The Experts below are selected from a list of 318 Experts worldwide ranked by ideXlab platform
Dae Gill Kang - One of the best experts on this subject based on the ideXlab platform.
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ethanol extract of Lycopus lucidus elicits positive inotropic effect via activation of ca2 entry and ca2 release in beating rabbit atria
Journal of Medicinal Food, 2013Co-Authors: Hyun Cheol Oh, Xiang Li, Dae Gill KangAbstract:Abstract Lycopus lucidus Turcz has been widely used as a traditional Oriental medicine (TOM) in Korea and China and prescribed for the enhancement of heart function. However, the precise effects have yet to be defined. The purpose of the present study was, therefore, to address whether the ethanol extract of Lycopus lucidus Turcz (ELT) has a positive inotropic effect. ELT-induced changes in atrial mechanical dynamics (pulse pressure, dp/dt, and stroke volume), and cAMP efflux were measured in perfused beating rabbit atria. Three active components, rosmarinic acid, betulinic acid, and oleanolic acid were identified in ELT by high performance liquid chromatography analysis. ELT increased atrial dynamics in a concentration-dependent manner without changes in atrial cAMP levels and cAMP efflux. The ELT-induced positive inotropic effect was blocked by inhibition of the L-type Ca2+ channels and sarcoplasmic reticulum (SR). Inhibitors of β-adrenoceptors had no effect on the ELT-induced positive inotropic effect....
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effect of Lycopus lucidus on high glucose induced vascular inflammation in human umbilical vein endothelial cells
The FASEB Journal, 2008Co-Authors: Dae Gill Kang, Mi Kyoung Moon, Sun Mi HwangAbstract:High glucose-induced vascular inflammatory process has been suggested to play a key role in the initiation and progression of atherosclerosis. Lycopus lucidus Turcz. has been used as an Oriental tr...
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Lycopus lucidus inhibits high glucose induced vascular inflammation in human umbilical vein endothelial cells
Vascular Pharmacology, 2008Co-Authors: Dae Gill KangAbstract:Vascular inflammatory process has been suggested to play a key role in the initiation and progression of atherosclerosis, a major complication of diabetes mellitus. Lycopus lucidus Turcz. has been used as an oriental traditional medicine including Korea and its crude drug is known to have an anti-inflammatory effect. Thus we investigated whether the aqueous extract of the leaves of L. lucidus Turcz. (ALT) suppresses vascular inflammatory process induced by high glucose in primary cultured human umbilical vein endothelial cells (HUVEC). Western blot analysis revealed that incubation of HUVEC with high glucose increased cell adhesion molecules (CAMs) expression levels. However, high glucose-induced increase of CAMs expression was significantly attenuated by pretreatment with ALT in a dose-dependent manner. The enhanced cell adhesion between monocyte and HUVEC induced by high glucose was also blocked by pretreatment with ALT. High glucose-induced hydrogen peroxide production and DCF-sensitive intracellular reactive oxygen species (ROS) formation. Pretreatment with ALT inhibited high glucose-induced ROS formation. In addition, ALT suppressed the translocation and promoter transcriptional activity of NF-κB increased in high glucose condition. Taken together, the present data suggested that ALT could suppress high glucose-induced vascular inflammatory process, which may be closely related with the inhibition of ROS and NF-κB activation in HUVEC.
Sun Mi Hwang - One of the best experts on this subject based on the ideXlab platform.
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effect of Lycopus lucidus on high glucose induced vascular inflammation in human umbilical vein endothelial cells
The FASEB Journal, 2008Co-Authors: Dae Gill Kang, Mi Kyoung Moon, Sun Mi HwangAbstract:High glucose-induced vascular inflammatory process has been suggested to play a key role in the initiation and progression of atherosclerosis. Lycopus lucidus Turcz. has been used as an Oriental tr...
Zhixiong Liao - One of the best experts on this subject based on the ideXlab platform.
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anticancer antioxidant and antimicrobial activities of the essential oil of Lycopus lucidus turcz var hirtus regel
Food Chemistry, 2011Co-Authors: Jianqing Yu, Xiuqiao Zhang, Huaidong Yu, Daizhi Tian, Zhixiong LiaoAbstract:Abstract This study was designed to examine the anticancer, antioxidant and antimicrobial activities of the essential oil from Lycopus lucidus Turcz. var. hirtus Regel. The essential oil treatment to six human cancer cell lines resulted in a dose-dependent inhibition of cell growth. The cytotoxicity of the essential oil on liver carcinoma and breast cancer cell lines was significantly stronger than on other cell lines. The essential oil can induce apoptosis of the liver carcinoma cell line Bel-7402 and decrease the intracellular GSH level. The antioxidant effect of the essential oil was evaluated by using 2,2-diphenyl-1-picrylhydrazyl (DPPH) and hydroxyl radical (OH ) scavenging assays. The essential oil exhibited moderate antioxidant activity. The antimicrobial activity of the essential oil was evaluated against eight microorganisms using the disc diffusion and broth microdilution methods. The essential oil also showed moderate antimicrobial activity. These suggest that the essential oil could hold a good potential for use in the pharmaceutical industry.
Xiaoxiang Guan - One of the best experts on this subject based on the ideXlab platform.
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the aqueous extract of Lycopus lucidus turcz ameliorates streptozotocin induced diabetic renal damage via inhibiting tgf β1 signaling pathway
Phytomedicine, 2013Co-Authors: Jie Yang, Dawei Wang, Fei Zhou, Wuguang Lu, Chunping Hu, Zhenghua Gu, Shihui Qian, Xiaoxiang GuanAbstract:Abstract Purpose Renal fibrosis characterized by accumulation of extracellular matrix protein results in chronic renal diseases including diabetic nephropathy. Transforming growth factor β1 (TGF-β1) signaling pathway plays a key role in mediating renal fibrosis. Hence, agents that antagonize TGF-β signaling could be candidate for kidney disease therapy. Methods We established renal fibrosis model both in vitro with fibroblast cells treated with rhTGF-β1 and streptozocin(STZ)-induced diabetic nephropathy rats model in vivo and evaluated the effect of the aqueous extract of Lycopus lucidus Turcz , the blood-circulation-promoting Chinese herb, on diabetic nephropathy and investigated the mechanism of action. Results We found that Lycopus suppressed rhTGF-β1-induced Smad2 and ERK1/2 activation, down-regulated the expression of TGF-βRI, TGF-βRII, Smad4 and Smad7 in SV40 MES13 cells without inhibiting cell viability. In vivo , Lycopus inhibited Smad2 phosphorylation, reduced mRNA level of TGF-β1, ameliorated expansion of the mesangial area in glomerular tissue and reduced the levels of Scr and BUN of serum and total-SOD (superoxide dismutase) activity in STZ-induced diabetic rats. Conclusion Lycopus is a novel inhibitor of renal fibrosis by blocking TGF-β signaling pathway and possess a protective effect on renal damage of STZ-induced diabetic nephropathy in rats.
Ding Qu - One of the best experts on this subject based on the ideXlab platform.
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the aqueous extract of Lycopus lucidus turcz exerts protective effects on podocytes injury of diabetic nephropathy via inhibiting tgf β1 signal pathway
American Journal of Translational Research, 2019Co-Authors: Fengfeng Ge, Wei Zhang, Shuopeng Wang, Min Zhang, Rongling Zhong, Liming Fang, Ding QuAbstract:Diabetic nephropathy (DN) is known as a major microvascular complication leading cause of end-stage renal disease, it generally followed by the process of podocyte fragmentation and detachment. Transforming growth factor β1 (TGF-β1) signaling pathway plays a pivotal role in the initiation and progression of DN. In present study, we aim to investigate the effect of Lycopus extracts on podocytes injury and TGF-β signaling. In present study, Lycopus extracts treatment abolished the gain in blood glucose and body weight in a dose dependent manner and possessed protective effect on the renal damage, which was indicated by the decreased concentration of Scr, BUN and urine creatinine of serum. Histopathological examination also demonstrated Lycopus extracts exert protective effect on renal damage. Western blotting and immunohistochemical results revealed Lycopus extracts treatment upregulated the expression of nephrin and down-regulated the expression levels of TGF-β1 and Smad4. Moreover, Lycopus extracts treatment suppressed TGF-β1-induced phosphorylation of Smad2/3, ERK1/2 and p38 both in vivo and vitro. In conclusion, Lycopus extracts is a novel agent that ameliorate podocytes injury by inhibiting TGF-β signaling pathway and possess potential therapeutic effect on renal damage of DN rats.
