lung edema. Methods: In all experiments porcine models under general anesthesia were used. The effects of high extracorporeal blood flow (EBF) on LV heart work were assessed in a chronic heart failure model. The effects of LV afterload on Lung fluid accumulation were evaluated by electrical impedance tomography (EIT) on acute heart failure models. Phase and frequency filtration and mathematical analysis were applied to the raw EIT data. Subsequently, mini- invasive techniques of LV decompression were evaluated for LV work. Results: The stepwise increases of VA ECMO flow improved both hemodynamic and oxygenation parameters. Nevertheless, it also caused distension and increased work of LV. The rise in EBF led to increased pulmonary capillary wedge pressure and Lung fluid accumulation assessed by EIT in heart failure. The methods for LV decompression (Impella pump, atrial..
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Pulmonary pathophysiology during circulatory support.
Univerzita Karlova 1. lékařská fakulta, 2020Co-Authors: Popková MichaelaAbstract:Úvod: Distenze levé komory srdeční a následně až vznik plicního edému jsou často diskutované komplikace veno-arteriální membránové oxygenace (VA ECMO) u pacientů s těžkým srdečním selháním. Cílem studie bylo na experimentálním modelu srdečního selhání sledovat vliv VA ECMO na distenzi levé komory, plicní hemodynamiku a akumulaci tekutin v plicích a navrhnout postup, jímž by bylo možné vzniku plicního edému předejít. Metodika: Experimenty probíhaly na prasečích modelech v celkové anestézii. Na modelu chronického srdečního selhání byly sledovány vlivy zvyšujícího se "afterloadu" na práci levé komory. Vliv zvyšujícího se "afterloadu" na objem tekutin v plicích byl pak sledován na modelu akutního ischemického srdečního selhání. K detekci změn objemu tekutin byla využita elektrická impedanční tomografie (EIT). EIT data byla analyzována fázovou a frekvenční filtrací tak, aby byl zahrnut pouze funkční region plic. V rámci studie byly porovnány i různé metody dekomprese levé komory při současném užití s VA ECMO. Výsledky: Postupné zvyšování průtoku mimotělní podporou VA ECMO vedlo u akutně i chronicky selhávající cirkulace ke zlepšení hemodynamických a oxygenačních parametrů. Vyšší průtoky VA ECMO však způsobily také významnou distenzi levé komory srdeční a zvýšení nároků na její práci. Navyšování...Introduction: Left-ventricular (LV) distension and consequent pulmonary congestion are complications frequently discussed in patients with severe LV dysfunction treated with veno- arterial extracorporeal membrane oxygenation (VA ECMO). The goal of this study was to describe the influence of high VA ECMO flows to LV distension, Lung Hemodynamics, and Lung fluid accumulation. Methods of LV decompression were studied to prevent Lung edema. Methods: In all experiments porcine models under general anesthesia were used. The effects of high extracorporeal blood flow (EBF) on LV heart work were assessed in a chronic heart failure model. The effects of LV afterload on Lung fluid accumulation were evaluated by electrical impedance tomography (EIT) on acute heart failure models. Phase and frequency filtration and mathematical analysis were applied to the raw EIT data. Subsequently, mini- invasive techniques of LV decompression were evaluated for LV work. Results: The stepwise increases of VA ECMO flow improved both hemodynamic and oxygenation parameters. Nevertheless, it also caused distension and increased work of LV. The rise in EBF led to increased pulmonary capillary wedge pressure and Lung fluid accumulation assessed by EIT in heart failure. The methods for LV decompression (Impella pump, atrial...Institute of Physiology First Faculty of Medicine Charles UniversityFyziologický ústav 1. LF UK1. lékařská fakultaFirst Faculty of Medicin
Evgeny Babarskov - One of the best experts on this subject based on the ideXlab platform.
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the influence of carboxyhemoglobin cohb generation on measured total Lung diffusion capacity
European Respiratory Journal, 2012Co-Authors: Evgeny Babarskov, Evgeny Stepanov, Yury Shulagin, Alexander Cherniak, Zaurbek Aisanov, Alexander ChuchalinAbstract:Background . We found earlier that as a result of single breath diffusion capacity test for CO and NO mean relative current COHb concentration in Lung capillary volume (Vc) reaches to 10% [Babarskov E. et al. ERJ 2009. v.34. suppl.53:391s]. Aim . To determine the influence of COHb generation on measured value of total Lung diffusion capacity (DLco) and calculated Vc. Methods . Dynamic balance equations of CO and COHb in alveolar and capillary volumes were solved by numerical method. Results . The dependence of average relative COHb concentration on breathholding time and initial CO alveolar concentration was determined, as well as relationship between measured DLco and COHb concentration. It was demonstrated, that using of gas mixtures with usually recommended CO content (0.28%) results in COHb concentration increase to about 10%, that in turn leads to reducing of DLco about by 5% and Vc by 10%. If initial CO content in gas mixture is increased three fold (0.84%), then COHb concentration reaches to about 30%, that in turn leads to reducing of DLco about by 15% and Vc by 30%. Conclusion . Our findings confirm possibility of experimental measurment of the difference between DLco values, which may be used for noninvasive investigating of Lung Hemodynamics. Particularly this allows to determine important diagnostic parameter - capillar blood flow rate across ventilated alveoli and correctly to calculate Vc.
Evgeny Stepanov - One of the best experts on this subject based on the ideXlab platform.
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the influence of carboxyhemoglobin cohb generation on measured total Lung diffusion capacity
European Respiratory Journal, 2012Co-Authors: Evgeny Babarskov, Evgeny Stepanov, Yury Shulagin, Alexander Cherniak, Zaurbek Aisanov, Alexander ChuchalinAbstract:Background . We found earlier that as a result of single breath diffusion capacity test for CO and NO mean relative current COHb concentration in Lung capillary volume (Vc) reaches to 10% [Babarskov E. et al. ERJ 2009. v.34. suppl.53:391s]. Aim . To determine the influence of COHb generation on measured value of total Lung diffusion capacity (DLco) and calculated Vc. Methods . Dynamic balance equations of CO and COHb in alveolar and capillary volumes were solved by numerical method. Results . The dependence of average relative COHb concentration on breathholding time and initial CO alveolar concentration was determined, as well as relationship between measured DLco and COHb concentration. It was demonstrated, that using of gas mixtures with usually recommended CO content (0.28%) results in COHb concentration increase to about 10%, that in turn leads to reducing of DLco about by 5% and Vc by 10%. If initial CO content in gas mixture is increased three fold (0.84%), then COHb concentration reaches to about 30%, that in turn leads to reducing of DLco about by 15% and Vc by 30%. Conclusion . Our findings confirm possibility of experimental measurment of the difference between DLco values, which may be used for noninvasive investigating of Lung Hemodynamics. Particularly this allows to determine important diagnostic parameter - capillar blood flow rate across ventilated alveoli and correctly to calculate Vc.
Yury Shulagin - One of the best experts on this subject based on the ideXlab platform.
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the influence of carboxyhemoglobin cohb generation on measured total Lung diffusion capacity
European Respiratory Journal, 2012Co-Authors: Evgeny Babarskov, Evgeny Stepanov, Yury Shulagin, Alexander Cherniak, Zaurbek Aisanov, Alexander ChuchalinAbstract:Background . We found earlier that as a result of single breath diffusion capacity test for CO and NO mean relative current COHb concentration in Lung capillary volume (Vc) reaches to 10% [Babarskov E. et al. ERJ 2009. v.34. suppl.53:391s]. Aim . To determine the influence of COHb generation on measured value of total Lung diffusion capacity (DLco) and calculated Vc. Methods . Dynamic balance equations of CO and COHb in alveolar and capillary volumes were solved by numerical method. Results . The dependence of average relative COHb concentration on breathholding time and initial CO alveolar concentration was determined, as well as relationship between measured DLco and COHb concentration. It was demonstrated, that using of gas mixtures with usually recommended CO content (0.28%) results in COHb concentration increase to about 10%, that in turn leads to reducing of DLco about by 5% and Vc by 10%. If initial CO content in gas mixture is increased three fold (0.84%), then COHb concentration reaches to about 30%, that in turn leads to reducing of DLco about by 15% and Vc by 30%. Conclusion . Our findings confirm possibility of experimental measurment of the difference between DLco values, which may be used for noninvasive investigating of Lung Hemodynamics. Particularly this allows to determine important diagnostic parameter - capillar blood flow rate across ventilated alveoli and correctly to calculate Vc.
