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Andrew G. Franks - One of the best experts on this subject based on the ideXlab platform.
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Lupus Erythematosus tumidus with discoid Lupus Erythematosus-induced alopecia of the scalp.
Dermatology online journal, 2011Co-Authors: Stephanie Lehrhoff, Julia Tzu, Rishi Patel, Miguel Sanchez, Andrew G. FranksAbstract:Lupus Erythematosus tumidus (LET) is an uncommon variant of cutaneous Lupus Erythematosus. Lupus erythematodes tumidus is characterized by smooth, erythematous plaques on sun-exposed areas without surface changes, such as follicular plugs, atrophy, or scale. Histopathologic features include a lymphocytic, perivascular and periadnexal infiltrate with abundant interstitial, superficial, and deep dermal mucin without appreciable epidermal and vacuolar changes. Typically, LET is responsive to treatment with systemic antimalarials. We present a unique case of alopecia associated with LET, which was partially responsive to hydroxychloroquine. We also note that the plaque of LET is adjacent to the plaque of discoid Lupus Erythematosus.
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Morphea with discoid Lupus Erythematosus.
Dermatology online journal, 2011Co-Authors: Adnan Mir, Julia Tzu, Brook E. Tlougan, Kathryn E. O'reilly, Shane A Meehan, Hideko Kamino, Andrew G. FranksAbstract:The presence of Lupus Erythematosus with morphea in the same patient has rarely been reported. In this case, we describe a woman with the overlap of discoid Lupus Erythematosus with superficial morphea, diagnoses that are supported by histopathologic features and laboratory studies.
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Incidence of alopecia areata in Lupus Erythematosus.
Archives of Dermatology, 1992Co-Authors: Victoria P. Werth, Miguel Sanchez, Wain L. White, Andrew G. FranksAbstract:• Background.— A small percentage of patients with alopecia areata have connective diseases such as systemic Lupus Erythematosus, discoid Lupus Erythematosus, rheumatoid arthritis, and scleroderma. Lupus Erythematosus is associated with a number of different types of alopecia, but the incidence of alopecia areata in Lupus Erythematosus has not been examined. Observations.— Of our cohort of 39 patients with Lupus Erythematosus, alopecia areata developed in 10% (four patients), in contrast to 0.42% of general dermatologic patients. Biopsy specimens of alopecia areata lesions in each of our patients showed continuous granular deposition of IgG at the dermoepidermal junction, a finding usually found in only a minority of alopecia areata cases. Intralesional injections of corticosteroids were effective treatment. Conclusions.— The incidence of alopecia areata in patients with Lupus Erythematosus is increased. Recognition of this form of alopecia allows for specific therapy with intralesional corticosteroids. ( Arch Dermatol. 1992;128:368-371)
Jeffrey P. Callen - One of the best experts on this subject based on the ideXlab platform.
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Cutaneous Lupus Erythematosus: A personal approach to management
Australasian Journal of Dermatology, 2006Co-Authors: Jeffrey P. CallenAbstract:SUMMARY Skin disease in patients with Lupus Erythematosus may be subdivided into two broad categories – those lesions that when biopsied demonstrate interface dermatitis and those that do not demonstrate interface dermatitis. The skin lesions that are represented by the interface dermatitis include discoid Lupus Erythematosus, subacute cutaneous Lupus Erythematosus and acute cutaneous Lupus Erythematosus. Patients with these ‘specific’ manifestations have varying degrees of systemic involvement from rare systemic disease in patients with localized discoid Lupus Erythematosus to common and often severe involvement in patients with acute cutaneous Lupus Erythematosus. Patients who do not demonstrate interface dermatitis also may have systemic disease and in some instances the skin manifestations are linked to some of the more severe systemic manifestations. Many patients with cutaneous lesions characterized by the interface dermatitis can be controlled with ‘standard’ therapies including sunscreens, protective clothing and behavioural alteration, and topical corticosteroids with or without an oral antimalarial agent. This review presents a brief summary of each common cutaneous manifestation of Lupus Erythematosus, its relationship to systemic involvement and treatment issues to effectively deal with the Lupus Erythematosus patient who has skin disease.
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Update on the management of cutaneous Lupus Erythematosus
British Journal of Dermatology, 2004Co-Authors: Jeffrey P. CallenAbstract:This paper reviews the latest treatments for cutaneous Lupus Erythematosus. It focuses on evidence-based guidance for the management of cutaneous Lupus Erythematosus, with identification of the strength of evidence available at this time. In addition, I have briefly reviewed the epidemiological aspects, diagnosis and evaluation of patients with cutaneous Lupus Erythematosus. This review reflects data available from the Cochrane Library, Medline, literature searches, and the experience of the author managing patients with cutaneous Lupus Erythematosus for over 25 years.
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Discoid Lupus Erythematosus in Children
NEJM Journal Watch, 2003Co-Authors: Jeffrey P. CallenAbstract:Chronic cutaneous Lupus Erythematosus, or discoid Lupus Erythematosus (DLE), is rare in children. Only 29 pediatric cases have previously been reported
Ahmet Yasar Turanli - One of the best experts on this subject based on the ideXlab platform.
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Linear Lupus Erythematosus profundus
Journal of Experimental and Clinical Medicine, 2012Co-Authors: Esra Pancar Yuksel, Fatma Aydin, Levent Yildiz, Müge Güler Özden, Nilgün Şentürk, Tayyar Cantürk, Ahmet Yasar TuranliAbstract:Lupus Erythematosus profundus is grouped within the chronic cutaneous Lupus Erythematosus and linear form of it has been rarely reported. Lesions are described as subcutaneous nodules and plaques with a distinctive distribution. We report a 16 years old girl with Lupus Erythematosus profundus in whom the lesions were at the upper extremity and showed a linear configuration following the lines of Blaschko. We also review the previous reported 12 cases of linear Lupus Erythematosus profundus in the literature. Patients with linear Lupus Erythematosus profundus had different features of age, racial characteristics and distribution of lesions when compared with Lupus Erythematosus profundus. J. Exp. Clin. Med., 2012; 29:64-67
Victoria P. Werth - One of the best experts on this subject based on the ideXlab platform.
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Subacute cutaneous Lupus Erythematosus and systemic Lupus Erythematosus associated with abatacept.
JAAD Case Reports, 2018Co-Authors: M. Tarazi, Kumpol Aiempanakit, Victoria P. WerthAbstract:Subacute cutaneous Lupus Erythematosus (SCLE) is a subtype of cutaneous Lupus Erythematosus (CLE) with distinct clinical and immunologic features. It can be associated with Sjogren syndrome and rheumatoid arthritis (RA) as well as several classes of medications. Here we present a patient with new-onset SCLE and systemic Lupus Erythematosus (SLE) after treatment with abatacept. There is one other case of SCLE and one of SLE associated with abatacept described in the literature.1, 2
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Incidence of alopecia areata in Lupus Erythematosus.
Archives of Dermatology, 1992Co-Authors: Victoria P. Werth, Miguel Sanchez, Wain L. White, Andrew G. FranksAbstract:• Background.— A small percentage of patients with alopecia areata have connective diseases such as systemic Lupus Erythematosus, discoid Lupus Erythematosus, rheumatoid arthritis, and scleroderma. Lupus Erythematosus is associated with a number of different types of alopecia, but the incidence of alopecia areata in Lupus Erythematosus has not been examined. Observations.— Of our cohort of 39 patients with Lupus Erythematosus, alopecia areata developed in 10% (four patients), in contrast to 0.42% of general dermatologic patients. Biopsy specimens of alopecia areata lesions in each of our patients showed continuous granular deposition of IgG at the dermoepidermal junction, a finding usually found in only a minority of alopecia areata cases. Intralesional injections of corticosteroids were effective treatment. Conclusions.— The incidence of alopecia areata in patients with Lupus Erythematosus is increased. Recognition of this form of alopecia allows for specific therapy with intralesional corticosteroids. ( Arch Dermatol. 1992;128:368-371)
Surbhi Dayal - One of the best experts on this subject based on the ideXlab platform.
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Lupus Erythematosus profundus.
Indian Journal of Dermatology Venereology and Leprology, 2010Co-Authors: Kamal Aggarwal, Viney Jain, Surbhi DayalAbstract:A case of Lupus Erythematosus profundus, with associated mastitis, but without any lesions of discoid Lupus Erythematosus or systemic Lupus Erythematosus is being reported.
