The Experts below are selected from a list of 279 Experts worldwide ranked by ideXlab platform
Angara Zambrano - One of the best experts on this subject based on the ideXlab platform.
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the effect of resveratrol on Cell viability in the burkitt s Lymphoma Cell line ramos
Molecules, 2017Co-Authors: Paola Jara, Johana Spies, Constanza Carcamo, Yennyfer Arancibia, Carolina Martin, Monica Salas, Carola Otth, Gabriela Vargas, Angara ZambranoAbstract:Resveratrol is a polyphenolic natural compound produced by a variety of crops. Currently, resveratrol is considered a multi-target anti-cancer agent with pleiotropic activity, including the ability to prevent the proliferation of malignant Cells by inhibiting angiogenesis and curtailing invasive and metastatic factors in many cancer models. However, the molecular mechanisms mediating resveratrol-specific effects on Lymphoma Cells remain unknown. To begin tackling this question, we treated the Burkitt’s Lymphoma Cell line Ramos with resveratrol and assessed Cell survival and gene expression. Our results suggest that resveratrol shows a significant anti-proliferative and pro-apoptotic activity on Ramos Cells, inducing the DNA damage response, DNA repairing, and modulating the expression of several genes that regulate the apoptotic process and their proliferative activity.
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The Effect of Resveratrol on Cell Viability in the Burkitt’s Lymphoma Cell Line Ramos
Molecules, 2017Co-Authors: Paola Jara, Johana Spies, Constanza Carcamo, Yennyfer Arancibia, Carolina Martin, Monica Salas, Carola Otth, Gabriela Vargas, Angara ZambranoAbstract:Resveratrol is a polyphenolic natural compound produced by a variety of crops. Currently, resveratrol is considered a multi-target anti-cancer agent with pleiotropic activity, including the ability to prevent the proliferation of malignant Cells by inhibiting angiogenesis and curtailing invasive and metastatic factors in many cancer models. However, the molecular mechanisms mediating resveratrol-specific effects on Lymphoma Cells remain unknown. To begin tackling this question, we treated the Burkitt’s Lymphoma Cell line Ramos with resveratrol and assessed Cell survival and gene expression. Our results suggest that resveratrol shows a significant anti-proliferative and pro-apoptotic activity on Ramos Cells, inducing the DNA damage response, DNA repairing, and modulating the expression of several genes that regulate the apoptotic process and their proliferative activity.
Paola Jara - One of the best experts on this subject based on the ideXlab platform.
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the effect of resveratrol on Cell viability in the burkitt s Lymphoma Cell line ramos
Molecules, 2017Co-Authors: Paola Jara, Johana Spies, Constanza Carcamo, Yennyfer Arancibia, Carolina Martin, Monica Salas, Carola Otth, Gabriela Vargas, Angara ZambranoAbstract:Resveratrol is a polyphenolic natural compound produced by a variety of crops. Currently, resveratrol is considered a multi-target anti-cancer agent with pleiotropic activity, including the ability to prevent the proliferation of malignant Cells by inhibiting angiogenesis and curtailing invasive and metastatic factors in many cancer models. However, the molecular mechanisms mediating resveratrol-specific effects on Lymphoma Cells remain unknown. To begin tackling this question, we treated the Burkitt’s Lymphoma Cell line Ramos with resveratrol and assessed Cell survival and gene expression. Our results suggest that resveratrol shows a significant anti-proliferative and pro-apoptotic activity on Ramos Cells, inducing the DNA damage response, DNA repairing, and modulating the expression of several genes that regulate the apoptotic process and their proliferative activity.
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The Effect of Resveratrol on Cell Viability in the Burkitt’s Lymphoma Cell Line Ramos
Molecules, 2017Co-Authors: Paola Jara, Johana Spies, Constanza Carcamo, Yennyfer Arancibia, Carolina Martin, Monica Salas, Carola Otth, Gabriela Vargas, Angara ZambranoAbstract:Resveratrol is a polyphenolic natural compound produced by a variety of crops. Currently, resveratrol is considered a multi-target anti-cancer agent with pleiotropic activity, including the ability to prevent the proliferation of malignant Cells by inhibiting angiogenesis and curtailing invasive and metastatic factors in many cancer models. However, the molecular mechanisms mediating resveratrol-specific effects on Lymphoma Cells remain unknown. To begin tackling this question, we treated the Burkitt’s Lymphoma Cell line Ramos with resveratrol and assessed Cell survival and gene expression. Our results suggest that resveratrol shows a significant anti-proliferative and pro-apoptotic activity on Ramos Cells, inducing the DNA damage response, DNA repairing, and modulating the expression of several genes that regulate the apoptotic process and their proliferative activity.
Thomas D Gilmore - One of the best experts on this subject based on the ideXlab platform.
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Inhibition of Oncogenic Transcription Factor REL by the Natural Product Derivative Calafianin Monomer 101 Induces Proliferation Arrest and Apoptosis in Human B-Lymphoma Cell Lines
Molecules (Basel Switzerland), 2015Co-Authors: Alan T. Yeo, John A. Porco, Spandan Chennamadhavuni, Adrian Whitty, Thomas D GilmoreAbstract:Increased activity of transcription factor NF-κB has been implicated in many B-Cell Lymphomas. We investigated effects of synthetic compound calafianin monomer (CM101) on biochemical and biological properties of NF-κB. In human 293 Cells, CM101 selectively inhibited DNA binding by overexpressed NF-κB subunits REL (human c-Rel) and p65 as compared to NF-κB p50, and inhibition of REL and p65 DNA binding by CM101 required a conserved cysteine residue. CM101 also inhibited DNA binding by REL in human B-Lymphoma Cell lines, and the sensitivity of several B-Lymphoma Cell lines to CM101-induced proliferation arrest and apoptosis correlated with levels of Cellular and nuclear REL. CM101 treatment induced both phosphorylation and decreased expression of anti-apoptotic protein Bcl-XL, a REL target gene product, in sensitive B-Lymphoma Cell lines. Ectopic expression of Bcl-XL protected SUDHL-2 B-Lymphoma Cells against CM101-induced apoptosis, and overexpression of a transforming mutant of REL decreased the sensitivity of BJAB B-Lymphoma Cells to CM101-induced apoptosis. Lipopolysaccharide-induced activation of NF-κB signaling upstream components occurred in RAW264.7 macrophages at CM101 concentrations that blocked NF-κB DNA binding. Direct inhibitors of REL may be useful for treating B-Cell Lymphomas in which REL is active, and may inhibit B-Lymphoma Cell growth at doses that do not affect some immune-related responses in normal Cells.
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a rearranged ep300 gene in the human b Cell Lymphoma Cell line rc k8 encodes a disabled transcriptional co activator that contributes to Cell growth and oncogenicity
Cancer Letters, 2011Co-Authors: Michael R Garbati, Ryan C Thompson, Leila Haery, Thomas D GilmoreAbstract:Human diffuse large B-Cell Lymphoma Cell line RC-K8 has an altered EP300 locus that encodes a C-terminally truncated histone acetyltransferase (HAT) protein (p300ΔC). We now show that p300ΔC contains 1047 N-terminal amino acids of p300 fused to 25 amino acids encoded by sequences from chromosome 6. Over-expressed p300ΔC localized to nuclear subdomains and interacted with transcription factor REL. p300ΔC did not function as a co-activator for REL-directed transactivation, and blocked the ability of wild-type p300 to enhance transcriptional activation by REL. Knock down of p300ΔC in RC-K8 Cells reduced their growth in both liquid culture and soft agar. Truncations of p300 were not found in eight other B-Lymphoma Cell lines. These results suggest that p300ΔC contributes to the oncogenic state of RC-K8 Cells by acting as a defective co-activator.
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The human B-Cell Lymphoma Cell line RC-K8 has multiple genetic alterations that dysregulate the Rel/NF-κB signal transduction pathway
Oncogene, 2002Co-Authors: Demetrios Kalaitzidis, R. Eric Davis, Andreas Rosenwald, Louis M. Staudt, Thomas D GilmoreAbstract:The human B-Cell Lymphoma Cell line RC-K8 has multiple genetic alterations that dysregulate the Rel/NF-κB signal transduction pathway
Constanza Carcamo - One of the best experts on this subject based on the ideXlab platform.
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the effect of resveratrol on Cell viability in the burkitt s Lymphoma Cell line ramos
Molecules, 2017Co-Authors: Paola Jara, Johana Spies, Constanza Carcamo, Yennyfer Arancibia, Carolina Martin, Monica Salas, Carola Otth, Gabriela Vargas, Angara ZambranoAbstract:Resveratrol is a polyphenolic natural compound produced by a variety of crops. Currently, resveratrol is considered a multi-target anti-cancer agent with pleiotropic activity, including the ability to prevent the proliferation of malignant Cells by inhibiting angiogenesis and curtailing invasive and metastatic factors in many cancer models. However, the molecular mechanisms mediating resveratrol-specific effects on Lymphoma Cells remain unknown. To begin tackling this question, we treated the Burkitt’s Lymphoma Cell line Ramos with resveratrol and assessed Cell survival and gene expression. Our results suggest that resveratrol shows a significant anti-proliferative and pro-apoptotic activity on Ramos Cells, inducing the DNA damage response, DNA repairing, and modulating the expression of several genes that regulate the apoptotic process and their proliferative activity.
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The Effect of Resveratrol on Cell Viability in the Burkitt’s Lymphoma Cell Line Ramos
Molecules, 2017Co-Authors: Paola Jara, Johana Spies, Constanza Carcamo, Yennyfer Arancibia, Carolina Martin, Monica Salas, Carola Otth, Gabriela Vargas, Angara ZambranoAbstract:Resveratrol is a polyphenolic natural compound produced by a variety of crops. Currently, resveratrol is considered a multi-target anti-cancer agent with pleiotropic activity, including the ability to prevent the proliferation of malignant Cells by inhibiting angiogenesis and curtailing invasive and metastatic factors in many cancer models. However, the molecular mechanisms mediating resveratrol-specific effects on Lymphoma Cells remain unknown. To begin tackling this question, we treated the Burkitt’s Lymphoma Cell line Ramos with resveratrol and assessed Cell survival and gene expression. Our results suggest that resveratrol shows a significant anti-proliferative and pro-apoptotic activity on Ramos Cells, inducing the DNA damage response, DNA repairing, and modulating the expression of several genes that regulate the apoptotic process and their proliferative activity.
Gabriela Vargas - One of the best experts on this subject based on the ideXlab platform.
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the effect of resveratrol on Cell viability in the burkitt s Lymphoma Cell line ramos
Molecules, 2017Co-Authors: Paola Jara, Johana Spies, Constanza Carcamo, Yennyfer Arancibia, Carolina Martin, Monica Salas, Carola Otth, Gabriela Vargas, Angara ZambranoAbstract:Resveratrol is a polyphenolic natural compound produced by a variety of crops. Currently, resveratrol is considered a multi-target anti-cancer agent with pleiotropic activity, including the ability to prevent the proliferation of malignant Cells by inhibiting angiogenesis and curtailing invasive and metastatic factors in many cancer models. However, the molecular mechanisms mediating resveratrol-specific effects on Lymphoma Cells remain unknown. To begin tackling this question, we treated the Burkitt’s Lymphoma Cell line Ramos with resveratrol and assessed Cell survival and gene expression. Our results suggest that resveratrol shows a significant anti-proliferative and pro-apoptotic activity on Ramos Cells, inducing the DNA damage response, DNA repairing, and modulating the expression of several genes that regulate the apoptotic process and their proliferative activity.
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The Effect of Resveratrol on Cell Viability in the Burkitt’s Lymphoma Cell Line Ramos
Molecules, 2017Co-Authors: Paola Jara, Johana Spies, Constanza Carcamo, Yennyfer Arancibia, Carolina Martin, Monica Salas, Carola Otth, Gabriela Vargas, Angara ZambranoAbstract:Resveratrol is a polyphenolic natural compound produced by a variety of crops. Currently, resveratrol is considered a multi-target anti-cancer agent with pleiotropic activity, including the ability to prevent the proliferation of malignant Cells by inhibiting angiogenesis and curtailing invasive and metastatic factors in many cancer models. However, the molecular mechanisms mediating resveratrol-specific effects on Lymphoma Cells remain unknown. To begin tackling this question, we treated the Burkitt’s Lymphoma Cell line Ramos with resveratrol and assessed Cell survival and gene expression. Our results suggest that resveratrol shows a significant anti-proliferative and pro-apoptotic activity on Ramos Cells, inducing the DNA damage response, DNA repairing, and modulating the expression of several genes that regulate the apoptotic process and their proliferative activity.
