The Experts below are selected from a list of 42 Experts worldwide ranked by ideXlab platform
Francis A Cucinotta - One of the best experts on this subject based on the ideXlab platform.
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analysis of the Lymphocytopoiesis dynamics in nonirradiated and irradiated humans a modeling approach
Radiation Research, 2014Co-Authors: Olga A Smirnova, Francis A CucinottaAbstract:In this work, a recently developed mathematical model of the lymphocytopoietic system in acutely irradiated humans was extended to predict the dynamics of this system both in nonirradiated and acutely/chronically irradiated humans. The mathematical implementation of this model is a system of nonlinear ordinary differential equations, whose variables and parameters have clear biological meaning. We demonstrate that the model is capable of reproducing the dynamic regimes that are typical for Lymphocytopoiesis in nonirradiated individuals with a hematological disorder (cyclic lymphocytopenia) and in patients receiving allogeneic stem cell transplantation. The model is also capable of predicting the dynamics of the lymphocytopoietic system in humans exposed to acute and chronic irradiation over a wide range of doses and dose rates. Additionally, the “lethal” dose rate of chronic irradiation, evaluated in the framework of the Lymphocytopoiesis model, agrees with the actual minimum dose rate of lethal chronic i...
Bernd Tibken - One of the best experts on this subject based on the ideXlab platform.
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chapter 7 biomathematical engineering of cell renewal systems an approach to a biomathematical model of Lymphocytopoiesis
Stem Cells, 1995Co-Authors: Eberhard P Hofer, Stefan Brucher, Karin Mehr, Bernd TibkenAbstract:Fundamental principles for the development of a biomathematical model of Lymphocytopoiesis are presented in this paper. The first step in this modeling approach is the definition of appropriate anatomical compartments in order to identify dominant locations of lymphocytes in the human body, and the definition of functional compartments in order to model different maturation stages. In the second step these compartment structures are combined, and thus form the basis of a dynamical model consisting of linear differential equations. Cell balance equations are used to derive the biomathematical dynamical model which is presented using the tools of modern systems theory. As a result of intensive discussions between engineers and medical doctors, our model of Lymphocytopoiesis consists of six anatomical and six functional compartments. Virtual marking technique plays a key role for the interpretation of the simulation results which are in solid agreement with biological observations. Future work is directed towards implementation of radiation damages in order to meet the final goal, namely, the evaluation of our model against the data derived from a group of chronically irradiated uranium miners.
Olga A Smirnova - One of the best experts on this subject based on the ideXlab platform.
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Modeling analysis of the Lymphocytopoiesis dynamics in chronically irradiated residents of Techa riverside villages
Radiation and Environmental Biophysics, 2014Co-Authors: Olga A Smirnova, Alexander V. Akleyev, Georgy P. DimovAbstract:A biologically motivated dynamical model of the lymphocytopoietic system in irradiated humans is applied here to analyze the data obtained under hematological examinations of residents of Techa riverside villages. Those people were exposed to chronic irradiation with varying dose rates, due to the radioactive contamination of the river basin by the Mayak Production Association. Modeling studies revealed the relationship between the dynamics of the lymphocytopoietic system in the examined individuals and the variation of dose rate over the considered period of time. It is found that the developed model is capable of reproducing the decreased level of blood lymphocyte concentration observed during the period of maximum radiation exposure, the recovery processes in the system observed during the period of decreasing dose rate, as well as the enhanced mitotic activity of bone marrow precursor cells in this hematopoietic lineage observed during the entire period under consideration. Mechanisms of these effects of chronic irradiation on the human lymphocytopoietic system are elucidated based on the applied model. The results obtained demonstrate the efficiency of the developed model in the analysis, investigation, and prediction of effects of chronic irradiation with varying dose rate on the human lymphocytopoietic system. In particular, the developed model can be used for predicting any radiation injury of this vital system in people exposed to chronic irradiation due to environmental radiological events, such as anthropogenic radiation accidents or radiological terroristic attacks.
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analysis of the Lymphocytopoiesis dynamics in nonirradiated and irradiated humans a modeling approach
Radiation Research, 2014Co-Authors: Olga A Smirnova, Francis A CucinottaAbstract:In this work, a recently developed mathematical model of the lymphocytopoietic system in acutely irradiated humans was extended to predict the dynamics of this system both in nonirradiated and acutely/chronically irradiated humans. The mathematical implementation of this model is a system of nonlinear ordinary differential equations, whose variables and parameters have clear biological meaning. We demonstrate that the model is capable of reproducing the dynamic regimes that are typical for Lymphocytopoiesis in nonirradiated individuals with a hematological disorder (cyclic lymphocytopenia) and in patients receiving allogeneic stem cell transplantation. The model is also capable of predicting the dynamics of the lymphocytopoietic system in humans exposed to acute and chronic irradiation over a wide range of doses and dose rates. Additionally, the “lethal” dose rate of chronic irradiation, evaluated in the framework of the Lymphocytopoiesis model, agrees with the actual minimum dose rate of lethal chronic i...
Eberhard P Hofer - One of the best experts on this subject based on the ideXlab platform.
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chapter 7 biomathematical engineering of cell renewal systems an approach to a biomathematical model of Lymphocytopoiesis
Stem Cells, 1995Co-Authors: Eberhard P Hofer, Stefan Brucher, Karin Mehr, Bernd TibkenAbstract:Fundamental principles for the development of a biomathematical model of Lymphocytopoiesis are presented in this paper. The first step in this modeling approach is the definition of appropriate anatomical compartments in order to identify dominant locations of lymphocytes in the human body, and the definition of functional compartments in order to model different maturation stages. In the second step these compartment structures are combined, and thus form the basis of a dynamical model consisting of linear differential equations. Cell balance equations are used to derive the biomathematical dynamical model which is presented using the tools of modern systems theory. As a result of intensive discussions between engineers and medical doctors, our model of Lymphocytopoiesis consists of six anatomical and six functional compartments. Virtual marking technique plays a key role for the interpretation of the simulation results which are in solid agreement with biological observations. Future work is directed towards implementation of radiation damages in order to meet the final goal, namely, the evaluation of our model against the data derived from a group of chronically irradiated uranium miners.
Karin Mehr - One of the best experts on this subject based on the ideXlab platform.
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chapter 7 biomathematical engineering of cell renewal systems an approach to a biomathematical model of Lymphocytopoiesis
Stem Cells, 1995Co-Authors: Eberhard P Hofer, Stefan Brucher, Karin Mehr, Bernd TibkenAbstract:Fundamental principles for the development of a biomathematical model of Lymphocytopoiesis are presented in this paper. The first step in this modeling approach is the definition of appropriate anatomical compartments in order to identify dominant locations of lymphocytes in the human body, and the definition of functional compartments in order to model different maturation stages. In the second step these compartment structures are combined, and thus form the basis of a dynamical model consisting of linear differential equations. Cell balance equations are used to derive the biomathematical dynamical model which is presented using the tools of modern systems theory. As a result of intensive discussions between engineers and medical doctors, our model of Lymphocytopoiesis consists of six anatomical and six functional compartments. Virtual marking technique plays a key role for the interpretation of the simulation results which are in solid agreement with biological observations. Future work is directed towards implementation of radiation damages in order to meet the final goal, namely, the evaluation of our model against the data derived from a group of chronically irradiated uranium miners.
