The Experts below are selected from a list of 129 Experts worldwide ranked by ideXlab platform
Sören Andersson - One of the best experts on this subject based on the ideXlab platform.
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kinetics of the immune response associated with tularemia comparison of an enzyme linked immunosorbent assay a tube agglutination test and a novel whole blood Lymphocyte Stimulation test
Clinical and Vaccine Immunology, 2008Co-Authors: Henrik Eliasson, Per Olcén, Anders Sjöstedt, Margareta Jurstrand, Erik Bäck, Sören AnderssonAbstract:We have developed and evaluated a novel and simplified whole-blood Lymphocyte Stimulation assay that focuses on the measurement of gamma interferon after 24 h of Stimulation with whole-cell tularemia antigen and a tularemia enzyme-linked immunosorbent assay (ELISA) based on highly purified lipopolysaccharide antigen. Comparison of the kinetics of the two assays and those of the traditional tube agglutination test shows that the cellular immune response can be detected earlier by the Lymphocyte Stimulation assay. This test already shows a high proportion of positive results during the first week after the onset of the disease, may be applicable in everyday laboratory practice, and has the potential of changing routine diagnostics for tularemia. The new ELISA has a high sensitivity and becomes positive to a high degree during the second week of disease.
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Kinetics of immune response in tularemia : comparison between ELISA, tube agglutination and a novel whole blood Lymphocyte Stimulation test
2008Co-Authors: Henrik Eliasson, Per Olcén, Anders Sjöstedt, Margareta Jurstrand, Erik Bäck, Sören AnderssonAbstract:Kinetics of immune response in tularemia : comparison between ELISA, tube agglutination and a novel whole blood Lymphocyte Stimulation test
Henrik Eliasson - One of the best experts on this subject based on the ideXlab platform.
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kinetics of the immune response associated with tularemia comparison of an enzyme linked immunosorbent assay a tube agglutination test and a novel whole blood Lymphocyte Stimulation test
Clinical and Vaccine Immunology, 2008Co-Authors: Henrik Eliasson, Per Olcén, Anders Sjöstedt, Margareta Jurstrand, Erik Bäck, Sören AnderssonAbstract:We have developed and evaluated a novel and simplified whole-blood Lymphocyte Stimulation assay that focuses on the measurement of gamma interferon after 24 h of Stimulation with whole-cell tularemia antigen and a tularemia enzyme-linked immunosorbent assay (ELISA) based on highly purified lipopolysaccharide antigen. Comparison of the kinetics of the two assays and those of the traditional tube agglutination test shows that the cellular immune response can be detected earlier by the Lymphocyte Stimulation assay. This test already shows a high proportion of positive results during the first week after the onset of the disease, may be applicable in everyday laboratory practice, and has the potential of changing routine diagnostics for tularemia. The new ELISA has a high sensitivity and becomes positive to a high degree during the second week of disease.
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Kinetics of immune response in tularemia : comparison between ELISA, tube agglutination and a novel whole blood Lymphocyte Stimulation test
2008Co-Authors: Henrik Eliasson, Per Olcén, Anders Sjöstedt, Margareta Jurstrand, Erik Bäck, Sören AnderssonAbstract:Kinetics of immune response in tularemia : comparison between ELISA, tube agglutination and a novel whole blood Lymphocyte Stimulation test
A J Bircher - One of the best experts on this subject based on the ideXlab platform.
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severe hypersensitivity syndrome to lamotrigine confirmed by Lymphocyte Stimulation in vitro
Allergy, 2000Co-Authors: N Schaub, A J BircherAbstract:Background: The anticonvulsant lamotrigine has been associated with severe adverse events such as the hypersensitivity syndrome and severe bullous reactions. So far, specific immunologic tests have rarely been performed to demonstrate specific sensitization. Methods: A 36-year-old man suffering from epilepsy was concomitantly treated with high doses of sodium valproate and lamotrigine. About 1 month later, a severe hypersensitivity syndrome occurred affecting skin, lymph nodes, and liver. Three months later, skin tests and Lymphocyte Stimulation tests with anticonvulsants were performed. Results: Skin tests were negative with all drugs; Lymphocyte Stimulation tests were twice positive with lamotrigine. Later re-exposure to sodium valproate was tolerated. Conclusions: Lamotrigine may elicit a severe hypersensitivity syndrome. Particularly high initial doses and concomitant treatment with sodium valproate increase the risk of cutaneous reactions. The Lymphocyte Stimulation test was used to identify the culprit drug. Lymphocyte sensitization to the drug or a metabolite may be involved in the pathogenesis.
Margareta Jurstrand - One of the best experts on this subject based on the ideXlab platform.
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kinetics of the immune response associated with tularemia comparison of an enzyme linked immunosorbent assay a tube agglutination test and a novel whole blood Lymphocyte Stimulation test
Clinical and Vaccine Immunology, 2008Co-Authors: Henrik Eliasson, Per Olcén, Anders Sjöstedt, Margareta Jurstrand, Erik Bäck, Sören AnderssonAbstract:We have developed and evaluated a novel and simplified whole-blood Lymphocyte Stimulation assay that focuses on the measurement of gamma interferon after 24 h of Stimulation with whole-cell tularemia antigen and a tularemia enzyme-linked immunosorbent assay (ELISA) based on highly purified lipopolysaccharide antigen. Comparison of the kinetics of the two assays and those of the traditional tube agglutination test shows that the cellular immune response can be detected earlier by the Lymphocyte Stimulation assay. This test already shows a high proportion of positive results during the first week after the onset of the disease, may be applicable in everyday laboratory practice, and has the potential of changing routine diagnostics for tularemia. The new ELISA has a high sensitivity and becomes positive to a high degree during the second week of disease.
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Kinetics of immune response in tularemia : comparison between ELISA, tube agglutination and a novel whole blood Lymphocyte Stimulation test
2008Co-Authors: Henrik Eliasson, Per Olcén, Anders Sjöstedt, Margareta Jurstrand, Erik Bäck, Sören AnderssonAbstract:Kinetics of immune response in tularemia : comparison between ELISA, tube agglutination and a novel whole blood Lymphocyte Stimulation test
Erik Bäck - One of the best experts on this subject based on the ideXlab platform.
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kinetics of the immune response associated with tularemia comparison of an enzyme linked immunosorbent assay a tube agglutination test and a novel whole blood Lymphocyte Stimulation test
Clinical and Vaccine Immunology, 2008Co-Authors: Henrik Eliasson, Per Olcén, Anders Sjöstedt, Margareta Jurstrand, Erik Bäck, Sören AnderssonAbstract:We have developed and evaluated a novel and simplified whole-blood Lymphocyte Stimulation assay that focuses on the measurement of gamma interferon after 24 h of Stimulation with whole-cell tularemia antigen and a tularemia enzyme-linked immunosorbent assay (ELISA) based on highly purified lipopolysaccharide antigen. Comparison of the kinetics of the two assays and those of the traditional tube agglutination test shows that the cellular immune response can be detected earlier by the Lymphocyte Stimulation assay. This test already shows a high proportion of positive results during the first week after the onset of the disease, may be applicable in everyday laboratory practice, and has the potential of changing routine diagnostics for tularemia. The new ELISA has a high sensitivity and becomes positive to a high degree during the second week of disease.
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Kinetics of immune response in tularemia : comparison between ELISA, tube agglutination and a novel whole blood Lymphocyte Stimulation test
2008Co-Authors: Henrik Eliasson, Per Olcén, Anders Sjöstedt, Margareta Jurstrand, Erik Bäck, Sören AnderssonAbstract:Kinetics of immune response in tularemia : comparison between ELISA, tube agglutination and a novel whole blood Lymphocyte Stimulation test
