The Experts below are selected from a list of 1173 Experts worldwide ranked by ideXlab platform
Pierre-edouard Fournier - One of the best experts on this subject based on the ideXlab platform.
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Genome Sequence of “Rickettsia sibirica subsp. mongolitimonae”
2016Co-Authors: Erwin Sentausa, Pierre-edouard FournierAbstract:“Rickettsia sibirica subsp.mongolitimonae ” is the agent of Lymphangitis-associated rickettsiosis, an emerging human disease that has been diagnosed in Europe and Africa. The present study reports the draft genome of Rickettsia sibirica subsp.mongoliti-monae strain HA-91. “Rickettsia sibirica subsp. mongolitimonae ” is a spotted fevergroup (SFG) Rickettsia first isolated from Hyalomma asiati
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genome sequence of rickettsia sibirica subsp mongolitimonae
Journal of Bacteriology, 2012Co-Authors: Erwin Sentausa, Pierre-edouard FournierAbstract:"Rickettsia sibirica subsp. mongolitimonae" is the agent of Lymphangitis-associated rickettsiosis, an emerging human disease that has been diagnosed in Europe and Africa. The present study reports the draft genome of Rickettsia sibirica subsp. mongolitimonae strain HA-91.
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Lymphangitis associated rickettsiosis a new rickettsiosis caused by rickettsia sibirica mongolotimonae seven new cases and review of the literature
Clinical Infectious Diseases, 2005Co-Authors: Pierre-edouard Fournier, Philippe Brouqui, Frederique Gouriet, Frédéric LuchtAbstract:BACKGROUND: Rickettsia sibirica mongolotimonae has been found in Hyalomma ticks in Inner Mongolia (in China) and Niger and in humans in France and South Africa. To date, only 3 cases of human infection have been reported. METHODS: Patients received a diagnosis of R. sibirica mongolotimonae infection on the basis of culture and/or PCR results plus serological test results. RESULTS: From January 2000 to June 2004, R. sibirica mongolotimonae infection was diagnosed in 7 patients. In 3 patients, the bacterium was cultivated from the inoculation eschar. The other 4 patients had cases that were diagnosed with use of PCR of samples obtained from the eschar (2 patients) or blood (2 patients), plus specific Western blot before (2 patients) and after (2 patients) cross-adsorption. The clinical presentation included fever (temperature, >38.5 degrees C), a maculopapular rash, and > or =1 inoculation eschar in 6 patients, enlarged regional lymph nodes in 4 patients, and Lymphangitis in 3 patients. On the basis of the study of 9 cases, R. sibirica mongolotimonae infection differed from other tick-borne rickettsioses in the Mediterranean area in the following ways: it involved a specific incidence in the spring, the presence of 2 eschars in 2 (22%) of the patients, the presence of a draining lymph node in 5 (55%) of the patients, and Lymphangitis expanding from the inoculation eschar to the draining node in 4 (44%) of the patients. The most recent patient in our series received a clinical diagnosis on the basis of such findings. All patients recovered without any sequelae. CONCLUSIONS: We propose that this new rickettsiosis be named "Lymphangitis-associated rickettsiosis." Lymphangitis-associated rickettsiosis should be considered in the differential diagnosis of tick-borne rickettsioses in Europe, Africa, and Asia.
Subba R Digumarthy - One of the best experts on this subject based on the ideXlab platform.
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the added value of quantitative 18f fdg pet ct parameters in the assessment of pulmonary lymphangitic carcinomatosis in lung cancer
Journal of Thoracic Disease, 2019Co-Authors: Dexter P Mendoza, Subba R DigumarthyAbstract:Lymphangitic carcinomatosis is the infiltration and spread of malignant cells through the pulmonary lymphatics. In non-lung malignancies such as breast, gastric, and colon cancer, this typically occurs via hematogenous dissemination of tumor cells to the lung with subsequent extension to the lymphatics (1-3). In primary lung cancers, on the other hand, lymphangitic carcinomatosis may also result from direct invasion from the tumor, through direct spread from pleural metastasis, or via retrograde extension from a metastatic lymph node (4-6).
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fdg pet ct in assessment of pulmonary lymphangitic carcinomatosis
American Journal of Roentgenology, 2010Co-Authors: Priyanka Prakash, Mannudeep K Kalra, Amita Sharma, Joanne O Shepard, Subba R DigumarthyAbstract:OBJECTIVE. The purpose of this study was to assess the role of PET/CT in the diagnosis of pulmonary lymphangitic carcinomatosis.MATERIALS AND METHODS. Integrated PET/CT images of 35 patients (15 men, 20 women; mean age, 64.5 years) with pulmonary lymphangitic carcinomatosis confirmed at follow-up chest CT or histopathologic examination were analyzed retrospectively. Standardized uptake value based on body weight and the initial injected activity was measured in the affected lung, the normal lung, and the mediastinal blood pool. Two radiologists independently assessed abnormal PET activity in the lungs. Both radiologists reviewed the CT images to determine the presence, size, location, and extent of pulmonary lymphangitic carcinomatosis. The data were analyzed to determine the sensitivity and specificity of PET for pulmonary lymphangitic carcinomatosis.RESULTS. Among the 35 patients with pulmonary lymphangitic carcinomatosis, 17 (49%), 13 (37%), and five (14%) patients had diffuse, focal, and bilateral pul...
Erwin Sentausa - One of the best experts on this subject based on the ideXlab platform.
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Genome Sequence of “Rickettsia sibirica subsp. mongolitimonae”
2016Co-Authors: Erwin Sentausa, Pierre-edouard FournierAbstract:“Rickettsia sibirica subsp.mongolitimonae ” is the agent of Lymphangitis-associated rickettsiosis, an emerging human disease that has been diagnosed in Europe and Africa. The present study reports the draft genome of Rickettsia sibirica subsp.mongoliti-monae strain HA-91. “Rickettsia sibirica subsp. mongolitimonae ” is a spotted fevergroup (SFG) Rickettsia first isolated from Hyalomma asiati
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genome sequence of rickettsia sibirica subsp mongolitimonae
Journal of Bacteriology, 2012Co-Authors: Erwin Sentausa, Pierre-edouard FournierAbstract:"Rickettsia sibirica subsp. mongolitimonae" is the agent of Lymphangitis-associated rickettsiosis, an emerging human disease that has been diagnosed in Europe and Africa. The present study reports the draft genome of Rickettsia sibirica subsp. mongolitimonae strain HA-91.
Hidetoshi Okabe - One of the best experts on this subject based on the ideXlab platform.
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metastatic crohn s disease accompanying granulomatous vasculitis and Lymphangitis in the vulva
International Journal of Clinical and Experimental Pathology, 2013Co-Authors: Mitsuaki Ishida, Muneo Iwai, Keiko Yoshida, Akiko Kagotani, Hidetoshi OkabeAbstract:Metastatic Crohn’s disease (CD) is an extremely rare extragastrointestinal manifestation of CD, and is characterized histopathologically by the presence of non-caseating granulomatous inflammation. Granulomatous vasculitis and Lymphangitis have rarely been documented in metastatic CD. Herein, we report the first documented case of metastatic CD accompanied by both granulomatous vasculitis and Lymphangitis in the vulva. A 35-year-old Japanese female with CD presented with multiple small nodules in her vulva. Biopsy was performed under a clinical diagnosis of genital warts. A histopathological study revealed marked lymphangiectasia in the papillary dermis. Within the dilated lymphatics, lymphocytes and aggregates of macrophages were present, which are typical features of granulomatous Lymphangitis. Tiny non-caseating granulomas and granulomatous vasculitis were also observed. Accordingly, a diagnosis of metastatic CD accompanied by both granulomatous vasculitis and Lymphangitis was made. The occurrence of cutaneous lesions in patients with CD is well known. Albeit extremely rare, lymphangiectasia has been reported in the vulva of CD patients that clinically mimicked viral warts, as in the present case. The diagnosis of metastatic CD in the present case was not difficult because characteristic histopathological features were present, and a clinical history of CD was available. However, a few cases of genital swelling associated with granulomatous inflammation prior to a diagnosis of gastrointestinal CD have been documented. Therefore, granulomatous vasculitis and Lymphangitis in the external genitals should be considered as potential indication of metastatic CD even in cases without a history of gastrointestinal CD.
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case report metastatic crohn s disease accompanying granulomatous vasculitis and Lymphangitis in the vulva
2013Co-Authors: Mitsuaki Ishida, Muneo Iwai, Keiko Yoshida, Akiko Kagotani, Hidetoshi OkabeAbstract:Metastatic Crohn's disease (CD) is an extremely rare extragastrointestinal manifestation of CD, and is characterized histopathologically by the presence of non-caseating granulomatous inflammation. Granulomatous vasculitis and Lymphangitis have rarely been documented in metastatic CD. Herein, we report the first documented case of metastatic CD accompanied by both granulomatous vasculitis and Lymphangitis in the vulva. A 35-year-old Japanese female with CD presented with multiple small nodules in her vulva. Biopsy was performed under a clini- cal diagnosis of genital warts. A histopathological study revealed marked lymphangiectasia in the papillary dermis. Within the dilated lymphatics, lymphocytes and aggregates of macrophages were present, which are typical features of granulomatous Lymphangitis. Tiny non-caseating granulomas and granulomatous vasculitis were also observed. Accordingly, a diagnosis of metastatic CD accompanied by both granulomatous vasculitis and Lymphangitis was made. The occurrence of cutaneous lesions in patients with CD is well known. Albeit extremely rare, lymphangiec- tasia has been reported in the vulva of CD patients that clinically mimicked viral warts, as in the present case. The diagnosis of metastatic CD in the present case was not difficult because characteristic histopathological features were present, and a clinical history of CD was available. However, a few cases of genital swelling associated with granulomatous inflammation prior to a diagnosis of gastrointestinal CD have been documented. Therefore, granu - lomatous vasculitis and Lymphangitis in the external genitals should be considered as potential indication of meta- static CD even in cases without a history of gastrointestinal CD.
Mitsuaki Ishida - One of the best experts on this subject based on the ideXlab platform.
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metastatic crohn s disease accompanying granulomatous vasculitis and Lymphangitis in the vulva
International Journal of Clinical and Experimental Pathology, 2013Co-Authors: Mitsuaki Ishida, Muneo Iwai, Keiko Yoshida, Akiko Kagotani, Hidetoshi OkabeAbstract:Metastatic Crohn’s disease (CD) is an extremely rare extragastrointestinal manifestation of CD, and is characterized histopathologically by the presence of non-caseating granulomatous inflammation. Granulomatous vasculitis and Lymphangitis have rarely been documented in metastatic CD. Herein, we report the first documented case of metastatic CD accompanied by both granulomatous vasculitis and Lymphangitis in the vulva. A 35-year-old Japanese female with CD presented with multiple small nodules in her vulva. Biopsy was performed under a clinical diagnosis of genital warts. A histopathological study revealed marked lymphangiectasia in the papillary dermis. Within the dilated lymphatics, lymphocytes and aggregates of macrophages were present, which are typical features of granulomatous Lymphangitis. Tiny non-caseating granulomas and granulomatous vasculitis were also observed. Accordingly, a diagnosis of metastatic CD accompanied by both granulomatous vasculitis and Lymphangitis was made. The occurrence of cutaneous lesions in patients with CD is well known. Albeit extremely rare, lymphangiectasia has been reported in the vulva of CD patients that clinically mimicked viral warts, as in the present case. The diagnosis of metastatic CD in the present case was not difficult because characteristic histopathological features were present, and a clinical history of CD was available. However, a few cases of genital swelling associated with granulomatous inflammation prior to a diagnosis of gastrointestinal CD have been documented. Therefore, granulomatous vasculitis and Lymphangitis in the external genitals should be considered as potential indication of metastatic CD even in cases without a history of gastrointestinal CD.
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case report metastatic crohn s disease accompanying granulomatous vasculitis and Lymphangitis in the vulva
2013Co-Authors: Mitsuaki Ishida, Muneo Iwai, Keiko Yoshida, Akiko Kagotani, Hidetoshi OkabeAbstract:Metastatic Crohn's disease (CD) is an extremely rare extragastrointestinal manifestation of CD, and is characterized histopathologically by the presence of non-caseating granulomatous inflammation. Granulomatous vasculitis and Lymphangitis have rarely been documented in metastatic CD. Herein, we report the first documented case of metastatic CD accompanied by both granulomatous vasculitis and Lymphangitis in the vulva. A 35-year-old Japanese female with CD presented with multiple small nodules in her vulva. Biopsy was performed under a clini- cal diagnosis of genital warts. A histopathological study revealed marked lymphangiectasia in the papillary dermis. Within the dilated lymphatics, lymphocytes and aggregates of macrophages were present, which are typical features of granulomatous Lymphangitis. Tiny non-caseating granulomas and granulomatous vasculitis were also observed. Accordingly, a diagnosis of metastatic CD accompanied by both granulomatous vasculitis and Lymphangitis was made. The occurrence of cutaneous lesions in patients with CD is well known. Albeit extremely rare, lymphangiec- tasia has been reported in the vulva of CD patients that clinically mimicked viral warts, as in the present case. The diagnosis of metastatic CD in the present case was not difficult because characteristic histopathological features were present, and a clinical history of CD was available. However, a few cases of genital swelling associated with granulomatous inflammation prior to a diagnosis of gastrointestinal CD have been documented. Therefore, granu - lomatous vasculitis and Lymphangitis in the external genitals should be considered as potential indication of meta- static CD even in cases without a history of gastrointestinal CD.
